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FETUA (human)

Overview FETUA Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region Molecular Function: receptor signaling protein tyrosine kinase inhibitor activity; kinase inhibitor activity; cysteine protease inhibitor activity Biological Process: pinocytosis; organ regeneration; ossification; male gonad development; negative regulation of insulin receptor signaling pathway; negative regulation of bone mineralization; cellular response to insulin stimulus; positive regulation of phagocytosis; regulation of inflammatory response; acute-phase response; positive regulation of bone resorption; negative regulation of phosphorylation; cerebral cortex development; negative regulation of cell growth; skeletal development; regulation of bone mineralization Reference #:  P02765 (UniProtKB) Alt. Names/Synonyms: A2HS; AHS; AHSG; Alpha-2-HS-glycoprotein; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; FETUA; Fetuin-A; HSGA Gene Symbols: AHSG Molecular weight: 39,325 Da Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FETUA

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		E65	HTLNQIDEVKVWPQQ
0	4		S134-p	VVYAKCDssPDsAED
0	9		S135-p	VYAKCDssPDsAEDV
1	559		S138-p	KCDssPDsAEDVRkV
0	1		K144-a	DsAEDVRkVCQDCPL
0	7		K225-a	KCNLLAEkQyGFCKA
0	2		K225-u	KCNLLAEkQyGFCKA
0	1		Y227-p	NLLAEkQyGFCKATL
0	2		M321	YDLRHTFMGVVSLGS
1	27		S325	HTFMGVVSLGSPsGE
1	31		S328	MGVVSLGSPsGEVsH
1	0		P329	GVVSLGSPsGEVsHP
1	23		S330-p	VVSLGSPsGEVsHPR
0	2		V333	LGSPsGEVsHPRKTR
0	2		S334-p	GSPsGEVsHPRKTRT
0	2		T339	EVsHPRKTRTVVQPS

	mouse
K65-u	QVLNQIDkVKVWSRR
S134-p	VMHTQCHstPDsAED
T135-p	MHTQCHstPDsAEDV
S138-p	QCHstPDsAEDVRKL
K144	DsAEDVRKLCPRCPL
K225	KCNLLAEKQHGFCKA
K225-u	KCNLLAEkQHGFCKA
H227	NLLAEkQHGFCKANL
S305-p	HDLRHAFsPVAsVEs
S309-p	HAFsPVAsVEsAsGE
S312-p	sPVAsVEsAsGEtLH
A313	PVAsVEsAsGEtLHs
S314-p	VAsVEsAsGEtLHsP
T317-p	VEsAsGEtLHsPKVG
-	gap
S320-p	AsGEtLHsPKVGQPG

	rat
K65	QILNQIDKVKVWSRR
S134-p	VLHAQCHstPDsAED
T135-p	LHAQCHstPDsAEDV
S138-p	QCHstPDsAEDVRKF
K144	DsAEDVRKFCPRCPI
K225	KCNLLAEKQYGFCKA
K225	KCNLLAEKQYGFCKA
Y227	NLLAEKQYGFCKATL
S309-p	HDLRHAFsPVAsVEs
S313-p	HAFsPVAsVEsAsGE
S316-p	sPVAsVEsAsGEVLH
A317	PVAsVEsAsGEVLHs
S318-p	VAsVEsAsGEVLHsP
V321	VEsAsGEVLHsPKVG
-	gap
S324-p	AsGEVLHsPKVGQPG

	cow
S65	HTLNQIDSVKVWPRR
S134	VLFTKCDSSPDSAED
S135	LFTKCDSSPDSAEDV
S138	KCDSSPDSAEDVRKL
K144	DSAEDVRKLCPDCPL
K225	KCNLLAEKQYGFCKG
K225	KCNLLAEKQYGFCKG
Y227	NLLAEKQYGFCKGSV
S316	YDLRHTFSGVAsVEs
S320-p	HTFSGVAsVEssSGE
S323-p	SGVAsVEssSGEAFH
S324-p	GVAsVEssSGEAFHV
S325	VAsVEssSGEAFHVG
A328	VEssSGEAFHVGKTP
-	gap
T334	EAFHVGKTPIVGQPS

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