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Protein Page:
STAT5A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT5A transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA binding protein
Cellular Component: nucleoplasm; cytosol
Molecular Function: signal transducer activity; protein binding; calcium ion binding; transcription factor activity
Biological Process: lactation; succinate metabolic process; peptidyl-tyrosine phosphorylation; oxaloacetate metabolic process; positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; female pregnancy; positive regulation of multicellular organism growth; positive regulation of activated T cell proliferation; positive regulation of mitotic cell cycle; fatty acid metabolic process; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; natural killer cell differentiation; allantoin metabolic process; negative regulation of mast cell apoptosis; luteinization; development of secondary male sexual characteristics; regulation of steroid metabolic process; creatinine metabolic process; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; Peyer's patch development; regulation of cell adhesion; isoleucine metabolic process; negative regulation of erythrocyte differentiation; transcription, DNA-dependent; valine metabolic process; citrate metabolic process; regulation of multicellular organism growth; development of secondary female sexual characteristics; positive regulation of natural killer cell mediated cytotoxicity; JAK-STAT cascade; creatine metabolic process; regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell differentiation; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; positive regulation of inflammatory response
Reference #:  P42229 (UniProtKB)
Alt. Names/Synonyms: MGF; Signal transducer and activator of transcription 5A; STA5A; STAT5; STAT5A
Gene Symbols: STAT5A
Molecular weight: 90,647 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT5A

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y694‑p
activity, induced: Y694‑p
molecular association, regulation: S780‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 12 Y22-p LRQMQVLyGQHFPIE
0 1 K71-ub LVQELQKkAEHQVGE
0 1 K84-ac GEDGFLLkIKLGHyA
0 270 Y90-p LkIKLGHyAtQLQKT
0 3 T92-p IKLGHyAtQLQKTYD
1 0 T92-gl IKLGHyAtQLQKTYD
0 199 Y114-p RCIRHILyNEQRLVR
1 2 S127-p VREANNCssPAGILV
1 3 S128-p REANNCssPAGILVD
0 1 K164-ub DTENELKkLQQTQEY
0 2 Y171 kLQQTQEYFIIQYQE
0 4 S193-p FAQLAQLsPQERLSR
0 1 K232-ub YRVELAEkHQKTLQL
0 1 K242-ub KTLQLLRkQQTIILD
0 1 K380-ub IISEQQAkSLLkNEN
0 3 K384-ac QQAkSLLkNENTRNE
0 1 T647-p LWNLKPFttRDFSIR
0 1 T648-p WNLKPFttRDFSIRS
0 8 Y668-p GDLSYLIyVFPDRPk
0 1 K675-ub yVFPDRPkDEVFSky
0 1 K681-ub PkDEVFSkyyTPVLA
1 16 Y682-p kDEVFSkyyTPVLAK
1 12 Y683-p DEVFSkyyTPVLAKA
100 2176 Y694-p LAKAVDGyVKPQIKQ
15 1 S726-p TYMDQAPsPAVCPQA
3 0 T757 GEFDLDETMDVARHV
0 2 S774-p LLRRPMDsLDsRLsP
0 1 S777-p RPMDsLDsRLsPPAG
9 11 S780-p DsLDsRLsPPAGLFT
0 1 S794-p TSARGSLs_______
0 1 - gap
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  mouse

► Hide Isoforms
 
Y22 LRQMQVLYGQHFPIE
K71 LVQELQKKAEHQVGE
K84 GEDGFLLKIKLGHyA
Y90-p LKIKLGHyATQLQNT
T92 IKLGHyATQLQNTYD
T92 IKLGHyATQLQNTYD
Y114-p RCIRHILyNEQRLVR
S127-p VREANNCssPAGVLV
S128-p REANNCssPAGVLVD
K164 DTENELKKLQQTQEy
Y171-p KLQQTQEyFIIQYQE
N193 FAQLGQLNPQERMSR
K232 YRVELAEKHQKTLQL
K242 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRNE
T647 LWNLKPFTTRDFSIR
T648 WNLKPFTTRDFSIRS
Y668 GDLNYLIYVFPDRPK
K675 YVFPDRPKDEVFAKy
K681 PKDEVFAKyyTPVLA
Y682-p KDEVFAKyyTPVLAK
Y683-p DEVFAKyyTPVLAKA
Y694-p LAKAVDGyVKPQIKQ
S725-p TYMDQAPsPVVCPQP
S756-p GEFDLDEsMDVARHV
S773-p LLRRPMDsLDARLsP
A776 RPMDsLDARLsPPAG
S779-p DsLDARLsPPAGLFT
S793 TSARSSLS_______
- gap
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  STAT5A iso2  
Y22 LRQMQVLYGQHFPIE
K71 LVQELQKKAEHQVGE
K84 GEDGFLLKIKLGHYA
Y90 LKIKLGHYATQLQNT
T92 IKLGHYATQLQNTYD
T92 IKLGHYATQLQNTYD
Y114 RCIRHILYNEQRLVR
S127 VREANNCSSPAGVLV
S128 REANNCSSPAGVLVD
K164 DTENELKKLQQTQEY
Y171 KLQQTQEYFIIQYQE
N193 FAQLGQLNPQERMSR
K232 YRVELAEKHQKTLQL
K242 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRNE
T647 LWNLKPFTTRDFSIR
T648 WNLKPFTTRDFSIRS
Y668 GDLNYLIYVFPDRPK
K675 YVFPDRPKDEVFAKY
K681 PKDEVFAKYYTPVLG
Y682 KDEVFAKYYTPVLGS
Y683 DEVFAKYYTPVLGSS
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T758-p AGPWTVStPASPHLL
  rat

 
Y22 LRQMQVLYGQHFPIE
K71 LVQELQKKAEHQVGE
K84 GEDGFVLKIKLGHyA
Y90-p LKIKLGHyATQLQNT
T92 IKLGHyATQLQNTYD
T92 IKLGHyATQLQNTYD
Y114 RCIRHILYNEQRLVR
S127 VREANNCSSPAGVLV
S128 REANNCSSPAGVLVD
K164 DTESELKKLQQTQEY
Y171 KLQQTQEYFIIQYQE
N193 FGQLAQLNPQERMSR
K232 YRVELVEKHQKTLQL
K242 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRND
T647 LWNLKPFTTRDFSIR
T648 WNLKPFTTRDFSIRS
Y668 GDLNYLIYVFPDRPK
K675 YVFPDRPKDEVFAKY
K681 PKDEVFAKYYTPVLA
Y682 KDEVFAKYYTPVLAK
Y683 DEVFAKYYTPVLAKA
Y694-p LAKAVDGyVKPQIKQ
S725-p TYMDQAPsPVVCPQA
T756 GEFDLDETMDVARHV
S773 LLRRPMDSLDPRLSP
P776 RPMDSLDPRLSPPAG
S779 DSLDPRLSPPAGLFT
S793 TSARSSLS_______
- gap
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  fruit fly

 
Y21 EQRMAAYYEEKGMLE
K68 FNEDLQQKLLSTRTA
K81 TASDQALKFRVVELC
- gap
- gap
- gap
- gap
A121 VTEKSVAATAGQSMP
T122 TEKSVAATAGQSMPL
V161 SNSCNPPVVQGIGPI
I168 VVQGIGPIHNVQNTG
N202 HQIMQSLNEFGNCAN
K241 YRSLIDEKAAIVLTM
- gap
Q390 IMSEIQSQRFVTRNT
- gap
T652 VTMLAPWTARDFQVL
A653 TMLAPWTARDFQVLN
- gap
- gap
- gap
F693 RDVAFGEFYSKRQEP
Y694 DVAFGEFYSKRQEPE
Y711 VLDPVTGYVKSTLHV
- gap
T729 RNGENGSTSGTPHHA
- gap
- gap
- gap
- gap
- gap
  sheep

 
Y22 LRQMQVLYGQHFPIE
K71 LVQELQKKAEHQVGE
K84 GEDGFLLKIKLGHYV
Y90 LKIKLGHYVHVSSRT
H92 IKLGHYVHVSSRTRT
H92 IKLGHYVHVSSRTRT
Y115 RCIRHILYNEQRLVR
N128 VREATNGNSSAGILV
S129 REATNGNSSAGILVD
K165 DTENELKKLQQTQEY
Y172 KLQQTQEYFIIQYQE
N194 FAQLAQLNPQERLSR
K233 YRVELAEKHQKTLQL
K243 KTLQLLRKQQTIILD
K380 IISEQQAKSLLKNEN
K384 QQAKSLLKNENTRNE
T647 LWNLKPFTTREGSIR
T648 WNLKPFTTREGSIRS
Y668 GDLNYLIYVFPDRPK
K675 YVFPDRPKDEVFSKY
K681 PKDEVFSKYYTPVLA
Y682 KDEVFSKYYTPVLAK
Y683 DEVFSKYYTPVLAKA
Y694-p LAKAVDGyVKPQIKQ
S726 TYMDQAPSPAVCPQP
T757-p GEFDLDEtMDVARHV
- gap
- gap
P780 GQSGPLSPPPAGLFT
S794 TPARGSLS_______
- gap
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
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