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Protein Page:
PLXNA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLXNA2 Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2. Interacts with RND1. Detected in fetal brain. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: integral to plasma membrane; plasma membrane; intracellular
Molecular Function: protein binding; semaphorin receptor activity
Biological Process: neural tube development; limb bud formation; axon guidance; somitogenesis; pharyngeal system development; centrosome localization; regulation of cell migration; granule cell precursor tangential migration
Reference #:  O75051 (UniProtKB)
Alt. Names/Synonyms: FLJ11751; FLJ30634; KIAA0463; OCT; plexin 2; plexin A2; Plexin-A2; PLXA2; PLXN2; PLXNA2; Semaphorin receptor OCT; transmembrane protein OCT
Gene Symbols: PLXNA2
Molecular weight: 211,104 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLXNA2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y293-p DDPKFHSyVSLPFGC
0 1 Y470-p PPHGGVQyEMVsVLK
0 1 S474-p GVQyEMVsVLKDGSP
0 1 S668 LCLSCVNSAFRCHWC
0 3 S1264-p LIAYKRKsRENDLTL
0 1 K1415 LLSDLIDKNLENKNH
0 18 Y1605-p VPKQTSSyNIPASAs
0 1 S1610 SSyNIPASAsISRTS
0 4 S1612-p yNIPASAsISRTSIS
0 8 S1630-p SSFRYTGsPDsLRSR
0 7 S1633-p RYTGsPDsLRSRAPM
0 2 Y1800-p SPSNKLLyAKDIPSY
  mouse

 
Y293-p DDPKFHSyVSLPFGC
Y470 PPHGGVQYEMVSVFK
S474 GVQYEMVSVFKDGSP
S668-p LCLSCVNsAFRCHWC
S1264-p LIAYKRKsRENDLTL
K1415-u LLSDLIDkNLENKNH
Y1605 VPKQTSSYNIPAsAs
S1610-gl SSYNIPAsAsISRTS
S1612-p YNIPAsAsISRTSIS
S1630-p SSFRYTGsPDsLRSR
S1633-p RYTGsPDsLRSRVPM
Y1800 SPSNKLLYAKDIPSY
  rat

 
Y293 DDPKFHSYVSLPFGC
Y470 PPHGGVQYEMVSVFK
S474 GVQYEMVSVFKDGSP
S668 LCLSCVNSAFRCHWC
S1264 LIAYKRKSRENDLTL
K1415 LLSDLIDKNLENKNH
Y1605 VPKQTSSYNIPASAS
S1610 SSYNIPASASISRTS
S1612 YNIPASASISRTSIS
S1630 SSFRYTGSPDSLRSR
S1633 RYTGSPDSLRSRVPM
Y1800 SPSNKLLYAKDIPSY
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