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VAV1 (human)

Overview VAV1 a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB. Protein type: Guanine nucleotide exchange factor, Rac/Rho; Motility/polarity/chemotaxis Cellular Component: plasma membrane; cytosol Molecular Function: protein binding; metal ion binding; guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; phospholipid binding; transcription factor activity Biological Process: integrin-mediated signaling pathway; platelet activation; regulation of GTPase activity; positive regulation of cell adhesion; T cell activation; nerve growth factor receptor signaling pathway; apoptosis; phagocytosis; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; regulation of Rho protein signal transduction; immune response; blood coagulation Reference #:  P15498 (UniProtKB) Alt. Names/Synonyms: oncogene vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene; VAV1 Gene Symbols: VAV1 Molecular weight: 98,314 Da Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Regulation of Actin Dynamics  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below VAV1 2CRH - A=661-775 (human) 2LCT - A=664-767 (human) 2ROR - A=629-775 (human) 3BJI - A/B=189-565 (human) 3KY9 - A/B=2-584 (human) 1F5X - A=170-375 (mouse) 1GCP - A/B/C/D=595-660 (mouse) 1GCQ - C=595-660 (mouse) 1K1Z - A=583-660 (mouse) 2KBT - A=784-844 (mouse) 2VRW - B=170-575 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2CRH 2LCT 2ROR 3BJI 3KY9  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
carcinogenesis, altered: Y826‑p, Y836‑p, Y841‑p, Y844‑p cell adhesion, altered: Y160‑p cell differentiation, altered: Y174‑p, Y745‑p cell growth, altered: Y174‑p, Y826‑p, Y836‑p, Y841‑p, Y844‑p cell motility, altered: Y745‑p cytoskeletal reorganization: Y160‑p transcription, altered: Y174‑p activation: Y826‑p, Y841‑p inhibition: Y160‑p, Y174‑p intracellular localization: Y174‑p molecular association, regulation: Y142‑p, Y160‑p, Y174‑p, Y826‑p, Y841‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K73-u	MSQFLCLkNIRTFLS
0	2		K85-u	FLSTCCEkFGLkRSE
0	1		K89-u	CCEkFGLkRSELFEA
0	10		Y110-p	QDFGKVIyTLsALSW
0	1		S113-p	GKVIyTLsALSWTPI
4	0		Y142-p	SVGDEDIySGLSDQI
6	0		Y160-p	VEEDEDLyDCVENEE
13	0		Y174-p	EAEGDEIyEDLMRSE
0	1		P182	EDLMRSEPVSMPPKM
0	11		Y192-p	MPPKMTEyDkRCCCL
0	1		K194-a	PKMTEyDkRCCCLRE
0	1		K194-u	PKMTEyDkRCCCLRE
0	1		K222-a	SIQQHFLkPLQRFLK
0	1		K222-u	SIQQHFLkPLQRFLK
0	1		K252-a	RVHTHFLkEMKEALG
1	33		Y267-p	TPGAANLyQVFIKYK
0	3		Y280-p	YKERFLVyGRYCsQV
0	7		S285-p	LVyGRYCsQVESASK
0	11		K307-u	AREDVQMkLEECSQR
0	8		K335-u	VPMQRVLkYHLLLQE
0	1		K345-a	LLLQELVkHTQEAME
0	13		K353-u	HTQEAMEkENLRLAL
0	9		K374-u	AQCVNEVkRDNETLR
0	1		S396-p	SIENLDQsLAHYGRP
0	3		K410-u	PKIDGELkITSVERR
0	4		K444-u	RGDSYDLkDFVNLHS
0	1		K487-a	QGYELFFkTRELKKK
0	2		Y541-p	MLLRGTFyQGYRCHR
0	1		K555-u	RCRASAHkECLGRVP
0	7		T574-p	HGQDFPGtMKKDKLH
0	1		K587	LHRRAQDKKRNELGL
0	1		K588	HRRAQDKKRNELGLP
0	1		Y603-p	KMEVFQEyYGLPPPP
0	1		K629-u	GDIVELTkAEAEQNW
0	2		Y658	PCNRVKPYVHGPPQD
0	1		K716-a	IKYNVEVkHIKIMTA
0	1		K732-a	GLYRITEkkAFRGLT
0	1		K733-a	LYRITEkkAFRGLTE
1	1		Y745-p	LTELVEFyQQNSLkD
0	6		K751-u	FyQQNSLkDCFkSLD
0	1		K755-u	NSLkDCFkSLDTTLQ
0	2		K770-u	FPFKEPEkRTISRPA
0	1		S780-p	ISRPAVGsTKyFGtA
0	1		Y783-p	PAVGsTKyFGtAkAR
0	1		T786-p	GsTKyFGtAkARyDF
0	1		K788-u	TKyFGtAkARyDFCA
0	60		Y791-p	FGtAkARyDFCARDR
0	1		S802	ARDRSELSLKEGDII
1	82		Y826-p	GWWRGEIyGRVGWFP
1	0		Y836-p	VGWFPANyVEEDysE
1	58		Y841-p	ANyVEEDysEyC___
0	6		S842-p	NyVEEDysEyC____
1	468		Y844-p	VEEDysEyC______

	mouse
K73	MSQFLCLKNIRTFLS
K85	FLSTCCEKFGLKRSE
K89	CCEKFGLKRSELFEA
Y110-p	QDFGKVIyTLSALSW
S113	GKVIyTLSALSWTPI
Y142-p	ALNDEDIySGLSDQI
Y160-p	AEEDEDLyDCVENEE
Y174-p	EAEGDEIyEDLMRLE
S182-p	EDLMRLEsVPTPPKM
Y192-p	TPPKMTEyDKRCCCL
K194	PKMTEyDKRCCCLRE
K194	PKMTEyDKRCCCLRE
K222	SIQQHFMKPLQRFLK
K222	SIQQHFMKPLQRFLK
K252	SVHTHFLKELKDALA
Y267-p	GPGATTLyQVFIKYK
Y280	YKERFLVYGRYCSQV
S285	LVYGRYCSQVESASK
K307	AREDVQMKLEECSQR
K335	VPMQRVLKYHLLLQE
K345	LLLQELVKHTQDATE
K353	HTQDATEKENLRLAL
K374	AQCVNEVKRDNETLR
S396	SIENLDQSLANYGRP
K410	PKIDGELKITSVERR
K444	RGDSYDLKASVNLHS
K487	QGYELFFKTRELKKK
Y541	MLLRGTFYQGYRCYR
K555	RCRAPAHKECLGRVP
T574	HGQDFAGTMKKDKLH
K587-a	LHRRAQDkkRNELGL
K588-a	HRRAQDkkRNELGLP
Y603	KMEVFQEYYGIPPPP
K629	GDIVELTKAEAEHNW
Y658-p	PCNRVHPyVHGPPQD
K716	IKYNVEVKHIKIMTS
K732	GLYRITEKKAFRGLL
K733	LYRITEKKAFRGLLE
Y745	LLELVEFYQQNSLKD
K751	FYQQNSLKDCFKSLD
K755	NSLKDCFKSLDTTLQ
R770	FPYKEPERRAISKPP
S780	ISKPPAGSTKYFGTA
Y783	PPAGSTKYFGTAKAR
T786	GSTKYFGTAKARyDF
K788	TKYFGTAKARyDFCA
Y791-p	FGTAKARyDFCARDR
S802-p	ARDRSELsLKEGDII
Y826-p	GWWRGEIyGRIGWFP
Y836	IGWFPSNYVEEDysE
Y841-p	SNYVEEDysEyC___
S842-p	NYVEEDysEyC____
Y844-p	VEEDysEyC______

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