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TRF1 (human)

Overview TRF1 a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleoplasm; chromosome, telomeric region; nuclear telomere cap complex; cytoplasm; spindle; nucleus Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; microtubule binding; telomeric DNA binding; double-stranded telomeric DNA binding; caspase activator activity; chromatin binding; DNA bending activity Biological Process: response to drug; caspase activation; mitosis; positive regulation of mitosis; negative regulation of telomere maintenance via semi-conservative replication; positive regulation of microtubule polymerization; telomere maintenance via telomerase; positive regulation of mitotic cell cycle; negative regulation of telomerase activity; cell division; negative regulation of DNA replication; mitotic cell cycle spindle assembly checkpoint; induction of apoptosis; G2/M transition of mitotic cell cycle; age-dependent telomere shortening; telomere maintenance; negative regulation of telomere maintenance via telomerase; protein homooligomerization Reference #:  P54274 (UniProtKB) Alt. Names/Synonyms: FLJ41416; hTRF1-AS; NIMA-interacting protein 2; PIN2; t-TRF1; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; telomeric repeat binding protein 1; Telomeric repeat-binding factor 1; TERF1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1 Gene Symbols: TERF1 Molecular weight: 50,246 Da Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TRF1 1BA5 - A=378-430 (human) 1H6O - A=62-265 (human) 1ITY - A=371-439 (human) 1IV6 - A=371-439 (human) 1W0T - A/B=379-431 (human) 3BQO - A=58-268 (human) 3L82 - A=58-268 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, induced: S435‑p apoptosis, inhibited: S219‑p intracellular localization: T122‑p molecular association, regulation: T122‑p phosphorylation: T344‑p, T371‑p protein stabilization: T122‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S11-p	DVSSAAPsPRGCADG
1	0		T122-p	LTACQLRtIYICQFL
0	1		K136-u	LTRIAAGkTLDAQFE
1	0		S219-p	SKLLMIIsQKDTFHS
0	1		S252-p	NYVLSEKsstFLMKA
0	1		S253-p	YVLSEKsstFLMKAA
0	1		T254-p	VLSEKsstFLMKAAA
1	0		T273-p	SKRTRTItSQDKPSG
0	1		S274	KRTRTItSQDKPSGN
0	1		N281	SQDKPSGNDVEMETE
0	1		V283	DKPSGNDVEMETEAN
0	1		K295-a	EANLDTRksVSDkQS
0	2		S296-p	ANLDTRksVSDkQSA
0	1		K300-a	TRksVSDkQSAVTES
0	1		S308-p	QSAVTESsEGtVSLL
0	1		T311-p	VTESsEGtVSLLRSH
1	0		T344-p	KKERRVGtPQsTKKK
0	2		S347-p	RRVGtPQsTKKKKES
0	1		T358-p	KKESRRAtESRIPVS
1	0		S367-p	SRIPVSKsQPVtPEK
2	5		T371-p	VSKsQPVtPEKHRAR
0	1		Y398	LRSGVRKYGEGNWSK
0	1		K411-u	SKILLHYkFNNRTSV
0	1		S434-p	MKKLKLIssDsED__
1	1		S435-p	KKLKLIssDsED___
0	1		S437-p	LKLIssDsED_____

	mouse
-	gap
T109	LTAYQLKTVYICQFL
K123	LTRVASGKALDAQFE
S206	RKLLKIISQKDVFHS
S239	GDVLSEKSSTFLMKA
S240	DVLSEKSSTFLMKAA
T241	VLSEKSSTFLMKAAT
A260	NEKARTQAsKDRPDA
S261-p	EKARTQAsKDRPDAt
T268-p	sKDRPDAtNtGMDTE
T270-p	DRPDAtNtGMDTEVG
K282	EVGLNKEKSVNGQQS
S283	VGLNKEKSVNGQQST
Q287	KEKSVNGQQSTETEP
L295	QSTETEPLVDTVSSI
T298	ETEPLVDTVSSIRSH
T330	RNEARTGTLQCETTM
C333	ARTGTLQCETTMERN
S344	MERNRRTSGRNRLCV
N354	NRLCVSENQPDTDDK
T358	VSENQPDTDDKSGRR
Y385-p	LKCGVKKyGEGNWAK
K398	AKILSHYKFNNRTSV
S421	MKRLKLIS_______
-	gap
-	gap

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