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PPIB (human)

Overview PPIB PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. Note: This description may include information from UniProtKB. Protein type: EC 5.2.1.8; Cyclophilin; Secreted; Isomerase; Chaperone; Secreted, signal peptide Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; melanosome Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; peptide binding Biological Process: extracellular matrix organization and biogenesis; protein peptidyl-prolyl isomerization; protein folding Reference #:  P23284 (UniProtKB) Alt. Names/Synonyms: Cyclophilin B; cyclophilin-like protein; CYP-S1; CYPB; MGC14109; MGC2224; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase B; PPIB; Rotamase B; S-cyclophilin; SCYLP Gene Symbols: PPIB Molecular weight: 23,743 Da Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states

Select Structure to View Below PPIB 1CYN - A=31-208 (human) 3ICH - A=34-216 (human) 3ICI - A/B=34-216 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1CYN 3ICH 3ICI  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K67-u	VIFGLFGkTVPKTVD
0	1		K84	VALATGEKGFGYkNS
0	1		K89-a	GEKGFGYkNSKFHRV
0	18		K98-a	SKFHRVIkDFMIQGG
0	1		K98-u	SKFHRVIkDFMIQGG
0	1		T108	MIQGGDFTRGDGTGG
0	1		K116-u	RGDGTGGkSIYGERF
0	1		K131-u	PDENFKLkHYGPGWV
0	2		S139-p	HYGPGWVsMANAGKD
0	1		K158-u	QFFITTVkTAWLDGk
0	2		K165-u	kTAWLDGkHVVFGkV
0	1		K171-a	GkHVVFGkVLEGMEV
0	1		S184-p	EVVRKVEstKTDSRD
0	1		T185-p	VVRKVEstKTDSRDK
0	1		K209-a	CGKIEVEkPFAIAkE
0	3		K209-u	CGKIEVEkPFAIAkE
0	7		K215-a	EkPFAIAkE______

	mouse
K67	VVFGLFGKTVPKTVD
K84-u	VALATGEkGFGYkNS
K89-a	GEkGFGYkNSKFHRV
K98	SKFHRVIKDFMIQGG
K98	SKFHRVIKDFMIQGG
T108-p	MIQGGDFtRGDGTGG
K116	RGDGTGGKSIYGERF
K131	PDENFKLKHYGPGWV
S139	HYGPGWVSMANAGKD
K158	QFFITTVKTSWLDGk
K165-u	KTSWLDGkHVVFGKV
K171	GkHVVFGKVLEGMDV
S184	DVVRKVESTKTDSRD
T185	VVRKVESTKTDSRDK
K209	SGKIEVEKPFAIAkE
K209-u	SGKIEVEkPFAIAkE
K215-a	EkPFAIAkE______

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