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Protein Page:
CTNNA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTNNA2 May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Interacts with ZNF639. Belongs to the vinculin/alpha-catenin family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein; Cancer Testis Antigen (CTA)
Cellular Component: cell-cell adherens junction; adherens junction; basolateral plasma membrane; lamellipodium; axon; cytoplasm; cytosol; actin cytoskeleton
Molecular Function: protein binding; structural constituent of cytoskeleton; cadherin binding
Biological Process: muscle cell differentiation; cell-cell adhesion; prepulse inhibition; axonogenesis; radial glia guided migration of Purkinje cell; dendrite morphogenesis; brain morphogenesis; positive regulation of muscle cell differentiation; regulation of synapse structural plasticity
Reference #:  P26232 (UniProtKB)
Alt. Names/Synonyms: Alpha N-catenin; Alpha-catenin-related protein; alpha-N-catenin; cadherin-associated protein, related; CAP-R; CAPR; catenin (cadherin-associated protein), alpha 2; Catenin alpha-2; CT 114; CTNA2; CTNNA2; CTNR; DKFZp686H02198
Gene Symbols: CTNNA2
Molecular weight: 105,313 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTNNA2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T5 ___MTSATSPIILKW
0 3 S6 __MTSATSPIILKWD
0 6 K15-ub IILKWDPkSLEIRTL
0 1 T41-p QVTTLVNtsNKGPSG
0 2 S42-p VTTLVNtsNKGPSGK
0 1 K44 TLVNtsNKGPSGKKK
0 1 K49 sNKGPSGKKKGRSKK
0 2 K50 NKGPSGKKKGRSKKA
0 1 K51 KGPSGKKKGRSKKAH
0 2 S151-p ADVMRLLsHLKIVEE
0 1 S224 ATMLYTASQAFLRHP
0 1 T261 ISNAAQATSPTDEAK
0 6 S262 SNAAQATSPTDEAKG
0 2 S302 SEARFRPSLEERLES
0 1 S321-p AALMADSsCTRDDRR
0 1 K358 NNTGRKEKGDPLNIA
0 25 Y417-p NEKEVKEyAQVFREH
0 3 T632 KAVLMIRTPEELEDD
0 23 S640-p PEELEDDsDFEQEDy
0 2 Y647-p sDFEQEDyDVRsRts
0 27 S651-p QEDyDVRsRtsVQtE
0 25 T653-p DyDVRsRtsVQtEDD
0 46 S654-p yDVRsRtsVQtEDDQ
0 48 T657-p RsRtsVQtEDDQLIA
0 2 S667-p DQLIAGQsARAIMAQ
0 1 T738-p GKGPLKNtsDVINAA
0 1 S739-p KGPLKNtsDVINAAK
0 2 S753-p KKIAEAGsRMDKLAR
0 1 K796 LNICSKVKAEVQNLG
0 2 K889-ac ASYVASTkYQKVYGT
0 1 Y894 STkYQKVYGTAAVNS
0 1 T896 kYQKVYGTAAVNSPV
0 7 S901 YGTAAVNSPVVSWKM
0 1 S905 AVNSPVVSWKMKAPE
0 1 T927 EKPEEFQTRVRRGSQ
0 5 S933 QTRVRRGSQKKHIsP
0 8 S939-p GSQKKHIsPVQALsE
0 2 S945-p IsPVQALsEFKAMDS
  mouse

► Hide Isoforms
 
T5-p ___MTSAtsPIILKW
S6-p __MTSAtsPIILKWD
K15-ub IILKWDPkSLEIRTL
T41 QVTTLVNTSNkGPSG
S42 VTTLVNTSNkGPSGk
K44-ub TLVNTSNkGPSGkkk
K49-ac SNkGPSGkkkGRSKK
K50-ac NkGPSGkkkGRSKKA
K51-ac kGPSGkkkGRSKKAH
S151 ADVMRLLSHLKIVEE
S224-p ATMLYTAsQAFLRHP
T261-p ISSAAQAtsPTDEAK
S262-p SSAAQAtsPTDEAKG
S302-p SEARFRPsLEERLES
S321 AALMADSSCTRDDRR
K358-ub NNTGRKEkGDPLNIA
Y417-p NEKEVKEyAQVFREH
T632-p KAVLMIRtPEELEDD
S640-p PEELEDDsDFEQEDy
Y647-p sDFEQEDyDVRsRts
S651-p QEDyDVRsRtsVQtE
T653-p DyDVRsRtsVQtEDD
S654-p yDVRsRtsVQtEDDQ
T657-p RsRtsVQtEDDQLIA
S667-p DQLIAGQsARAIMAQ
T738 GKGPLKNTSDVINAA
S739 KGPLKNTSDVINAAK
S753 KKIAEAGSRMDKLAR
K796 LNICSKVKAEVQNLG
K889-ac ASYVASTkYQKVyGt
Y894-p STkYQKVyGtAAVNs
T896-p kYQKVyGtAAVNsPV
S901-p yGtAAVNsPVVsWKM
S905-p AVNsPVVsWKMKAPE
T927-p EKPEEFQtRVRRGsQ
S933-p QtRVRRGsQKKHIsP
S939-p GsQKKHIsPVQALsE
S945-p IsPVQALsEFKAMDS
  CTNNA2 iso3  
T18 TGSMTSATsPIILKW
S19-p GSMTSATsPIILKWD
K28 IILKWDPKSLEIRTL
T54 QVTTLVNTSNKGPSG
S55 VTTLVNTSNKGPSGK
K57 TLVNTSNKGPSGKKK
K62 SNKGPSGKKKGRSKK
K63 NKGPSGKKKGRSKKA
K64 KGPSGKKKGRSKKAH
S164 ADVMRLLSHLKIVEE
S237 ATMLYTASQAFLRHP
T274 ISSAAQATSPTDEAK
S275 SSAAQATSPTDEAKG
S315 SEARFRPSLEERLES
S334 AALMADSSCTRDDRR
K371 NNTGRKEKGDPLNIA
Y430 NEKEVKEYAQVFREH
T645 KAVLMIRTPEELEDD
S653 PEELEDDSDFEQEDY
Y660 SDFEQEDYDVRSRTS
S664 QEDYDVRSRTSVQTE
T666 DYDVRSRTSVQTEDD
S667 YDVRSRTSVQTEDDQ
T670 RSRTSVQTEDDQLIA
S680 DQLIAGQSARAIMAQ
T751 GKGPLKNTSDVINAA
S752 KGPLKNTSDVINAAK
S766 KKIAEAGSRMDKLAR
K809-ub LNICSKVkAEVQNLG
K854 ASYVASTKYQKVYGT
Y859 STKYQKVYGTAAVNS
T861 KYQKVYGTAAVNSPV
S866 YGTAAVNSPVVSWKM
S870 AVNSPVVSWKMKAPE
T892 EKPEEFQTRVRRGSQ
S898 QTRVRRGSQKKHISP
S904 GSQKKHISPVQALSE
S910 ISPVQALSEFKAMDS
  rat

 
T18 TGSMTSATsPIILKW
S19-p GSMTSATsPIILKWD
K28 IILKWDPKSLEIRTL
T54 QVTTLVNTSNKGPSG
S55 VTTLVNTSNKGPSGK
K57 TLVNTSNKGPSGKKK
K62 SNKGPSGKKKGRSKK
K63 NKGPSGKKKGRSKKA
K64 KGPSGKKKGRSKKAH
S164 ADVMRLLSHLKIVEE
S237 ATMLYTASQAFLRHP
T274 ISSAAQATsPTDEAK
S275-p SSAAQATsPTDEAKG
S315-p SEARFRPsLEERLES
S334 AALMADSSCTRDDRR
K371 NNTGRKEKGDPLNIA
Y430 NEKEVKEYAQVFREH
T645-p KAVLMIRtPEELEDD
S653-p PEELEDDsDFEQEDY
Y660 sDFEQEDYDVRsRts
S664-p QEDYDVRsRtsVQtE
T666-p DYDVRsRtsVQtEDD
S667-p YDVRsRtsVQtEDDQ
T670-p RsRtsVQtEDDQLIA
S680 DQLIAGQSARAIMAQ
T751 GKGPLKNTSDVINAA
S752 KGPLKNTSDVINAAK
S766 KKIAEAGSRMDKLAR
K809 LNICSKVKAEVQNLG
K902-ac ASYVASTkYQKVYGT
Y907 STkYQKVYGTAAVNS
T909 kYQKVYGTAAVNSPV
S914 YGTAAVNSPVVSWKM
S918 AVNSPVVSWKMKAPE
T940 EKPEEFQTRVRRGSQ
S946 QTRVRRGSQKKHISP
S952 GSQKKHISPVQALSE
S958 ISPVQALSEFKAMDS
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