Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
VAV1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VAV1 a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; GEFs; GEFs, Rac/Rho
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding; metal ion binding; Rac guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of cell adhesion; phosphoinositide-mediated signaling; T cell activation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; innate immune response; blood coagulation
Reference #:  P15498 (UniProtKB)
Alt. Names/Synonyms: oncogene vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene; VAV1
Gene Symbols: VAV1
Molecular weight: 98,314 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VAV1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
carcinogenesis, altered: Y826‑p, Y836‑p, Y841‑p, Y844‑p
cell adhesion, altered: Y160‑p
cell differentiation, altered: Y174‑p, Y745‑p
cell growth, altered: Y174‑p, Y826‑p, Y836‑p, Y841‑p, Y844‑p
cell motility, altered: Y745‑p
cytoskeletal reorganization: Y160‑p
transcription, inhibited: Y174‑p
activity, induced: Y826‑p, Y841‑p
activity, inhibited: Y160‑p, Y174‑p
intracellular localization: Y174‑p
molecular association, regulation: Y142‑p, Y160‑p, Y174‑p, Y826‑p, Y841‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K85-u FLSTCCEkFGLKRSE
0 10 Y110-p QDFGKVIyTLSALSW
4 0 Y142-p SVGDEDIySGLSDQI
6 0 Y160-p VEEDEDLyDCVENEE
14 0 Y174-p EAEGDEIyEDLMRSE
0 1 P182 EDLMRSEPVSMPPKM
0 11 Y192-p MPPKMTEyDKRCCCL
0 1 K222-a SIQQHFLkPLQRFLK
0 1 K222-u SIQQHFLkPLQRFLK
0 1 K252-a RVHTHFLkEMKEALG
1 33 Y267-p TPGAANLyQVFIKYK
0 3 Y280-p YKERFLVyGRYCsQV
0 7 S285-p LVyGRYCsQVESASK
0 11 K307-u AREDVQMkLEECSQR
0 8 K335-u VPMQRVLkYHLLLQE
0 13 K353-u HTQEAMEkENLRLAL
0 9 K374-u AQCVNEVkRDNETLR
0 3 K410-u PKIDGELkITSVERR
0 4 K444-u RGDSYDLkDFVNLHS
0 2 Y541-p MLLRGTFyQGYRCHR
0 7 T574-p HGQDFPGtMKKDKLH
0 2 Y658 PCNRVKPYVHGPPQD
0 1 K716-a IKYNVEVkHIKIMTA
1 1 Y745-p LTELVEFyQQNSLkD
0 6 K751-u FyQQNSLkDCFKSLD
0 2 K770-u FPFKEPEkRTISRPA
0 60 Y791-p FGTAKARyDFCARDR
0 1 S802 ARDRSELSLKEGDII
1 82 Y826-p GWWRGEIyGRVGWFP
1 0 Y836-p VGWFPANyVEEDysE
1 58 Y841-p ANyVEEDysEyC___
0 6 S842-p NyVEEDysEyC____
1 468 Y844-p VEEDysEyC______
  mouse

 
K85 FLSTCCEKFGLKRSE
Y110-p QDFGKVIyTLSALSW
Y142-p ALNDEDIySGLSDQI
Y160-p AEEDEDLyDCVENEE
Y174-p EAEGDEIyEDLMRLE
S182-p EDLMRLEsVPTPPKM
Y192-p TPPKMTEyDKRCCCL
K222 SIQQHFMKPLQRFLK
K222 SIQQHFMKPLQRFLK
K252 SVHTHFLKELKDALA
Y267-p GPGATTLyQVFIKYK
Y280 YKERFLVYGRYCSQV
S285 LVYGRYCSQVESASK
K307 AREDVQMKLEECSQR
K335 VPMQRVLKYHLLLQE
K353 HTQDATEKENLRLAL
K374 AQCVNEVKRDNETLR
K410 PKIDGELKITSVERR
K444 RGDSYDLKASVNLHS
Y541 MLLRGTFYQGYRCYR
T574 HGQDFAGTMKKDKLH
Y658-p PCNRVHPyVHGPPQD
K716 IKYNVEVKHIKIMTS
Y745 LLELVEFYQQNSLKD
K751 FYQQNSLKDCFKSLD
R770 FPYKEPERRAISKPP
Y791-p FGTAKARyDFCARDR
S802-p ARDRSELsLKEGDII
Y826-p GWWRGEIyGRIGWFP
Y836 IGWFPSNYVEEDysE
Y841-p SNYVEEDysEyC___
S842-p NYVEEDysEyC____
Y844-p VEEDysEyC______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.