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PLXNA2 (human)

Overview PLXNA2 Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2. Interacts with RND1. Detected in fetal brain. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, misc. Cellular Component: integral to plasma membrane; plasma membrane; intracellular Molecular Function: semaphorin receptor activity Biological Process: neural tube development; axon guidance; limb bud formation; somitogenesis; pharyngeal system development; centrosome localization; regulation of cell migration; granule cell precursor tangential migration Reference #:  O75051 (UniProtKB) Alt. Names/Synonyms: FLJ11751; FLJ30634; KIAA0463; OCT; plexin 2; plexin A2; Plexin-A2; PLXA2; PLXN2; PLXNA2; Semaphorin receptor OCT; transmembrane protein OCT Gene Symbols: PLXNA2 Molecular weight: 211,104 Da Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PLXNA2 3Q3J - A=1490-1600 (human) 3AL8 - B=31-561 (mouse) 3AL9 - A/B=31-561 (mouse) 3OKT - A=35-703 (mouse) 3OKY - A=33-701 (mouse) 4GZA - G=21-555 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K138-a	SLYQGVCkLLRLDDL
0	1		K154-a	ILVEPSHkKEHYLSS
0	2		Y293-p	DDPKFHSyVsLPFGC
0	1		S295-p	PKFHSyVsLPFGCTR
0	1		S434-p	TSRDRMTsVASYVYN
0	1		S444-p	SYVYNGYsVVFVGTK
0	1		Y470-p	PPHGGVQyEMVsVLK
0	1		S474-p	GVQyEMVsVLKDGSP
0	1		K542	NMCSRRDKCQQAWEP
0	1		S648	ETGKIFVSTEFKFYN
0	1		T649	TGKIFVSTEFKFYNC
0	1		S668	LCLSCVNSAFRCHWC
0	1		S850-p	SPWLDWSsHNVKCSN
0	3		S1264-p	LIAYKRKsRENDLTL
0	1		S1305	TDINELTSDLDRSGI
0	1		S1388-p	RDRGNVAsLIMTGLQ
0	1		K1415	LLSDLIDKNLENKNH
0	1		K1451-a	FLLHKFLkECAGEPL
0	18		Y1605-p	VPKQTSSyNIPASAs
0	1		S1610	SSyNIPASAsISRTS
0	3		S1612-p	yNIPASAsISRTSIS
0	1		T1628-p	YDSSFRYtGsPDsLR
0	7		S1630-p	SSFRYtGsPDsLRsR
0	6		S1633-p	RYtGsPDsLRsRAPM
0	1		S1636-p	GsPDsLRsRAPMITP
0	2		Y1800-p	SPSNKLLyAKDIPsy
0	1		S1806-p	LyAKDIPsyKSWVER
0	1		Y1807-p	yAKDIPsyKSWVERY
0	1		Y1860-p	IYSYVSKysEELIGA
0	1		S1861-p	YSYVSKysEELIGAL

	mouse
K138	SLYQGVCKLLRLDDL
K154	ILVEPSHKKEHYLSS
Y293-p	DDPKFHSyVSLPFGC
S295	PKFHSyVSLPFGCTR
S434	TSRDRLTSVASYVYN
S444	SYVYNGYSVVFVGTK
Y470	PPHGGVQYEMVSVFK
S474	GVQYEMVSVFKDGSP
K542-a	NMCSRRDkCQRAWEA
S648-p	ETGKIFVstEFKFYN
T649-p	TGKIFVstEFKFYNC
S668-p	LCLSCVNsAFRCHWC
S850	SPWLDWSSHNVKCSN
S1264-p	LIAYKRKsRENDLTL
S1305-p	TDINELTsDLDRSGI
S1388	RDRGNVASLIMTGLQ
K1415-u	LLSDLIDkNLENKNH
K1451	FLLHKFLKECAGEPL
Y1605	VPKQTSSYNIPAsAs
S1610-g	SSYNIPAsAsISRTS
S1612-p	YNIPAsAsISRTSIS
T1628	YDSSFRYTGsPDsLR
S1630-p	SSFRYTGsPDsLRSR
S1633-p	RYTGsPDsLRSRVPM
S1636	GsPDsLRSRVPMITP
Y1800	SPSNKLLYAKDIPSY
S1806	LYAKDIPSYKNWVER
Y1807	YAKDIPSYKNWVERY
Y1860	IYSYVSKYSEELIGA
S1861	YSYVSKYSEELIGAL

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