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Protein Page:
STAT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT2 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: identical protein binding; signal transducer activity; protein binding; DNA binding; calcium ion binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; defense response to virus
Reference #:  P52630 (UniProtKB)
Alt. Names/Synonyms: interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113; STAT2
Gene Symbols: STAT2
Molecular weight: 97,916 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: Y631‑p
cell growth, inhibited: S287‑p
transcription, inhibited: S287‑p
intracellular localization: S287‑p, Y690‑p
molecular association, regulation: S287‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12-p EMLQNLDsPFQDQLH
0 1 K158-ac DLRAMMEkLVKSISQ
0 1 S187-p QAKGKTPsLDPHQTK
0 1 K239 LPKLEEWKAQQQKAC
0 1 S283-p LKELKGLsCLVsYQD
1 1 S287-p KGLsCLVsYQDDPLt
0 1 Q289 LsCLVsYQDDPLtkG
0 1 T294-p sYQDDPLtkGVDLRN
0 2 K295-ub YQDDPLtkGVDLRNA
0 1 K375-ac PQLQGFRkFNILTSN
0 1 K384-ac NILTSNQkTLTPEKG
0 1 K384-ub NILTSNQkTLTPEKG
0 3 K523-ub QLSMLRNkLFGQNCR
0 1 K543-ub LSWADFTkRESPPGK
0 2 S595-p RLLKKTMsGtFLLRF
0 1 T597-p LKKTMsGtFLLRFSE
1 0 Y631-p LIYSVQPyTKEVLQS
0 2 K681-ub FGCYYQEkVNLQERR
10 0 Y690-p NLQERRKyLKHRLIV
0 1 S699 KHRLIVVSNRQVDEL
0 1 S753-p DLGPELEsVLESTLE
0 7 T800-p CDLRHLNtEPMEIFR
0 1 Y833-p QNTVDEVyVSRPSHF
4441 : Phospho-Stat2 (Tyr690) Antibody
  mouse

► Hide Isoforms
 
S12 EMLQNLDSPFLDQLH
F157 GLHVDIEFLVRSIRQ
S186 FSLKKTSSSDPHQSQ
K238-ub LPKLDEWkVQQQKSC
S284 LKQLKEMSCLRYQGD
- gap
Q289 EMSCLRYQGDMFAKG
A294 RYQGDMFAKGVDLRN
K295 YQGDMFAKGVDLRNA
K374 SDLPGFRKFNILTSN
K383 NILTSNQKTLTPEKG
K383 NILTSNQKTLTPEKG
K522 QLGMLRTKLFGKSCK
K542 LSWVDFCKRESPPGK
S594-p RLLKKMLsGTFLLRF
T596 LKKMLsGTFLLRFSE
Y630 EIYSVQPYTKEVLQS
K680 FGCYYQEKVNLEEQE
Y689-p NLEEQEEyLKHKLIV
S698 KHKLIVISNRQVDEL
- gap
- gap
- gap
  STAT2 iso3  
S12 EMLQNLDSLFLDQLH
F157 GLHVDIEFLVRSIRQ
S186 FSLKKTSSSDPHQSQ
K238 LPKLDEWKVQQQKSC
S283 LKQLKEMSHMLRYkG
- gap
K289-ub MSHMLRYkGDMFGQG
G294 RYkGDMFGQGVDLQN
Q295 YkGDMFGQGVDLQNA
K374 SDLPGFRKFNILTSN
K383 NILTSNQKTLTPEEG
K383 NILTSNQKTLTPEEG
K521 QLGMLRTKLFGKSCK
K541 LSWVDFCKRESPPGK
S593 RLLKKMLSGTFLLRF
T595 LKKMLSGTFLLRFSE
Y629 EIYSVQPYTKEVLQS
K679 FGCYYQEKVNFEEQR
Y688 NFEEQRKYLKHKLIV
S697 KHKLIVISNRQVDEL
- gap
- gap
- gap
  rat

 
S12 EMLQNLDSPFLDQLH
A158 DLQTAVEALVRSIRQ
S187 LNHKKTSSLDPHQSQ
K239 LPKLDEWKAQQQKSC
S284 LKQLKDMSLMLRYEG
- gap
E290 MSLMLRYEGDMFGQG
G295 RYEGDMFGQGVDLQN
Q296 YEGDMFGQGVDLQNA
K375 SELPGFRKFNILTSN
K384 NILTSNQKSLTPEEG
K384 NILTSNQKSLTPEEG
K523 QLGMLRNKLFGKNCK
K543 LSWADFSKRESPPGK
S595 RLLKKMVSGTFLLRF
T597 LKKMVSGTFLLRFSE
Y631 LIYSVQPYTKEVLQS
K681 FGCYYQEKVNLEERR
Y690 NLEERRKYLKHRLIV
S699-p KHRLIVIsNRQADEL
- gap
T791 QDLQQLNTGEMEIFR
Y824 QSIIEEAYRSCPSHF
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