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Protein Page:
Smad1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Smad1 transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; protein complex; mitochondrion; cytoplasm; integral to membrane; nucleolus; nuclear inner membrane; intracellular; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; metal ion binding; receptor signaling protein activity; transcription factor activity; protein kinase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: wound healing; cardiac muscle cell proliferation; primary microRNA processing; embryonic pattern specification; signal transduction; protein amino acid phosphorylation; mesodermal cell fate commitment; BMP signaling pathway; negative regulation of cell proliferation; homeostatic process; ureteric bud development; transforming growth factor beta receptor signaling pathway; midbrain development; inflammatory response; kidney development; hindbrain development; response to drug; transcription, DNA-dependent; MAPKKK cascade; positive regulation of dendrite morphogenesis; response to organic nitrogen; SMAD protein complex assembly; positive regulation of osteoblast differentiation; cartilage development; gamete generation; positive regulation of transcription from RNA polymerase II promoter; osteoblast fate commitment
Reference #:  Q15797 (UniProtKB)
Alt. Names/Synonyms: BSP-1; BSP1; hSMAD1; JV4-1; JV41; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; SMAD 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; SMAD1; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1
Gene Symbols: SMAD1
Molecular weight: 52,260 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Smad1

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S206‑p, S462‑p, S463‑p, S465‑p
activity, induced: S462‑p, S463‑p, S465‑p
intracellular localization: S187‑p, S195‑p, S206‑p, S214‑p, S462‑p, S463‑p, S465‑p
molecular association, regulation: S206‑p, S214‑p, S462‑p, S463‑p, S465‑p
protein degradation: S206‑p
ubiquitination: S206‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K116-ub CEFPFGSkQkEVCIN
1 0 K118-ub FPFGSkQkEVCINPY
0 5 S132-p YHYKRVEsPVLPPVL
0 1 Y146-p LVPRHSEyNPQHSLL
3 0 S187-p NSHPFPHsPNSSYPN
3 0 S195-p PNSSYPNsPGSSSSt
1 0 T202-p sPGSSSStYPHsPTS
3 0 S206-p SSStYPHsPTSSDPG
3 0 S214-p PTSSDPGsPFQMPAD
1 0 S239-p DPMTQDGsQPMDTNM
1 0 K269-ub AVAYEEPkHWCSIVY
0 1 T300 SVLVDGFTDPSNNKN
0 1 S303 VDGFTDPSNNKNRFC
1 0 T322-p SNVNRNStIENTRRH
2 7 S462-p GSPHNPIssVs____
8 64 S463-p SPHNPIssVs_____
8 67 S465-p HNPIssVs_______
5753 : Phospho-Smad1 (Ser206) (D40B7) Rabbit mAb
9553 : Phospho-Smad1 (Ser206) Antibody
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
  mouse

 
K116 CEFPFGSKQKEVCIN
K118 FPFGSKQKEVCINPY
S132-p YHYKRVEsPVLPPVL
Y146 LVPRHSEYNPQHSLL
S187 NSHPFPHSPNSSYPN
S195 PNSSYPNSPGGSSST
T202 SPGGSSSTYPHSPTS
S206 SSSTYPHSPTSSDPG
S214 PTSSDPGSPFQMPAD
S239 DPMAQDGSQPMDTNM
K269 AVAYEEPKHWCSIVY
T300 SVLVDGFTDPSNNKN
S303 VDGFTDPSNNKNRFC
T322 SNVNRNSTIENTRRH
S462-p GSPHNPIssVs____
S463-p SPHNPIssVs_____
S465-p HNPIssVs_______
5753 : Phospho-Smad1 (Ser206) (D40B7) Rabbit mAb
9553 : Phospho-Smad1 (Ser206) Antibody
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
  rat

 
K116 CEFPFGSKQKEVCIN
K118 FPFGSKQKEVCINPY
S132 YHYKRVESPVLPPVL
Y146 LVPRHSEYNPQHSLL
S187 HSHPFPQSPNSSYPN
S195 PNSSYPNSPGSSSST
T202 SPGSSSSTYPHSPTS
S206 SSSTYPHSPTSSDPG
S214 PTSSDPGSPFQMPAD
S239 DPMAQDGSQPMDTNM
K272 AVAYEEPKHWCSIVY
T303-p SVLVDGFtDPsNNKN
S306-p VDGFtDPsNNKNRFC
T325 SNVNRNSTIENTRRH
S465 GSPHNPISsVs____
S466-p SPHNPISsVs_____
S468-p HNPISsVs_______
5753 : Phospho-Smad1 (Ser206) (D40B7) Rabbit mAb
9553 : Phospho-Smad1 (Ser206) Antibody
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
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