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Protein Page:
SDHA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SDHA is the catalytic subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. Complex II contains four subunits: the flavoprotein catalytic subunit SDHA, iron-sulfur protein SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interaction with SDH5 is required for FAD attachment. Responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHA cause defective mitochondrial oxidative phosphorylation, giving rise to heterogeneous clinical symptoms ranging from isolated organ dysfunction to multisystem disorder. Acetylation of SDHA may control entry of the substrate into the active site, thus regulating its enzymatic activity. Acetylated SDHA may be a SIRT3 substrate SIRT3 is a mitochondrial NAD(+)-dependent deacetylase. Increased succinate levels as a consequence of SDH deficiency inhibit hypoxia inducible factor-1alpha (HIF-1alpha) prolyl hydroxylases leading to sustained HIF-1alpha expression in tumours. Defects in SDHA cause of Leigh syndrome, a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.3.5.1; Mitochondrial; Energy Metabolism - oxidative phosphorylation; Carbohydrate Metabolism - citrate (TCA) cycle
Cellular Component: mitochondrial respiratory chain complex II; mitochondrion; mitochondrial inner membrane
Molecular Function: succinate dehydrogenase (ubiquinone) activity; protein binding; FAD binding; succinate dehydrogenase activity
Biological Process: succinate metabolic process; nervous system development; tricarboxylic acid cycle
Reference #:  P31040 (UniProtKB)
Alt. Names/Synonyms: DHSA; Flavoprotein subunit of complex II; Fp; SDH1; SDH2; SDHA; SDHF; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex flavoprotein subunit; succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Gene Symbols: SDHA
Molecular weight: 72,692 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SDHA
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 T24-p ALAKAWPtVLQTGTR
0 1 K92-u FNTACVTkLFPTRSH
1 10 K179-a AFGGQSLkFGkGGQA
0 3 K179-u AFGGQSLkFGkGGQA
0 8 K182-a GQSLkFGkGGQAHRC
1 0 Y215-p SLRYDTSyFVEYFAL
0 1 K250 SIHRIRAKNTVVATG
0 1 K250-u SIHRIRAkNTVVATG
0 3 K335-a ERYAPVAkDLASRDV
0 2 K335-u ERYAPVAkDLASRDV
0 1 Y365-p GPEKDHVyLQLHHLP
0 1 R423 NYKGQVLRHVNGQDQ
0 1 R423 NYKGQVLRHVNGQDQ
0 2 S456-p ANRLGANsLLDLVVF
0 1 K480 ESCRPGDKVPPIKPN
1 3 K485 GDKVPPIKPNAGEES
1 13 K498-a ESVMNLDkLRFADGS
0 1 K498 ESVMNLDKLRFADGS
0 1 S509 ADGSIRTSELRLSMQ
0 5 K517-a ELRLSMQkSMQNHAA
0 2 K517-u ELRLSMQkSMQNHAA
0 1 S530 AAVFRVGSVLQEGCG
1 12 K538 VLQEGCGKISkLYGD
0 2 K541-a EGCGKISkLYGDLkH
2 0 Y543 CGKISkLYGDLkHLk
0 17 K547-a SkLYGDLkHLkTFDR
0 1 K547 SkLYGDLKHLkTFDR
0 6 K550-a YGDLkHLkTFDRGMV
0 20 K598-a AHAREDYkVRIDEyD
2 2 Y604-p YkVRIDEyDySkPIQ
0 1 Y606-p VRIDEyDySkPIQGQ
0 16 K608-a IDEyDySkPIQGQQK
0 2 K608-u IDEyDySkPIQGQQK
0 1 K624 PFEEHWRKHTLSyVD
0 19 Y629-p WRKHTLSyVDVGTGK
0 1 G633 TLSyVDVGTGKVTLE
0 1 G633 TLSyVDVGTGKVTLE
0 1 T638 DVGTGKVTLEYRPVI
0 1 Y641 TGKVTLEYRPVIDKT
  mouse

 
G24 ALTGAWPGTLQKQTC
K92 FNTACLTKLFPTRSH
K179-a AFGGQSLkFGkGGQA
K179-u AFGGQSLkFGkGGQA
K182-a GQSLkFGkGGQAHRC
Y215 SLRYDTSYFVEYFAL
K250-a SIHRIRAkNTVIATG
K250 SIHRIRAKNTVIATG
K335-a ERYAPVAkDLASRDV
K335-u ERYAPVAkDLASRDV
Y365 GPEKDHVYLQLHHLP
K423-a NYKGQVLkHVNGQDQ
K423-m1 NYKGQVLkHVNGQDQ
S456 ANRLGANSLLDLVVF
K480-a ESCRPGDkVPSIkAN
K485-a GDkVPSIkANAGEES
K498-a ESVMNLDkLRFADGS
K498-u ESVMNLDkLRFADGS
S509-p ADGSIRTsELRLNMQ
K517-a ELRLNMQkSMQNHAA
K517-u ELRLNMQkSMQNHAA
S530-p AAVFRVGsVLQEGCE
K538-a VLQEGCEkISQLYGD
Q541 EGCEkISQLYGDLkH
Y543 CEkISQLYGDLkHLk
K547-a SQLYGDLkHLkTFDR
K547-u SQLYGDLkHLkTFDR
K550-a YGDLkHLkTFDRGMV
K598-a AHAREDYkVRVDEYD
Y604 YkVRVDEYDYSkPIQ
Y606 VRVDEYDYSkPIQGQ
K608-a VDEYDYSkPIQGQQK
K608 VDEYDYSKPIQGQQK
K624-a PFGEHWRkHTLSyVD
Y629-p WRkHTLSyVDIkTGK
K633-a TLSyVDIkTGKVtLE
K633-u TLSyVDIkTGKVtLE
T638-p DIkTGKVtLEyRPVI
Y641-p TGKVtLEyRPVIDKT
  rat

 
- gap
K84 FNTACLTKLFPTRSH
K171 AFGGQSLKFGKGGQA
K171 AFGGQSLKFGKGGQA
K174 GQSLKFGKGGQAHRC
Y207 SLRYDTSYFVEYFAL
K242 SIHRIRAKNTIIATG
K242 SIHRIRAKNTIIATG
K327 ERYAPVAKDLASRDV
K327 ERYAPVAKDLASRDV
Y357 GPEKDHVYLQLHHLP
K415 NYKGQVLKHVNGQDQ
K415 NYKGQVLKHVNGQDQ
S448 ANRLGANSLLDLVVF
K472 ESCRPGDKVPPIKAN
K477 GDKVPPIKANAGEES
K490 ESVMNLDKLRFADGS
K490 ESVMNLDKLRFADGS
S501 ADGSVRTSELRLSMQ
K509 ELRLSMQKSMQSHAA
K509 ELRLSMQKSMQSHAA
S522 AAVFRVGSVLQEGCE
K530 VLQEGCEKVSQLyGD
Q533 EGCEKVSQLyGDLQH
Y535-p CEKVSQLyGDLQHLk
Q539 SQLyGDLQHLkTFDR
Q539 SQLyGDLQHLkTFDR
K542-a yGDLQHLkTFDRGMV
K590 AHAREDYKVRIDEyD
Y596-p YKVRIDEyDYSKPIE
Y598 VRIDEyDYSKPIEGQ
K600 IDEyDYSKPIEGQQK
K600 IDEyDYSKPIEGQQK
K616 PFAEHWRKHTLSYVD
Y621 WRKHTLSYVDTKTGK
K625 TLSYVDTKTGKVTLD
K625 TLSYVDTKTGKVTLD
T630 DTKTGKVTLDYRPVI
Y633 TGKVTLDYRPVIDKT
  pig

 
A24 ALTWAQPAASPIGAR
K92 FNTACVTKLFPTRSH
K179 AFGGQSLKFGKGGQA
K179 AFGGQSLKFGKGGQA
K182 GQSLKFGKGGQAHRC
Y215 SLRYDTSYFVEYFAL
R250 SIHRIRARNTVVATG
R250 SIHRIRARNTVVATG
K335 ERYAPVAKDLASRDV
K335 ERYAPVAKDLASRDV
Y365 GPEKDHVYLQLHHLP
R423 NYKGQVLRHVNGQDQ
R423 NYKGQVLRHVNGQDQ
S456 ANRLGANSLLDLVVF
K480 ESCRPGDKVPSIKPN
K485 GDKVPSIKPNAGEES
K498 ESVMNLDKLRFANGT
K498 ESVMNLDKLRFANGT
S509 ANGTIRTSELRLSMQ
K517 ELRLSMQKSMQSHAA
K517 ELRLSMQKSMQSHAA
S530 AAVFRVGSVLQEGCE
K538 VLQEGCEKILRLYGD
R541 EGCEKILRLYGDLQH
Y543 CEKILRLYGDLQHLK
Q547 LRLYGDLQHLKTFDR
Q547 LRLYGDLQHLKTFDR
K550 YGDLQHLKTFDRGMV
K598 AHAREDFKERVDEYD
Y604 FKERVDEYDYSKPIQ
Y606 ERVDEYDYSKPIQGQ
K608 VDEYDYSKPIQGQQK
K608 VDEYDYSKPIQGQQK
K624 PFQEHWRKHTLSYVD
Y629 WRKHTLSYVDVKTGK
K633 TLSYVDVKTGKVSLE
K633 TLSYVDVKTGKVSLE
S638 DVKTGKVSLEYRPVI
Y641 TGKVSLEYRPVIDKT
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