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Protein Page:
SLC20A1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SLC20A1 Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family
Cellular Component: membrane; integral to plasma membrane; plasma membrane
Molecular Function: signal transducer activity; high affinity inorganic phosphate:sodium symporter activity; receptor activity; sodium:phosphate symporter activity; inorganic phosphate transmembrane transporter activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transport; ion transport; signal transduction; phosphate metabolic process; transmembrane transport
Reference #:  Q8WUM9 (UniProtKB)
Alt. Names/Synonyms: DKFZp686J2397; FLJ41426; Gibbon ape leukemia virus receptor 1; GLVR-1; GLVR1; Leukemia virus receptor 1 homolog; Phosphate transporter 1; PiT-1; PIT1; S20A1; SLC20A1; Sodium-dependent phosphate transporter 1; solute carrier family 20 (phosphate transporter), member 1; Solute carrier family 20 member 1
Gene Symbols: SLC20A1
Molecular weight: 73,700 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC20A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 C264 KIEREIKCsPsEsPL
0 10 S265-p IEREIKCsPsEsPLM
0 3 S267-p REIKCsPsEsPLMEK
0 16 S269-p IKCsPsEsPLMEKKN
0 2 S277-p PLMEKKNsLkEDHEE
0 2 K279-u MEKKNsLkEDHEETk
0 1 K286-u kEDHEETkLsVGDIE
0 2 S288-p DHEETkLsVGDIENk
0 1 K295-u sVGDIENkHPVSEVG
0 4 K320-u EERTVSFkLGDLEEA
0 103 S335-p PERERLPsVDLKEET
0 3 Y376-p QINSSGHyQyHTVHK
0 2 Y378-p NSSGHyQyHTVHKDS
0 80 Y388-p VHKDSGLykELLHkL
0 31 K389-u HKDSGLykELLHkLH
0 2 K394-u LykELLHkLHLAKVG
0 21 S417-p KPLRRNNsyTsyTMA
0 3 Y418-p PLRRNNsyTsyTMAI
0 2 S420-p RRNNsyTsyTMAICG
0 5 Y421-p RNNsyTsyTMAICGM
0 1 K436-u PLDSFRAkEGEQkGE
0 1 K441-u RAkEGEQkGEEMEkL
0 1 K447-u QkGEEMEkLTWPNAD
0 1 K456-u TWPNADSkKRIRMDs
0 118 S463-p kKRIRMDsytsyCNA
0 22 Y464-p KRIRMDsytsyCNAV
0 14 T465-p RIRMDsytsyCNAVS
0 18 S466-p IRMDsytsyCNAVSD
0 10 Y467-p RMDsytsyCNAVSDL
0 6 S476-p NAVSDLHsAsEIDMS
0 24 S478-p VSDLHsAsEIDMSVK
  mouse

► Hide Isoforms
 
S268-p KIEREVKssPsEsPL
S269-p IEREVKssPsEsPLM
S271-p REVKssPsEsPLMEK
S273-p VKssPsEsPLMEKKS
N281 PLMEKKSNLKEDHEE
K283 MEKKSNLKEDHEETK
K290 KEDHEETKMAPGDVE
A292 DHEETKMAPGDVEHR
R299 APGDVEHRNPVSEVV
K324-u EERTVSFkLGDLEEA
- gap
Y379 QINSSGHYQYHTVHK
Y381 NSSGHYQYHTVHKDS
Y391 VHKDSGLYkELLHKL
K392-u HKDSGLYkELLHKLH
K397 LYkELLHKLHLAKVG
S420-p KPLRRNNsyTSYTMA
Y421-p PLRRNNsyTSYTMAI
S423 RRNNsyTSYTMAICG
Y424 RNNsyTSYTMAICGM
K439 PLDSFRAKEGEQKGD
K444 RAKEGEQKGDEMETL
T450 QKGDEMETLTWPNAD
K459 TWPNADTKKRIRMDs
S466-p KKRIRMDsYTSYCNA
Y467 KRIRMDsYTSYCNAV
T468 RIRMDsYTSYCNAVS
S469 IRMDsYTSYCNAVSD
Y470 RMDsYTSYCNAVSDL
S479 NAVSDLHSESEMDMS
S481 VSDLHSESEMDMSVK
  SLC20A1 iso4  
S265-p KIERDIKssPSEsPL
S266-p IERDIKssPSEsPLM
S268 RDIKssPSEsPLMEK
S270-p IKssPSEsPLMEKKC
S278 PLMEKKCSLKEDHEE
K280 MEKKCSLKEDHEETK
K287 KEDHEETKLSLGDAE
S289 DHEETKLSLGDAENR
R296 SLGDAENRSPASEVG
K321 EERTVSFKLGDLEEA
- gap
Y377 QVNSSGHYQYHTVHK
Y379 NSSGHYQYHTVHKDS
Y389 VHKDSGLYKELLHKL
K390 HKDSGLYKELLHKLH
K395 LYKELLHKLHLAKVG
S418 KPLRRNNSYTSYTMA
Y419 PLRRNNSYTSYTMAI
S421 RRNNSYTSYTMAICG
Y422 RNNSYTSYTMAICGM
K437 PLDPFRAKEGEQKGE
K442 RAKEGEQKGEEMEKL
K448 QKGEEMEKLTWPNTD
K457 TWPNTDTKKRIRMDS
S464 KKRIRMDSYTSYCNA
Y465 KRIRMDSYTSYCNAV
T466 RIRMDSYTSYCNAVS
S467 IRMDSYTSYCNAVSE
Y468 RMDSYTSYCNAVSEL
S477 NAVSELHSASEMDMS
S479 VSELHSASEMDMSIK
  rat

 
S268 KIEREVKSSPSESPL
S269 IEREVKSSPSESPLM
S271 REVKSSPSESPLMEK
S273 VKSSPSESPLMEKKN
N281 PLMEKKNNLKDHEET
K283 MEKKNNLKDHEETKM
K289 LKDHEETKMAPGDVE
A291 DHEETKMAPGDVENR
R298 APGDVENRNPVSEVV
K323 EERTVSFKLGDLEEA
- gap
Y378 QINSSGHYQYHTVHK
Y380 NSSGHYQYHTVHKDS
Y390 VHKDSGLYkELLHKL
K391-u HKDSGLYkELLHKLH
K396 LYkELLHKLHLAKVG
S419 KPLRRNNSYTSYTMA
Y420 PLRRNNSYTSYTMAI
S422 RRNNSYTSYTMAICG
Y423 RNNSYTSYTMAICGM
K438 PLDSFRAKEGEQKGD
K443 RAKEGEQKGDEMETL
T449 QKGDEMETLTWPNAD
K458 TWPNADTKKRIRMDS
S465 KKRIRMDSYTSYCNA
Y466 KRIRMDSYTSYCNAV
T467 RIRMDSYTSYCNAVS
S468 IRMDSYTSYCNAVSD
Y469 RMDSYTSYCNAVSDL
S478 NAVSDLHSESEMDMS
S480 VSDLHSESEMDMSVK
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