Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. Expressed in various cell lines and in skin fibroblasts. Belongs to the XPA family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: nucleoplasm; Golgi apparatus; intercellular bridge; DNA replication factor A complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; metal ion binding; damaged DNA binding
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; nucleotide-excision repair; multicellular organism growth; response to toxin; nucleotide-excision repair, DNA damage removal; response to oxidative stress; DNA repair; response to UV
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.