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FBW1B
a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system |
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Cellular Component: centrosome; SCF ubiquitin ligase complex; nucleus; cytosol; ubiquitin ligase complex
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Molecular Function: protein dimerization activity; protein binding; ubiquitin-protein ligase activity
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Biological Process: proteasomal ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; Wnt receptor signaling pathway; protein destabilization; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; negative regulation of NF-kappaB import into nucleus; positive regulation of circadian rhythm; protein amino acid dephosphorylation; cell cycle; negative regulation of transcription, DNA-dependent
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Reference #:
Q9UKB1 (UniProtKB)
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| Alt. Names/Synonyms: beta-transducin repeat-containing protein 2; BTRC2; BTRCP2; F-box and WD repeat domain containing 11; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Fbw11; FBW1B; FBXW11; FBXW1B; Homologous to Slimb protein; HOS; KIAA0696 |
| Gene Symbols: FBXW11 |
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Molecular weight: 62,091 Da
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Basal Isoelectric point: 6.73
Predict pI for various phosphorylation states
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