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survivin (human)

Overview survivin an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Apoptosis Cellular Component: centriole; nuclear chromosome; microtubule; spindle microtubule; cytoplasmic microtubule; cytoplasm; spindle; midbody; interphase microtubule organizing center; cytosol; nucleus; chromosome, pericentric region Molecular Function: tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; microtubule binding; metal ion binding; caspase inhibitor activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; Ran GTPase binding; cobalt ion binding Biological Process: mitosis; transcription, DNA-dependent; spindle checkpoint; apoptosis; establishment of chromosome localization; cytokinesis; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; regulation of apoptosis; M phase of mitotic cell cycle; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; mitotic prometaphase; positive regulation of exit from mitosis; negative regulation of apoptosis Reference #:  O15392 (UniProtKB) Alt. Names/Synonyms: API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; Baculoviral IAP repeat-containing protein 5; BIRC5; EPR-1; IAP4; survivin variant 3 alpha Gene Symbols: BIRC5 Molecular weight: 16,389 Da Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below survivin 1E31 - A/B=1-142 (human) 1F3H - A/B=1-142 (human) 1XOX - A/B=1-117 (human) 2RAW - A=1-142 (human) 2RAX - A/X/E=1-120 (human) 3UEC - A=1-142 (human) 3UED - A/C=1-142 (human) 3UEE - A/C=1-142 (human) 3UEF - A/C=1-142 (human) 3UEG - A/B=1-142 (human) 3UEH - A/B=1-142 (human) 3UEI - A/B=1-142 (human) 3UIG - A/B=1-142 (human) 3UIH - A/B=1-142 (human) 3UII - A/B=1-142 (human) 3UIJ - A/B=1-142 (human) 3UIK - A/B=1-142 (human) 4A0I - A/B=1-142 (human) 4A0J - A/B=1-142 (human) 4A0N - A=1-142 (human) 1M4M - A=1-140 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1.00E 31 1E31 1F3H 1XOX 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T48‑p apoptosis, induced: S20‑p apoptosis, inhibited: T34‑p cell cycle regulation: S20‑p, T48‑p, T117‑p cell growth, altered: T34‑p cytoskeletal reorganization: T34‑p activation: T34‑p intracellular localization: S20‑p, T34‑p, T48‑p, T117‑p, K129‑a molecular association, regulation: S20‑p, T34‑p, T48‑p, T117‑p, K129‑a phosphorylation: S20‑p protein stabilization: T34‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
3	0		S20-p	FLKDHRIstFkNWPF
2	0		T21-p	LKDHRIstFkNWPFL
1	0		K23-a	DHRIstFkNWPFLEG
0	2		K23	DHRIstFKNWPFLEG
10	8		T34-p	FLEGCACtPERMAEA
1	0		T48-p	AGFIHCPtENEPDLA
0	1		K78-u	DDPIEEHkKHSSGCA
1	1		K90-a	GCAFLSVkKQFEELT
1	2		K110-a	KLDRERAkNkIAkEt
1	1		K112-a	DRERAkNkIAkEtNN
1	1		K115-a	RAkNkIAkEtNNkkk
2	0		T117-p	kNkIAkEtNNkkkEF
1	1		K120-a	IAkEtNNkkkEFEET
1	1		K121-a	AkEtNNkkkEFEETA
1	1		K122-a	kEtNNkkkEFEETAk
1	1		K129-a	kEFEETAkkVRRAIE
1	1		K130-a	EFEETAkkVRRAIEQ

	mouse ► Hide Isoforms
A20	YLKNYRIATFkNWPF
T21	LKNYRIATFkNWPFL
K23	NYRIATFKNWPFLED
K23-u	NYRIATFkNWPFLED
T34-p	FLEDCACtPERMAEA
T48	AGFIHCPTENEPDLA
R78	DNPIEEHRKHSPGCA
K90	GCAFLTVKKQMEELT
K110	KLDRQRAKNKIAKET
K112	DRQRAKNKIAKETNN
K115	RAKNKIAKETNNKQK
T117	KNKIAKETNNKQKEF
K120	IAKETNNKQKEFEET
Q121	AKETNNKQKEFEETA
K122	KETNNKQKEFEETAK
K129	KEFEETAKTTRQSIE
T130	EFEETAKTTRQSIEQ

	survivin iso2
A20	YLKNYRIATFKNWPF
T21	LKNYRIATFKNWPFL
K23	NYRIATFKNWPFLED
K23	NYRIATFKNWPFLED
T34	FLEDCACTPERMAEA
T48	AGFIHCPTENEPDLA
R78	DNPIEEHRKHSPGCA
K90	GCAFLTVKKQMEELT
K110-a	KLDRQRAkNKIVCMI
K112	DRQRAkNKIVCMIEN
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	rat
Y20	YLKDHRIYTFKNWPF
T21	LKDHRIYTFKNWPFL
K23	DHRIYTFKNWPFLED
K23	DHRIYTFKNWPFLED
T34	FLEDCSCTPERMAEA
T48	AGFIHCPTENEPDLA
R78	DNPIEEHRKHSPGCA
K90	GCAFLTVKKQVEELT
K110	KLDKQRAKNKIAKET
K112	DKQRAKNKIAKETNN
K115	RAKNKIAKETNNKQK
T117	KNKIAKETNNKQKEF
K120	IAKETNNKQKEFEET
Q121	AKETNNKQKEFEETR
K122	KETNNKQKEFEETRR
R129	KEFEETRRTVRQSIE
T130	EFEETRRTVRQSIEQ

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