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Protein Page:
SNCA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SNCA a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; rough endoplasmic reticulum; lysosome; fibril; extracellular region; terminal button; cell cortex; inclusion body; mitochondrial respiratory chain complex I; cytosol; actin cytoskeleton; platelet alpha granule membrane; synaptic vesicle; growth cone; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; ribosome; nucleus; cell junction
Molecular Function: protein domain specific binding; identical protein binding; zinc ion binding; histone binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; protein N-terminus binding; phosphoprotein binding; oxidoreductase activity; calcium ion binding; Hsp70 protein binding; dynein binding; protein binding; phospholipase binding; copper ion binding; phospholipid binding; tau protein binding; fatty acid binding; alpha-tubulin binding
Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; positive regulation of apoptosis; response to lipopolysaccharide; positive regulation of endocytosis; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; calcium ion homeostasis; response to magnesium ion; fibril organization and biogenesis; synapse organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; negative regulation of caspase activity; negative regulation of monooxygenase activity; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; regulation of dopamine secretion; negative regulation of dopamine uptake; negative regulation of histone acetylation; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; regulation of glutamate secretion; negative regulation of microtubule polymerization; regulation of macrophage activation; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential
Disease: Parkinson Disease 4, Autosomal Dominant; Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant
Reference #:  P37840 (UniProtKB)
Alt. Names/Synonyms: Alpha-synuclein; alpha-synuclein, isoform NACP140; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; SNCA; synuclein, alpha (non A4 component of amyloid precursor); SYUA
Gene Symbols: SNCA
Molecular weight: 14,460 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SNCA

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y39‑p
apoptosis, induced: S87‑p, S129‑p
apoptosis, inhibited: S129‑p
activity, induced: S129‑p
activity, inhibited: Y125‑p
intracellular localization: S129‑p
molecular association, regulation: Y39‑p, S129‑p
phosphorylation: Y39‑p
protein conformation: S129‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K6 __MDVFMKGLSkAkE
0 1 K6 __MDVFMKGLSkAkE
1 0 K6-sm __MDVFMkGLSkAkE
1 0 K10-sm VFMkGLSkAkEGVVA
0 1 K12 MkGLSkAKEGVVAAA
0 1 K12-ub MkGLSkAkEGVVAAA
1 0 K12-sm MkGLSkAkEGVVAAA
0 1 K21-ub GVVAAAEkTkQGVAE
1 0 K21-sm GVVAAAEkTkQGVAE
0 3 K23-ub VAAAEkTkQGVAEAA
1 0 K23-sm VAAAEkTkQGVAEAA
1 0 K34-sm AEAAGKTkEGVLyVG
2 12 Y39-p KTkEGVLyVGSKTkE
0 4 S42 EGVLyVGSKTkEGVV
0 2 K43 GVLyVGSKTkEGVVH
0 1 K45 LyVGSKTKEGVVHGV
0 1 K45 LyVGSKTKEGVVHGV
1 0 K45-sm LyVGSKTkEGVVHGV
0 1 T54 GVVHGVATVAEkTkE
0 1 T54-ga GVVHGVAtVAEkTkE
0 1 K58-ac GVAtVAEkTkEQVTN
0 1 T59 VAtVAEkTkEQVTNV
1 0 K60-sm AtVAEkTkEQVTNVG
1 1 T72 NVGGAVVTGVTAVAQ
1 0 K80-sm GVTAVAQkTVEGAGs
4 0 S87-p kTVEGAGsIAAATGF
0 1 S87-gl kTVEGAGsIAAATGF
0 1 K96-ac AAATGFVkKDQLGkN
0 1 K96 AAATGFVKKDQLGkN
3 0 K96-sm AAATGFVkKDQLGkN
3 0 K102-sm VkKDQLGkNEEGAPQ
6 0 Y125-p VDPDNEAyEMPsEEG
34 3 S129-p NEAyEMPsEEGyQDy
2 0 Y133-p EMPsEEGyQDyEPEA
2 0 Y136-p sEEGyQDyEPEA___
  mouse

 
K6 __MDVFMKGLSKAkE
K6-ub __MDVFMkGLSKAkE
K6 __MDVFMKGLSKAkE
K10 VFMkGLSKAkEGVVA
K12-m1 MkGLSKAkEGVVAAA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K21 GVVAAAEKTKQGVAE
K21 GVVAAAEKTKQGVAE
K23 VAAAEKTKQGVAEAA
K23 VAAAEKTKQGVAEAA
K34 AEAAGKTKEGVLyVG
Y39-p KTKEGVLyVGsKTkE
S42-p EGVLyVGsKTkEGVV
K43 GVLyVGsKTkEGVVH
K45 LyVGsKTKEGVVHGV
K45-m1 LyVGsKTkEGVVHGV
K45 LyVGsKTKEGVVHGV
T54-gl GVVHGVTtVAEKtKE
T54 GVVHGVTTVAEKtKE
K58 GVTtVAEKtKEQVTN
T59-gl VTtVAEKtKEQVTNV
K60 TtVAEKtKEQVTNVG
T72-gl NVGGAVVtGVTAVAQ
K80 GVTAVAQKTVEGAGN
N87 KTVEGAGNIAAATGF
N87 KTVEGAGNIAAATGF
K96 AAATGFVKKDQMGKG
K96-ub AAATGFVkKDQMGKG
K96 AAATGFVKKDQMGKG
K102 VkKDQMGKGEEGYPQ
Y125 VDPGSEAYEMPsEEG
S129-p SEAYEMPsEEGYQDY
Y133 EMPsEEGYQDYEPEA
Y136 sEEGYQDYEPEA___
  rat

 
K6-ac __MDVFMkGLSKAKE
K6 __MDVFMKGLSKAKE
K6 __MDVFMKGLSKAKE
K10 VFMkGLSKAKEGVVA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K21 GVVAAAEKTKQGVAE
K21 GVVAAAEKTKQGVAE
K23 VAAAEKTKQGVAEAA
K23 VAAAEKTKQGVAEAA
K34 AEAAGKTKEGVLyVG
Y39-p KTKEGVLyVGskTkE
S42-p EGVLyVGskTkEGVV
K43-ub GVLyVGskTkEGVVH
K45-ac LyVGskTkEGVVHGV
K45 LyVGskTKEGVVHGV
K45 LyVGskTKEGVVHGV
T54 GVVHGVTTVAEKTKE
T54 GVVHGVTTVAEKTKE
K58 GVTTVAEKTKEQVTN
T59 VTTVAEKTKEQVTNV
K60 TTVAEKTKEQVTNVG
T72-gl NVGGAVVtGVTAVAQ
K80 GVTAVAQKTVEGAGN
N87 KTVEGAGNIAAATGF
N87 KTVEGAGNIAAATGF
K96 AAATGFVKKDQMGKG
K96 AAATGFVKKDQMGKG
K96 AAATGFVKKDQMGKG
K102 VKKDQMGKGEEGYPQ
Y125 VDPSSEAYEMPSEEG
S129 SEAYEMPSEEGYQDY
Y133 EMPSEEGYQDYEPEA
Y136 SEEGYQDYEPEA___
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