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Protein Page:
TUBB3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TUBB3 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: microtubule; axon; cytoplasm
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton; peptide binding
Biological Process: protein polymerization; mitosis; axon guidance; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; microtubule-based process
Reference #:  Q13509 (UniProtKB)
Alt. Names/Synonyms: beta-4; CFEOM3A; MC1R; TBB3; TUBB3; TUBB4; Tubulin beta-3 chain; tubulin beta-4; Tubulin beta-4 chain; Tubulin beta-III; tubulin, beta 3; tubulin, beta, 4
Gene Symbols: TUBB3
Molecular weight: 50,433 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TUBB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K19-a CGNQIGAkFWEVISD
0 1 S48 DLQLERISVYYNEAS
0 4 K58-u YNEASSHkYVPRAIL
0 1 K58-a YNEASSHkYVPRAIL
0 2 T72-p LVDLEPGtMDsVRSG
0 7 S75-p LEPGtMDsVRSGAFG
0 133 Y106-p NNWAKGHytEGAELV
1 8 T107-p NWAKGHytEGAELVD
0 4 S115-p EGAELVDsVLDVVRK
0 1 T149-p GTGSGMGtLLISKVr
0 3 R156-m1 tLLISKVrEEYPDRI
0 2 S168-p DRIMNTFsVVPsPKV
0 11 S172-p NTFsVVPsPKVSDTV
0 171 Y208-p CIDNEALyDICFRTL
0 9 K216-u DICFRTLkLATPTYG
0 83 K252-u QLNADLRkLAVNMVP
0 2 T274 MPGFAPLTARGSQQY
0 12 K297-u TQQMFDAkNMMAACD
0 1 Y310-p CDPRHGRyLtVAtVF
0 3 T312-p PRHGRyLtVAtVFRG
0 2 T315-p GRyLtVAtVFRGRMs
0 2 S322-p tVFRGRMsMkEVDEQ
0 2 K324-u FRGRMsMkEVDEQML
0 6 S338-p LAIQSKNsSyFVEWI
0 359 Y340-p IQSKNsSyFVEWIPN
0 10 K362-u DIPPRGLkMsSTFIG
0 2 S364-p PPRGLkMsSTFIGNS
0 23 K379-a TAIQELFkRIsEQFT
0 3 K379-u TAIQELFkRIsEQFT
0 2 S382-p QELFkRIsEQFTAMF
0 3 K392-u FTAMFRRkAFLHWYT
0 5 Y425-p LVSEYQQyQDATAEE
2 2 S444 YEDDEEESEAQGPK_
  mouse

 
K19 CGNQIGAKFWEVISD
S48-p DLQLERIsVYYNEAS
K58-u YNEASSHkYVPRAIL
K58 YNEASSHKYVPRAIL
T72-p LVDLEPGtMDsVRSG
S75-p LEPGtMDsVRSGAFG
Y106-p NNWAKGHytEGAELV
T107-p NWAKGHytEGAELVD
S115-p EGAELVDsVLDVVRK
T149 GTGSGMGTLLISKVr
R156-m1 TLLISKVrEEYPDRI
S168-p DRIMNTFsVVPsPKV
S172-p NTFsVVPsPKVSDTV
Y208-p CIDNEALyDICFRTL
K216-u DICFRTLkLATPTYG
K252-u QLNADLRkLAVNMVP
T274-p MPGFAPLtARGSQQY
K297-u TQQMFDAkNMMAACD
Y310 CDPRHGRYLtVAtVF
T312-p PRHGRYLtVAtVFRG
T315-p GRYLtVAtVFRGRMS
S322 tVFRGRMSMkEVDEQ
K324-u FRGRMSMkEVDEQML
S338 LAIQSKNSSyFVEWI
Y340-p IQSKNSSyFVEWIPN
K362-u DIPPRGLkMSSTFIG
S364 PPRGLkMSSTFIGNS
K379-a TAIQELFkRIsEQFT
K379-u TAIQELFkRIsEQFT
S382-p QELFkRIsEQFTAMF
K392 FTAMFRRKAFLHWYT
Y425 LVSEYQQYQDATAEE
S444-p YEDDDEEsEAQGPK_
  rat

 
K19 CGNQIGAKFWEVISD
S48 DLQLERISVYYNEAS
K58-u YNEASSHkYVPRAIL
K58 YNEASSHKYVPRAIL
T72 LVDLEPGTMDSVRSG
S75 LEPGTMDSVRSGAFG
Y106-p NNWAKGHyTEGAELV
T107 NWAKGHyTEGAELVD
S115 EGAELVDSVLDVVRK
T149 GTGSGMGTLLISKVR
R156 TLLISKVREEYPDRI
S168 DRIMNTFSVVPSPKV
S172 NTFSVVPSPKVSDTV
Y208 CIDNEALYDICFRTL
K216-u DICFRTLkLATPTYG
K252 QLNADLRKLAVNMVP
T274 MPGFAPLTARGSQQY
K297 TQQMFDAKNMMAACD
Y310 CDPRHGRYLTVATVF
T312 PRHGRYLTVATVFRG
T315 GRYLTVATVFRGRMS
S322 TVFRGRMSMKEVDEQ
K324 FRGRMSMKEVDEQML
S338 LAIQSKNSSyFVEWI
Y340-p IQSKNSSyFVEWIPN
K362-u DIPPRGLkMSSTFIG
S364 PPRGLkMSSTFIGNS
K379-a TAIQELFkRISEQFT
K379 TAIQELFKRISEQFT
S382 QELFkRISEQFTAMF
K392 FTAMFRRKAFLHWYT
Y425 LVSEYQQYQDATAEE
S444-p YEDDDEEsEAQGPK_
  cow

 
K19 CGNQIGAKFWEVISD
S48 DLQLERISVYYNEAS
K58 YNEASSHKYVPRAIL
K58 YNEASSHKYVPRAIL
T72 LVDLEPGTMDSVRSG
S75 LEPGTMDSVRSGAFG
Y106 NNWAKGHYtEGAELV
T107-p NWAKGHYtEGAELVD
S115 EGAELVDSVLDVVRK
T149 GTGSGMGTLLISKVR
R156 TLLISKVREEYPDRI
S168 DRIMNTFSVVPSPKV
S172 NTFSVVPSPKVSDTV
Y208 CIDNEALYDICFRTL
K216 DICFRTLKLATPTYG
K252 QLNADLRKLAVNMVP
T274 MPGFAPLTARGSQQY
K297 TQQMFDAKNMMAACD
Y310 CDPRHGRYLTVATVF
T312 PRHGRYLTVATVFRG
T315 GRYLTVATVFRGRMS
S322 TVFRGRMSMKEVDEQ
K324 FRGRMSMKEVDEQML
S338 LAIQSKNSSYFVEWI
Y340 IQSKNSSYFVEWIPN
K362 DIPPRGLKMSSTFIG
S364 PPRGLKMSSTFIGNS
K379 TAIQELFKRISEQFT
K379 TAIQELFKRISEQFT
S382 QELFKRISEQFTAMF
K392 FTAMFRRKAFLHWYT
Y425 LVSEYQQYQDATAEE
S444 YEDDEEESEAQGPK_
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