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WASP (human)

Overview WASP a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Cellular Component: vesicle membrane; cytosol; actin cytoskeleton Molecular Function: identical protein binding; protein binding; actin binding; small GTPase regulator activity Biological Process: epidermis development; T cell activation; actin filament polymerization; actin filament-based movement; actin polymerization and/or depolymerization; immune response; defense response; protein complex assembly; blood coagulation; endosome transport; T cell receptor signaling pathway Reference #:  P42768 (UniProtKB) Alt. Names/Synonyms: IMD2; THC; THC1; thrombocytopenia 1 (X-linked); WAS; WASp; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); Wiskott-Aldrich syndrome protein Gene Symbols: WAS Molecular weight: 52,913 Da Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Regulation of Actin Dynamics  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WASP 1CEE - B=230-288 (human) 1EJ5 - A=242-326 (human) 1T84 - A=242-326 (human) 2A3Z - C=430-458 (human) 2K42 - A=242-310 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1CEE 1EJ5 1T84 2A3Z 2K42  |  Phospho3D  |  DISEASE 300299 300392 301000 313900  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: Y291‑p cytoskeletal reorganization: Y291‑p, S483‑p, S484‑p activation: Y291‑p molecular association, regulation: Y291‑p, S483‑p, S484‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y83-p	KDNPQKSyFIRLYGL
0	2		K144-u	FRALVQEkIQKRNQR
0	1		S221-p	GLPAPGPsPADKKRS
0	1		S277-p	LFSRAGIsEAQLtDA
0	1		T282-p	GIsEAQLtDAEtsKL
0	4		T286-p	AQLtDAEtsKLIyDF
0	2		S287-p	QLtDAEtsKLIyDFI
10	698		Y291-p	AEtsKLIyDFIEDQG
0	1		S320-p	LPPPPPPsRGGNQLP
0	1		R338-m1	IVGGNKGrSGPLPPV
0	5		T355-p	GIAPPPPtPrGPPPP
0	1		R357-m2	APPPPtPrGPPPPGR
0	4		R364	rGPPPPGRGGPPPPP
1	6		S483-p	KRSRAIHssDEGEDQ
1	7		S484-p	RSRAIHssDEGEDQA

	mouse
Y85	KDNPQKSYFIRLYGL
K146	FRALVQEKIQKRNQR
G223	GLPAPGPGPTDKKRS
S279	LFSRAGISEAQLTDA
T284	GISEAQLTDAETsKL
T288	AQLTDAETsKLIyDF
S289-p	QLTDAETsKLIyDFI
Y293-p	AETsKLIyDFIEDQG
C322	LPPPPPPCRGGGGGG
R355	VVGSNKGRSGPLPPV
T372	GGAPPPPTPRGPPPP
R374	APPPPTPRGPPPPGr
R381-m1	RGPPPPGrGGPPPPP
S501-p	KRSRVIHssDEGEDQ
S502-p	RSRVIHssDEGEDQT

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