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Smad1 (human)

Overview Smad1 transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; integral to membrane; nuclear inner membrane; intracellular; nucleus; cytosol Molecular Function: identical protein binding; protein binding; receptor signaling protein activity; protein kinase binding; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Biological Process: wound healing; primary microRNA processing; signal transduction; embryonic pattern specification; protein amino acid phosphorylation; mesodermal cell fate commitment; BMP signaling pathway; negative regulation of cell proliferation; homeostatic process; ureteric bud development; transforming growth factor beta receptor signaling pathway; midbrain development; inflammatory response; kidney development; hindbrain development; response to drug; transcription, DNA-dependent; MAPKKK cascade; positive regulation of dendrite morphogenesis; response to organic nitrogen; SMAD protein complex assembly; positive regulation of osteoblast differentiation; gamete generation; positive regulation of transcription from RNA polymerase II promoter; osteoblast fate commitment Reference #:  Q15797 (UniProtKB) Alt. Names/Synonyms: BSP-1; BSP1; hSMAD1; JV4-1; JV41; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; SMAD 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; SMAD1; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1 Gene Symbols: SMAD1 Molecular weight: 52,260 Da Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Smad1 1KHU - A/B/C/D=248-465 (human) 2LAW - B=222-233 (human) 2LAX - B=201-209 (human) 2LAY - B=201-209 (human) 2LAZ - B=210-217 (human) 2LB0 - B=208-217 (human) 2LB1 - B=221-233 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S206‑p, S462‑p, S463‑p, S465‑p activation: S462‑p, S463‑p, S465‑p intracellular localization: S187‑p, S195‑p, S206‑p, S214‑p, S462‑p, S463‑p, S465‑p molecular association, regulation: S206‑p, S214‑p, S462‑p, S463‑p, S465‑p protein degradation: S206‑p ubiquitination: S206‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K116-u	CEFPFGSkQkEVCIN
1	0		K118-u	FPFGSkQkEVCINPY
0	1		S132-p	YHYKRVEsPVLPPVL
0	1		Y146-p	LVPRHSEyNPQHSLL
3	0		S187-p	NSHPFPHsPNSSYPN
3	0		S195-p	PNSSYPNsPGSSSSt
1	0		T202-p	sPGSSSStYPHsPTS
3	0		S206-p	SSStYPHsPTSSDPG
3	0		S214-p	PTSSDPGsPFQMPAD
1	0		S239-p	DPMTQDGsQPMDTNM
1	0		K269-u	AVAYEEPkHWCSIVY
0	1		T300	SVLVDGFTDPSNNKN
0	1		S303	VDGFTDPSNNKNRFC
1	0		T322-p	SNVNRNStIENTRRH
2	6		S462-p	GSPHNPIssVs____
8	63		S463-p	SPHNPIssVs_____
8	64		S465-p	HNPIssVs_______

	mouse
K116	CEFPFGSKQKEVCIN
K118	FPFGSKQKEVCINPY
S132-p	YHYKRVEsPVLPPVL
Y146	LVPRHSEYNPQHSLL
S187	NSHPFPHSPNSSYPN
S195	PNSSYPNSPGGSSST
T202	SPGGSSSTYPHSPTS
S206	SSSTYPHSPTSSDPG
S214	PTSSDPGSPFQMPAD
S239	DPMAQDGSQPMDTNM
K269	AVAYEEPKHWCSIVY
T300	SVLVDGFTDPSNNKN
S303	VDGFTDPSNNKNRFC
T322	SNVNRNSTIENTRRH
S462	GSPHNPISsVs____
S463-p	SPHNPISsVs_____
S465-p	HNPISsVs_______

	rat
K116	CEFPFGSKQKEVCIN
K118	FPFGSKQKEVCINPY
S132	YHYKRVESPVLPPVL
Y146	LVPRHSEYNPQHSLL
S187	HSHPFPQSPNSSYPN
S195	PNSSYPNSPGSSSST
T202	SPGSSSSTYPHSPTS
S206	SSSTYPHSPTSSDPG
S214	PTSSDPGSPFQMPAD
S239	DPMAQDGSQPMDTNM
K272	AVAYEEPKHWCSIVY
T303-p	SVLVDGFtDPsNNKN
S306-p	VDGFtDPsNNKNRFC
T325	SNVNRNSTIENTRRH
S465	GSPHNPISsVs____
S466-p	SPHNPISsVs_____
S468-p	HNPISsVs_______

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