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Protein Page:
PDIA4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDIA4 Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Belongs to the protein disulfide isomerase family. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Isomerase; Endoplasmic reticulum; EC 5.3.4.1
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome
Molecular Function: protein binding; protein disulfide isomerase activity
Biological Process: protein folding; cell redox homeostasis; protein secretion
Reference #:  P13667 (UniProtKB)
Alt. Names/Synonyms: Endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; ERp-72; ERP70; ERP72; PDIA4; protein disulfide isomerase family A, member 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide isomerase-associated 4; Protein disulfide-isomerase A4
Gene Symbols: PDIA4
Molecular weight: 72,932 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDIA4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y101-p CKQFAPEyEkIANIL
0 1 K103-ub QFAPEyEkIANILKD
0 1 K109 EkIANILKDKDPPIP
0 1 K109 EkIANILKDKDPPIP
0 1 S130-p TSASVLAsRFDVSGY
0 1 R131 SASVLAsRFDVSGYP
0 2 K141-ub VSGYPTIkILKKGQA
0 1 S168-p VAKVREVsQPDWTPP
0 1 T238-p PLAKVDAtAETDLAk
0 11 K245 tAETDLAKRFDVSGY
0 3 K245-ub tAETDLAkRFDVSGY
0 1 K245-sc tAETDLAkRFDVSGY
0 9 K256-ac VSGYPTLkIFRKGRP
0 2 K256-ub VSGYPTLkIFRKGRP
0 1 Y266-p RKGRPYDyNGPREKY
0 1 K272 DyNGPREKYGIVDYM
0 1 Y273 yNGPREKYGIVDYMI
0 1 Y278 EKYGIVDYMIEQSGP
0 2 K294-ub SKEILTLkQVQEFLK
0 1 K335 NNLREDYKFHHTFST
0 1 K349 TEIAKFLKVsQGQLV
0 1 S351-p IAKFLKVsQGQLVVM
0 1 Q354 FLKVsQGQLVVMQPE
0 1 K366-ac QPEKFQSkyEPRSHM
0 2 Y367-p PEKFQSkyEPRSHMM
0 1 S379-p HMMDVQGstQDsAIK
0 1 T380-p MMDVQGstQDsAIKD
0 1 S383-p VQGstQDsAIKDFVL
0 1 K391-ub AIKDFVLkYALPLVG
0 11 K484-ac AILDESGkkFAMEPE
0 1 K484 AILDESGKkFAMEPE
0 9 K485-ac ILDESGkkFAMEPEE
0 1 T503-ga DTLREFVtAFkKGkL
0 1 K506-ac REFVtAFkKGkLKPV
0 1 K506 REFVtAFKKGkLKPV
0 1 K509-ac VtAFkKGkLKPVIKs
0 1 S516-p kLKPVIKsQPVPKNN
0 13 K533-ac PVKVVVGkTFDSIVM
0 1 K543-sc DSIVMDPkKDVLIEF
0 1 K570-sc PVYNSLAkKYKGQKG
0 1 K576 AkKYKGQKGLVIAKM
0 1 K582 QKGLVIAKMDAtAND
0 1 T586-p VIAKMDAtANDVPsD
0 1 S592-p AtANDVPsDRYkVEG
0 1 K596-ac DVPsDRYkVEGFPTI
0 1 S608-p PTIYFAPsGDKKNPV
0 3 K637 FIEEHATKLSRTKEE
0 1 K637 FIEEHATKLSRTKEE
  mouse

 
Y94 CKQFAPEYEKIASTL
K96 QFAPEYEKIASTLkD
K102-ac EKIASTLkDNDPPIA
K102-ub EKIASTLkDNDPPIA
S123 TSASMLASkFDVSGY
K124-ub SASMLASkFDVSGYP
K134-ub VSGYPTIkILKKGQA
S161 VAKVREVSQPDWTPP
T231 PLAKVDATEQTDLAk
K238-ac TEQTDLAkRFDVSGY
K238-ub TEQTDLAkRFDVSGY
K238-sc TEQTDLAkRFDVSGY
K249 VSGYPTLKIFRKGRP
K249-ub VSGYPTLkIFRKGRP
Y259 RKGRPFDYNGPREky
K265-ac DYNGPREkyGIVDyM
Y266-p YNGPREkyGIVDyMI
Y271-p EkyGIVDyMIEQSGP
K287-ub SKEILTLkQVQEFLK
K328-ac NNLREDYkFHHTFSP
K342-sc PEIAKFLkVSLGkLV
S344 IAKFLkVSLGkLVLT
K347-ub FLkVSLGkLVLTHPE
K359 HPEKFQSKYEPRFHV
Y360 PEKFQSKYEPRFHVM
S372 HVMDVQGSTEASAIK
T373 VMDVQGSTEASAIKD
S376 VQGSTEASAIKDYVV
K384 AIKDYVVKHALPLVG
K477-ac AILDESGkkFAMEPE
K477-sc AILDESGkkFAMEPE
K478-ac ILDESGkkFAMEPEE
T496 DTLREFVTAFkKGKL
K499 REFVTAFKKGKLKPV
K499-sc REFVTAFkKGKLKPV
K502 VTAFkKGKLKPVIKS
S509 KLKPVIKSQPVPKNN
K526 PVKVVVGKTFDAIVM
K536-sc DAIVMDPkKDVLIEF
K563-sc PIYTSLGkKYKGQkD
K569-ub GkKYKGQkDLVIAkM
K575-sc QkDLVIAkMDATAND
T579 VIAkMDATANDITND
N585 ATANDITNDQYKVEG
K589 DITNDQYKVEGFPTI
S601 PTIYFAPSGDKKNPI
K630-ac FIDEHATkRSRTKEE
K630-sc FIDEHATkRSRTKEE
  rat

 
Y99 CKQFAPEYEKIASTL
K101 QFAPEYEKIASTLKD
K107 EKIASTLKDNDPPIA
K107 EKIASTLKDNDPPIA
S128 TSASMLASKFDVSGY
K129 SASMLASKFDVSGYP
K139 VSGYPTIKILKKGQA
S166 VAKVREVSQPDWTPP
T236 PLAKVDATEQTDLAK
K243 TEQTDLAKRFDVSGY
K243 TEQTDLAKRFDVSGY
K243 TEQTDLAKRFDVSGY
K254 VSGYPTLKIFRKGRP
K254 VSGYPTLKIFRKGRP
Y264 RKGRPFDYNGPREKY
K270 DYNGPREKYGIVDYM
Y271 YNGPREKYGIVDYMV
Y276 EKYGIVDYMVEQSGP
K292 SKEILTLKQVQEFLK
K333 NTLREDYKFHHTFST
K347 TEIAKFLKVSLGKLV
S349 IAKFLKVSLGKLVLM
K352 FLKVSLGKLVLMQPE
K364 QPEKFQSKYEPRMHV
Y365 PEKFQSKYEPRMHVM
S377 HVMDVQGSTEASAIK
T378 VMDVQGSTEASAIKD
S381 VQGSTEASAIKDYVV
K389 AIKDYVVKHALPLVG
K482 AILDESGKKFAMEPE
K482 AILDESGKKFAMEPE
K483 ILDESGKKFAMEPEE
M501 DALQEFVMAFKKGKL
K504 QEFVMAFKKGKLKPV
K504 QEFVMAFKKGKLKPV
K507 VMAFKKGKLKPVIKS
S514 KLKPVIKSQPVPKNN
K531 PVRVVVGKTFDAIVM
K541 DAIVMDPKKDVLIEF
K568 PVYTSLGKKYKGQKD
K574 GKKYKGQKDLVIAKM
K580 QKDLVIAKMDATAND
T584 VIAKMDATANDITND
N590 ATANDITNDRYKVEG
K594 DITNDRYKVEGFPTI
S606 PTIYFAPSGDKKNPI
K635 FIDEHATKRSRTKEE
K635 FIDEHATKRSRTKEE
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