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JARID1B (human)

Overview JARID1B Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cancer Testis Antigen (CTA); Oxidoreductase; EC 1.14.11.-; Transcription, coactivator/corepressor; Demethylase Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; DNA binding; zinc ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; transcription corepressor activity; transcription factor activity Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent Reference #:  Q9UGL1 (UniProtKB) Alt. Names/Synonyms: Cancer/testis antigen 31; CT31; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; Histone demethylase JARID1B; JARID1B; jumonji, AT rich interactive domain 1B; Jumonji/ARID domain-containing protein 1B; KDM5B; lysine (K)-specific demethylase 5B; Lysine-specific demethylase 5B; PLU-1; PLU1; PUT1; putative DNA/chromatin binding motif; RBBP2H1; RBBP2H1A; RBP2-H1; RBP2-like; Retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A Gene Symbols: KDM5B Molecular weight: 175,658 Da Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below JARID1B 2EQY - A=94-208 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K109-u	NFLDQIAkyWELQGS
0	1		K100	LEAQTRVKLNFLDQI
0	1		Y110-p	FLDQIAkyWELQGST
0	1		T157-p	RKWTKIAtKMGFAPG
0	1		K196-a	DSLRCLQkPNLTTDT
0	1		T264-p	RRRMGCPtPKCENEK
0	2		S415-p	KEFWRLVsTIEEDVT
0	1		S457-p	EEEEYLDsGWNLNNM
0	1		T476-p	QSVLAHItADICGMK
0	1		Y730-p	CSCPPYKyKLRyRyT
0	1		Y734-p	PYKyKLRyRyTLDDL
0	2		Y736-p	KyKLRyRyTLDDLyP
0	2		Y742-p	RyTLDDLyPMMNALK
0	1		K774-a	EAKINKKkSLVSFKA
0	1		S812-p	QDAEKCAsVAQQLLN
0	4		K832-u	RYRSGGGkSQNQLTV
0	2		K956-u	APYSAVEkAMARLQE
0	2		S986-p	LKARPRHsLNSLATA
0	1		N988	ARPRHsLNSLATAVK
0	1		K1011-u	LPNGAALkDSVQRAR
0	1		K1107-a	GLKRKQRkLKEPLPN
0	18		S1135-p	LERALTEskETASAM
0	2		K1136-u	ERALTEskETASAMA
0	19		T1144-p	ETASAMAtLGEARLR
0	1		K1166-u	LRLANEGkLLSPLQD
0	4		K1276-u	LLSSGNLkFVQDRVG
0	2		S1328-p	NRTSYLHsPFSTGRS
0	1		S1384-p	AQQTDRSsPVRPSSE
0	4		S1405-p	GKRDGINsLERKLKR

	mouse
K109	NFLDQIAKYWELQGS
K100-u	LEAQTRVkLNFLDQI
Y110	FLDQIAKYWELQGST
T157	RKWTKIATKMGFAPG
K196	DSLRCLQKPNLTSDT
T264	RRRMGCTTPKWENEK
S415	KEFWRLVSTIEEDVT
S457	EEEEYLDSGWNLNNM
T476	QSVLAHITADICGMK
Y730	CSCPPYKYNLRYRYT
Y734	PYKYNLRYRYTLDDL
Y736	KYNLRYRYTLDDLYP
Y742	RYTLDDLYPMMNALK
K774-a	EAKINKKkSLVSFKA
S812	QDAEKCASVAQQLLN
K832-u	RYRSGGGkSQNQLTV
K956	APYSAVEKAMARLQE
S986	LRARPRHSLsSLATA
S988-p	ARPRHSLsSLATAVK
K1011	LPNGTVLKDSVQRAR
K1107	GLKRKQRKLKEPLPS
S1135	LERALMESkETAAAM
K1136-u	ERALMESkETAAAMA
T1144	ETAAAMATLGEARLR
K1166	LRFANEEKLLSPVQD
K1276-u	LLSSGNLkLVQDQVG
S1328	NRTSYLHSPFSTGQS
S1384	VQQADRSSPVRSSSE
S1405-p	GKRDAINsPERKLKR

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