Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ACSS2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ACSS2 Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pyruvate; Ligase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 6.2.1.1; Carbohydrate Metabolism - propanoate
Cellular Component: cytoplasm; cytosol
Molecular Function: acetate-CoA ligase activity; ATP binding; AMP binding
Biological Process: acetyl-CoA biosynthetic process from acetate; xenobiotic metabolic process; lipid biosynthetic process; ethanol oxidation; propionate biosynthetic process; acetate biosynthetic process
Reference #:  Q9NR19 (UniProtKB)
Alt. Names/Synonyms: ACAS2; AceCS; acetate thiokinase; Acetate--CoA ligase; acetate-CoA ligase; Acetyl-CoA synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming); Acetyl-coenzyme A synthetase, cytoplasmic; ACS; ACSA; ACSS2; Acyl-activating enzyme; Acyl-CoA synthetase short-chain family member 2; cytoplasmic acetyl-coenzyme A synthetase; dJ1161H23.1; DKFZp762G026
Gene Symbols: ACSS2
Molecular weight: 78,580 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACSS2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S28-p GAGGRARsWsPPPEV
0 31 S30-p GGRARsWsPPPEVSR
0 1 K67 EFWGDIAKEFYWKTP
0 1 K88 RYNFDVTKGKIFIEW
0 4 T100-p IEWMKGAttNICYNV
0 2 T101-p EWMKGAttNICYNVL
0 2 K227-u GEKLVNLkELADEAL
0 1 K236 LADEALQKCQEKGFP
0 8 S263-p AELGMGDsTsQsPPI
0 1 S265-p LGMGDsTsQsPPIkR
0 10 S267-p MGDsTsQsPPIkRSC
0 2 K271-u TsQsPPIkRSCPDVQ
0 1 K400 RLWSIVDKYKVTKFY
0 1 K405 VDKYKVTKFYTAPtA
0 2 T411-p TKFYTAPtAIRLLMk
0 29 K418-a tAIRLLMkFGDEPVT
0 2 K418-u tAIRLLMkFGDEPVT
0 2 K426-u FGDEPVTkHSRASLQ
0 2 K542 RFETTYFKKFPGYYV
0 1 K542 RFETTYFKKFPGYYV
0 6 Y561-p CQRDQDGyYWITGRI
0 1 K638 LKKQIREKIGPIATP
  mouse

► Hide Isoforms
 
G28 GAEGRVRGWsPPPEV
S30-p EGRVRGWsPPPEVRR
K67-u EFWGNIAkEFYWKTA
K88-u QYNFDVTkGKIFTEW
T100 TEWMKGATTNICYNV
T101 EWMKGATTNICYNVL
K227-u GEKLVNLkELADESL
K236-u LADESLEkCREKGFP
S263-p AELGMNDsPsQsPPV
S265-p LGMNDsPsQsPPVkR
S267-p MNDsPsQsPPVkRPC
K271-u PsQsPPVkRPCPDVQ
K400-u RLWSIVDkYKVTkFY
K405-u VDkYKVTkFYTAPtA
T411-p TkFYTAPtAIRMLMk
K418-a tAIRMLMkFGDDPVT
K418-u tAIRMLMkFGDDPVT
K426-u FGDDPVTkHSRASLQ
K542-a RFETTYFkKFPGYYV
K542-u RFETTYFkKFPGYYV
Y561-p CRRDQDGyYWITGRI
K638-u LKKQIREkIGPIATP
  ACSS2 iso3  
G28 GAEGRVRGWSPPPEV
S30 EGRVRGWSPPPEVRR
K67 EFWGNIAKEFYWKTA
K88 QYNFDVTKGKIFTEW
T100 TEWMKGATTNICYNV
T101 EWMKGATTNICYNVL
K227 GEKLVNLKELADESL
K236 LADESLEKCREKGFP
S263-p AELGMNDsPSQsPPV
S265 LGMNDsPSQsPPVKR
S267-p MNDsPSQsPPVKRPC
K271 PSQsPPVKRPCPDVQ
K413 RLWSIVDKYKVTKFY
K418 VDKYKVTKFYTAPTA
T424 TKFYTAPTAIRMLMK
K431 TAIRMLMKFGDDPVT
K431 TAIRMLMKFGDDPVT
K439 FGDDPVTKHSRASLQ
K555 RFETTYFKKFPGYYV
K555 RFETTYFKKFPGYYV
Y574 CRRDQDGYYWITGRI
K651 LKKQIREKIGPIATP
  rat

 
G28 GAEGRVRGWsPPPEV
S30-p EGRVRGWsPPPEVRR
K67 EFWGNIAKEFYWKTP
K88 QYNFDVTKGKIFTEW
T100 TEWMKGATTNICYNV
T101 EWMKGATTNICYNVL
K227 GEKLVNLKELADESL
K236 LADESLEKCREKGFP
S263-p AELGMNDsPsQsPPV
S265-p LGMNDsPsQsPPVKR
S267-p MNDsPsQsPPVKRPC
K271 PsQsPPVKRPCPDVQ
K400 RLWSIVDKYKVTKFY
K405 VDKYKVTKFYTAPTA
T411 TKFYTAPTAIRMLMK
K418 TAIRMLMKFGDDPVT
K418 TAIRMLMKFGDDPVT
K426 FGDDPVTKHSRASLQ
K542 RFETTYFKKFPGYYV
K542 RFETTYFKKFPGYYV
Y561 CRRDQDGYYWITGRI
K638 LKKQIREKIGPIATP
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.