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Protein Page:
TRF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRF1 a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleoplasm; chromosome, telomeric region; nuclear telomere cap complex; cytoplasm; nucleolus; spindle; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; microtubule binding; telomeric DNA binding; double-stranded telomeric DNA binding; chromatin binding; DNA bending activity
Biological Process: response to drug; mitosis; positive regulation of mitosis; negative regulation of telomere maintenance via semi-conservative replication; positive regulation of apoptosis; positive regulation of microtubule polymerization; telomere maintenance via telomerase; positive regulation of mitotic cell cycle; negative regulation of telomerase activity; negative regulation of DNA replication; mitotic cell cycle spindle assembly checkpoint; G2/M transition of mitotic cell cycle; age-dependent telomere shortening; negative regulation of telomere maintenance via telomerase; telomere maintenance; protein homooligomerization
Reference #:  P54274 (UniProtKB)
Alt. Names/Synonyms: FLJ41416; hTRF1-AS; NIMA-interacting protein 2; PIN2; t-TRF1; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; telomeric repeat binding protein 1; Telomeric repeat-binding factor 1; TERF1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1
Gene Symbols: TERF1
Molecular weight: 50,246 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRF1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S435‑p
apoptosis, inhibited: S219‑p
intracellular localization: T122‑p
molecular association, regulation: T122‑p
phosphorylation: T344‑p, T371‑p
protein stabilization: T122‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MAEDVSsAAPsPRG
0 5 S11-p DVSsAAPsPRGCADG
0 1 - gap
2 0 T122-p LTACQLRtIYICQFL
0 1 K136-ub LTRIAAGkTLDAQFE
0 1 T149-p FENDERItPLESALM
0 1 S160-p SALMIWGsIEKEHDK
1 0 S219-p SKLLMIIsQKDTFHS
0 1 S252-p NYVLSEKsstFLMKA
0 1 S253-p YVLSEKsstFLMKAA
0 1 T254-p VLSEKsstFLMKAAA
1 0 T273-p SKRTRTItSQDKPSG
0 1 S274 KRTRTItSQDKPSGN
0 1 N281 SQDKPSGNDVEMETE
0 1 V283 DKPSGNDVEMETEAN
0 1 K295-ac EANLDTRksVSDkQS
0 2 S296-p ANLDTRksVSDkQSA
0 1 K300-ac TRksVSDkQSAVTES
0 1 S308-p QSAVTESsEGtVSLL
0 1 T311-p VTESsEGtVSLLRSH
1 0 T344-p KKERRVGtPQsTKKK
0 2 S347-p RRVGtPQsTKKKKES
0 1 T358-p KKESRRAtESRIPVS
1 0 S367-p SRIPVSKsQPVtPEK
3 5 T371-p VSKsQPVtPEKHRAR
0 1 Y398 LRSGVRKYGEGNWSK
0 1 K411-ub SKILLHYkFNNRTSV
0 2 S434-p MKKLKLIssDsED__
1 2 S435-p KKLKLIssDsED___
0 2 S437-p LKLIssDsED_____
  mouse

 
S7 _MAETVSSAARDAPS
- gap
S23 EGWTDSDSPEQEEVG
T109 LTAYQLKTVYICQFL
K123 LTRVASGKALDAQFE
T136 FEVDERITPLESALM
S147 SALMIWNSIEKEHDK
S206 RKLLKIISQKDVFHS
S239 GDVLSEKSSTFLMKA
S240 DVLSEKSSTFLMKAA
T241 VLSEKSSTFLMKAAT
A260 NEKARTQAsKDRPDA
S261-p EKARTQAsKDRPDAt
T268-p sKDRPDAtNtGMDTE
T270-p DRPDAtNtGMDTEVG
K282 EVGLNKEKSVNGQQS
S283 VGLNKEKSVNGQQST
Q287 KEKSVNGQQSTETEP
L295 QSTETEPLVDTVSSI
T298 ETEPLVDTVSSIRSH
T330 RNEARTGTLQCETTM
- gap
S344 MERNRRTSGRNRLCV
- gap
T358 VSENQPDTDDKSGRR
Y385-p LKCGVKKyGEGNWAK
K398 AKILSHYKFNNRTSV
S421 MKRLKLIS_______
- gap
- gap
  rat

 
- under review  
- gap
S23-p AGGTSADsPEKEAAR
T109 LTAYQLKTVYICQFL
K123 LTRVAAGKSLDAQFE
T136 FEVDERITPLESALM
S147 SALMIWDSIEKEHDK
S206 RKLLKIISQKDVFHV
S239 ECVLNEKSSTFLMKA
S240 CVLNEKSSTFLMKAA
T241 VLNEKSSTFLMKAAT
A260 NEKARTVASEDKAKA
S261 EKARTVASEDKAKAT
T268 SEDKAKATNTGTETE
T270 DKAKATNTGTETEVN
E282 EVNSNKGESVNGQQS
S283 VNSNKGESVNGQQSV
Q287 KGESVNGQQSVETES
L295 QSVETESLVDTGSSV
T298 ETESLVDTGSSVRSH
T330 RNEARTGTLQCEIAT
- gap
S344 TKRNRRTSGGNRLRI
- gap
T358 ISKNQPDTNEKHGRR
Y385 LKCGVRKYGEGNWAK
K398 AKILSHYKFNNRTSV
S421 MRRLRLIS_______
- gap
- gap
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