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PhosphoSitePlus
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Protein Page:
GSC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GSC Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Belongs to the paired homeobox family. Bicoid subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: transcription factor complex; nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: neural crest cell fate specification; negative regulation of Wnt receptor signaling pathway; forebrain development; gastrulation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; muscle morphogenesis; dorsoventral neural tube patterning; embryonic skeletal morphogenesis
Reference #:  P56915 (UniProtKB)
Alt. Names/Synonyms: goosecoid homeobox; GSC; Homeobox protein goosecoid
Gene Symbols: GSC
Molecular weight: 28,150 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below

GSC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K183 ENLFQETKYPDVGTR
1 0 K196 TREQLARKVHLREEK
1 0 K203 KVHLREEKVEVWFKN
1 0 K209 EKVEVWFKNRRAKWR
1 0 K214 WFKNRRAKWRRQKRS
1 0 K239 WNKTSSSKAsPEKRE
0 1 S241-p KTSSSKAsPEKREEE
0 1 K250-ac EKREEEGksDLDSDS
0 1 S251-p KREEEGksDLDSDS_
  mouse

 
K183-sm ENLFQETkYPDVGTR
K196-sm TREQLARkVHLREEk
K203-sm kVHLREEkVEVWFkN
K209-sm EkVEVWFkNRRAkWR
K214-sm WFkNRRAkWRRQKRS
K238-sm KWNKTSSkASPEKRE
S240 NKTSSkASPEKREEE
K249 EKREEEGKSDLDSDS
S250 KREEEGKSDLDSDS_
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