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Protein Page:
STAT4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT4 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 2q32.2-q32.3
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: signal transducer activity; sequence-specific DNA binding; calcium ion binding; transcription factor activity
Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation
Reference #:  Q14765 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 4; SLEB11; STAT4
Gene Symbols: STAT4
Molecular weight: 85,941 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S130-p VQGPLEKsLQSSSVs
0 1 S137-p sLQSSSVsERQRNVE
0 1 T284-p EKLEEQStKMtyEGD
0 2 T287-p EEQStKMtyEGDPIP
0 1 Y288-p EQStKMtyEGDPIPM
0 1 T298-p DPIPMQRtHMLERVT
0 1 T341 LKTLIQFTVKLRLLI
0 1 Y355-p IKLPELNyQVKVKAs
0 1 S362-p yQVKVKAsIDKNVSt
0 1 T369-p sIDKNVStLsNRRFV
0 1 S371-p DKNVStLsNRRFVLC
0 1 S386-p GTNVKAMsIEESSNG
0 1 S394-p IEESSNGsLsVEFRH
0 1 S396-p ESSNGsLsVEFRHLQ
0 1 K630 HSVEPYNKGRLSALP
0 1 Y645-p FADILRDyKVIMAEN
0 1 Y662 ENPLKYLYPDIPKDK
8 4 Y693-p TERGDKGyVPSVFIP
4 0 S721-p PSDLLPMsPSVYAVL
0 1 S733 AVLRENLSPTTIETA
0 1 S743-p TIETAMKsPysAE__
0 1 Y745-p ETAMKsPysAE____
0 1 S746-p TAMKsPysAE_____
4134 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb
5267 : Phospho-Stat4 (Tyr693) Antibody
13223 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate)
  mouse

 
S130 IQGPLEKSLQSSSVS
S137 SLQSSSVSERQRNVE
T285 EKLQEQSTKMTYEGD
T288 QEQSTKMTYEGDPIP
Y289 EQSTKMTYEGDPIPA
A299 DPIPAQRAHLLERAT
T342-p LKTLIQFtVKLRLLI
Y356 IKLPELNYQVKVKAS
S363 YQVKVKASIDKNVST
T370 SIDKNVSTLSNRRFV
S372 DKNVSTLSNRRFVLC
S387 GTHVKAMSSEESSNG
S395 SEESSNGSLSVEFRH
S397 ESSNGSLSVEFRHLQ
K631-ub HSVEPYNkGRLSALA
Y646 FADILRDYKVIMAEN
Y663-p ENPLKYLyPDIPKDK
Y694-p TERGDKGyVPSVFIP
S722-p PSDLLPMsPSAYAVL
S734 AVLRENLSPTTIETA
S744 TIETAMNSPYSAE__
Y746 ETAMNSPYSAE____
S747 TAMNSPYSAE_____
4134 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb
5267 : Phospho-Stat4 (Tyr693) Antibody
13223 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate)
  rat

 
S130 IQGPLEKSLQSSSVS
S137 SLQSSSVSERQRNVE
T284 EKLQEQSTKMTYEGD
T287 QEQSTKMTYEGDPIP
Y288 EQSTKMTYEGDPIPA
V298 DPIPAQRVHLLERAT
T341 LKTLIQFTVKLRLLI
Y355 IKLPELNYQVKVKAS
S362 YQVKVKASIDKNVST
T369 SIDKNVSTLSNRRFV
S371 DKNVSTLSNRRFVLC
S386 GTHIKAMSSEESSNG
S394 SEESSNGSLSVEFRH
S396 ESSNGSLSVEFRHLQ
K630 HSVEPYNKARLSALP
Y645 FADILRDYKVIMAEN
Y662 ENPLKYLYPDIPKDK
Y693 TERGDKGYVPSVFIP
S721 PSDLLPMSPSAYAVL
S733-p AVLRENLsPTTIETA
S743 TIETAMNSPYSAE__
Y745 ETAMNSPYSAE____
S746 TAMNSPYSAE_____
4134 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb
5267 : Phospho-Stat4 (Tyr693) Antibody
13223 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate)
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