Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PLXNA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLXNA2 Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2. Interacts with RND1. Detected in fetal brain. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: integral to plasma membrane; plasma membrane; intracellular
Molecular Function: protein binding; semaphorin receptor activity
Biological Process: neural tube development; axon guidance; limb bud formation; somitogenesis; pharyngeal system development; centrosome localization; regulation of cell migration; granule cell precursor tangential migration
Reference #:  O75051 (UniProtKB)
Alt. Names/Synonyms: FLJ11751; FLJ30634; KIAA0463; OCT; plexin 2; plexin A2; Plexin-A2; PLXA2; PLXN2; PLXNA2; Semaphorin receptor OCT; transmembrane protein OCT
Gene Symbols: PLXNA2
Molecular weight: 211,104 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLXNA2

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K138-ac SLYQGVCkLLRLDDL
0 1 K154-ac ILVEPSHkKEHYLSS
0 2 Y293-p DDPKFHSyVsLPFGC
0 1 S295-p PKFHSyVsLPFGCTR
0 1 S434-p TSRDRMTsVASYVYN
0 1 S444-p SYVYNGYsVVFVGTK
0 1 Y470-p PPHGGVQyEMVsVLK
0 1 S474-p GVQyEMVsVLKDGSP
0 1 K542 NMCSRRDKCQQAWEP
0 1 S648 ETGKIFVSTEFKFYN
0 1 T649 TGKIFVSTEFKFYNC
0 1 S668 LCLSCVNSAFRCHWC
0 1 S850-p SPWLDWSsHNVKCSN
0 3 S1264-p LIAYKRKsRENDLTL
0 1 S1305 TDINELTSDLDRSGI
0 1 S1388-p RDRGNVAsLIMTGLQ
0 1 K1415 LLSDLIDKNLENKNH
0 1 K1451-ac FLLHKFLkECAGEPL
0 1 T1524-p VKVLNCDtITQVKEK
0 18 Y1605-p VPKQTSSyNIPASAs
0 1 S1610 SSyNIPASAsISRTS
0 4 S1612-p yNIPASAsISRTSIS
0 2 T1628-p YDSSFRYtGsPDsLR
0 9 S1630-p SSFRYtGsPDsLRsR
0 7 S1633-p RYtGsPDsLRsRAPM
0 1 S1636-p GsPDsLRsRAPMITP
0 2 Y1800-p SPSNKLLyAKDIPsy
0 1 S1806-p LyAKDIPsyKSWVER
0 1 Y1807-p yAKDIPsyKSWVERY
0 1 Y1860-p IYSYVSKysEELIGA
0 1 S1861-p YSYVSKysEELIGAL
  mouse

 
K138 SLYQGVCKLLRLDDL
K154 ILVEPSHKKEHYLSS
Y293-p DDPKFHSyVSLPFGC
S295 PKFHSyVSLPFGCTR
S434 TSRDRLTSVASYVYN
S444 SYVYNGYSVVFVGTK
Y470 PPHGGVQYEMVSVFK
S474 GVQYEMVSVFKDGSP
K542-ac NMCSRRDkCQRAWEA
S648-p ETGKIFVstEFKFYN
T649-p TGKIFVstEFKFYNC
S668-p LCLSCVNsAFRCHWC
S850 SPWLDWSSHNVKCSN
S1264-p LIAYKRKsRENDLTL
S1305-p TDINELTsDLDRSGI
S1388 RDRGNVASLIMTGLQ
K1415-ub LLSDLIDkNLENKNH
K1451 FLLHKFLKECAGEPL
T1524 VKVLNCDTITQVKEK
Y1605 VPKQTSSYNIPAsAs
S1610-gl SSYNIPAsAsISRTS
S1612-p YNIPAsAsISRTSIS
T1628 YDSSFRYTGsPDsLR
S1630-p SSFRYTGsPDsLRSR
S1633-p RYTGsPDsLRSRVPM
S1636 GsPDsLRSRVPMITP
Y1800 SPSNKLLYAKDIPSY
S1806 LYAKDIPSYKNWVER
Y1807 YAKDIPSYKNWVERY
Y1860 IYSYVSKYSEELIGA
S1861 YSYVSKYSEELIGAL
  rat

 
K138 SLYQGVCKLLRLDDL
K154 ILVEPSHKKEHYLSS
Y293 DDPKFHSYVSLPFGC
S295 PKFHSYVSLPFGCTR
S434 TSRDRLTSVASYVYN
S444 SYVYNGYSVVFVGTK
Y470 PPHGGVQYEMVSVFK
S474 GVQYEMVSVFKDGSP
K542 NMCSRRDKCQRAWEA
S648 ETGKIFVSTEFKFYN
T649 TGKIFVSTEFKFYNC
S668 LCLSCVNSAFRCHWC
S850 SPWLDWSSHNVKCSN
S1264 LIAYKRKSRENDLTL
S1305 TDINELTSDLDRSGI
S1388 RDRGNVASLIMTGLQ
K1415 LLSDLIDKNLENKNH
K1451 FLLHKFLKECAGEPL
T1524 VKVLNCDTITQVKEK
Y1605 VPKQTSSYNIPASAS
S1610 SSYNIPASASISRTS
S1612 YNIPASASISRTSIS
T1628 YDSSFRYTGSPDSLR
S1630 SSFRYTGSPDSLRSR
S1633 RYTGSPDSLRSRVPM
S1636 GSPDSLRSRVPMITP
Y1800 SPSNKLLYAKDIPSY
S1806 LYAKDIPSYKNWVER
Y1807 YAKDIPSYKNWVERY
Y1860 IYSYVSKYSEELIGA
S1861 YSYVSKYSEELIGAL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.