Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
LSP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
LSP1 May play a role in mediating neutrophil activation and chemotaxis. Binds actin. Activated T-lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein
Cellular Component: plasma membrane; actin cytoskeleton
Molecular Function: signal transducer activity; actin binding
Biological Process: cellular defense response; cell motility; chemotaxis
Reference #:  P33241 (UniProtKB)
Alt. Names/Synonyms: 47 kDa actin binding protein; 47 kDa actin-binding protein; 52 kDa phosphoprotein; F-actin binding and cytoskeleton associated protein; leufactin (leukocyte F-actin binding protein); leukocyte-specific protein 1; LSP1; Lymphocyte-specific antigen WP34; Lymphocyte-specific protein 1; lymphocyte-specific protein pp52; pp52; WP34
Gene Symbols: LSP1
Molecular weight: 37,192 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LSP1
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
intracellular localization: S252‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S6-p __MAEASsDPGAEER
0 3 V55 DEEGGGHVPERPkQE
0 1 K60-u GHVPERPkQEMLLSL
0 1 S66 PkQEMLLSLkPSEAP
0 23 K68-u QEMLLSLkPSEAPEL
0 2 P69 EMLLSLkPSEAPELD
0 1 S85 DEGFGDWSQRPEQRQ
0 1 S111-p GEPPQCRsPEGEQED
0 1 Y125-p DRPGLHAyEKEDsDE
0 2 S130-p HAyEKEDsDEVHLEE
0 1 S139-p EVHLEELsLsKEGPG
0 1 S141-p HLEELsLsKEGPGPE
0 2 - gap
0 20 T175-p QKCQQPRtPsPLVLE
0 22 S177-p CQQPRtPsPLVLEGt
0 6 T184-p sPLVLEGtIEQssPP
0 4 S188-p LEGtIEQssPPLsPt
0 17 S189-p EGtIEQssPPLsPtt
0 14 S193-p EQssPPLsPttKLID
0 2 T195-p ssPPLsPttKLIDRT
0 5 T196-p sPPLsPttKLIDRTE
1 6 S204-p KLIDRTEsLNRSIEK
0 2 S218-p KSNSVKKsQPDLPIS
0 1 K226-u QPDLPISkIDQWLEQ
0 9 Y234-p IDQWLEQytQAIETA
0 1 T235-p DQWLEQytQAIETAG
0 3 T244-p AIETAGRtPKLARQA
0 7 A248 AGRtPKLARQAsIEL
2 179 S252-p PKLARQAsIELPSMA
0 2 S257 QAsIELPSMAVASTK
0 1 S265-p MAVASTKsRWEtGEV
0 1 T269-p STKsRWEtGEVQAQS
0 1 S282-p QSAAKTPsCKDIVAG
0 1 K300 KKSLWEQKGGSKTSS
0 1 K310 SKTSSTIKSTPSGKR
0 2 T323-p KRYKFVAtGHGkyEK
0 1 K327-a FVAtGHGkyEKVLVE
0 15 Y328-p VAtGHGkyEKVLVEG
  mouse

► Hide Isoforms 		 
I6 __MAEAAIDPRCEEQ
S63-p KEDDGGHsLEQPGQQ
G68 GHsLEQPGQQTLIsL
S74-p PGQQTLIsLKsSELD
K76 QQTLIsLKsSELDED
S77-p QTLIsLKsSELDEDE
S90-p DEGFGDWsQKPEPRQ
R116 TEPSQSERPEEKQTE
- gap
Q128 QTEESSHQAKVHLEE
S136-p AKVHLEEsNLsYREP
S139-p HLEEsNLsYREPDPE
S152-p PEDAVGGsGEAEEHL
T166-p LIRHQVRtPsPLALE
S168-p RHQVRtPsPLALEDt
T175-p sPLALEDtVELssPP
S179-p LEDtVELssPPLsPt
S180-p EDtVELssPPLsPtt
S184-p ELssPPLsPttKLAD
T186-p ssPPLsPttKLADRT
T187-p sPPLsPttKLADRTE
S195-p KLADRTEsLNRSIKK
S209-p KSNSVKKsQPTLPIS
T217 QPTLPISTIDERLQQ
Y225-p IDERLQQyTQATESS
T226 DERLQQyTQATESSG
T235-p ATESSGRtPKLsRQP
S239-p SGRtPKLsRQPsIEL
S243-p PKLsRQPsIELPsMA
S248-p QPsIELPsMAVASTK
T256 MAVASTKTLWETGEV
T260 STKTLWETGEVQSQS
S273-p QSASKTPsCQDIVAG
K291-a KKSLWEQkGGSKISS
K301-a SKISSTIkSTPSGKR
T314 KRYKFVATGHGKyEK
K318 FVATGHGKyEKVLVD
Y319-p VATGHGKyEKVLVDE
  LSP1 iso3  
- gap
S61 KEDDGGHSLEQPGQQ
G66 GHSLEQPGQQTLISL
S72 PGQQTLISLKSSELD
K74 QQTLISLKSSELDED
S75 QTLISLKSSELDEDE
S88 DEGFGDWSQKPEPRQ
R114 TEPSQSERPEEKQTE
- gap
Q126 QTEESSHQAKVHLEE
S134 AKVHLEESNLSYREP
S137 HLEESNLSYREPDPE
S150-p PEDAVGGsGEAEEVR
T158-p GEAEEVRtPsPLALE
S160-p AEEVRtPsPLALEDt
T167-p sPLALEDtVELssPP
S171-p LEDtVELssPPLsPT
S172-p EDtVELssPPLsPTT
S176-p ELssPPLsPTTKLAD
T178 ssPPLsPTTKLADRT
T179 sPPLsPTTKLADRTE
S187 KLADRTESLNRSIKK
S201 KSNSVKKSQPTLPIS
T209 QPTLPISTIDERLQQ
Y217 IDERLQQYTQATESS
T218 DERLQQYTQATESSG
T227 ATESSGRTPKLSRQP
S231 SGRTPKLSRQPSIEL
S235 PKLSRQPSIELPSMA
S240 QPSIELPSMAVASTK
T248 MAVASTKTLWETGEV
T252 STKTLWETGEVQSQS
S265 QSASKTPSCQDIVAG
K283 KKSLWEQKGGSKISS
K293 SKISSTIKSTPSGKR
T306 KRYKFVATGHGKYEK
K310 FVATGHGKYEKVLVD
Y311 VATGHGKYEKVLVDE
  rat

 
S6 __MAEAASDPRCQEQ
F63 EEDEGGHFLEQPGQQ
G68 GHFLEQPGQQALVSL
S74 PGQQALVSLKSSELD
K76 QQALVSLKSSELDED
S77 QALVSLKSSELDEDE
S90 DEGFGDWSQKQEPPR
S117 SEPSPSESAEEKQTE
- gap
Q129 QTEDSSHQAKVHLEE
S137 AKVHLEESNLSHSDP
S140 HLEESNLSHSDPNIE
S153 IEDDVGGSGETEEHL
T167 LISHQARTPSPLALE
S169 SHQARTPSPLALEDT
T176 SPLALEDTAELSSPP
S180 LEDTAELSSPPLSPT
S181 EDTAELSSPPLSPTV
S185 ELSSPPLSPTVKLAD
T187 SSPPLSPTVKLADRT
V188 SPPLSPTVKLADRTE
S196 KLADRTESLNRSIQK
S210 KSNSVKKSQPTLPIS
T218 QPTLPISTIDERLQQ
Y226 IDERLQQYTQATESA
T227 DERLQQYTQATESAG
T236 ATESAGRTPKLSRQP
S240 AGRTPKLSRQPSIEL
S244 PKLSRQPSIELPSMA
S249 QPSIELPSMAVASTK
T257 MAVASTKTLWETGEV
T261 STKTLWETGEVQTQS
S274 QSASKTPSCQDIVAG
K292 KKSLWEQKGGSKISS
K302 SKISSTIKSTPSGKR
T315 KRYKFVATGHGKyEK
K319 FVATGHGKyEKVLVD
Y320-p VATGHGKyEKVLVDE
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.