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Protein Page:
STAT6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT6 transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; cytoplasm; nuclear chromatin; nucleolus; nucleus; cytosol; lipid raft
Molecular Function: identical protein binding; signal transducer activity; protein binding; calcium ion binding; transcription factor activity; protein phosphatase binding
Biological Process: regulation of transcription from RNA polymerase II promoter; T-helper 1 cell lineage commitment; negative regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interferon type I production; mammary gland epithelial cell proliferation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation
Reference #:  P42226 (UniProtKB)
Alt. Names/Synonyms: D12S1644; IL-4 Stat; IL-4-STAT; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT, interleukin4-induced; STAT6; STAT6B; STAT6C; transcription factor IL-4 STAT
Gene Symbols: STAT6
Molecular weight: 94,135 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT6

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S707‑p
molecular association, regulation: S707‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsLWGLVsK
0 2 S8-p MsLWGLVsKMPPEKV
1 0 R27 VDFPQHLRHLLGDWL
0 1 K94 IYQRDPLKLVATFRQ
0 1 K129 HWKQEELKFKTGLRR
0 1 K277 TSCFLVEKQPPQVLK
1 0 S407-p PIQLQALsLPLVVIV
0 1 T525-p FDGVLDLtKRCLRSY
0 2 K595-ub NIQPFSAkDLSIRSL
0 1 K619 LKNLYPKKPKDEAFR
0 1 K621 NLYPKKPKDEAFRSH
15 81 Y641-p MGKDGRGyVPAtIKM
0 2 T645-p GRGyVPAtIKMTVER
1 0 S707-p IPPYQGLsPEESVNV
1 0 S756-p PQEHAVSsPDPLLCS
9361 : Phospho-Stat6 (Tyr641) Antibody
9364 : Phospho-Stat6 (Tyr641) (C11A12) Rabbit mAb
  mouse

 
S2 ______MSLWGLISK
S8 MSLWGLISKMSPEKL
R27-me VDFPQRLrHLLADWL
K94-ub IYQRDPLkLVATIRQ
K129-ac HRKQEELkFTTALGR
K277-ub TSSFLVEkQPPQVLK
S407 LIQLQALSLPLVVIV
T525 FDGVLDLTKRCLRSY
K595-ub NIQPFSAkDLSIRSL
K619-ac LKNLYPKkPkDEAFR
K621-ac NLYPKkPkDEAFRSH
Y641-p MGKDGRGyVSTTIKM
T645 GRGyVSTTIKMTVER
- gap
S747 SQEHAVSSPEPMLCS
  rat

 
S2 ______MSLWSLVSK
S8 MSLWSLVSKMSPEKL
R27 VDFPQHLRHLLAEWL
K94 IYQRDPLKLVATIRQ
K129 HRKQEELKFTTALGR
K277 TSSFLVEKQPPQVLK
S407 LIQLQALSLPLVVIV
T525 FDGVLDLTKRCLRSY
K595 NIQPFSAKDLSIRSL
K619 LKNLYPKKPKDEAFR
K621 NLYPKKPKDEAFRSH
Y641-p MGKDGRGyVSTTIKM
T645 GRGyVSTTIKMTVER
P702 IHSFQSIPLEESMSV
S751 SQEHAVSSPEPLLCS
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