Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
STAT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT2 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: identical protein binding; signal transducer activity; protein binding; DNA binding; calcium ion binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; defense response to virus
Reference #:  P52630 (UniProtKB)
Alt. Names/Synonyms: interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113; STAT2
Gene Symbols: STAT2
Molecular weight: 97,916 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT2

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, inhibited: Y631‑p
cell growth, inhibited: S287‑p
transcription, inhibited: S287‑p
intracellular localization: S287‑p, Y690‑p
molecular association, regulation: S287‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K158-ac DLRAMMEkLVKSISQ
0 1 K239 LPKLEEWKAQQQKAC
0 1 S283-p LKELKGLsCLVsYQD
1 1 S287-p KGLsCLVsYQDDPLt
0 1 - gap
0 1 T294-p sYQDDPLtkGVDLRN
0 2 K295-ub YQDDPLtkGVDLRNA
0 1 K375-ac PQLQGFRkFNILTSN
0 1 K384-ac NILTSNQkTLTPEKG
0 1 K384-ub NILTSNQkTLTPEKG
0 3 K523-ub QLSMLRNkLFGQNCR
0 1 K543-ub LSWADFTkRESPPGK
0 2 S595-p RLLKKTMsGtFLLRF
0 1 T597-p LKKTMsGtFLLRFSE
1 0 Y631-p LIYSVQPyTKEVLQS
0 2 K681-ub FGCYYQEkVNLQERR
10 0 Y690-p NLQERRKyLKHRLIV
0 1 S753-p DLGPELEsVLESTLE
0 7 T800-p CDLRHLNtEPMEIFR
0 1 Y833-p QNTVDEVyVSRPSHF
4441 : Phospho-Stat2 (Tyr690) Antibody
  mouse

► Hide Isoforms
 
F157 GLHVDIEFLVRSIRQ
K238-ub LPKLDEWkVQQQKSC
S284 LKQLKEMSCLRYQGD
R287 LKEMSCLRYQGDMFA
- gap
A294 RYQGDMFAKGVDLRN
K295 YQGDMFAKGVDLRNA
K374 SDLPGFRKFNILTSN
K383 NILTSNQKTLTPEKG
K383 NILTSNQKTLTPEKG
K522 QLGMLRTKLFGKSCK
K542 LSWVDFCKRESPPGK
S594-p RLLKKMLsGTFLLRF
T596 LKKMLsGTFLLRFSE
Y630 EIYSVQPYTKEVLQS
K680 FGCYYQEKVNLEEQE
Y689-p NLEEQEEyLKHKLIV
- under review  
- gap
S903 ESSGDETSIPYHSHF
  STAT2 iso3  
F157 GLHVDIEFLVRSIRQ
K238 LPKLDEWKVQQQKSC
S283 LKQLKEMSHMLRYkG
R287 KEMSHMLRYkGDMFG
K289-ub MSHMLRYkGDMFGQG
G294 RYkGDMFGQGVDLQN
Q295 YkGDMFGQGVDLQNA
K374 SDLPGFRKFNILTSN
K383 NILTSNQKTLTPEEG
K383 NILTSNQKTLTPEEG
K521 QLGMLRTKLFGKSCK
K541 LSWVDFCKRESPPGK
S593 RLLKKMLSGTFLLRF
T595 LKKMLSGTFLLRFSE
Y629 EIYSVQPYTKEVLQS
K679 FGCYYQEKVNFEEQR
Y688 NFEEQRKYLKHKLIV
V821 QLEPAPQVLLELAPQ
- gap
S902 ESSGDETSIPYHSHF
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.