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STF-1
a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor |
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Cellular Component: nucleoplasm; nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein binding; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; double-stranded DNA binding; transcription coactivator activity; steroid hormone receptor activity; phospholipid binding; chromatin binding
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Biological Process: tissue development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; adrenal gland development; primary sex determination; male gonad development; regulation of steroid biosynthetic process; cell-cell signaling; luteinization; positive regulation of transcription from RNA polymerase II promoter; gene expression; maintenance of protein localization in nucleus; cell differentiation
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Reference #:
Q13285 (UniProtKB)
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| Alt. Names/Synonyms: AD4BP; adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ1; FTZF1; Fushi tarazu factor homolog 1; NR5A1; nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; nuclear receptor subfamily 5, group A, member 1; POF7; SF-1; SF1; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; steroidogenic factor-1; STF-1; STF1 |
| Gene Symbols: NR5A1 |
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Molecular weight: 51,636 Da
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Basal Isoelectric point: 7.81
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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