a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Guanine nucleotide exchange factor, Rac/Rho
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; metal ion binding; phospholipid binding; transcription factor activity
Biological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; platelet activation; regulation of GTPase activity; phosphoinositide-mediated signaling; positive regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; T cell activation; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; regulation of Rho protein signal transduction; innate immune response; blood coagulation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.