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Protein Page:
DAZL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DAZL RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts. Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2. Testis specific. Belongs to the RRM DAZ family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Translation
Chromosomal Location of Human Ortholog: 3p24.3
Cellular Component: polysome; cytoplasm; nucleus
Molecular Function: identical protein binding; protein binding; translation activator activity; mRNA 3'-UTR binding; RNA binding; nucleotide binding
Biological Process: positive regulation of translational initiation; positive regulation of meiosis; multicellular organismal development; spermatogenesis; germ cell development
Reference #:  Q92904 (UniProtKB)
Alt. Names/Synonyms: DAZ homolog; DAZ-like autosomal; DAZH; DAZL; DAZL1; DAZLA; Deleted in azoospermia-like; Deleted in azoospermia-like 1; deleted in azoospermia-like autosomal; germline specific RNA binding protein; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; SPGYLA
Gene Symbols: DAZL
Molecular weight: 33,178 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DAZL

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsTANPETP
0 1 S65 SFFARYGSVkEVKII
0 9 K67-ub FARYGSVkEVKIITD
0 7 K109-ub NFHGKKLkLGPAIRK
0 1 Y276 SVVTQDDYFKDKRVH
  mouse

 
S2 ______MSATTSEAP
S65-p SFFARYGsVKEVKII
K67 FARYGsVKEVKIITD
K109 NFHGKKLKLGPAIRK
Y276-p SLVTQDDyFKDKRVH
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