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Protein Page:
STF-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STF-1 a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor
Cellular Component: nucleoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; double-stranded DNA binding; transcription coactivator activity; steroid hormone receptor activity; phospholipid binding; chromatin binding
Biological Process: tissue development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; adrenal gland development; primary sex determination; male gonad development; multicellular organismal aging; regulation of steroid biosynthetic process; cell-cell signaling; luteinization; hormone metabolic process; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; maintenance of protein localization in nucleus; cell differentiation
Reference #:  Q13285 (UniProtKB)
Alt. Names/Synonyms: AD4BP; adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ1; FTZF1; Fushi tarazu factor homolog 1; NR5A1; nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; nuclear receptor subfamily 5, group A, member 1; POF7; SF-1; SF1; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; steroidogenic factor-1; STF-1; STF1
Gene Symbols: NR5A1
Molecular weight: 51,636 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STF-1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S203‑p
activity, induced: S203‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K34-ac LLTCESCkGFFkRTV
1 1 K38-ac ESCkGFFkRTVQNNK
1 0 K72-ac CPFCRFQkCLTVGMR
0 1 K100-m2 NKFGPMYkRDRALKQ
1 0 K119-ub QIRANGFkLETGPPM
7 0 K119-sm QIRANGFkLETGPPM
9 0 K194-sm AFPGRAIkSEYPEPY
10 0 S203-p EYPEPYAsPPQPGLP
1 0 S430-p LVEVRALsMQAKEYL
  mouse

 
K34 LLTCESCKGFFKRTV
K38 ESCKGFFKRTVQNNK
K72 CPFCRFQKCLTVGMR
K100 NKFGPMYKRDRALKQ
K119 QIRANGFKLETGPPM
K119-sm QIRANGFkLETGPPM
K194-sm AFSNRTIkSEYPEPY
S203-p EYPEPYAsPPQQPGP
S431 LVEVRALSMQAKEYL
  rat

 
K34 LLTCESCKGFFKRTV
K38 ESCKGFFKRTVQNNK
K72 CPFCRFQKCLTVGMR
K100 NKFGPMYKRDRALKQ
K119 QIRANGFKLETGPPM
K119 QIRANGFKLETGPPM
K194 AFSNRTIKSEYPEPY
S203 EYPEPYASPPQQPGP
S431 LVEVRALSMQAKEYL
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