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Protein Page:
PLCB4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLCB4 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Defects in PLCB4 are the cause of auriculocondylar syndrome type 2 (ARCND2). ARCND2 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase
Cellular Component: smooth endoplasmic reticulum; postsynaptic density; nucleus; cytosol
Molecular Function: signal transducer activity; mitogen-activated protein kinase binding; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: negative regulation of potassium ion transport; lipid catabolic process
Reference #:  Q15147 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4; dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)); FLJ16169; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-4; phospholipase C, beta 4; Phospholipase C-beta-4; PI-PLC; PLC-beta-4; PLCB4; triphosphoinositide phosphodiesterase
Gene Symbols: PLCB4
Molecular weight: 134,464 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Regulation of Actin Dynamics
Select Structure to View Below

PLCB4
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 K3 _____MAKPYEFNWQ
0 1 K266 LFPFYDAKRAMQIIE
0 1 K284 PDEDLKKKGLISSDG
0 1 K461 LKRKILIKNKRLKPE
0 1 R621 YNKRQMSRIYPKGGR
0 1 Y721-p SDKKIGTyVEVDMYG
0 1 K761 EESFVFRKVILPDLA
0 3 S843-p SDPKKFLsITEKRAD
0 1 S867-p SDIADVPsDTSKNDK
0 8 T886-p NTAKANVtPQSsSEL
0 3 S889 KANVtPQSsSELRPT
0 3 S890-p ANVtPQSsSELRPTT
0 2 S891 NVtPQSsSELRPTTT
0 1 S903 TTTAALASGVEAKKG
0 1 K923-u QVRIEDLkQMkAYLK
0 1 K926-u IEDLkQMkAYLKHLK
0 1 K934-a AYLKHLKkQQkELNS
0 1 K937-a KHLKkQQkELNSLkk
0 2 K943-a QkELNSLkkkHAKEH
0 1 K944-a kELNSLkkkHAKEHS
0 1 K945-a ELNSLkkkHAKEHST
0 1 K986-a LEKAMKKkGGSNCLE
0 1 K995-a GSNCLEMkkEtEIKI
0 2 K996-a SNCLEMkkEtEIKIQ
0 1 T998-p CLEMkkEtEIKIQtL
0 1 T1004-p EtEIKIQtLTSDHKS
0 1 T1021-p KEIVAQHtkEWSEMI
0 2 K1022-u EIVAQHtkEWSEMIN
0 1 K1138 KEMDQLKKVQLEHLE
  PLCB4 iso4  
K3 _____MAKPYEFNWQ
K266 LFPFYDAKRAMQIIE
K284 PDEDLKKKGLISSDG
K461 LKRKILIKNKRLKPE
R621 YNKRQMSRIYPKGGR
Y721 SDKKIGTYVEVDMYG
K761 EESFVFRKVILPDLA
S843 SDPKKFLSITEKRAD
S867 SDIADVPSDTSKNDK
T886 NTAKANVTPQSSSEL
S889 KANVTPQSSSELRPT
S890 ANVTPQSSSELRPTT
S891 NVTPQSSSELRPTTT
S903 TTTAALASGVEAKKG
K923 QVRIEDLKQMKAYLK
K926 IEDLKQMKAYLKHLK
K934 AYLKHLKKQQKELNS
K937 KHLKKQQKELNSLKK
K943 QKELNSLKKKHAKEH
K944 KELNSLKKKHAKEHS
K945 ELNSLKKKHAKEHST
K986 LEKAMKKKGGSNCLE
K995 GSNCLEMKKETEIKI
K996 SNCLEMKKETEIKIQ
T998 CLEMKKETEIKIQTL
T1004 ETEIKIQTLTSDHKS
T1021 KEIVAQHTKEWSEMI
K1022 EIVAQHTKEWSEMIN
K1138 KEMDQLKKVQLEHLE
  PLCB4 iso5  
- under review  
K102 LFPFYDAKRAMQIIE
K120 PDEDLKKKGLISSDG
K297 LKRKILIKNKRLKPE
R469 YNKRQMSRIYPKGGR
Y569 SDKKIGTYVEVDMYG
K609 EESFVFRKVILPDLA
S691 SDPKKFLSITEKRAD
S715 SDIADVPSDTSKNDK
T734 NTAKANVTPQSSSEL
S737 KANVTPQSSSELRPT
S738 ANVTPQSSSELRPTT
S739 NVTPQSSSELRPTTT
S751 TTTAALASGVEAKKG
K771 QVRIEDLKQMKAYLK
K774 IEDLKQMKAYLKHLK
K782 AYLKHLKKQQKELNS
K785 KHLKKQQKELNSLKK
K791 QKELNSLKKKHAKEH
K792 KELNSLKKKHAKEHS
K793 ELNSLKKKHAKEHST
K834 LEKAMKKKGGSNCLE
K843 GSNCLEMKKETEIKI
K844 SNCLEMKKETEIKIQ
T846 CLEMKKETEIKIQTL
T852 ETEIKIQTLTSDHKS
T869 KEIVAQHTKEWSEMI
K870 EIVAQHTKEWSEMIN
K986 KEMDQLKKVQLEHLE
  mouse

 
K3-u _____MAkPYEFNWQ
K266-u LFPFYDAkRAMQIIE
K284-u PDEELKKkGLISSDG
K461 LKRKILIKNKRLKPE
R621-m1 YNKRQMSrIYPKGGR
Y721 SDKKIGTYVEVDMYG
K761-u EESFVFRkVILPDLA
S843-p SDPKKFLsITEKRAD
S867 SDIADVPSDTSKNDK
T886-p NPAKANVtPQsssEL
S889-p KANVtPQsssELRPT
S890-p ANVtPQsssELRPTT
S891-p NVtPQsssELRPTTT
S903-p TTTAALGsGQEAKKG
K923 QVRIEDLKQMKAYLK
K926 IEDLKQMKAYLKHLK
K934 AYLKHLKKQQKELNS
K937 KHLKKQQKELNSLKK
K943 QKELNSLKKKHAKEH
K944 KELNSLKKKHAKEHS
K945 ELNSLKKKHAKEHST
K986 LEKAMKKKGGSNCLE
K995 GSNCLEIKKETEIKI
K996 SNCLEIKKETEIKIQ
T998 CLEIKKETEIKIQTL
T1004 ETEIKIQTLTTDHKS
T1021 KEIVAQHTkEWSEMI
K1022-u EIVAQHTkEWSEMIN
K1138-m1 KEMDQLKkVQLEHLE
  rat

 
K3 _____MAKPYEFNWQ
K266 LFPFYDAKRAMQIIE
K284 PDEELKKKGLISSDG
K461-u LKRKILIkNKRLKPE
R621 YNKRQMSRIYPKGGR
Y721 SDKKIGTYVEVDMYG
K761 EESFVFRKVILPDLA
S843 SDPKKFLSITEKRAD
S867 SDIADVPSDTSKNDK
T886 NPAKANVTPQSSSEL
S889 KANVTPQSSSELRPT
S890 ANVTPQSSSELRPTT
S891 NVTPQSSSELRPTTT
S903 TTTAALGSGQEAKKG
K923 QVRIEDLKQMKAYLK
K926 IEDLKQMKAYLKHLK
K934 AYLKHLKKQQKELNS
K937 KHLKKQQKELNSLKK
K943 QKELNSLKKKHAKEH
K944 KELNSLKKKHAKEHS
K945 ELNSLKKKHAKEHST
K986 LEKAMKKKGGSNCLE
K995 GSNCLEIKKETEIKI
K996 SNCLEIKKETEIKIQ
T998 CLEIKKETEIKIQTL
T1004 ETEIKIQTLTSDHKS
T1021 KEIVAQHTKEWSEMI
K1022 EIVAQHTKEWSEMIN
K1138 KEMDQLKKVQLEHLE
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