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Protein Page:
FBW1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FBW1B a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: centrosome; SCF ubiquitin ligase complex; cytosol; nucleus; ubiquitin ligase complex
Molecular Function: protein dimerization activity; protein binding; ubiquitin-protein ligase activity
Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein polyubiquitination; protein destabilization; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; positive regulation of circadian rhythm; negative regulation of NF-kappaB import into nucleus; protein amino acid dephosphorylation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent
Reference #:  Q9UKB1 (UniProtKB)
Alt. Names/Synonyms: beta-transducin repeat-containing protein 2; BTRC2; BTRCP2; F-box and WD repeat domain containing 11; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Fbw11; FBW1B; FBXW11; FBXW1B; Homologous to Slimb protein; HOS; KIAA0696
Gene Symbols: FBXW11
Molecular weight: 62,091 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Select Structure to View Below

FBW1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 S65-p IVSRKRPsEGNYQKE
0 1 S159-p KEWQRVIsEGMLWKK
0 2 K179-ub VRTDPLWkGLSERRG
0 1 K179-m2 VRTDPLWkGLSERRG
0 41 Y537-p TRSPSRTyTyISR__
0 35 Y539-p SPSRTyTyISR____
  FBW1B iso3  
S28-p EDQNEDEsPKKNTLW
S52 IVSRKRPSEGNYQKE
S146 KEWQRVISEGMLWKK
K166 VRTDPLWKGLSERRG
K166 VRTDPLWKGLSERRG
Y524 TRSPSRTYTYISR__
Y526 SPSRTYTYISR____
  mouse

 
- gap
S65 IVSRKRPSEGNYQKE
S159 KEWQRVISEGMLWKK
K179-ub VRTDPLWkGLSERRG
K179 VRTDPLWKGLSERRG
Y537-p TRSPSRTyTYISR__
Y539 SPSRTyTYISR____
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