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STAT4 (human)

Overview STAT4 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function: signal transducer activity; sequence-specific DNA binding; calcium ion binding; transcription factor activity Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation Reference #:  Q14765 (UniProtKB) Alt. Names/Synonyms: Signal transducer and activator of transcription 4; SLEB11; STAT4 Gene Symbols: STAT4 Molecular weight: 85,941 Da Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STAT4 1BGF - A=2-123 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 152700 180300 600558 612253  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T284-p	EKLEEQStKMtyEGD
0	2		T287-p	EEQStKMtyEGDPIP
0	1		Y288-p	EQStKMtyEGDPIPM
0	1		T298-p	DPIPMQRtHMLERVT
0	1		T341	LKTLIQFTVKLRLLI
0	1		Y355-p	IKLPELNyQVKVKAS
0	1		S386-p	GTNVKAMsIEESSNG
0	1		S394-p	IEESSNGsLsVEFRH
0	1		S396-p	ESSNGsLsVEFRHLQ
0	1		K630	HSVEPYNKGRLSALP
0	1		Y645-p	FADILRDyKVIMAEN
0	1		Y662	ENPLKYLYPDIPKDK
8	4		Y693-p	TERGDKGyVPSVFIP
4	0		S721-p	PSDLLPMsPSVYAVL

	mouse
T285	EKLQEQSTKMTYEGD
T288	QEQSTKMTYEGDPIP
Y289	EQSTKMTYEGDPIPA
A299	DPIPAQRAHLLERAT
T342-p	LKTLIQFtVKLRLLI
Y356	IKLPELNYQVKVKAS
S387	GTHVKAMSSEESSNG
S395	SEESSNGSLSVEFRH
S397	ESSNGSLSVEFRHLQ
K631-u	HSVEPYNkGRLSALA
Y646	FADILRDYKVIMAEN
Y663-p	ENPLKYLyPDIPKDK
Y694-p	TERGDKGyVPSVFIP
S722-p	PSDLLPMsPSAYAVL

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