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Protein Page:
DAP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DAP a 15 kDa, proline rich protein that possesses one SH3 binding motif. Negatively regulates autophagy and is involved in mediating interferon-gamma-induced cell death. Localizes in the cytoplasm, but the detailed mechanism of its proapoptotic function is unclear. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Biological Process: caspase activation; negative regulation of autophagy; inhibition of NF-kappaB transcription factor; apoptosis; cellular response to amino acid starvation; autophagy; negative regulation of transcription, DNA-dependent
Reference #:  P51397 (UniProtKB)
Alt. Names/Synonyms: DAP; DAP-1; DAP1; death-associated protein; Death-associated protein 1; MGC99796
Gene Symbols: DAP
Molecular weight: 11,165 Da
Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DAP

Protein Structure Not Found.


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Sites Implicated In
autophagy, altered: S3‑p, S51‑p
activity, inhibited: S3‑p, S51‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S2 ______MSsPPEGKL
2 2 S3-p _____MSsPPEGKLE
0 1 K29-u GGMRIVQkHPHTGDT
1 11 S49-p KDDQEWEsPsPPKPt
0 8 P50 DDQEWEsPsPPKPtV
2 20 S51-p DQEWEsPsPPKPtVF
0 2 T56-p sPsPPKPtVFISGVI
0 1 S85-p AHQKPHAsMDKHPsP
0 4 S91-p AsMDKHPsPRTQHIQ
  DAP iso3  
S2 ______MSSPPEGKL
S3 _____MSSPPEGKLE
K29 GGMRIVQKHPHTGDT
S49-p KDDQEWEsPRVTKIS
P50 DDQEWEsPRVTKISP
- gap
- gap
- gap
- gap
  mouse

 
S2-p ______MsSPPEGKL
S3 _____MsSPPEGKLE
K29 GGMRIVQKHPHTGDG
S49-p KDDQEWEstsPPKPt
T50-p DDQEWEstsPPKPtV
S51-p DQEWEstsPPKPtVF
T56-p stsPPKPtVFISGVI
S85 AHQKPHASMDKHVsP
S91-p ASMDKHVsPRTQHIQ
  rat

 
S2 ______MSSPPEGKL
S3 _____MSSPPEGKLE
K29 AGIRIVQKHPHTGDG
S49 KDDQEWEStsPPKPT
T50-p DDQEWEStsPPKPTV
S51-p DQEWEStsPPKPTVY
T56 StsPPKPTVYISGVI
S85 AHQKPHASMDKHVSP
S91 ASMDKHVSPRTQHIQ
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