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STAT6
transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription factor |
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Cellular Component: nuclear chromatin; cytoplasm; nucleolus; cytosol; nucleus
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Molecular Function: identical protein binding; signal transducer activity; protein binding; sequence-specific DNA binding; calcium ion binding; transcription factor activity
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Biological Process: regulation of transcription from RNA polymerase II promoter; T-helper 1 cell lineage commitment; transcription, DNA-dependent; negative regulation of T-helper 2 type immune response; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation
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Reference #:
P42226 (UniProtKB)
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| Alt. Names/Synonyms: D12S1644; IL-4 Stat; IL-4-STAT; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT, interleukin4-induced; STAT6; STAT6B; STAT6C; transcription factor IL-4 STAT |
| Gene Symbols: STAT6 |
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Molecular weight: 94,135 Da
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Basal Isoelectric point: 5.84
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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