transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm; transcription factor complex; protein complex; cytoplasm; integral to membrane; nuclear inner membrane; intracellular; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; metal ion binding; receptor signaling protein activity; transcription factor activity; protein kinase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: transcription from RNA polymerase II promoter; MAPKKK cascade; cardiac muscle cell proliferation; primary microRNA processing; signal transduction; embryonic pattern specification; SMAD protein complex assembly; mesodermal cell fate commitment; BMP signaling pathway; negative regulation of cell proliferation; positive regulation of osteoblast differentiation; homeostatic process; ureteric bud development; gamete generation; transforming growth factor beta receptor signaling pathway; cartilage development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; hindbrain development; osteoblast fate commitment
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.