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Protein Page:
SAPAP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SAPAP1 Part of the postsynaptic scaffold in neuronal cells. Belongs to the SAPAP family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: postsynaptic membrane; cellular_component; cell junction
Molecular Function: protein binding
Biological Process: synaptic transmission
Reference #:  O14490 (UniProtKB)
Alt. Names/Synonyms: DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1; discs, large (Drosophila) homolog-associated protein 1; Disks large-associated protein 1; DLGAP1; DLGP1; GKAP; Guanylate kinase-associated protein; hGKAP; MGC88156; PSD-95/SAP90 binding protein 1; PSD-95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1; SAPAP1
Gene Symbols: DLGAP1
Molecular weight: 108,873 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Select Structure to View Below

SAPAP1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S375‑p, S406‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S52 PYYTQRNSFQAECVG
0 24 Y75 STFPRRHYTSQQELK
1 0 S77 FPRRHYTSQQELKDE
1 24 Y118-p LPLSRDGyHTLQYKR
0 9 Y123 DGyHTLQYKRTAVEH
0 1 S134 AVEHRSDSPGRIRHL
0 3 S154 KLFTKSHSLEGPSKG
0 3 S169-p SVNGGKAsPDEAQAA
0 2 K305 NMDQAMVKSESCQQE
0 12 Y317 QQERSCQYLQVPQDE
2 2 S346-p CRRMRSGsYIKAMGD
0 9 S356 KAMGDEDSGDSDTSP
0 8 S359 GDEDSGDSDTSPKPS
0 2 T361 EDSGDSDTSPKPSPK
0 5 S362 DSGDSDTSPKPSPKV
0 3 S366 SDTSPKPSPKVAARR
2 0 S375-p KVAARREsYLKATQP
0 1 K378 ARREsYLKATQPSLT
0 1 T380 REsYLKATQPSLTEL
1 5 S383 YLKATQPSLTELTTL
0 1 K391 LTELTTLKISNEHsP
0 2 S397-p LKISNEHsPKLQIRS
0 3 K399 ISNEHsPKLQIRSHs
2 2 S406-p KLQIRSHsYLRAVSE
0 4 S412 HsYLRAVSEVSINRS
0 7 S415 LRAVSEVSINRSLDS
0 7 S419 SEVSINRSLDSLDPA
0 1 S422 SINRSLDSLDPAGLL
0 1 T430-p LDPAGLLtsPKFRSR
0 9 S431-p DPAGLLtsPKFRSRN
0 1 K433 AGLLtsPKFRSRNEs
2 1 S440-p KFRSRNEsYMRAMST
2 5 S493-p CFRMRSHsYVRAIEk
0 8 K500-u sYVRAIEkGCSQDDE
0 12 S503 RAIEkGCSQDDECVS
0 8 S510 SQDDECVSLRSSSPP
0 2 T519 RSSSPPRTTTTVRTI
0 2 T520 SSSPPRTTTTVRTIQ
0 1 T522 SPPRTTTTVRTIQSS
0 1 T525 RTTTTVRTIQSStVS
0 1 S528 TTVRTIQSStVSSCI
0 1 S529 TVRTIQSStVSSCIt
0 1 T530-p VRTIQSStVSSCItt
0 1 T536-p StVSSCIttYKKtPP
0 1 T537-p tVSSCIttYKKtPPP
0 2 T541-p CIttYKKtPPPVPPR
0 1 T558 TKPFISITAQSSTES
0 2 S561 FISITAQSSTESAQD
0 2 S562 ISITAQSSTESAQDA
0 1 T563 SITAQSSTESAQDAY
0 1 S565 TAQSSTESAQDAYMD
0 1 S589 SQSGLSNSTEsLDsM
0 2 T590 QSGLSNSTEsLDsMK
0 6 S592-p GLSNSTEsLDsMKAL
0 4 S595-p NSTEsLDsMKALTAA
1 1 S651 FKKNRCLSIGIQVDD
1 0 S676 KAPSKFQSVGVQVEE
1 0 S695 RRFTRSNSVTTAVQA
0 5 K798 RDGHWFLKLLQAERD
0 2 K900 QLKANNWKQMDPLDK
0 4 K922 PVPKKPAKGPAPLIR
1 5 S932 APLIRERSLESSQRQ
1 3 S958-p AASVRQNsATESAES
13638 : Phospho-GKAP (Ser346) Antibody
  SAPAP1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S44-p CRRMRSGsYIKAMGD
S54 KAMGDEDSGDSDTSP
S57 GDEDSGDSDTSPKPS
T59 EDSGDSDTSPKPSPK
S60 DSGDSDTSPKPSPKV
S64 SDTSPKPSPKVAARR
S73-p KVAARREsYLKATQP
K76 ARREsYLKATQPSLT
T78 REsYLKATQPSLTEL
S81 YLKATQPSLTELTTL
K89 LTELTTLKISNEHSP
S95 LKISNEHSPKLQIRS
K97 ISNEHSPKLQIRSHs
S104-p KLQIRSHsYLRAVSE
S110 HsYLRAVSEVSINRS
S113 LRAVSEVSINRSLDS
S117 SEVSINRSLDSLDPA
S120 SINRSLDSLDPAGLL
T128 LDPAGLLTSPKFRSR
S129 DPAGLLTSPKFRSRN
K131 AGLLTSPKFRSRNEs
S138-p KFRSRNEsYMRAMST
S191-p CFRMRSHsYVRAIEK
K198 sYVRAIEKGCSQDDE
S201 RAIEKGCSQDDECVS
S208 SQDDECVSLRSSSPP
T217 RSSSPPRTTTTVRTI
T218 SSSPPRTTTTVRTIQ
T220 SPPRTTTTVRTIQSS
T223 RTTTTVRTIQSSTVS
S226 TTVRTIQSSTVSSCI
S227 TVRTIQSSTVSSCIT
T228 VRTIQSSTVSSCITT
T234 STVSSCITTYKKTPP
T235 TVSSCITTYKKTPPP
T239 CITTYKKTPPPVPPR
T256 TKPFISITAQSSTES
S259 FISITAQSSTESAQD
S260 ISITAQSSTESAQDA
T261 SITAQSSTESAQDAY
S263 TAQSSTESAQDAYMD
S287 SQSGLSNSTESLDSM
T288 QSGLSNSTESLDSMK
S290 GLSNSTESLDSMKAL
S293 NSTESLDSMKALTAA
S349-p FKKNRCLsIGIQVDD
S374 KAPSKFQSVGVQVEE
S393-p RRFTRSNsVTTAVQA
K496 RDGHWFLKLLQAERD
K598 QLKANNWKQMDPLDK
K620 PVPKKPAKGPAPLIR
S630 APLIRERSLESSQRQ
S656 AASVRQNSATESAES
13638 : Phospho-GKAP (Ser346) Antibody
  mouse

► Hide Isoforms
 
S52-p PYYTQRNsFQAECVG
Y75 STFPRRHYTSQQELK
S77 FPRRHYTSQQELKDE
Y118 LPLSRDGYHTLQyKR
Y123-p DGYHTLQyKRTAVEH
S134-p AVEHRSDsPGRIRHL
S154-p KLFTKSHsLEGPSKG
S169-p SVNGGKAsPDESQTL
K311-u NMDQAMVkSEACQQE
Y323 QQERSCQYLQVPQDE
S352-p CRRMRSGsYIKAMGD
S362-p KAMGDEDsGDsDtsP
S365-p GDEDsGDsDtsPKPs
T367-p EDsGDsDtsPKPsPK
S368-p DsGDsDtsPKPsPKV
S372-p sDtsPKPsPKVAARR
S381 KVAARRESYLkAtQP
K384-u ARRESYLkAtQPsLT
T386-gl RESYLkAtQPsLTEL
S389-p YLkAtQPsLTELTTL
K397-u LTELTTLkISNEHsP
S403-p LkISNEHsPKLQIRS
K405 ISNEHsPKLQIRSHs
S412-p KLQIRSHsYLRAVsE
S418-p HsYLRAVsEVsINRs
S421-p LRAVsEVsINRsLDs
S425-p sEVsINRsLDsLDPA
S428-p sINRsLDsLDPAGLL
T436-p LDPAGLLtsPkFRSR
S437-p DPAGLLtsPkFRSRN
K439-u AGLLtsPkFRSRNEs
S446-p kFRSRNEsYMRAMST
S499-p CFRMRSHsYVRAIEk
K506-u sYVRAIEkGCsQDDE
S509-p RAIEkGCsQDDECVs
S516-p sQDDECVsLRSSSPP
T525-gl RSSSPPRttTtVRtI
T526-gl SSSPPRttTtVRtIQ
T528-gl SPPRttTtVRtIQss
T531-p RttTtVRtIQssTGV
S534-p TtVRtIQssTGVIKL
S535-p tVRtIQssTGVIKLS
T536 VRtIQssTGVIKLSS
T552 VEVSSCITTYKKtPP
T553 EVSSCITTYKKtPPP
T557-p CITTYKKtPPPVPPR
T574-p TKPFISItAQsstEs
S577-p FISItAQsstEsAQD
S578-p ISItAQsstEsAQDA
T579-p SItAQsstEsAQDAY
S581-p tAQsstEsAQDAYMD
S605-p SQSGLSNstEsLDsM
T606-p QSGLSNstEsLDsMK
S608-p GLSNstEsLDsMKAL
S611-p NstEsLDsMKALTAA
S666-p FKKNRCLsIGIQVDD
S691 KTSNKFQSVGVQVEE
S710-p RRFTRSNsVTTAVQA
K813 RDGHWFLKLLQAERD
K915 QLKANNWKQMDPLDK
K937 PVPKKPAKGPAPLIR
S947-p APLIRERsLESSQRQ
S973-p AASVRQNsATESAES
13638 : Phospho-GKAP (Ser346) Antibody
  SAPAP1 iso2  
S52 PYYTQRNSFQAECVG
Y75 STFPRRHYTSQQELK
S77 FPRRHYTSQQELKDE
Y118 LPLSRDGYHTLQYKR
Y123 DGYHTLQYKRTAVEH
S134 AVEHRSDSPGRIRHL
S154 KLFTKSHSLEGPSKG
S169 SVNGGKASPDESQTL
K311 NMDQAMVKSEACQQE
Y323 QQERSCQYLQVPQDE
S352 CRRMRSGSYIKAMGD
S362 KAMGDEDSGDSDTSP
S365 GDEDSGDSDTSPKPS
T367 EDSGDSDTSPKPSPK
S368 DSGDSDTSPKPSPKV
S372 SDTSPKPSPKVAARR
S381 KVAARRESYLKATQP
K384 ARRESYLKATQPSLT
T386 RESYLKATQPSLTEL
S389 YLKATQPSLTELTTL
K397 LTELTTLKISNEHSP
S403 LKISNEHSPKLQIRS
K405 ISNEHSPKLQIRSHS
S412 KLQIRSHSYLRAVSE
S418 HSYLRAVSEVSINRS
S421 LRAVSEVSINRSLDS
S425 SEVSINRSLDSLDPA
S428 SINRSLDSLDPAGLL
T436 LDPAGLLTSPKFRSR
S437 DPAGLLTSPKFRSRN
K439 AGLLTSPKFRSRNES
S446 KFRSRNESYMRAMST
S499 CFRMRSHSYVRAIEK
K506 SYVRAIEKGCSQDDE
S509 RAIEKGCSQDDECVS
S516 SQDDECVSLRSSSPP
T525 RSSSPPRTTTTVRTI
T526 SSSPPRTTTTVRTIQ
T528 SPPRTTTTVRTIQSS
T531 RTTTTVRTIQSSTVS
S534 TTVRTIQSSTVSSCI
S535 TVRTIQSSTVSSCIT
T536 VRTIQSSTVSSCITT
T542 STVSSCITTYKKTPP
T543 TVSSCITTYKKTPPP
T547 CITTYKKTPPPVPPR
T564 TKPFISITAQSSTES
S567 FISITAQSSTESAQD
S568 ISITAQSSTESAQDA
T569 SITAQSSTESAQDAY
S571 TAQSSTESAQDAYMD
S595 SQSGLSNSTESLDSM
T596 QSGLSNSTESLDSMK
S598 GLSNSTESLDSMKAL
S601 NSTESLDSMKALTAA
S656 FKKNRCLSIGIQVDD
S681 KTSNKFQSVGVQVEE
S700 RRFTRSNSVTTAVQA
K803 RDGHWFLKLLQAERD
K905 QLKANNWKQMDPLDK
K927 PVPKKPAKGPAPLIR
S937 APLIRERSLESSQRQ
S963 AASVRQNSATESAES
13638 : Phospho-GKAP (Ser346) Antibody
  SAPAP1 iso4  
S52 PYYTQRNSFQAECVG
Y75 STFPRRHYTSQQELK
S77 FPRRHYTSQQELKDE
Y118 LPLSRDGYHTLQYKR
Y123 DGYHTLQYKRTAVEH
S134 AVEHRSDSPGRIRHL
S154 KLFTKSHSLEGPSKG
S169 SVNGGKASPDESQTL
K311 NMDQAMVKSEACQQE
Y323 QQERSCQYLQVPQDE
S352 CRRMRSGSYIKAMGD
S362 KAMGDEDSGDSDTSP
S365 GDEDSGDSDTSPKPS
T367 EDSGDSDTSPKPSPK
S368 DSGDSDTSPKPSPKV
S372 SDTSPKPSPKVAARR
S381 KVAARRESYLKATQP
K384 ARRESYLKATQPSLT
T386 RESYLKATQPSLTEL
S389 YLKATQPSLTELTTL
K397 LTELTTLKISNEHSP
S403 LKISNEHSPKLQIRS
K405 ISNEHSPKLQIRSHS
S412 KLQIRSHSYLRAVSE
S418 HSYLRAVSEVSINRS
S421 LRAVSEVSINRSLDS
S425 SEVSINRSLDSLDPA
S428 SINRSLDSLDPAGLL
T436 LDPAGLLTSPKFRSR
S437 DPAGLLTSPKFRSRN
K439 AGLLTSPKFRSRNES
S446 KFRSRNESYMRAMST
S499 CFRMRSHSYVRAIEK
K506 SYVRAIEKGCSQDDE
S509 RAIEKGCSQDDECVS
S516 SQDDECVSLRSSSPP
T525 RSSSPPRTTTTVRTI
T526 SSSPPRTTTTVRTIQ
T528 SPPRTTTTVRTIQSS
T531 RTTTTVRTIQSSTVS
S534 TTVRTIQSSTVSSCI
S535 TVRTIQSSTVSSCIT
T536 VRTIQSSTVSSCITT
T542 STVSSCITTYKKTPP
T543 TVSSCITTYKKTPPP
T547 CITTYKKTPPPVPPR
T564 TKPFISITAQSSTES
S567 FISITAQSSTESAQD
S568 ISITAQSSTESAQDA
T569 SITAQSSTESAQDAY
S571 TAQSSTESAQDAYMD
S595 SQSGLSNSTESLDSM
T596 QSGLSNSTESLDSMK
S598 GLSNSTESLDSMKAL
S601 NSTESLDSMKALTAA
S656 FKKNRCLSIGIQVDD
S681 KTSNKFQSVGVQVEE
S700 RRFTRSNSVTTAVQA
K803 RDGHWFLKLLQAERD
K905 QLKANNWKQMDPLDK
- gap
- gap
- gap
13638 : Phospho-GKAP (Ser346) Antibody
  rat

 
S52 PYYTQRNSFQAECVG
Y75-p STFPRRHyTsQQELK
S77-p FPRRHyTsQQELKDE
Y118-p LPLSRDGyHTLQyKR
Y123-p DGyHTLQyKRTAVEH
S134 AVEHRSDSPGRIRHL
S154 KLFTKSHSLEGASKG
S169 GVNGGKASPDGSQTV
K311-u NMDQAVVkSEACQQE
Y323-p QQERSCQyLQVPQDE
S352 CRRMRSGSYIKAMGD
S362 KAMGDEDSGDSDTSP
S365 GDEDSGDSDTSPKPS
T367 EDSGDSDTSPKPSPK
S368 DSGDSDTSPKPSPKV
S372 SDTSPKPSPKVAARR
S381 KVAARRESYLKATQP
K384 ARRESYLKATQPsLT
T386 RESYLKATQPsLTEL
S389-p YLKATQPsLTELTTL
K397 LTELTTLKISNEHSP
S403 LKISNEHSPkLQIRS
K405-u ISNEHSPkLQIRSHS
S412 kLQIRSHSYLRAVSE
S418 HSYLRAVSEVSINRS
S421 LRAVSEVSINRSLDS
S425 SEVSINRSLDSLDPA
S428 SINRSLDSLDPAGLL
T436 LDPAGLLTSPKFRSR
S437 DPAGLLTSPKFRSRN
K439 AGLLTSPKFRSRNES
S446 KFRSRNESYMRAMST
S499 CFRMRSHSYVRAIEk
K506-u SYVRAIEkGCsQDDE
S509-p RAIEkGCsQDDECVs
S516-p sQDDECVsLRSSSPP
T525-gl RSSSPPRttTTVRTI
T526-gl SSSPPRttTTVRTIQ
T528 SPPRttTTVRTIQSS
T531 RttTTVRTIQSSTGV
S534 TTVRTIQSSTGVIKL
S535 TVRTIQSSTGVIKLS
T536 VRTIQSSTGVIKLSS
T552 VEVSSCITTYKKTPP
T553 EVSSCITTYKKTPPP
T557 CITTYKKTPPPVPPR
T574 TKPFISITAQSSTES
S577 FISITAQSSTESAQD
S578 ISITAQSSTESAQDA
T579 SITAQSSTESAQDAY
S581 TAQSSTESAQDAYMD
S605 SQSGLSNSTESLDSM
T606 QSGLSNSTESLDSMK
S608 GLSNSTESLDSMKAL
S611 NSTESLDSMKALTAA
S666 FKKNRCLSIGIQVDD
S691-p KTSSKFQsVGVQVEE
S710 RRFTRSNSVTTAVQA
K813-u RDGHWFLkLLQAERD
K915-u QLKANNWkQMDPLDK
K937-u PVPKKPAkGPAPLIR
S947-p APLIRERsLESSQRQ
S973-p AASVRQNsATESAES
13638 : Phospho-GKAP (Ser346) Antibody
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