a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding; Rac guanyl-nucleotide exchange factor activity; metal ion binding; guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; T cell activation; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; innate immune response; positive regulation of Rac GTPase activity; blood coagulation; positive regulation of GTPase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.