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TUBB3 (human)

Overview TUBB3 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: microtubule cytoskeleton; microtubule; axon; cytoplasm; plasma membrane Molecular Function: GTPase activity; GTP binding; structural molecule activity; peptide binding Biological Process: protein polymerization; mitosis; axon guidance; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; microtubule-based movement Reference #:  Q13509 (UniProtKB) Alt. Names/Synonyms: beta-4; CFEOM3A; MC1R; TBB3; TUBB3; TUBB4; Tubulin beta-3 chain; tubulin beta-4; Tubulin beta-4 chain; Tubulin beta-III; tubulin, beta 3; tubulin, beta, 4 Gene Symbols: TUBB3 Molecular weight: 50,433 Da Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TUBB3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K19-a	CGNQIGAkFWEVISD
0	1		K19-m2	CGNQIGAkFWEVISD
0	1		S48	DLQLERISVYYNEAS
0	4		K58-u	YNEASSHkYVPRAIL
0	1		K58-a	YNEASSHkYVPRAIL
0	6		S75-p	LEPGTMDsVRSGAFG
0	1		K103-u	GAGNNWAkGHytEGA
0	133		Y106-p	NNWAkGHytEGAELV
1	8		T107-p	NWAkGHytEGAELVD
0	4		S115-p	EGAELVDsVLDVVRK
0	1		T149-p	GTGSGMGtLLISKVr
0	3		R156-m1	tLLISKVrEEYPDRI
0	10		S172-p	NTFSVVPsPKVSDTV
0	171		Y208-p	CIDNEALyDICFRTL
0	9		K216-u	DICFRTLkLATPTYG
0	1		Y222	LkLATPTYGDLNHLV
0	1		K252	QLNADLRKLAVNMVP
0	83		K252-u	QLNADLRkLAVNMVP
0	2		T274	MPGFAPLTARGSQQY
0	1		T290	ALTVPELTQQMFDAk
0	1		K297-a	TQQMFDAkNMMAACD
0	12		K297-u	TQQMFDAkNMMAACD
0	1		Y310-p	CDPRHGRyLtVAtVF
0	3		T312-p	PRHGRyLtVAtVFRG
0	2		T315-p	GRyLtVAtVFRGRMs
0	2		S322-p	tVFRGRMsMkEVDEQ
0	2		K324-u	FRGRMsMkEVDEQML
0	6		S338-p	LAIQSKNsSyFVEWI
0	359		Y340-p	IQSKNsSyFVEWIPN
0	10		K362-u	DIPPRGLkMssTFIG
0	2		S364-p	PPRGLkMssTFIGNS
0	1		S365-p	PRGLkMssTFIGNST
0	23		K379-a	TAIQELFkRIsEQFT
0	3		K379-u	TAIQELFkRIsEQFT
0	2		S382-p	QELFkRIsEQFTAMF
0	3		K392-u	FTAMFRRkAFLHWYT
0	5		Y425-p	LVSEYQQyQDATAEE
0	1		Y437-p	AEEEGEMyEDDEEES
2	2		S444	yEDDEEESEAQGPK_

	mouse
K19	CGNQIGAKFWEVISD
K19	CGNQIGAKFWEVISD
S48-p	DLQLERIsVYYNEAS
K58-u	YNEASSHkYVPRAIL
K58	YNEASSHKYVPRAIL
S75-p	LEPGTMDsVRSGAFG
K103	GAGNNWAKGHytEGA
Y106-p	NNWAKGHytEGAELV
T107-p	NWAKGHytEGAELVD
S115-p	EGAELVDsVLDVVRK
T149	GTGSGMGTLLISKVr
R156-m1	TLLISKVrEEYPDRI
S172-p	NTFSVVPsPKVSDTV
Y208-p	CIDNEALyDICFRTL
K216-u	DICFRTLkLATPTyG
Y222-p	LkLATPTyGDLNHLV
K252-a	QLNADLRkLAVNMVP
K252-u	QLNADLRkLAVNMVP
T274-p	MPGFAPLtARGSQQY
T290	ALTVPELTQQMFDAk
K297	TQQMFDAKNMMAACD
K297-u	TQQMFDAkNMMAACD
Y310	CDPRHGRYLtVAtVF
T312-p	PRHGRYLtVAtVFRG
T315-p	GRYLtVAtVFRGRMS
S322	tVFRGRMSMkEVDEQ
K324-u	FRGRMSMkEVDEQML
S338	LAIQSKNSSyFVEWI
Y340-p	IQSKNSSyFVEWIPN
K362-u	DIPPRGLkMSSTFIG
S364	PPRGLkMSSTFIGNS
S365	PRGLkMSSTFIGNST
K379-a	TAIQELFkRIsEQFT
K379-u	TAIQELFkRIsEQFT
S382-p	QELFkRIsEQFTAMF
K392	FTAMFRRKAFLHWYT
Y425	LVSEYQQYQDATAEE
Y437	AEEEGEMYEDDDEEs
S444-p	YEDDDEEsEAQGPK_

	rat
K19	CGNQIGAKFWEVISD
K19	CGNQIGAKFWEVISD
S48	DLQLERISVYYNEAS
K58-u	YNEASSHkYVPRAIL
K58	YNEASSHKYVPRAIL
S75	LEPGTMDSVRSGAFG
K103	GAGNNWAKGHyTEGA
Y106-p	NNWAKGHyTEGAELV
T107	NWAKGHyTEGAELVD
S115	EGAELVDSVLDVVRK
T149	GTGSGMGTLLISKVR
R156	TLLISKVREEYPDRI
S172	NTFSVVPSPKVSDTV
Y208	CIDNEALYDICFRTL
K216-u	DICFRTLkLATPTYG
Y222	LkLATPTYGDLNHLV
K252	QLNADLRKLAVNMVP
K252	QLNADLRKLAVNMVP
T274	MPGFAPLTARGSQQY
T290-p	ALTVPELtQQMFDAK
K297	tQQMFDAKNMMAACD
K297	tQQMFDAKNMMAACD
Y310	CDPRHGRYLTVATVF
T312	PRHGRYLTVATVFRG
T315	GRYLTVATVFRGRMS
S322	TVFRGRMSMKEVDEQ
K324	FRGRMSMKEVDEQML
S338	LAIQSKNSSyFVEWI
Y340-p	IQSKNSSyFVEWIPN
K362-u	DIPPRGLkMSSTFIG
S364	PPRGLkMSSTFIGNS
S365	PRGLkMSSTFIGNST
K379-a	TAIQELFkRISEQFT
K379	TAIQELFKRISEQFT
S382	QELFkRISEQFTAMF
K392	FTAMFRRKAFLHWYT
Y425	LVSEYQQYQDATAEE
Y437	AEEEGEMYEDDDEEs
S444-p	YEDDDEEsEAQGPK_

	cow
K19	CGNQIGAKFWEVISD
K19	CGNQIGAKFWEVISD
S48	DLQLERISVYYNEAS
K58	YNEASSHKYVPRAIL
K58	YNEASSHKYVPRAIL
S75	LEPGTMDSVRSGAFG
K103	GAGNNWAKGHYtEGA
Y106	NNWAKGHYtEGAELV
T107-p	NWAKGHYtEGAELVD
S115	EGAELVDSVLDVVRK
T149	GTGSGMGTLLISKVR
R156	TLLISKVREEYPDRI
S172	NTFSVVPSPKVSDTV
Y208	CIDNEALYDICFRTL
K216	DICFRTLKLATPTYG
Y222	LKLATPTYGDLNHLV
K252	QLNADLRKLAVNMVP
K252	QLNADLRKLAVNMVP
T274	MPGFAPLTARGSQQY
T290	ALTVPELTQQMFDAK
K297	TQQMFDAKNMMAACD
K297	TQQMFDAKNMMAACD
Y310	CDPRHGRYLTVATVF
T312	PRHGRYLTVATVFRG
T315	GRYLTVATVFRGRMS
S322	TVFRGRMSMKEVDEQ
K324	FRGRMSMKEVDEQML
S338	LAIQSKNSSYFVEWI
Y340	IQSKNSSYFVEWIPN
K362	DIPPRGLKMSSTFIG
S364	PPRGLKMSSTFIGNS
S365	PRGLKMSSTFIGNST
K379	TAIQELFKRISEQFT
K379	TAIQELFKRISEQFT
S382	QELFKRISEQFTAMF
K392	FTAMFRRKAFLHWYT
Y425	LVSEYQQYQDATAEE
Y437	AEEEGEMYEDDEEES
S444	YEDDEEESEAQGPK_

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