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Protein Page:
FETUA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FETUA Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: kinase inhibitor activity; cysteine protease inhibitor activity
Biological Process: negative regulation of bone mineralization; pinocytosis; ossification; positive regulation of phagocytosis; regulation of inflammatory response; acute-phase response; negative regulation of phosphorylation; negative regulation of insulin receptor signaling pathway; regulation of bone mineralization; skeletal development
Reference #:  P02765 (UniProtKB)
Alt. Names/Synonyms: A2HS; AHS; AHSG; Alpha-2-HS-glycoprotein; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; FETUA; Fetuin-A; HSGA
Gene Symbols: AHSG
Molecular weight: 39,325 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FETUA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 - gap
0 4 S134-p VVYAKCDssPDsAED
0 10 S135-p VYAKCDssPDsAEDV
1 561 S138-p KCDssPDsAEDVRKV
0 7 K225-a KCNLLAEkQYGFCKA
0 2 K225-u KCNLLAEkQYGFCKA
0 2 - gap
1 29 S325 HTFMGVVSLGSPsGE
1 33 S328 MGVVSLGSPsGEVsH
1 25 S330-p VVSLGSPsGEVsHPR
0 2 - gap
0 2 - gap
1 0 - gap
0 2 S334-p GSPsGEVsHPRKTRT
0 1 S346-ga TRTVVQPsVGAAAGP
  mouse

 
K65-u QVLNQIDkVKVWSRR
T130-p GQFRVMHtQCHstPD
S134-p VMHtQCHstPDsAED
T135-p MHtQCHstPDsAEDV
S138-p QCHstPDsAEDVRKL
K225 KCNLLAEKQHGFCKA
K225-u KCNLLAEkQHGFCKA
S305-p HDLRHAFsPVAsVEs
S309-p HAFsPVAsVEsAsGE
S312-p sPVAsVEsAsGEtLH
S314-p VAsVEsAsGEtLHsP
T317-p VEsAsGEtLHsPKVG
S320-p AsGEtLHsPKVGQPG
- gap
- gap
- gap
  rat

 
K65 QILNQIDKVKVWSRR
- gap
S134-p VLHAQCHstPDsAED
T135-p LHAQCHstPDsAEDV
S138-p QCHstPDsAEDVRKF
K225 KCNLLAEKQYGFCKA
K225 KCNLLAEKQYGFCKA
S309-p HDLRHAFsPVAsVEs
S313-p HAFsPVAsVEsAsGE
S316-p sPVAsVEsAsGEVLH
S318-p VAsVEsAsGEVLHsP
- gap
S324-p AsGEVLHsPKVGQPG
- gap
- gap
- gap
  cow

 
- gap
T130 GQFSVLFTKCDSSPD
S134 VLFTKCDSSPDSAED
S135 LFTKCDSSPDSAEDV
S138 KCDSSPDSAEDVRKL
K225 KCNLLAEKQYGFCKG
K225 KCNLLAEKQYGFCKG
S316 YDLRHTFSGVAsVEs
S320-p HTFSGVAsVEssSGE
S323-p SGVAsVEssSGEAFH
S325 VAsVEssSGEAFHVG
- gap
- gap
S324-p GVAsVEssSGEAFHV
- gap
- gap
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