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Protein Page:
JARID1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JARID1B Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase; Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; transcription factor activity; transcription corepressor activity
Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent
Reference #:  Q9UGL1 (UniProtKB)
Alt. Names/Synonyms: Cancer/testis antigen 31; CT31; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; Histone demethylase JARID1B; JARID1B; jumonji, AT rich interactive domain 1B; Jumonji/ARID domain-containing protein 1B; KDM5B; lysine (K)-specific demethylase 5B; Lysine-specific demethylase 5B; PLU-1; PLU1; PUT1; putative DNA/chromatin binding motif; RBBP2H1; RBBP2H1A; RBP2-H1; RBP2-like; Retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A
Gene Symbols: KDM5B
Molecular weight: 175,658 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JARID1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K100 LEAQTRVKLNFLDQI
0 1 K109-ub NFLDQIAkyWELQGS
0 1 Y110-p FLDQIAkyWELQGST
0 1 T157-p RKWTKIAtKMGFAPG
0 1 K196-ac DSLRCLQkPNLTTDT
1 0 K242-sm RAEAMNIkIEPEETT
0 1 T264-p RRRMGCPtPKCENEK
1 0 K278-sm KEMKSSIkQEPIERK
0 2 S415-p KEFWRLVsTIEEDVT
0 1 S457-p EEEEYLDsGWNLNNM
0 1 T476-p QSVLAHItADICGMK
0 1 Y730-p CSCPPYKyKLRyRyT
0 1 Y734-p PYKyKLRyRyTLDDL
0 2 Y736-p KyKLRyRyTLDDLyP
0 2 Y742-p RyTLDDLyPMMNALK
0 1 K774 EAKINKKKSLVSFKA
0 1 S812-p QDAEKCAsVAQQLLN
0 1 K832-ac RYRSGGGkSQNQLTV
0 4 K832-ub RYRSGGGkSQNQLTV
0 2 K956-ub APYSAVEkAMARLQE
0 4 S986-p LKARPRHsLNSLATA
0 1 N988 ARPRHsLNSLATAVK
0 1 K1011-ub LPNGAALkDSVQRAR
0 1 K1107-ac GLKRKQRkLKEPLPN
0 18 S1135-p LERALTEskETASAM
0 2 K1136-ub ERALTEskETASAMA
0 19 T1144-p ETASAMAtLGEARLR
0 1 K1166-ub LRLANEGkLLSPLQD
0 4 K1276-ub LLSSGNLkFVQDRVG
0 3 S1328-p NRTSYLHsPFSTGRS
0 1 S1384-p AQQTDRSsPVRPSSE
0 6 S1405-p GKRDGINsLERKLKR
0 4 S1456-p FKLERERsYELVRSA
  mouse

 
K100-ub LEAQTRVkLNFLDQI
K109 NFLDQIAKYWELQGS
Y110 FLDQIAKYWELQGST
T157 RKWTKIATKMGFAPG
K196 DSLRCLQKPNLTSDT
K242 RAEAMNIKIEPEEAT
T264 RRRMGCTTPKWENEK
K278 KEMKSTIKQEPTEKK
S415 KEFWRLVSTIEEDVT
S457 EEEEYLDSGWNLNNM
T476 QSVLAHITADICGMK
Y730 CSCPPYKYNLRYRYT
Y734 PYKYNLRYRYTLDDL
Y736 KYNLRYRYTLDDLYP
Y742 RYTLDDLYPMMNALK
K774-ac EAKINKKkSLVSFKA
S812 QDAEKCASVAQQLLN
K832 RYRSGGGKSQNQLTV
K832-ub RYRSGGGkSQNQLTV
K956 APYSAVEKAMARLQE
S986 LRARPRHSLsSLATA
S988-p ARPRHSLsSLATAVK
K1011 LPNGTVLKDSVQRAR
K1107 GLKRKQRKLKEPLPS
S1135 LERALMESkETAAAM
K1136-ub ERALMESkETAAAMA
T1144 ETAAAMATLGEARLR
K1166 LRFANEEKLLSPVQD
K1276-ub LLSSGNLkLVQDQVG
S1328 NRTSYLHSPFSTGQS
S1384 VQQADRSSPVRSSSE
S1405-p GKRDAINsPERKLKR
S1456 FKLERERSYDLVRNA
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