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Protein Page:
PLCB4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCB4 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Defects in PLCB4 are the cause of auriculocondylar syndrome type 2 (ARCND2). ARCND2 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate
Cellular Component: smooth endoplasmic reticulum; postsynaptic density; dendrite; cytosol; nucleus
Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: inositol phosphate metabolic process; lipid catabolic process
Reference #:  Q15147 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4; dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)); FLJ16169; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-4; phospholipase C, beta 4; Phospholipase C-beta-4; PI-PLC; PLC-beta-4; PLCB4; triphosphoinositide phosphodiesterase
Gene Symbols: PLCB4
Molecular weight: 134,464 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below

PLCB4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K3 _____MAKPYEFNWQ
0 1 S63-p EGQVLECsLINsIRS
0 1 S67-p LECsLINsIRSGAIP
0 1 K266 LFPFYDAKRAMQIIE
0 1 K284 PDEDLKKKGLISSDG
0 1 K461 LKRKILIKNKRLKPE
0 1 R621 YNKRQMSRIYPKGGR
0 1 Y721-p SDKKIGTyVEVDMYG
0 1 K761 EESFVFRKVILPDLA
0 1 S800 QAGYRHISLRNEGNK
0 3 S843-p SDPKKFLsITEKRAD
0 1 S867-p SDIADVPsDTSKNDK
0 12 T886-p NTAKANVtPQSsSEL
0 4 S889 KANVtPQSsSELRPT
0 3 S890-p ANVtPQSsSELRPTT
0 3 S891 NVtPQSsSELRPTTT
0 1 S903 TTTAALASGVEAKKG
0 1 K923-ub QVRIEDLkQMkAYLK
0 1 K926-ub IEDLkQMkAYLKHLK
0 1 K934-ac AYLKHLKkQQkELNS
0 1 K937-ac KHLKkQQkELNSLkk
0 2 K943-ac QkELNSLkkkHAKEH
0 1 K944-ac kELNSLkkkHAKEHS
0 1 K945-ac ELNSLkkkHAKEHST
0 1 K986-ac LEKAMKKkGGSNCLE
0 1 K995-ac GSNCLEMkkEtEIKI
0 2 K996-ac SNCLEMkkEtEIKIQ
0 1 T998-p CLEMkkEtEIKIQtL
0 1 T1004-p EtEIKIQtLTSDHKS
0 1 T1021-p KEIVAQHtkEWSEMI
0 2 K1022-ub EIVAQHtkEWSEMIN
0 1 K1138 KEMDQLKKVQLEHLE
  PLCB4 iso4  
K3 _____MAKPYEFNWQ
S63 EGQVLECSLINSIRS
S67 LECSLINSIRSGAIP
K266 LFPFYDAKRAMQIIE
K284 PDEDLKKKGLISSDG
K461 LKRKILIKNKRLKPE
R621 YNKRQMSRIYPKGGR
Y721 SDKKIGTYVEVDMYG
K761 EESFVFRKVILPDLA
S800 QAGYRHISLRNEGNK
S843 SDPKKFLSITEKRAD
S867 SDIADVPSDTSKNDK
T886 NTAKANVTPQSSSEL
S889 KANVTPQSSSELRPT
S890 ANVTPQSSSELRPTT
S891 NVTPQSSSELRPTTT
S903 TTTAALASGVEAKKG
K923 QVRIEDLKQMKAYLK
K926 IEDLKQMKAYLKHLK
K934 AYLKHLKKQQKELNS
K937 KHLKKQQKELNSLKK
K943 QKELNSLKKKHAKEH
K944 KELNSLKKKHAKEHS
K945 ELNSLKKKHAKEHST
K986 LEKAMKKKGGSNCLE
K995 GSNCLEMKKETEIKI
K996 SNCLEMKKETEIKIQ
T998 CLEMKKETEIKIQTL
T1004 ETEIKIQTLTSDHKS
T1021 KEIVAQHTKEWSEMI
K1022 EIVAQHTKEWSEMIN
K1138 KEMDQLKKVQLEHLE
  PLCB4 iso5  
K3 _____MAKPYEFNWQ
S63 EGQVLECSLINSIRS
S67 LECSLINSIRSGAIP
K266 LFPFYDAKRAMQIIE
K284 PDEDLKKKGLISSDG
K461 LKRKILIKNKRLKPE
R633 YNKRQMSRIYPKGGR
Y733 SDKKIGTYVEVDMYG
K773 EESFVFRKVILPDLA
S812 QAGYRHISLRNEGNK
S855 SDPKKFLSITEKRAD
S879 SDIADVPSDTSKNDK
T898 NTAKANVTPQSSSEL
S901 KANVTPQSSSELRPT
S902 ANVTPQSSSELRPTT
S903 NVTPQSSSELRPTTT
S915 TTTAALASGVEAKKG
K935 QVRIEDLKQMKAYLK
K938 IEDLKQMKAYLKHLK
K946 AYLKHLKKQQKELNS
K949 KHLKKQQKELNSLKK
K955 QKELNSLKKKHAKEH
K956 KELNSLKKKHAKEHS
K957 ELNSLKKKHAKEHST
K998 LEKAMKKKGGSNCLE
K1007 GSNCLEMKKETEIKI
K1008 SNCLEMKKETEIKIQ
T1010 CLEMKKETEIKIQTL
T1016 ETEIKIQTLTSDHKS
T1033 KEIVAQHTKEWSEMI
K1034 EIVAQHTKEWSEMIN
K1150 KEMDQLKKVQLEHLE
  mouse

 
K3-ub _____MAkPYEFNWQ
S63 EGQVLECSLINSIRQ
S67 LECSLINSIRQAAIP
K266-ub LFPFYDAkRAMQIIE
K284-ub PDEELKKkGLISSDG
K461 LKRKILIKNKRLKPE
R621-m1 YNKRQMSrIYPKGGR
Y721 SDKKIGTYVEVDMYG
K761-ub EESFVFRkVILPDLA
S800-p QAGYRHIsLRNEGNK
S843-p SDPKKFLsITEKRAD
S867 SDIADVPSDTSKNDK
T886-p NPAKANVtPQsssEL
S889-p KANVtPQsssELRPT
S890-p ANVtPQsssELRPTT
S891-p NVtPQsssELRPTTT
S903-p TTTAALGsGQEAKKG
K923 QVRIEDLKQMKAYLK
K926 IEDLKQMKAYLKHLK
K934 AYLKHLKKQQKELNS
K937 KHLKKQQKELNSLKK
K943 QKELNSLKKKHAKEH
K944 KELNSLKKKHAKEHS
K945 ELNSLKKKHAKEHST
K986 LEKAMKKKGGSNCLE
K995 GSNCLEIKKETEIKI
K996 SNCLEIKKETEIKIQ
T998 CLEIKKETEIKIQTL
T1004 ETEIKIQTLTTDHKS
T1021 KEIVAQHTkEWSEMI
K1022-ub EIVAQHTkEWSEMIN
K1138-m1 KEMDQLKkVQLEHLE
  rat

 
K3 _____MAKPYEFNWQ
S63 EGQVLECSLINSIRL
S67 LECSLINSIRLAAIP
K266 LFPFYDAKRAMQIIE
K284 PDEELKKKGLISSDG
K461-ub LKRKILIkNKRLKPE
R621 YNKRQMSRIYPKGGR
Y721 SDKKIGTYVEVDMYG
K761 EESFVFRKVILPDLA
S800 QAGYRHISLRNEGNK
S843 SDPKKFLSITEKRAD
S867 SDIADVPSDTSKNDK
T886 NPAKANVTPQSSSEL
S889 KANVTPQSSSELRPT
S890 ANVTPQSSSELRPTT
S891 NVTPQSSSELRPTTT
S903 TTTAALGSGQEAKKG
K923 QVRIEDLKQMKAYLK
K926 IEDLKQMKAYLKHLK
K934 AYLKHLKKQQKELNS
K937 KHLKKQQKELNSLKK
K943 QKELNSLKKKHAKEH
K944 KELNSLKKKHAKEHS
K945 ELNSLKKKHAKEHST
K986 LEKAMKKKGGSNCLE
K995 GSNCLEIKKETEIKI
K996 SNCLEIKKETEIKIQ
T998 CLEIKKETEIKIQTL
T1004 ETEIKIQTLTSDHKS
T1021 KEIVAQHTKEWSEMI
K1022 EIVAQHTKEWSEMIN
K1138 KEMDQLKKVQLEHLE
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