an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Molecular Function: tubulin binding; identical protein binding; protein binding; protein homodimerization activity; enzyme binding; zinc ion binding; protein heterodimerization activity; chaperone binding; microtubule binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; cysteine protease inhibitor activity; cofactor binding; Ran GTPase binding; cobalt ion binding
Biological Process: mitosis; transcription, DNA-dependent; spindle checkpoint; establishment of chromosome localization; cytokinesis; regulation of signal transduction; protein ubiquitination; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of exit from mitosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.