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Protein Page:
XPA (human)

Overview
XPA Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. Expressed in various cell lines and in skin fibroblasts. Belongs to the XPA family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; Golgi apparatus; intercellular bridge; DNA replication factor A complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; metal ion binding; damaged DNA binding
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; nucleotide-excision repair; multicellular organism growth; response to toxin; nucleotide-excision repair, DNA damage removal; response to oxidative stress; DNA repair; response to UV
Reference #:  P23025 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein complementing XP-A cells; excision repair-controlling; Xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPA; XPAC
Gene Symbols: XPA
Molecular weight: 31,368 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Select Structure to View Below

XPA

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S196‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 L8 MAAADGALPEAAALE
0 1 Y48-p ARLAARPySATAAAA
1 0 S173-p VKKNPHHsQWGDMKL
3 3 S196-p RSLEVWGsQEALEEA
0 1 T239-p SSVWKREtIVHQHEY
0 3 Y257-p ENLEDDMyRKTCTMC
  mouse

 
S10-p TAEEKQTsPEPVAAD
Y50 ARLAARPYPAAAATG
S172 VKKNPRHSQWGDMKL
S195 RALEVWGSQEALEDA
T238 SSVWKRETTTHQHKY
Y256 ENLEDDMYRKTCTLC
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