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Protein Page:
Survivin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Survivin an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: centriole; nuclear chromosome; microtubule; spindle microtubule; cytoplasmic microtubule; cytoplasm; spindle; midbody; nucleus; interphase microtubule organizing center; cytosol; chromosome, pericentric region
Molecular Function: tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; microtubule binding; metal ion binding; caspase inhibitor activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cysteine protease inhibitor activity; cofactor binding; Ran GTPase binding; cobalt ion binding
Biological Process: mitosis; transcription, DNA-dependent; spindle checkpoint; apoptosis; establishment of chromosome localization; cytokinesis; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle; negative regulation of apoptosis; positive regulation of exit from mitosis
Reference #:  O15392 (UniProtKB)
Alt. Names/Synonyms: API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; Baculoviral IAP repeat-containing protein 5; BIRC5; EPR-1; IAP4; survivin variant 3 alpha
Gene Symbols: BIRC5
Molecular weight: 16,389 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Survivin

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T48‑p
apoptosis, induced: S20‑p
apoptosis, inhibited: T34‑p
cell cycle regulation: S20‑p, T48‑p, T117‑p
cell growth, altered: T34‑p
cytoskeletal reorganization: T34‑p
transcription, induced: T34‑p
transcription, inhibited: T34‑p
activity, induced: T34‑p
intracellular localization: S20‑p, T34‑p, T48‑p, T117‑p, K129‑ac
molecular association, regulation: S20‑p, T34‑p, T48‑p, T117‑p, K129‑ac
phosphorylation: S20‑p
protein stabilization: T34‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
4 0 S20-p FLKDHRIstFkNWPF
2 0 T21-p LKDHRIstFkNWPFL
1 0 K23-ac DHRIstFkNWPFLEG
0 2 K23 DHRIstFKNWPFLEG
11 10 T34-p FLEGCACtPERMAEA
1 0 T48-p AGFIHCPtENEPDLA
0 1 K78-ub DDPIEEHkKHSSGCA
1 1 K90-ac GCAFLSVkKQFEELT
1 2 K110-ac KLDRERAkNkIAkEt
1 1 K112-ac DRERAkNkIAkEtNN
1 1 K115-ac RAkNkIAkEtNNkkk
2 0 T117-p kNkIAkEtNNkkkEF
1 1 K120-ac IAkEtNNkkkEFEET
1 1 K121-ac AkEtNNkkkEFEETA
1 1 K122-ac kEtNNkkkEFEETAk
1 1 K129-ac kEFEETAkkVRRAIE
1 1 K130-ac EFEETAkkVRRAIEQ
  mouse

► Hide Isoforms
 
A20 YLKNYRIATFkNWPF
T21 LKNYRIATFkNWPFL
K23 NYRIATFKNWPFLED
K23-ub NYRIATFkNWPFLED
T34-p FLEDCACtPERMAEA
T48 AGFIHCPTENEPDLA
R78 DNPIEEHRKHSPGCA
K90 GCAFLTVKKQMEELT
K110 KLDRQRAKNKIAKET
K112 DRQRAKNKIAKETNN
K115 RAKNKIAKETNNKQK
T117 KNKIAKETNNKQKEF
K120 IAKETNNKQKEFEET
Q121 AKETNNKQKEFEETA
K122 KETNNKQKEFEETAK
K129 KEFEETAKTTRQSIE
T130 EFEETAKTTRQSIEQ
  Survivin iso2  
A20 YLKNYRIATFKNWPF
T21 LKNYRIATFKNWPFL
K23 NYRIATFKNWPFLED
K23 NYRIATFKNWPFLED
T34 FLEDCACTPERMAEA
T48 AGFIHCPTENEPDLA
R78 DNPIEEHRKHSPGCA
K90 GCAFLTVKKQMEELT
K110-ac KLDRQRAkNKIVCMI
K112 DRQRAkNKIVCMIEN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
Y20 YLKDHRIYTFKNWPF
T21 LKDHRIYTFKNWPFL
K23 DHRIYTFKNWPFLED
K23 DHRIYTFKNWPFLED
T34 FLEDCSCTPERMAEA
T48 AGFIHCPTENEPDLA
R78 DNPIEEHRKHSPGCA
K90 GCAFLTVKKQVEELT
K110 KLDKQRAKNKIAKET
K112 DKQRAKNKIAKETNN
K115 RAKNKIAKETNNKQK
T117 KNKIAKETNNKQKEF
K120 IAKETNNKQKEFEET
Q121 AKETNNKQKEFEETR
K122 KETNNKQKEFEETRR
R129 KEFEETRRTVRQSIE
T130 EFEETRRTVRQSIEQ
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