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STAT1 (human)

Overview STAT1 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: nucleoplasm; axon; cytoplasm; dendrite; nucleolus; cytosol; nucleus Molecular Function: signal transducer activity; protein binding; enzyme binding; protein homodimerization activity; double-stranded DNA binding; calcium ion binding; tumor necrosis factor receptor binding; transcription factor activity Biological Process: response to peptide hormone stimulus; response to cAMP; blood circulation; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; negative regulation of angiogenesis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; response to cytokine stimulus; virus-host interaction; induction of apoptosis; positive regulation of mesenchymal cell proliferation; negative regulation of endothelial cell proliferation; lipopolysaccharide-mediated signaling pathway; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter; defense response to virus Reference #:  P42224 (UniProtKB) Alt. Names/Synonyms: DKFZp686B04100; ISGF-3; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT1; STAT91; Transcription factor ISGF-3 components p91/p84 Gene Symbols: STAT1 Molecular weight: 87,335 Da Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below STAT1 1BF5 - A=136-683 (human) 1YVL - A/B=1-683 (human) 2KA6 - B=710-750 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BF5 1YVL 2KA6  |  Phospho3D  |  DISEASE 209950 600555  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, induced: S727‑p apoptosis, inhibited: S727‑p cell cycle regulation: Y701‑p cell differentiation, altered: Y701‑p cell growth, altered: Y701‑p, S727‑p transcription, altered: Y701‑p, S727‑p transcription, induced: Y701‑p activation: Y701‑p, S727‑p intracellular localization: Y701‑p molecular association, regulation: Y701‑p, S727‑p phosphorylation: K703‑s sumoylation: S727‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		R31-m1	DSFPMEIrQYLAQWL
1	0		R31-m2	DSFPMEIrQYLAQWL
0	1		K40-u	YLAQWLEkQDWEHAA
0	11		Y68-p	LSQLDDQySRFSLEN
0	18		Y106-p	IQMSMIIySCLKEER
0	2		K138-u	QSTVMLDkQKELDSK
0	3		Y170-p	LEDLQDEyDFkCKTL
0	1		K173-a	LQDEyDFkCKTLQNR
0	2		K173-u	LQDEyDFkCKTLQNR
0	1		T184-p	LQNREHEtNGVAKSD
0	6		K193-u	GVAKSDQkQEQLLLK
0	1		Y203-p	QLLLKKMyLMLDNkR
0	1		K209-u	MyLMLDNkRKEVVHK
0	1		V223	KIIELLNVTELTQNA
0	1		T227	LLNVTELTQNALIND
0	4		K240-u	NDELVEWkRRQQSAC
0	7		K296-u	YEHDPITkNkQVLWD
0	1		K298-u	HDPITkNkQVLWDRT
0	2		K375-u	VNERNTVkGFRKFNI
0	1		K379	NTVkGFRKFNILGTH
2	1		K410-a	EFRHLQLkEQkNAGt
0	11		K410-u	EFRHLQLkEQkNAGt
2	1		K413-a	HLQLkEQkNAGtRTN
0	1		T417-p	kEQkNAGtRTNEGPL
0	5		K511-u	WQFSSVTkRGLNVDQ
0	2		K525-u	QLNMLGEkLLGPNAS
0	2		K544-u	IPWTRFCkENINDKN
0	13		K592-u	ERERALLkDQQPGTF
0	1		K636-u	HAVEPYTkKELSAVT
0	1		K637	AVEPYTkKELSAVTF
0	14		K652-u	PDIIRNYkVMAAENI
0	2		K665-u	NIPENPLkYLyPNID
0	3		Y668-p	ENPLkYLyPNIDKDH
0	1		K673	YLyPNIDKDHAFGKY
0	1		K679	DKDHAFGKYYSRPKE
0	7		T699-p	ELDGPKGtGyIktEL
123	66		Y701-p	DGPKGtGyIktELIs
6	1		K703-s	PKGtGyIktELIsVS
0	2		T704-p	KGtGyIktELIsVSE
1	0		S708-p	yIktELIsVSEVHPS
78	88		S727-p	TDNLLPMsPEEFDEV
1	0		S745	VGSVEFDSMMNTV__
1	0		N748	VEFDSMMNTV_____

	mouse
R31	DSFPMEIRQYLAQWL
R31	DSFPMEIRQYLAQWL
K40	YLAQWLEKQDWEHAA
Y68	LSQLDDQYSRFSLEN
Y106	VQMSMIIYNCLKEER
K138-u	QNTVMLDkQKELDSK
Y170	LEELQDEYDFKCKTS
K173	LQDEYDFKCKTSQNR
K173	LQDEYDFKCKTSQNR
A184	SQNREGEANGVAKSD
K193-u	GVAKSDQkQEQLLLH
F203	QLLLHKMFLMLDNKR
K209	MFLMLDNKRKEIIHK
S223	KIRELLNSIELTQNT
T227	LLNSIELTQNTLIND
K240	NDELVEWKRRQQSAC
K296-u	YEPDPITkNKQVLSD
K298	PDPITkNKQVLSDRT
K375	VNEKNTVKGFRkFNI
K379-u	NTVKGFRkFNILGTH
K410	ELRHLQLKEQKNAGN
K410	ELRHLQLKEQKNAGN
K413	HLQLKEQKNAGNRTN
N417	KEQKNAGNRTNEGPL
K511	WQFSSVTKRGLNADQ
K525-u	QLSMLGEkLLGPNAG
K544-u	IPWTRFCkENINDKN
K592-u	ERERALLkDQQPGTF
K636	HAVEPYTKkELSAVT
K637-u	AVEPYTKkELSAVTF
K652-u	PDIIRNYkVMAAENI
K665-u	NIPENPLkYLYPNID
Y668	ENPLkYLYPNIDkDH
K673-u	YLYPNIDkDHAFGkY
K679-u	DkDHAFGkYYSRPKE
T699	ELDDPKRTGyIKTEL
Y701-p	DDPKRTGyIKTELIs
K703	PKRTGyIKTELIsVS
T704	KRTGyIKTELIsVSE
S708-p	yIKTELIsVSEVHPS
S727-p	TDNLLPMsPEEFDEM
S744-p	IVGPEFDsMMsTV__
S747-p	PEFDsMMsTV_____

	rat
R31	DSFPMEIRQYLAQWL
R31	DSFPMEIRQYLAQWL
K40	YLAQWLEKQDWEHAA
Y68	LSQLDDQYSRFSLEN
H106	VQMSMIIHNCLKEER
K138	QNTVMLDKQKELDSK
Y170	LEDLQDEYDFKCKTS
K173	LQDEYDFKCKTSQNR
K173	LQDEYDFKCKTSQNR
A184	SQNRESEANGVAKSD
K193	GVAKSDQKQEQLLLH
F203	QLLLHKMFLMLDNKR
K209	MFLMLDNKRKEIIHK
S223-p	KIRELLNsIELtQNT
T227-p	LLNsIELtQNTLIND
K240	NDELVEWKRRQQSAC
K296	YEQDPITKNKQVLSD
K298	QDPITKNKQVLSDRT
K375	VNEKNTVKGFRKFNI
K379	NTVKGFRKFNILGTH
K410	EFRHLQLKEQKNAGN
K410	EFRHLQLKEQKNAGN
K413	HLQLKEQKNAGNRTN
N417	KEQKNAGNRTNEGPL
K511	WQFSSVTKRGLNADQ
K525	QLSMLGEKLLGPNAG
K544	IPWTRFCKENINDKN
K592	ERERALLKDQQPGTF
K636	HAVEPYTKKELSAVT
K637	AVEPYTKKELSAVTF
K652	PDIIRNYKVMAAENI
K665	NIPENPLKYLYPNID
Y668	ENPLKYLYPNIDKDH
K673	YLYPNIDKDHAFGKY
K679	DKDHAFGKYYSRPKE
T699	ELDDPKRTGyIKTEL
Y701-p	DDPKRTGyIKTELIS
K703	PKRTGyIKTELISVS
T704	KRTGyIKTELISVSE
S708	yIKTELISVSEVHPS
S727-p	TENLLPMsPEEFDEM
S744	IVGSEFDSMMSAV__
S747	SEFDSMMSAV_____

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