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GSC
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Belongs to the paired homeobox family. Bicoid subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein |
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Cellular Component: transcription factor complex; nucleus
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Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
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Biological Process: negative regulation of Wnt receptor signaling pathway; forebrain development; gastrulation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; muscle morphogenesis; dorsoventral neural tube patterning; embryonic skeletal morphogenesis
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Reference #:
P56915 (UniProtKB)
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| Alt. Names/Synonyms: goosecoid homeobox; GSC; Homeobox protein goosecoid |
| Gene Symbols: GSC |
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Molecular weight: 28,150 Da
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Basal Isoelectric point: 8.86
Predict pI for various phosphorylation states
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