a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding; metal ion binding; guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; platelet activation; regulation of small GTPase mediated signal transduction; fibroblast growth factor receptor signaling pathway; positive regulation of cell adhesion; phosphoinositide-mediated signaling; T cell activation; regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; T cell costimulation; innate immune response; blood coagulation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.