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Protein Page:
PDIA4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PDIA4 Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Belongs to the protein disulfide isomerase family. Note: This description may include information from UniProtKB.
Protein type: EC 5.3.4.1; Chaperone; Endoplasmic reticulum; Isomerase
Cellular Component: cell surface; endoplasmic reticulum lumen; melanosome
Molecular Function: protein binding; protein disulfide oxidoreductase activity; protein disulfide isomerase activity
Biological Process: cell redox homeostasis; protein secretion; glycerol ether metabolic process
Reference #:  P13667 (UniProtKB)
Alt. Names/Synonyms: Endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; ERp-72; ERP70; ERP72; PDIA4; protein disulfide isomerase family A, member 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide isomerase-associated 4; Protein disulfide-isomerase A4
Gene Symbols: PDIA4
Molecular weight: 72,932 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDIA4

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K103-u QFAPEYEkIANILKD
0 1 K109 EkIANILKDKDPPIP
0 1 R131 SASVLASRFDVSGYP
0 2 K141-u VSGYPTIkILKKGQA
0 11 K245 TAETDLAKRFDVSGY
0 3 K245-u TAETDLAkRFDVSGY
0 9 K256-a VSGYPTLkIFRKGRP
0 2 K256-u VSGYPTLkIFRKGRP
0 1 Y273 YNGPREKYGIVDYMI
0 1 Y278 EKYGIVDYMIEQSGP
0 2 K294-u SKEILTLkQVQEFLK
0 1 Q354 FLKVSQGQLVVMQPE
0 1 K366-a QPEKFQSkyEPRSHM
0 2 Y367-p PEKFQSkyEPRSHMM
0 1 K391-u AIKDFVLkYALPLVG
0 11 K484-a AILDESGkkFAMEPE
0 9 K485-a ILDESGkkFAMEPEE
0 1 T503-ga DTLREFVtAFKKGKL
0 13 K533-a PVKVVVGkTFDSIVM
0 1 K576 AKKYKGQKGLVIAKM
0 1 S608-p PTIYFAPsGDKKNPV
0 3 K637 FIEEHATKLSRTKEE
  mouse

 
K96 QFAPEYEKIASTLkD
K102-u EKIASTLkDNDPPIA
K124-u SASMLASkFDVSGYP
K134-u VSGYPTIkILKKGQA
K238-a TEQTDLAkRFDVSGY
K238-u TEQTDLAkRFDVSGY
K249 VSGYPTLKIFRKGRP
K249-u VSGYPTLkIFRKGRP
Y266-p YNGPREKyGIVDyMI
Y271-p EKyGIVDyMIEQSGP
K287-u SKEILTLkQVQEFLK
K347-u FLKVSLGkLVLTHPE
K359 HPEKFQSKYEPRFHV
Y360 PEKFQSKYEPRFHVM
K384 AIKDYVVKHALPLVG
K477-a AILDESGkkFAMEPE
K478-a ILDESGkkFAMEPEE
T496 DTLREFVTAFKKGKL
K526 PVKVVVGKTFDAIVM
K569-u GKKYKGQkDLVIAKM
S601 PTIYFAPSGDKKNPI
K630-a FIDEHATkRSRTKEE
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