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Protein Page:
SYN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SYN1 neuronal phosphoprotein which associates with the cytoplasmic surface of synaptic vesicles and binds to the cytoskeleton. May function in the regulation of neurotransmitter release and of axonogenesis and synaptogenesis. Mutations may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Two differentially spiced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein; Transporter
Cellular Component: Golgi apparatus; synaptic vesicle membrane; presynaptic active zone; synaptonemal complex; cell junction
Molecular Function: transporter activity; actin binding; catalytic activity; ATP binding
Biological Process: synaptic transmission; neurotransmitter secretion
Reference #:  P17600 (UniProtKB)
Alt. Names/Synonyms: Brain protein 4.1; SYN1; SYN1a; SYN1b; Synapsin I; Synapsin-1; SYNI
Gene Symbols: SYN1
Molecular weight: 74,111 Da
Basal Isoelectric point: 9.84  Predict pI for various phosphorylation states
CST Pathways:  GPCRs Signaling to MAPK/Erk
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SYN1
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
16 5 S9-p NYLRRRLsDsNFMAN
0 2 S11-p LRRRLsDsNFMANLP
0 1 G36 QPPPPPPGAHsPGAT
0 4 S39-p PPPPGAHsPGATPGP
2 0 S55 TATAERSSGVAPAAS
1 0 G56 ATAERSSGVAPAASP
11 4 S62 SGVAPAASPAAPsPG
10 6 S67-p AASPAAPsPGSSGGG
0 1 S79 GGGGFFSSLSNAVKQ
1 2 T87 LSNAVKQTTAAAAAT
1 0 S96 AAAAATFSEQVGGGS
0 1 S103 SEQVGGGSGGAGRGG
1 0 S103 SEQVGGGSGGAGRGG
0 1 K128 EPHTDWAKyFKGKKI
0 85 Y129-p PHTDWAKyFKGKKIH
0 1 K179 VKVVRSLKPDFVLIR
0 1 K238 QMVRLHKKLGTEEFP
0 1 T241 RLHKKLGTEEFPLID
0 1 K256 QTFYPNHKEMLSSTT
1 0 S261 NHKEMLSSTTYPVVV
0 1 K281 HSGMGKVKVDNQHDF
0 1 K299 ASVVALTKTyATAEP
2 2 Y301-p VVALTKTyATAEPFI
0 2 K311 AEPFIDAKYDVRVQK
0 12 Y312 EPFIDAKYDVRVQKI
0 1 K318 KYDVRVQKIGQNYKA
0 1 S332-p AYMRTSVsGNWKTNT
0 1 K336 TSVsGNWKTNTGSAM
0 1 T337 SVsGNWKTNTGSAML
0 3 S341 NWKTNTGSAMLEQIA
0 1 S390 HIIEVVGSSMPLIGD
0 1 S391 IIEVVGSSMPLIGDH
0 13 S427-p RQRQRDAsPGRGsHG
0 1 R430 QRDAsPGRGsHGQtP
0 6 S432-p DAsPGRGsHGQtPsP
1 1 S432 DAsPGRGSHGQtPsP
0 6 G434 sPGRGsHGQtPsPGA
0 3 T436-p GRGsHGQtPsPGALP
0 5 P437 RGsHGQtPsPGALPL
1 8 S438-p GsHGQtPsPGALPLG
0 2 T448-p ALPLGRQtsQQPAGP
0 4 S449-p LPLGRQtsQQPAGPP
0 1 S502 GLGPPAGSPLPQRLP
0 3 S510 PLPQRLPSPTSAPQQ
0 3 T512 PQRLPSPTSAPQQPA
2 0 P518 PTSAPQQPASQAAPP
0 2 S520 SAPQQPASQAAPPTQ
1 1 T526 ASQAAPPTQGQGRQS
5 18 S551-p PAARPPAsPsPQRQA
3 22 S553-p ARPPAsPsPQRQAGP
1 0 T564 QAGPPQATRQtSVSG
0 1 T567-p PPQATRQtSVSGPAP
1 10 S568 PQATRQtSVSGPAPP
0 1 S570 ATRQtSVSGPAPPKA
0 1 K576 VSGPAPPKASGAPPG
0 1 K576 VSGPAPPKASGAPPG
1 0 S578 GPAPPKASGAPPGGQ
0 5 K593 QRQGPPQKPPGPAGP
0 1 T601 PPGPAGPTRQAsQAG
13 12 S605-p AGPTRQAsQAGPVPR
0 1 T618 PRTGPPTTQQPRPSG
0 2 S641-p PQLAQKPsQDVPPPA
0 5 S663 PHPQLNKSQSLTNAF
0 13 S665 PQLNKSQSLTNAFNL
0 1 T667 LNKSQSLTNAFNLPE
0 4 S681 EPAPPRPSLsQDEVK
1 6 S683-p APPRPSLsQDEVKAE
0 1 T691 QDEVKAETIRSLRKS
0 4 S698 TIRSLRKSFASLFSD
0 5 S704 KSFASLFSD______
2311 : Phospho-Synapsin (Ser9) Antibody
  mouse

► Hide Isoforms 		 
S9-p NYLRRRLsDsNFMAN
S11-p LRRRLsDsNFMANLP
S36-p QPPPPPPsAAsPGAT
S39-p PPPPsAAsPGATPGS
S55 TASAERASTAAPVAs
T56 ASAERASTAAPVAsP
S62-p STAAPVAsPAAPsPG
S67-p VAsPAAPsPGSSGGG
S79-p GGGGFFSsLSNAVKQ
T87-g LSNAVKQtTAAAAAT
S96 AAAAATFSEQVGGGs
S103-p SEQVGGGsGGAGRGG
S103 SEQVGGGSGGAGRGG
K128-u EPHTDWAkyFKGKKI
Y129-p PHTDWAkyFKGKKIH
K179-u VKVVRSLkPDFVLIR
K238-u QMVRLHKkLGtEEFP
T241-p RLHKkLGtEEFPLID
K256-u QTFYPNHkEMLSSTT
S261 NHkEMLSSTTYPVVV
K281-u HSGMGKVkVDNQHDF
K299 ASVVALTKTyATAEP
Y301-p VVALTKTyATAEPFI
K311-u AEPFIDAkyDVRVQk
Y312-p EPFIDAkyDVRVQkI
K318-u kyDVRVQkIGQNYKA
S332 AYMRTSVSGNWktNT
K336-u TSVSGNWktNTGsAM
T337-p SVSGNWktNTGsAML
S341-p NWktNTGsAMLEQIA
S390-p HIIEVVGssMPLIGD
S391-p IIEVVGssMPLIGDH
S427-p RQPQRDAsPGrGsHs
R430-m1 QRDAsPGrGsHsQss
S432-p DAsPGrGsHsQsssP
S432-g DAsPGrGsHsQsssP
S434-p sPGrGsHsQsssPGA
S436-p GrGsHsQsssPGALT
S437-p rGsHsQsssPGALTL
S438-p GsHsQsssPGALTLG
T448-p ALTLGRQtsQQPAGP
S449-p LTLGRQtsQQPAGPP
S502-p GLGPPAGsPLPQRLP
S510-p PLPQRLPsPtAAPQQ
T512-p PQRLPsPtAAPQQSA
S518 PtAAPQQSAsQATPV
S520-p AAPQQSAsQATPVtQ
T526-g AsQATPVtQGQGRQS
S551-p PAARPPAsPsPQRQA
S553-p ARPPAsPsPQRQAGA
T564 QAGAPQATRQAsIsG
A567 APQATRQAsIsGPAP
S568-p PQATRQAsIsGPAPT
S570-p ATRQAsIsGPAPTkA
K576-m1 IsGPAPTkASGAPPG
K576-u IsGPAPTkASGAPPG
S578 GPAPTkASGAPPGGQ
K593-u QRQGPPQkPPGPAGP
T601-p PPGPAGPtRQAsQAG
S605-p AGPtRQAsQAGPGPR
T618-p PRTGPPTtQQPRPSG
S642-p PQLAQKPsQDVPPPI
S664-p PHPQLNKsQsLtNAF
S666-p PQLNKsQsLtNAFNL
T668-p LNKsQsLtNAFNLPE
S682-p EPAPPRPsLsQDEVK
S684-p APPRPsLsQDEVKAE
T692-p QDEVKAEtIRSLRKs
S699-p tIRSLRKsFASLFsD
S705-p KsFASLFsD______
2311 : Phospho-Synapsin (Ser9) Antibody
  SYN1 iso1  
S9 NYLRRRLSDSNFMAN
S11 LRRRLSDSNFMANLP
S36 QPPPPPPSAASPGAT
S39 PPPPSAASPGATPGS
S55 TASAERASTAAPVAS
T56 ASAERASTAAPVASP
S62 STAAPVASPAAPSPG
S67 VASPAAPSPGSSGGG
S79 GGGGFFSSLSNAVKQ
T87 LSNAVKQTTAAAAAT
S96 AAAAATFSEQVGGGS
S103 SEQVGGGSGGAGRGG
S103 SEQVGGGSGGAGRGG
K128 EPHTDWAKYFKGKKI
Y129 PHTDWAKYFKGKKIH
K179 VKVVRSLKPDFVLIR
K238 QMVRLHKKLGTEEFP
T241 RLHKKLGTEEFPLID
K256 QTFYPNHKEMLSSTT
S261 NHKEMLSSTTYPVVV
K281 HSGMGKVKVDNQHDF
K299 ASVVALTKTYATAEP
Y301 VVALTKTYATAEPFI
K311 AEPFIDAKYDVRVQK
Y312 EPFIDAKYDVRVQKI
K318 KYDVRVQKIGQNYKA
S332 AYMRTSVSGNWKTNT
K336 TSVSGNWKTNTGSAM
T337 SVSGNWKTNTGSAML
S341 NWKTNTGSAMLEQIA
S390 HIIEVVGSSMPLIGD
S391 IIEVVGSSMPLIGDH
S427 RQPQRDASPGRGSHS
R430 QRDASPGRGSHSQSS
S432 DASPGRGSHSQSSSP
S432 DASPGRGSHSQSSSP
S434 SPGRGSHSQSSSPGA
S436 GRGSHSQSSSPGALT
S437 RGSHSQSSSPGALTL
S438 GSHSQSSSPGALTLG
T448 ALTLGRQTSQQPAGP
S449 LTLGRQTSQQPAGPP
S502 GLGPPAGSPLPQRLP
S510 PLPQRLPSPTAAPQQ
T512 PQRLPSPTAAPQQSA
S518 PTAAPQQSASQATPV
S520 AAPQQSASQATPVTQ
T526 ASQATPVTQGQGRQS
S551 PAARPPASPSPQRQA
S553 ARPPASPSPQRQAGA
T564 QAGAPQATRQASISG
A567 APQATRQASISGPAP
S568 PQATRQASISGPAPT
S570 ATRQASISGPAPTKA
K576 ISGPAPTKASGAPPG
K576 ISGPAPTKASGAPPG
S578 GPAPTKASGAPPGGQ
K593 QRQGPPQKPPGPAGP
T601 PPGPAGPTRQASQAG
S605 AGPTRQASQAGPGPR
T618 PRTGPPTTQQPRPSG
S642-p PQLAQKPsQDVPPPI
S664 PHPQLKASPSQAQP_
S666 PQLKASPSQAQP___
A668 LKASPSQAQP_____
- gap
- gap
- gap
- gap
- gap
  SYN1 iso3  
S9 NYLRRRLSDSNFMAN
S11 LRRRLSDSNFMANLP
S36 QPPPPPPSAASPGAT
S39 PPPPSAASPGATPGS
S55 TASAERASTAAPVAS
T56 ASAERASTAAPVASP
S62 STAAPVASPAAPSPG
S67 VASPAAPSPGSSGGG
S79 GGGGFFSSLSNAVKQ
T87 LSNAVKQTTAAAAAT
S96 AAAAATFSEQVGGGS
S103 SEQVGGGSGGAGRGG
S103 SEQVGGGSGGAGRGG
K128 EPHTDWAKYFKGKKI
Y129 PHTDWAKYFKGKKIH
K179 VKVVRSLKPDFVLIR
K238 QMVRLHKKLGTEEFP
T241 RLHKKLGTEEFPLID
K256 QTFYPNHKEMLSSTT
S261 NHKEMLSSTTYPVVV
K281 HSGMGKVKVDNQHDF
K299 ASVVALTKTYATAEP
Y301 VVALTKTYATAEPFI
K311 AEPFIDAKYDVRVQK
Y312 EPFIDAKYDVRVQKI
K318 KYDVRVQKIGQNYKA
S332 AYMRTSVSGNWKTNT
K336 TSVSGNWKTNTGSAM
T337 SVSGNWKTNTGSAML
S341 NWKTNTGSAMLEQIA
S390 HIIEVVGSSMPLIGD
S391 IIEVVGSSMPLIGDH
S427 RQPQRDASPGRGSHS
R430 QRDASPGRGSHSQSS
S432 DASPGRGSHSQSSSP
S432 DASPGRGSHSQSSSP
S434 SPGRGSHSQSSSPGA
S436 GRGSHSQSSSPGALT
S437 RGSHSQSSSPGALTL
S438 GSHSQSSSPGALTLG
T448 ALTLGRQTSQQPAGP
S449 LTLGRQTSQQPAGPP
S502 GLGPPAGSPLPQRLP
S510 PLPQRLPSPTAAPQQ
T512 PQRLPSPTAAPQQSA
S518 PTAAPQQSASQATPV
S520 AAPQQSASQATPVTQ
T526 ASQATPVTQGQGRQS
S551 PAARPPASPSPQRQA
S553 ARPPASPSPQRQAGA
T564 QAGAPQATRQASISG
A567 APQATRQASISGPTR
S568 PQATRQASISGPTRQ
S570 ATRQASISGPTRQAS
- gap
- gap
- gap
- gap
T573 QASISGPTRQASQAG
S577 SGPTRQASQAGPGPR
T590 PRTGPPTTQQPRPSG
S614 PQLAQKPSQDVPPPI
S636 PHPQLNKSQSLTNAF
S638 PQLNKSQSLTNAFNL
T640 LNKSQSLTNAFNLPE
S654 EPAPPRPSLsQDEVK
S656-p APPRPSLsQDEVKAE
T664 QDEVKAETIRSLRKS
S671 TIRSLRKSFASLFSD
S677 KSFASLFSD______
  rat

 
S9-p NYLRRRLsDSNFMAN
S11 LRRRLsDSNFMANLP
S36 QPPPPPPSAASPGAT
S39 PPPPSAASPGATPGS
S55-g AASAERAstAAPVAs
T56-g ASAERAstAAPVAsP
S62-p stAAPVAsPAAPsPG
S67-p VAsPAAPsPGSSGGG
S79 GGGGFFSSLSNAVKQ
T87-g LSNAVKQtTAAAAAT
S96-g AAAAATFsEQVGGGs
S103 sEQVGGGSGGAGRGG
S103-g sEQVGGGsGGAGRGG
K128 EPHTDWAKyFKGKKI
Y129-p PHTDWAKyFKGKKIH
K179 VKVVRSLKPDFVLIR
K238 QMVRLHKKLGTEEFP
T241 RLHKKLGTEEFPLID
K256 QTFYPNHKEMLSsTT
S261-g NHKEMLSsTTYPVVV
K281 HSGMGKVKVDNQHDF
K299-u ASVVALTkTyATAEP
Y301-p VVALTkTyATAEPFI
K311 AEPFIDAKyDVRVQK
Y312-p EPFIDAKyDVRVQKI
K318 KyDVRVQKIGQNYKA
S332 AYMRTSVSGNWKTNT
K336 TSVSGNWKTNTGSAM
T337 SVSGNWKTNTGSAML
S341 NWKTNTGSAMLEQIA
S390 HIIEVVGSSMPLIGD
S391 IIEVVGSSMPLIGDH
S425 LPRQRDASPGRGsHS
R428 QRDASPGRGsHSQTP
S430 DASPGRGSHSQTPSP
S430-g DASPGRGsHSQTPSP
S432 SPGRGsHSQTPSPGA
T434 GRGsHSQTPSPGALP
P435 RGsHSQTPSPGALPL
S436 GsHSQTPSPGALPLG
T446 ALPLGRQTSQQPAGP
S447 LPLGRQTSQQPAGPP
S500 GLGPPAGSPLPQRLP
S508 PLPQRLPSPTAAPQQ
T510 PQRLPSPTAAPQQsA
S516-g PTAAPQQsASQATPM
S518 AAPQQsASQATPMtQ
T524-g ASQATPMtQGQGRQS
S549-p PAARPPAsPsPQRQA
S551-p ARPPAsPsPQRQAGP
T562-g QAGPPQAtRQAsISG
A565 PPQAtRQAsISGPAP
S566-p PQAtRQAsISGPAPP
S568 AtRQAsISGPAPPKV
K574 ISGPAPPKVsGASPG
K574 ISGPAPPKVsGASPG
S576-g GPAPPKVsGASPGGQ
K591-u QRQGPPQkPPGPAGP
I599 PPGPAGPIRQAsQAG
S603-p AGPIRQAsQAGPGPR
T616 PRTGPPTTQQPRPSG
S640 PQLAQKPSQDVPPPI
S662 PHPQLNKSQsLTNAF
S664-p PQLNKSQsLTNAFNL
T666 LNKSQsLTNAFNLPE
S680-p EPAPPRPsLsQDEVK
S682-p APPRPsLsQDEVKAE
T690 QDEVKAETIRSLRKS
S697 TIRSLRKSFASLFSD
S703 KSFASLFSD______
2311 : Phospho-Synapsin (Ser9) Antibody
  cow

 
S9-p NYLRRRLsDSNFMAN
S11 LRRRLsDSNFMANLP
A36 QPPPPPPAAPSPGAT
S39 PPPPAAPSPGATTGP
S55 TATAERASSAAPVAS
S56 ATAERASSAAPVASP
S62 SSAAPVASPAAPSPG
S67 VASPAAPSPGSSGGG
S79 GGGGFFSSLSNAVKQ
T87 LSNAVKQTTAAAAAT
S96 AAAAATFSEQVGGGS
S103 SEQVGGGSGGAGRGG
S103 SEQVGGGSGGAGRGG
K128 EPHTDWAKYFKGKKI
Y129 PHTDWAKYFKGKKIH
K179 VKVVRSLKPDFVLIR
K238 QMVRLHKKLGTEEFP
T241 RLHKKLGTEEFPLIN
K256 QTFYPNHKEMLSSTT
S261 NHKEMLSSTTYPVVV
K281 HSGMGKVKVDNQHDF
K299 ASVVALTKTyATTEP
Y301-p VVALTKTyATTEPFI
K311 TEPFIDAKYDVRIQK
Y312 EPFIDAKYDVRIQKI
K318 KYDVRIQKIGQNYKA
S332 AYMRTSVSGNWKTNT
K336 TSVSGNWKTNTGSAM
T337 SVSGNWKTNTGSAML
S341 NWKTNTGSAMLEQIA
S390 HIIQVVGSSMPLIGD
S391 IIQVVGSSMPLIGDH
S427 RQRQRDASPGRGSHS
R430 QRDASPGRGSHSQTP
S432 DASPGRGSHSQTPsP
S432 DASPGRGSHSQTPsP
S434 SPGRGSHSQTPsPGA
T436 GRGSHSQTPsPGALP
P437 RGSHSQTPsPGALPL
S438-p GSHSQTPsPGALPLG
I448 ALPLGRQISQQPAGP
S449 LPLGRQISQQPAGPP
S502 GLGPPAGSPLPQRLP
S510 PLPQRLPSPTSVPQQ
T512 PQRLPSPTSVPQQPA
P518 PTSVPQQPASQATPM
S520 SVPQQPASQATPMTQ
T526 ASQATPMTQGQGRQS
S551-p PATRPPAsPsPQRQA
S553-p TRPPAsPsPQRQAGP
T564 QAGPPQATRQTsVSG
T567 PPQATRQTsVSGQAP
S568-p PQATRQTsVSGQAPP
S570 ATRQTsVSGQAPPKA
K576 VSGQAPPKASGVPPG
K576 VSGQAPPKASGVPPG
S578 GQAPPKASGVPPGGQ
K593 QRQGPPQKPPGPAGP
T601 PPGPAGPTRQAsQAG
S605-p AGPTRQAsQAGPMPR
T618 PRTGPPTTQQPRPSG
S642 PQLAQKPSQDVPPPA
S664 PHPQLNKSQSLTNAF
S666 PQLNKSQSLTNAFNL
T668 LNKSQSLTNAFNLPE
S682 EPAPPRPSLSQDEVK
S684 APPRPSLSQDEVKAE
T692 QDEVKAETIRSLRKS
S699 TIRSLRKSFASLFSD
S705 KSFASLFSD______
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