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Protein Page:
Smad5 (human)

Overview
Smad5 transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; protein complex; integral to membrane; intracellular; cytosol; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding; metal ion binding; receptor signaling protein activity; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: Mullerian duct regression; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; embryonic pattern specification; signal transduction; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; positive regulation of osteoblast differentiation; ureteric bud development; transforming growth factor beta receptor signaling pathway; cartilage development; erythrocyte differentiation; cardiac muscle contraction; osteoblast fate commitment
Reference #:  Q99717 (UniProtKB)
Alt. Names/Synonyms: DKFZp781C1895; DKFZp781O1323; Dwfc; hSmad5; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; MADH5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against DPP homolog 5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; SMAD5
Gene Symbols: SMAD5
Molecular weight: 52,258 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Smad5

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S58-p ELEKALSsPGQPsKC
0 4 S63-p LSsPGQPsKCVTIPR
0 4 S133-p YHYKRVEsPVLPPVL
0 7 S462-p GSPLNPIssVs____
4 46 S463-p SPLNPIssVs_____
4 49 S465-p LNPIssVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
  mouse

 
S58 ELEKALSSPGQPSKC
S63 LSSPGQPSKCVTIPR
S133-p YHYKRVEsPVLPPVL
S462-p GSPLNPIssVs____
S463-p SPLNPIssVs_____
S465-p LNPIssVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
  rat

 
S58 ELEKALSSPGQPSKC
S63 LSSPGQPSKCVTIPR
S133 YHYKRVESPVLPPVL
S462 GSPLNPISSVS____
S463 SPLNPISSVS_____
S465 LNPISSVS_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
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