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DAP (human)

Overview DAP a 15 kDa, proline rich protein that possesses one SH3 binding motif. Negatively regulates autophagy and is involved in mediating interferon-gamma-induced cell death. Localizes in the cytoplasm, but the detailed mechanism of its proapoptotic function is unclear. Note: This description may include information from UniProtKB. Protein type: Autophagy Biological Process: caspase activation; negative regulation of autophagy; apoptosis; inhibition of NF-kappaB transcription factor; cellular response to amino acid starvation; autophagy; negative regulation of transcription, DNA-dependent Reference #:  P51397 (UniProtKB) Alt. Names/Synonyms: DAP; DAP-1; DAP1; death-associated protein; Death-associated protein 1; MGC99796 Gene Symbols: DAP Molecular weight: 11,165 Da Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DAP

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	Sites Implicated In
autophagy, altered: S3‑p, S51‑p inhibition: S3‑p, S51‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2	______MSsPPEGKL
1	1		S3-p	_____MSsPPEGKLE
0	1		K20-a	AGHPPAVkAGGMRIV
0	1		K29-u	GGMRIVQkHPHTGDT
0	1		K37	HPHTGDTKEEKDKDD
0	9		S49-p	KDDQEWEsPsPPKPt
0	8		P50	DDQEWEsPsPPKPtV
1	17		S51-p	DQEWEsPsPPKPtVF
0	2		T56-p	sPsPPKPtVFISGVI
0	1		S85-p	AHQKPHAsMDKHPsP
0	4		S91-p	AsMDKHPsPRTQHIQ

	mouse
S2-p	______MsSPPEGKL
S3	_____MsSPPEGKLE
K20	AGHPPAVKAGGMRIV
K29	GGMRIVQKHPHTGDG
K37-a	HPHTGDGkEERDKDD
S49-p	KDDQEWEstsPPKPt
T50-p	DDQEWEstsPPKPtV
S51-p	DQEWEstsPPKPtVF
T56-p	stsPPKPtVFISGVI
S85	AHQKPHASMDKHVsP
S91-p	ASMDKHVsPRTQHIQ

	rat
S2	______MSSPPEGKL
S3	_____MSSPPEGKLE
K20	AGHPPAVKVAGIRIV
K29	AGIRIVQKHPHTGDG
K37	HPHTGDGKEKKDKDD
S49	KDDQEWEStsPPKPT
T50-p	DDQEWEStsPPKPTV
S51-p	DQEWEStsPPKPTVY
T56	StsPPKPTVYISGVI
S85	AHQKPHASMDKHVSP
S91	ASMDKHVSPRTQHIQ

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