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Protein Page:
RPS17 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RPS17 Defects in RPS17 are the cause of Diamond-Blackfan anemia type 4 (DBA4). DBA4 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S17e family. Note: This description may include information from UniProtKB.
Protein type: Translation; Ribosomal protein
Chromosomal Location of Human Ortholog: 15q
Cellular Component: membrane; ribosome; cytosol
Molecular Function: structural constituent of ribosome
Biological Process: SRP-dependent cotranslational protein targeting to membrane; translation; viral reproduction; translational termination; viral infectious cycle; mRNA metabolic process; erythrocyte homeostasis; ribosomal small subunit biogenesis and assembly; cellular protein metabolic process; translational elongation; RNA metabolic process; translational initiation; mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit assembly and maintenance; gene expression; viral transcription; rRNA processing
Reference #:  P08708 (UniProtKB)
Alt. Names/Synonyms: 40S ribosomal protein S17; AC010724.3; DBA4; MGC72007; ribosomal protein S17; RPS17; RPS17L1; RPS17L2; RS17
Gene Symbols: RPS17
Molecular weight: 15,550 Da
Basal Isoelectric point: 9.85  Predict pI for various phosphorylation states
Select Structure to View Below

RPS17

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 9 K19-ac AARVIIEkYyTRLGN
0 75 K19-ub AARVIIEkYyTRLGN
0 7 Y21-p RVIIEkYyTRLGNDF
0 5 K32-ac GNDFHTNkRVCEEIA
0 3 K32-ub GNDFHTNkRVCEEIA
0 3 K44-ub EIAIIPSkKLRNkIA
0 29 K49-ub PSkKLRNkIAGYVtH
0 1 T55-p NkIAGYVtHLMkRIQ
0 2 K59-ub GYVtHLMkRIQRGPV
0 7 K72-ub PVRGISIkLQEEERE
0 2 T102-p IIEVDPDtkEMLkLL
0 11 K103-ub IEVDPDtkEMLkLLD
0 1 K103 IEVDPDtKEMLkLLD
0 1 K107 PDtkEMLKLLDFGsL
0 82 K107-ub PDtkEMLkLLDFGsL
0 59 S113-p LkLLDFGsLsNLQVT
0 16 S115-p LLDFGsLsNLQVTQP
0 2 K129-ac PTVGMNFktPRGPV_
0 38 K129-ub PTVGMNFktPRGPV_
0 35 T130-p TVGMNFktPRGPV__
  mouse

 
K19-ac AARVIIEkYyTRLGN
K19-ub AARVIIEkYyTRLGN
Y21-p RVIIEkYyTRLGNDF
K32 GNDFHTNKRVCEEIA
K32 GNDFHTNKRVCEEIA
K44 EIAIIPSKKLRNkIA
K49-ub PSKKLRNkIAGYVTH
T55 NkIAGYVTHLMKRIQ
K59 GYVTHLMKRIQRGPV
K72-ub PVRGISIkLQEEERE
T102-p IIEVDPDtkEMLkLL
K103-ub IEVDPDtkEMLkLLD
K103-sc IEVDPDtkEMLkLLD
K107-ac PDtkEMLkLLDFGsL
K107-ub PDtkEMLkLLDFGsL
S113-p LkLLDFGsLsNLQVT
S115-p LLDFGsLsNLQVTQP
K129 PTVGMNFKtPRGAV_
K129-ub PTVGMNFktPRGAV_
T130-p TVGMNFktPRGAV__
  rat

 
K19-ac AARVIIEkYYTRLGN
K19 AARVIIEKYYTRLGN
Y21 RVIIEkYYTRLGNDF
K32 GNDFHTNKRVCEEIA
K32 GNDFHTNKRVCEEIA
K44 EIAIIPSKNLRNKIA
K49 PSKNLRNKIAGYVTH
T55 NKIAGYVTHLMKRIQ
K59 GYVTHLMKRIQRGPV
K72 PVRGISIKLQEEERE
T102 IIEVDPDTKEMLKLL
K103 IEVDPDTKEMLKLLD
K103 IEVDPDTKEMLKLLD
K107 PDTKEMLKLLDFGsL
K107 PDTKEMLKLLDFGsL
S113-p LKLLDFGsLSNLQVT
S115 LLDFGsLSNLQVTQP
K129 PTVGMNFKTPRGAV_
K129 PTVGMNFKTPRGAV_
T130 TVGMNFKTPRGAV__
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