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Protein Page:
STAT4 (human)

Overview
STAT4 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: cytoplasm
Molecular Function: signal transducer activity; sequence-specific DNA binding; calcium ion binding; transcription factor activity
Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation
Reference #:  Q14765 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 4; SLEB11; STAT4
Gene Symbols: STAT4
Molecular weight: 85,941 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT4

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T284-p EKLEEQStKMtYEGD
0 2 T287-p EEQStKMtYEGDPIP
0 1 Y355-p IKLPELNyQVKVKAS
8 4 Y693-p TERGDKGyVPSVFIP
4 0 S721-p PSDLLPMsPSVYAVL
4134 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb
5267 : Phospho-Stat4 (Tyr693) Antibody
13223 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate)
  mouse

 
T285 EKLQEQSTKMTYEGD
T288 QEQSTKMTYEGDPIP
Y356 IKLPELNYQVKVKAS
Y694-p TERGDKGyVPSVFIP
S722-p PSDLLPMsPSAYAVL
4134 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb
5267 : Phospho-Stat4 (Tyr693) Antibody
13223 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate)
  rat

 
T284 EKLQEQSTKMTYEGD
T287 QEQSTKMTYEGDPIP
Y355 IKLPELNYQVKVKAS
Y693 TERGDKGYVPSVFIP
S721 PSDLLPMSPSAYAVL
4134 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb
5267 : Phospho-Stat4 (Tyr693) Antibody
13223 : Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate)
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