Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
WASP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WASP a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: vesicle membrane; cytosol; actin cytoskeleton
Molecular Function: identical protein binding; protein binding; actin binding; small GTPase regulator activity
Biological Process: epidermis development; T cell activation; regulation of catalytic activity; actin filament-based movement; actin filament polymerization; actin polymerization and/or depolymerization; innate immune response; defense response; protein complex assembly; immune response; blood coagulation; endosome transport; T cell receptor signaling pathway
Reference #:  P42768 (UniProtKB)
Alt. Names/Synonyms: IMD2; THC; THC1; thrombocytopenia 1 (X-linked); WAS; WASp; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); Wiskott-Aldrich syndrome protein
Gene Symbols: WAS
Molecular weight: 52,913 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WASP

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell motility, altered: Y291‑p
cytoskeletal reorganization: Y291‑p, S483‑p, S484‑p
activity, induced: Y291‑p
molecular association, regulation: Y291‑p, S483‑p, S484‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 G3 _____MSGGPMGGRP
0 1 Y83-p KDNPQKSyFIRLYGL
0 2 K144-ub FRALVQEkIQKRNQR
0 2 S221-p GLPAPGPsPADKKRS
0 1 S277-p LFSRAGIsEAQLtDA
0 1 T282-p GIsEAQLtDAEtsKL
0 4 T286-p AQLtDAEtsKLIyDF
0 3 S287-p QLtDAEtsKLIyDFI
10 666 Y291-p AEtsKLIyDFIEDQG
0 1 S320-p LPPPPPPsRGGNQLP
0 1 R338-m1 IVGGNKGrSGPLPPV
0 5 T355-p GIAPPPPtPrGPPPP
0 1 R357-m2 APPPPtPrGPPPPGR
0 5 R364 rGPPPPGRGGPPPPP
2 8 S483-p KRSRAIHssDEGEDQ
2 9 S484-p RSRAIHssDEGEDQA
  mouse

 
S3-p _____MNsGPGPVGG
Y85 KDNPQKSYFIRLYGL
K146 FRALVQEKIQKRNQR
G223 GLPAPGPGPTDKKRS
S279 LFSRAGISEAQLTDA
T284 GISEAQLTDAETsKL
T288 AQLTDAETsKLIyDF
S289-p QLTDAETsKLIyDFI
Y293-p AETsKLIyDFIEDQG
C322 LPPPPPPCRGGGGGG
R355 VVGSNKGRSGPLPPV
T372 GGAPPPPTPRGPPPP
R374 APPPPTPRGPPPPGr
R381-m1 RGPPPPGrGGPPPPP
S501-p KRSRVIHssDEGEDQ
S502-p RSRVIHssDEGEDQT
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.