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Protein Page:
VAV1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VAV1 a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding; Rac guanyl-nucleotide exchange factor activity; metal ion binding; guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; T cell activation; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; innate immune response; positive regulation of Rac GTPase activity; blood coagulation; positive regulation of GTPase activity
Reference #:  P15498 (UniProtKB)
Alt. Names/Synonyms: oncogene vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene; VAV1
Gene Symbols: VAV1
Molecular weight: 98,314 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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VAV1

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, altered: Y826‑p, Y836‑p, Y841‑p, Y844‑p
cell adhesion, altered: Y160‑p
cell differentiation, altered: Y174‑p, Y745‑p
cell growth, altered: Y174‑p, Y826‑p, Y836‑p, Y841‑p, Y844‑p
cell motility, altered: Y745‑p
cytoskeletal reorganization: Y160‑p, Y174‑p
transcription, inhibited: Y174‑p
activity, induced: Y174‑p, Y826‑p, Y841‑p
activity, inhibited: Y160‑p, Y174‑p
intracellular localization: Y174‑p
molecular association, regulation: Y142‑p, Y160‑p, Y174‑p, Y826‑p, Y841‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K73-ub MSQFLCLkNIRTFLS
0 2 K85-ub FLSTCCEkFGLkRSE
0 1 K89-ub CCEkFGLkRSELFEA
1 10 Y110-p QDFGKVIyTLsALSW
0 1 S113-p GKVIyTLsALSWTPI
5 0 Y142-p SVGDEDIySGLSDQI
7 0 Y160-p VEEDEDLyDCVENEE
15 0 Y174-p EAEGDEIyEDLMRsE
0 1 S180-p IyEDLMRsEPVSMPP
0 2 P182 EDLMRsEPVSMPPKM
0 1 M185 MRsEPVSMPPKMTEy
1 15 Y192-p MPPKMTEyDkRCCCL
0 1 K194-ac PKMTEyDkRCCCLRE
0 1 K194-ub PKMTEyDkRCCCLRE
0 1 K222-ac SIQQHFLkPLQRFLK
0 1 K222-ub SIQQHFLkPLQRFLK
0 1 K252-ac RVHTHFLkEMKEALG
2 35 Y267-p TPGAANLyQVFIKYK
0 3 Y280-p YKERFLVyGRYCsQV
0 7 S285-p LVyGRYCsQVESASK
0 11 K307-ub AREDVQMkLEECSQR
0 8 K335-ub VPMQRVLkYHLLLQE
0 1 K345-ac LLLQELVkHTQEAME
0 13 K353-ub HTQEAMEkENLRLAL
0 9 K374-ub AQCVNEVkRDNETLR
0 1 S396-p SIENLDQsLAHYGRP
0 3 K410-ub PKIDGELkITSVERR
1 0 Y423 RRSKMDRYAFLLDKA
0 4 K444-ub RGDSYDLkDFVNLHS
0 1 K487-ac QGYELFFkTRELKKK
1 2 Y541-p MLLRGTFyQGYRCHR
1 0 Y544 RGTFyQGYRCHRCRA
1 0 H547 FyQGYRCHRCRASAH
0 1 K555-ub RCRASAHkECLGRVP
0 11 T574-p HGQDFPGtMKKDKLH
0 1 K587 LHRRAQDKKRNELGL
0 1 K588 HRRAQDKKRNELGLP
0 1 Y603-p KMEVFQEyYGLPPPP
0 1 K629-ub GDIVELTkAEAEQNW
0 2 Y658 PCNRVKPYVHGPPQD
0 1 K716-ac IKYNVEVkHIKIMTA
0 1 K732-ac GLYRITEkkAFRGLT
0 1 K733-ac LYRITEkkAFRGLTE
2 1 Y745-p LTELVEFyQQNSLkD
0 6 K751-ub FyQQNSLkDCFkSLD
0 1 K755-ub NSLkDCFkSLDTTLQ
0 2 K770-ub FPFKEPEkRTISRPA
0 1 S780-p ISRPAVGsTKyFGtA
0 1 Y783-p PAVGsTKyFGtAkAR
0 1 T786-p GsTKyFGtAkARyDF
0 1 K788-ub TKyFGtAkARyDFCA
0 50 Y791-p FGtAkARyDFCARDR
0 1 S802 ARDRSELSLKEGDII
1 84 Y826-p GWWRGEIyGRVGWFP
2 0 Y836-p VGWFPANyVEEDysE
1 47 Y841-p ANyVEEDysEyC___
0 6 S842-p NyVEEDysEyC____
1 466 Y844-p VEEDysEyC______
  mouse

 
K73 MSQFLCLKNIRTFLS
K85 FLSTCCEKFGLKRSE
K89 CCEKFGLKRSELFEA
Y110-p QDFGKVIyTLSALSW
S113 GKVIyTLSALSWTPI
Y142-p ALNDEDIySGLSDQI
Y160-p AEEDEDLyDCVENEE
Y174-p EAEGDEIyEDLMRLE
L180 IyEDLMRLEsVPtPP
S182-p EDLMRLEsVPtPPKM
T185-p MRLEsVPtPPKMTEy
Y192-p tPPKMTEyDKRCCCL
K194 PKMTEyDKRCCCLRE
K194 PKMTEyDKRCCCLRE
K222 SIQQHFMKPLQRFLK
K222 SIQQHFMKPLQRFLK
K252 SVHTHFLKELKDALA
Y267-p GPGATTLyQVFIKYK
Y280 YKERFLVYGRYCSQV
S285 LVYGRYCSQVESASK
K307 AREDVQMKLEECSQR
K335 VPMQRVLKYHLLLQE
K345 LLLQELVKHTQDATE
K353 HTQDATEKENLRLAL
K374 AQCVNEVKRDNETLR
S396 SIENLDQSLANYGRP
K410 PKIDGELKITSVERR
Y423-p RRSKTDRyAFLLDKA
K444 RGDSYDLKASVNLHS
K487 QGYELFFKTRELKKK
Y541-p MLLRGTFyQGyRCyR
Y544-p RGTFyQGyRCyRCRA
Y547-p FyQGyRCyRCRAPAH
K555 RCRAPAHKECLGRVP
T574 HGQDFAGTMKKDKLH
K587-ac LHRRAQDkkRNELGL
K588-ac HRRAQDkkRNELGLP
Y603 KMEVFQEYYGIPPPP
K629 GDIVELTKAEAEHNW
Y658-p PCNRVHPyVHGPPQD
K716 IKYNVEVKHIKIMTS
K732 GLYRITEKKAFRGLL
K733 LYRITEKKAFRGLLE
Y745-p LLELVEFyQQNSLKD
K751 FyQQNSLKDCFKSLD
K755 NSLKDCFKSLDTTLQ
R770 FPYKEPERRAISKPP
S780 ISKPPAGSTKYFGTA
Y783 PPAGSTKYFGTAKAR
T786 GSTKYFGTAKARyDF
K788 TKYFGTAKARyDFCA
Y791-p FGTAKARyDFCARDR
S802-p ARDRSELsLKEGDII
Y826-p GWWRGEIyGRIGWFP
Y836-p IGWFPSNyVEEDysE
Y841-p SNyVEEDysEyC___
S842-p NyVEEDysEyC____
Y844-p VEEDysEyC______
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