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Protein Page:
STAT5A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
STAT5A transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein binding; signal transducer activity; calcium ion binding; transcription factor activity
Biological Process: lactation; succinate metabolic process; peptidyl-tyrosine phosphorylation; oxaloacetate metabolic process; positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; female pregnancy; positive regulation of multicellular organism growth; positive regulation of activated T cell proliferation; fatty acid metabolic process; positive regulation of mitotic cell cycle; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; natural killer cell differentiation; negative regulation of mast cell apoptosis; allantoin metabolic process; luteinization; regulation of steroid metabolic process; development of secondary male sexual characteristics; creatinine metabolic process; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; regulation of cell adhesion; Peyer's patch development; isoleucine metabolic process; negative regulation of erythrocyte differentiation; transcription, DNA-dependent; citrate metabolic process; regulation of multicellular organism growth; valine metabolic process; development of secondary female sexual characteristics; JAK-STAT cascade; positive regulation of natural killer cell mediated cytotoxicity; creatine metabolic process; regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell differentiation; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; positive regulation of inflammatory response
Reference #:  P42229 (UniProtKB)
Alt. Names/Synonyms: MGF; Signal transducer and activator of transcription 5A; STA5A; STAT5; STAT5A
Gene Symbols: STAT5A
Molecular weight: 90,647 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT5A

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y694‑p
activity, induced: Y694‑p
molecular association, regulation: S780‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 12 Y22-p LRQMQVLyGQHFPIE
0 1 K84-a GEDGFLLkIKLGHyA
0 270 Y90-p LkIKLGHyAtQLQKT
0 3 T92-p IKLGHyAtQLQKTYD
1 0 T92-gl IKLGHyAtQLQKTYD
0 201 Y114-p RCIRHILyNEQRLVR
1 2 S127-p VREANNCssPAGILV
1 2 S128-p REANNCssPAGILVD
0 2 Y171 KLQQTQEYFIIQYQE
0 3 S193-p FAQLAQLsPQERLSR
0 3 K384-a QQAKSLLkNENTRNE
0 6 Y668-p GDLSYLIyVFPDRPK
0 16 Y682-p KDEVFSKyyTPVLAK
0 14 Y683-p DEVFSKyyTPVLAKA
93 2168 Y694-p LAKAVDGyVKPQIKQ
15 1 S726-p TYMDQAPsPAVCPQA
3 0 T757 GEFDLDETMDVARHV
9 9 S780-p DSLDSRLsPPAGLFT
0 1 S794-p TSARGSLs_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  mouse

► Hide Isoforms
 
Y22 LRQMQVLYGQHFPIE
K84 GEDGFLLKIKLGHyA
Y90-p LKIKLGHyATQLQNT
T92 IKLGHyATQLQNTYD
T92 IKLGHyATQLQNTYD
Y114-p RCIRHILyNEQRLVR
S127-p VREANNCssPAGVLV
S128-p REANNCssPAGVLVD
Y171-p KLQQTQEyFIIQYQE
N193 FAQLGQLNPQERMSR
K384 QQAKSLLKNENTRNE
Y668 GDLNYLIYVFPDRPK
Y682 KDEVFAKYYTPVLAK
Y683 DEVFAKYYTPVLAKA
Y694-p LAKAVDGyVKPQIKQ
S725-p TYMDQAPsPVVCPQP
S756-p GEFDLDEsMDVARHV
S779-p DSLDARLsPPAGLFT
S793 TSARSSLS_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  STAT5A iso2  
Y22 LRQMQVLYGQHFPIE
K84 GEDGFLLKIKLGHYA
Y90 LKIKLGHYATQLQNT
T92 IKLGHYATQLQNTYD
T92 IKLGHYATQLQNTYD
Y114 RCIRHILYNEQRLVR
S127 VREANNCSSPAGVLV
S128 REANNCSSPAGVLVD
Y171 KLQQTQEYFIIQYQE
N193 FAQLGQLNPQERMSR
K384 QQAKSLLKNENTRNE
Y668 GDLNYLIYVFPDRPK
Y682 KDEVFAKYYTPVLGS
Y683 DEVFAKYYTPVLGSS
- gap
- gap
- gap
- gap
- gap
  rat

 
Y22 LRQMQVLYGQHFPIE
K84 GEDGFVLKIKLGHyA
Y90-p LKIKLGHyATQLQNT
T92 IKLGHyATQLQNTYD
T92 IKLGHyATQLQNTYD
Y114 RCIRHILYNEQRLVR
S127 VREANNCSSPAGVLV
S128 REANNCSSPAGVLVD
Y171 KLQQTQEYFIIQYQE
N193 FGQLAQLNPQERMSR
K384 QQAKSLLKNENTRND
Y668 GDLNYLIYVFPDRPK
Y682 KDEVFAKYYTPVLAK
Y683 DEVFAKYYTPVLAKA
Y694-p LAKAVDGyVKPQIKQ
S725-p TYMDQAPsPVVCPQA
T756 GEFDLDETMDVARHV
S779 DSLDPRLSPPAGLFT
S793 TSARSSLS_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9314 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb
9351 : Phospho-Stat5 (Tyr694) Antibody
9356 : Phospho-Stat5 (Tyr694) (14H2) Mouse mAb
9359 : Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
  fruit fly

 
Y21 EQRMAAYYEEKGMLE
K81 TASDQALKFRVVELC
- gap
- gap
- gap
- gap
A121 VTEKSVAATAGQSMP
T122 TEKSVAATAGQSMPL
I168 VVQGIGPIHNVQNTG
N202 HQIMQSLNEFGNCAN
- gap
- gap
F693 RDVAFGEFYSKRQEP
Y694 DVAFGEFYSKRQEPE
Y711 VLDPVTGYVKSTLHV
- gap
T729 RNGENGSTSGTPHHA
- gap
- gap
  sheep

 
Y22 LRQMQVLYGQHFPIE
K84 GEDGFLLKIKLGHYV
Y90 LKIKLGHYVHVSSRT
H92 IKLGHYVHVSSRTRT
H92 IKLGHYVHVSSRTRT
Y115 RCIRHILYNEQRLVR
N128 VREATNGNSSAGILV
S129 REATNGNSSAGILVD
Y172 KLQQTQEYFIIQYQE
N194 FAQLAQLNPQERLSR
K384 QQAKSLLKNENTRNE
Y668 GDLNYLIYVFPDRPK
Y682 KDEVFSKYYTPVLAK
Y683 DEVFSKYYTPVLAKA
Y694-p LAKAVDGyVKPQIKQ
S726 TYMDQAPSPAVCPQP
T757-p GEFDLDEtMDVARHV
P780 GQSGPLSPPPAGLFT
S794 TPARGSLS_______
3939 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4322 : Phospho-Stat5 (Tyr694) (D47E7) XP(R) Rabbit mAb
9365 : Phospho-Stat5 (Tyr694) (C71E5) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
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