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Protein Page:
STAT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT1 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component: nucleoplasm; axon; nuclear chromatin; dendrite; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; signal transducer activity; protein homodimerization activity; enzyme binding; double-stranded DNA binding; calcium ion binding; transcription factor activity; tumor necrosis factor receptor binding; CCR5 chemokine receptor binding
Biological Process: transcription from RNA polymerase II promoter; response to peptide hormone stimulus; response to cAMP; viral reproduction; apoptosis; blood circulation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; positive regulation of mesenchymal cell proliferation; lipopolysaccharide-mediated signaling pathway; defense response to virus; response to nutrient; response to drug; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; negative regulation of angiogenesis; response to hydrogen peroxide; cellular response to insulin stimulus; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P42224 (UniProtKB)
Alt. Names/Synonyms: DKFZp686B04100; ISGF-3; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT1; STAT91; Transcription factor ISGF-3 components p91/p84
Gene Symbols: STAT1
Molecular weight: 87,335 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S727‑p
apoptosis, inhibited: S727‑p
cell cycle regulation: Y701‑p
cell differentiation, altered: Y701‑p
cell growth, altered: Y701‑p, S727‑p
transcription, altered: Y701‑p, S727‑p
transcription, induced: Y701‑p, S727‑p
transcription, inhibited: Y701‑p
activity, induced: Y701‑p, S727‑p
intracellular localization: Y701‑p
molecular association, regulation: Y701‑p, S727‑p
phosphorylation: K703‑sm
sumoylation: S727‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 R31-m1 DSFPMEIrQYLAQWL
1 0 R31-m2 DSFPMEIrQYLAQWL
0 1 K40-ub YLAQWLEkQDWEHAA
0 12 Y68-p LSQLDDQySRFSLEN
0 19 Y106-p IQMSMIIySCLKEER
0 2 K138-ub QSTVMLDkQKELDSK
0 3 Y170-p LEDLQDEyDFkCKTL
0 1 K173-ac LQDEyDFkCKTLQNR
0 2 K173-ub LQDEyDFkCKTLQNR
0 1 T184-p LQNREHEtNGVAKSD
0 6 K193-ub GVAKSDQkQEQLLLK
0 1 Y203-p QLLLKKMyLMLDNkR
0 1 K209-ub MyLMLDNkRKEVVHK
0 1 V223 KIIELLNVTELTQNA
0 1 T227 LLNVTELTQNALIND
0 4 K240-ub NDELVEWkRRQQSAC
0 7 K296-ub YEHDPITkNkQVLWD
0 1 K298-ub HDPITkNkQVLWDRT
0 2 K375-ub VNERNTVkGFRKFNI
0 1 K379 NTVkGFRKFNILGTH
2 1 K410-ac EFRHLQLkEQkNAGt
0 11 K410-ub EFRHLQLkEQkNAGt
2 1 K413-ac HLQLkEQkNAGtRTN
0 1 T417-p kEQkNAGtRTNEGPL
0 5 K511-ub WQFSSVTkRGLNVDQ
0 2 K525-ub QLNMLGEkLLGPNAs
0 1 S532-p kLLGPNAsPDGLIPW
0 2 K544-ub IPWTRFCkENINDKN
0 13 K592-ub ERERALLkDQQPGTF
0 1 K636-ub HAVEPYTkKELsAVT
0 1 K637 AVEPYTkKELsAVTF
0 1 S640-p PYTkKELsAVTFPDI
0 14 K652-ub PDIIRNYkVMAAENI
0 2 K665-ub NIPENPLkYLyPNID
0 4 Y668-p ENPLkYLyPNIDKDH
0 1 K673 YLyPNIDKDHAFGKY
0 1 K679 DKDHAFGKYYSRPKE
0 5 T699-p ELDGPKGtGyIktEL
129 55 Y701-p DGPKGtGyIktELIs
6 1 K703-sm PKGtGyIktELIsVS
0 3 T704-p KGtGyIktELIsVSE
2 0 S708-p yIktELIsVSEVHPS
0 2 T719 VHPSRLQTTDNLLPM
0 1 T720 HPSRLQTTDNLLPMs
79 95 S727-p TDNLLPMsPEEFDEV
0 1 S735 PEEFDEVSRIVGSVE
1 0 S745 VGSVEFDSMMNTV__
1 0 N748 VEFDSMMNTV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
9174 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
  mouse

 
R31 DSFPMEIRQYLAQWL
R31 DSFPMEIRQYLAQWL
K40 YLAQWLEKQDWEHAA
Y68 LSQLDDQYSRFSLEN
Y106 VQMSMIIYNCLKEER
K138-ub QNTVMLDkQKELDSK
Y170 LEELQDEYDFKCKTS
K173 LQDEYDFKCKTSQNR
K173 LQDEYDFKCKTSQNR
A184 SQNREGEANGVAKSD
K193-ub GVAKSDQkQEQLLLH
F203 QLLLHKMFLMLDNKR
K209 MFLMLDNKRKEIIHK
S223 KIRELLNSIELTQNT
T227 LLNSIELTQNTLIND
K240 NDELVEWKRRQQSAC
K296-ub YEPDPITkNKQVLSD
K298 PDPITkNKQVLSDRT
K375 VNEKNTVKGFRkFNI
K379-ub NTVKGFRkFNILGTH
K410 ELRHLQLKEQKNAGN
K410 ELRHLQLKEQKNAGN
K413 HLQLKEQKNAGNRTN
N417 KEQKNAGNRTNEGPL
K511 WQFSSVTKRGLNADQ
K525-ub QLSMLGEkLLGPNAG
G532 kLLGPNAGPDGLIPW
K544-ub IPWTRFCkENINDKN
K592-ub ERERALLkDQQPGTF
K636 HAVEPYTKkELSAVT
K637-ub AVEPYTKkELSAVTF
S640 PYTKkELSAVTFPDI
K652-ub PDIIRNYkVMAAENI
K665-ub NIPENPLkYLYPNID
Y668 ENPLkYLYPNIDkDH
K673-ub YLYPNIDkDHAFGkY
K679-ub DkDHAFGkYYSRPKE
T699 ELDDPKRTGyIKTEL
Y701-p DDPKRTGyIKTELIs
K703 PKRTGyIKTELIsVS
T704 KRTGyIKTELIsVSE
S708-p yIKTELIsVSEVHPS
T719-p VHPSRLQttDNLLPM
T720-p HPSRLQttDNLLPMs
S727-p tDNLLPMsPEEFDEM
S735-p PEEFDEMsRIVGPEF
S744-p IVGPEFDsMMsTV__
S747-p PEFDsMMsTV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
9174 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
  rat

 
R31 DSFPMEIRQYLAQWL
R31 DSFPMEIRQYLAQWL
K40 YLAQWLEKQDWEHAA
Y68 LSQLDDQYSRFSLEN
H106 VQMSMIIHNCLKEER
K138 QNTVMLDKQKELDSK
Y170 LEDLQDEYDFKCKTS
K173 LQDEYDFKCKTSQNR
K173 LQDEYDFKCKTSQNR
A184 SQNRESEANGVAKSD
K193 GVAKSDQKQEQLLLH
F203 QLLLHKMFLMLDNKR
K209 MFLMLDNKRKEIIHK
S223-p KIRELLNsIELtQNT
T227-p LLNsIELtQNTLIND
K240 NDELVEWKRRQQSAC
K296 YEQDPITKNKQVLSD
K298 QDPITKNKQVLSDRT
K375 VNEKNTVKGFRKFNI
K379 NTVKGFRKFNILGTH
K410-ac EFRHLQLkEQKNAGN
K410 EFRHLQLKEQKNAGN
K413 HLQLkEQKNAGNRTN
N417 kEQKNAGNRTNEGPL
K511 WQFSSVTKRGLNADQ
K525 QLSMLGEKLLGPNAG
G532 KLLGPNAGPDGLIPW
K544 IPWTRFCKENINDKN
K592 ERERALLKDQQPGTF
K636 HAVEPYTKKELSAVT
K637 AVEPYTKKELSAVTF
S640 PYTKKELSAVTFPDI
K652 PDIIRNYKVMAAENI
K665 NIPENPLKYLYPNID
Y668 ENPLKYLYPNIDKDH
K673 YLYPNIDKDHAFGKY
K679 DKDHAFGKYYSRPKE
T699 ELDDPKRTGyIKTEL
Y701-p DDPKRTGyIKTELIS
K703 PKRTGyIKTELISVS
T704 KRTGyIKTELISVSE
S708 yIKTELISVSEVHPS
S719-p VHPSRLQsTENLLPM
T720 HPSRLQsTENLLPMs
S727-p TENLLPMsPEEFDEM
S735 PEEFDEMSKIVGSEF
S744 IVGSEFDSMMSAV__
S747 SEFDSMMSAV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
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