Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Mitochondrial; EC 18.104.22.168
Molecular Function: identical protein binding; manganese ion binding; superoxide dismutase activity
Biological Process: regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; oxygen homeostasis; response to reactive oxygen species; release of cytochrome c from mitochondria; response to superoxide; removal of superoxide radicals; acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to reactive oxygen species; regulation of blood pressure; superoxide metabolic process; negative regulation of neuron apoptosis; protein homotetramerization
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.