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CTNNA2 (human)

Overview CTNNA2 May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Interacts with ZNF639. Belongs to the vinculin/alpha-catenin family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cancer Testis Antigen (CTA); Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: cell-cell adherens junction; adherens junction; basolateral plasma membrane; lamellipodium; axon; cytoplasm; cytosol; actin cytoskeleton Molecular Function: protein binding; structural constituent of cytoskeleton; cadherin binding Biological Process: muscle cell differentiation; cell-cell adhesion; prepulse inhibition; axonogenesis; radial glia guided migration of Purkinje cell; dendrite morphogenesis; brain morphogenesis; positive regulation of muscle cell differentiation; regulation of synapse structural plasticity Reference #:  P26232 (UniProtKB) Alt. Names/Synonyms: Alpha N-catenin; Alpha-catenin-related protein; alpha-N-catenin; cadherin-associated protein, related; CAP-R; CAPR; catenin (cadherin-associated protein), alpha 2; Catenin alpha-2; CT 114; CTNA2; CTNNA2; CTNR; DKFZp686H02198 Gene Symbols: CTNNA2 Molecular weight: 105,313 Da Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states CST Pathways:  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CTNNA2 4K1O - A=651-905 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T5	___MTSATSPIILKW
0	3		S6	__MTSATSPIILKWD
0	6		K15-u	IILKWDPkSLEIRTL
0	1		T41-p	QVTTLVNtsNKGPSG
0	1		S42-p	VTTLVNtsNKGPSGK
0	1		K44	TLVNtsNKGPSGKKK
0	1		K49	sNKGPSGKKKGRSKK
0	2		K50	NKGPSGKKKGRSKKA
0	1		K51	KGPSGKKKGRSKKAH
0	1		S132-p	RAARALLsAVtRLLI
0	1		T135-p	RALLsAVtRLLILAD
0	2		S151-p	ADVMRLLsHLKIVEE
0	1		S224	ATMLYTASQAFLRHP
0	1		T261	ISNAAQATSPTDEAK
0	6		S262	SNAAQATSPTDEAKG
0	1		S321-p	AALMADSsCTRDDRR
0	1		K358	NNTGRKEKGDPLNIA
0	23		Y417-p	NEKEVKEyAQVFREH
0	3		T632	KAVLMIRTPEELEDD
0	22		S640-p	PEELEDDsDFEQEDY
0	2		Y647	sDFEQEDYDVRsRts
0	19		S651-p	QEDYDVRsRtsVQtE
0	18		T653-p	DYDVRsRtsVQtEDD
0	33		S654-p	YDVRsRtsVQtEDDQ
0	36		T657-p	RsRtsVQtEDDQLIA
0	1		K796	LNICSKVKAEVQNLG
0	1		Y894	STKYQKVYGTAAVNS
0	1		T896	KYQKVYGTAAVNSPV
0	7		S901	YGTAAVNSPVVSWKM
0	1		S905	AVNSPVVSWKMKAPE
0	1		T927	EKPEEFQTRVRRGsQ
0	5		S933-p	QTRVRRGsQKKHIsP
0	8		S939-p	GsQKKHIsPVQALsE
0	2		S945-p	IsPVQALsEFKAMDS

	mouse ► Hide Isoforms
T5-p	___MTSAtsPIILKW
S6-p	__MTSAtsPIILKWD
K15-u	IILKWDPkSLEIRTL
T41	QVTTLVNTSNkGPSG
S42	VTTLVNTSNkGPSGk
K44-u	TLVNTSNkGPSGkkk
K49-a	SNkGPSGkkkGRSKK
K50-a	NkGPSGkkkGRSKKA
K51-a	kGPSGkkkGRSKKAH
S132	RAARALLSAVTRLLI
T135	RALLSAVTRLLILAD
S151	ADVMRLLSHLKIVEE
S224-p	ATMLYTAsQAFLRHP
T261-p	ISSAAQAtsPTDEAK
S262-p	SSAAQAtsPTDEAKG
S321	AALMADSSCTRDDRR
K358-u	NNTGRKEkGDPLNIA
Y417-p	NEKEVKEyAQVFREH
T632-p	KAVLMIRtPEELEDD
S640-p	PEELEDDsDFEQEDy
Y647-p	sDFEQEDyDVRsRts
S651-p	QEDyDVRsRtsVQtE
T653-p	DyDVRsRtsVQtEDD
S654-p	yDVRsRtsVQtEDDQ
T657-p	RsRtsVQtEDDQLIA
K796	LNICSKVKAEVQNLG
Y894-p	STKYQKVyGtAAVNs
T896-p	KYQKVyGtAAVNsPV
S901-p	yGtAAVNsPVVsWKM
S905-p	AVNsPVVsWKMKAPE
T927-p	EKPEEFQtRVRRGsQ
S933-p	QtRVRRGsQKKHIsP
S939-p	GsQKKHIsPVQALsE
S945-p	IsPVQALsEFKAMDS

	CTNNA2 iso3
T18	TGSMTSATsPIILKW
S19-p	GSMTSATsPIILKWD
K28	IILKWDPKSLEIRTL
T54	QVTTLVNTSNKGPSG
S55	VTTLVNTSNKGPSGK
K57	TLVNTSNKGPSGKKK
K62	SNKGPSGKKKGRSKK
K63	NKGPSGKKKGRSKKA
K64	KGPSGKKKGRSKKAH
S145	RAARALLSAVTRLLI
T148	RALLSAVTRLLILAD
S164	ADVMRLLSHLKIVEE
S237	ATMLYTASQAFLRHP
T274	ISSAAQATSPTDEAK
S275	SSAAQATSPTDEAKG
S334	AALMADSSCTRDDRR
K371	NNTGRKEKGDPLNIA
Y430	NEKEVKEYAQVFREH
T645	KAVLMIRTPEELEDD
S653	PEELEDDSDFEQEDY
Y660	SDFEQEDYDVRSRTS
S664	QEDYDVRSRTSVQTE
T666	DYDVRSRTSVQTEDD
S667	YDVRSRTSVQTEDDQ
T670	RSRTSVQTEDDQLIA
K809-u	LNICSKVkAEVQNLG
Y859	STKYQKVYGTAAVNS
T861	KYQKVYGTAAVNSPV
S866	YGTAAVNSPVVSWKM
S870	AVNSPVVSWKMKAPE
T892	EKPEEFQTRVRRGSQ
S898	QTRVRRGSQKKHISP
S904	GSQKKHISPVQALSE
S910	ISPVQALSEFKAMDS

	rat
T18	TGSMTSATSPIILKW
S19	GSMTSATSPIILKWD
K28	IILKWDPKSLEIRTL
T54	QVTTLVNTSNKGPSG
S55	VTTLVNTSNKGPSGK
K57	TLVNTSNKGPSGKKK
K62	SNKGPSGKKKGRSKK
K63	NKGPSGKKKGRSKKA
K64	KGPSGKKKGRSKKAH
S145	RAARALLSAVTRLLI
T148	RALLSAVTRLLILAD
S164	ADVMRLLSHLKIVEE
S237	ATMLYTASQAFLRHP
T274	ISSAAQATSPTDEAK
S275	SSAAQATSPTDEAKG
S334	AALMADSSCTRDDRR
K371	NNTGRKEKGDPLNIA
Y430	NEKEVKEYAQVFREH
T645	KAVLMIRTPEELEDD
S653	PEELEDDSDFEQEDY
Y660	SDFEQEDYDVRsRts
S664-p	QEDYDVRsRtsVQtE
T666-p	DYDVRsRtsVQtEDD
S667-p	YDVRsRtsVQtEDDQ
T670-p	RsRtsVQtEDDQLIA
K809	LNICSKVKAEVQNLG
Y907	STKYQKVYGTAAVNS
T909	KYQKVYGTAAVNSPV
S914	YGTAAVNSPVVSWKM
S918	AVNSPVVSWKMKAPE
T940	EKPEEFQTRVRRGSQ
S946	QTRVRRGSQKKHISP
S952	GSQKKHISPVQALSE
S958	ISPVQALSEFKAMDS

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