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Protein Page:
ALDH2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALDH2 This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
Protein type: Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate; Oxidoreductase; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Lipid Metabolism - glycerolipid; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.3; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - arginine and proline; Mitochondrial; Secondary Metabolites Metabolism - limonene and pinene degradation; Lipid Metabolism - fatty acid; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation
Cellular Component: mitochondrial matrix
Molecular Function: aldehyde dehydrogenase (NAD) activity; electron carrier activity; aldehyde dehydrogenase [NAD(P)+] activity
Biological Process: synaptic transmission; ethanol catabolic process; xenobiotic metabolic process; carbohydrate metabolic process; alcohol metabolic process; ethanol oxidation; neurotransmitter biosynthetic process
Reference #:  P05091 (UniProtKB)
Alt. Names/Synonyms: acetaldehyde dehydrogenase 2; aldehyde dehydrogenase 2 family (mitochondrial); Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDH2; ALDHI; ALDM; liver mitochondrial ALDH; MGC1806; nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Gene Symbols: ALDH2
Molecular weight: 56,381 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
Select Structure to View Below

ALDH2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K52 WHDAVSRKTFPTVNP
0 1 K73 CQVAEGDKEDVDKAV
0 2 K78 GDKEDVDKAVkAARA
0 1 K78 GDKEDVDKAVkAARA
0 4 K81-ac EDVDKAVkAARAAFQ
0 3 S91-p RAAFQLGsPWRRMDA
0 1 Y131-p TLDNGKPyVISYLVD
0 1 Y135 GKPyVISYLVDLDMV
0 2 Y148-p MVLKCLRyyAGWADK
0 2 Y149-p VLKCLRyyAGWADKy
0 1 K155 yyAGWADKyHGKTIP
0 1 K155 yyAGWADKyHGKTIP
0 2 Y156-p yAGWADKyHGKTIPI
0 3 K159 WADKyHGKTIPIDGD
0 1 K159 WADKyHGKTIPIDGD
0 2 K159 WADKyHGKTIPIDGD
0 1 S169-p PIDGDFFsYTRHEPV
0 1 S277-p IQVAAGSsNLKRVtL
0 1 K280 AAGSsNLKRVtLELG
0 3 T283-p SsNLKRVtLELGGKS
0 1 S354 VVGNPFDSkTEQGPQ
0 2 K355-ac VGNPFDSkTEQGPQV
0 1 K355-ub VGNPFDSkTEQGPQV
0 77 K368-ac QVDETQFkkILGYIN
0 2 K368-ub QVDETQFkkILGYIN
0 2 K368-sc QVDETQFkkILGYIN
0 5 K369-ac VDETQFkkILGYINt
0 5 N375 kkILGYINtGKQEGA
0 1 N375 kkILGYINtGKQEGA
0 2 N375 kkILGYINtGKQEGA
0 1 T376-p kILGYINtGKQEGAK
0 1 K383 tGKQEGAKLLCGGGI
0 1 K383 tGKQEGAKLLCGGGI
0 1 K383 tGKQEGAKLLCGGGI
0 2 Q407 PTVFGDVQDGMTIAK
0 1 Q407 PTVFGDVQDGMTIAK
0 2 Q407 PTVFGDVQDGMTIAK
0 2 K414 QDGMTIAKEEIFGPV
0 2 K426 GPVMQILKFKTIEEV
0 1 K426 GPVMQILKFKTIEEV
0 2 K428 VMQILKFKTIEEVVG
0 1 K428 VMQILKFKTIEEVVG
0 2 K428 VMQILKFKTIEEVVG
0 3 T441 VGRANNSTyGLAAAV
0 1 T441 VGRANNSTyGLAAAV
0 2 T441 VGRANNSTyGLAAAV
0 3 Y442-p GRANNSTyGLAAAVF
0 1 T450-p GLAAAVFtKDLDKAN
0 1 K451 LAAAVFtKDLDKANY
0 1 K451 LAAAVFtKDLDKANY
0 1 K451 LAAAVFtKDLDKANY
0 2 Y497-p SGRELGEyGLQAYTE
0 2 K511-ub EVKTVTVkVPQKNS_
0 2 K511 EVKTVTVKVPQKNS_
  mouse

 
K54-ub WHDAVSRkTFPTVNP
K75-ac CQVAEGNkEDVDkAV
K80-ac GNkEDVDkAVKAARA
K80-sc GNkEDVDkAVKAARA
K83 EDVDkAVKAARAAFQ
S93-p RAAFQLGsPWRRMDA
Y133 TLDNGKPYVISYLVD
Y137 GKPYVISYLVDLDMV
Y150 MVLKCLRYYAGWADk
Y151 VLKCLRYYAGWADkY
K157-ac YYAGWADkYHGkTIP
K157-ub YYAGWADkYHGkTIP
Y158 YAGWADkYHGkTIPI
K161-ac WADkYHGkTIPIDGD
K161-ub WADkYHGkTIPIDGD
K161-sc WADkYHGkTIPIDGD
S171 PIDGDFFSYTRHEPV
S279 IQVAAGSSNLkRVtL
K282-ub AAGSSNLkRVtLELG
T285-p SSNLkRVtLELGGKS
S356-p VVGNPFDsRTEQGPQ
R357 VGNPFDsRTEQGPQV
R357 VGNPFDsRTEQGPQV
K370-ac QVDETQFkkILGYIk
K370-ub QVDETQFkkILGYIk
K370-sc QVDETQFkkILGYIk
K371-ac VDETQFkkILGYIkS
K377-ac kkILGYIkSGQQEGA
K377-ub kkILGYIkSGQQEGA
K377-sc kkILGYIkSGQQEGA
S378 kILGYIkSGQQEGAk
K385-ac SGQQEGAkLLCGGGA
K385-ub SGQQEGAkLLCGGGA
K385-sc SGQQEGAkLLCGGGA
K409-ac PTVFGDVkDGMTIAk
K409-ub PTVFGDVkDGMTIAk
K409-sc PTVFGDVkDGMTIAk
K416-ac kDGMTIAkEEIFGPV
K428-ac GPVMQILkFkTIEEV
K428-sc GPVMQILkFkTIEEV
K430-ac VMQILkFkTIEEVVG
K430-ub VMQILkFkTIEEVVG
K430-sc VMQILkFkTIEEVVG
K443-ac VGRANDSkYGLAAAV
K443-ub VGRANDSkYGLAAAV
K443-sc VGRANDSkYGLAAAV
Y444 GRANDSkYGLAAAVF
T452 GLAAAVFTkDLDKAN
K453-ac LAAAVFTkDLDKANY
K453-ub LAAAVFTkDLDKANY
K453-sc LAAAVFTkDLDKANY
Y499 SGRELGEYGLQAYTE
K513-ub EVKTVTVkVPQKNS_
K513-sc EVKTVTVkVPQKNS_
  rat

 
K54 WHDAVSKKTFPTVNP
K75-ac CQVAEGNkEDVDkAV
K80-ac GNkEDVDkAVKAAQA
K80 GNkEDVDKAVKAAQA
K83 EDVDkAVKAAQAAFQ
S93 QAAFQLGSPWRRMDA
Y133 TLDNGKPYVISyLVD
Y137-p GKPYVISyLVDLDMV
Y150 MVLKCLRYYAGWADk
Y151 VLKCLRYYAGWADkY
K157-ac YYAGWADkYHGkTIP
K157 YYAGWADKYHGkTIP
Y158 YAGWADkYHGkTIPI
K161-ac WADkYHGkTIPIDGD
K161 WADkYHGKTIPIDGD
K161 WADkYHGKTIPIDGD
S171 PIDGDFFSYTRHEPV
S279 IQVAAGSSNLKRVTL
K282 AAGSSNLKRVTLELG
T285 SSNLKRVTLELGGKS
S356-p VVGNPFDsRTEQGPQ
R357 VGNPFDsRTEQGPQV
R357 VGNPFDsRTEQGPQV
K370-ac QVDETQFkKILGYIk
K370 QVDETQFKKILGYIk
K370 QVDETQFKKILGYIk
K371 VDETQFkKILGYIkS
K377-ac kKILGYIkSGQQEGA
K377 kKILGYIKSGQQEGA
K377 kKILGYIKSGQQEGA
S378 KILGYIkSGQQEGAK
K385 SGQQEGAKLLCGGGA
K385 SGQQEGAKLLCGGGA
K385 SGQQEGAKLLCGGGA
K409-ac PTVFGDVkDGMTIAk
K409 PTVFGDVKDGMTIAk
K409 PTVFGDVKDGMTIAk
K416-ac kDGMTIAkEEIFGPV
K428-ac GPVMQILkFkTIEEV
K428 GPVMQILKFkTIEEV
K430-ac VMQILkFkTIEEVVG
K430 VMQILkFKTIEEVVG
K430 VMQILkFKTIEEVVG
K443-ac VGRANNSkYGLAAAV
K443 VGRANNSKYGLAAAV
K443 VGRANNSKYGLAAAV
Y444 GRANNSkYGLAAAVF
T452 GLAAAVFTKDLDKAN
K453 LAAAVFTKDLDKANY
K453 LAAAVFTKDLDKANY
K453 LAAAVFTKDLDKANY
Y499 SGRELGEYGLQAYTE
K513 EVKTVTVKVPQKNS_
K513 EVKTVTVKVPQKNS_
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