Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
IFT140 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IFT140 Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance. Defects in IFT140 are the cause of Mainzer-Saldino syndrome (MZSDS). MZSDS is a rare autosomal recessive disease characterized by phalangeal cone- shaped epiphyses, chronic renal disease, nearly constant retinal dystrophy, and mild radiographic abnormality of the proximal femur. Occasional features include short stature, cerebellar ataxia, and hepatic fibrosis. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: centrosome; axoneme; photoreceptor connecting cilium
Biological Process: retina development in camera-type eye; skeletal morphogenesis; cilium biogenesis
Reference #:  Q96RY7 (UniProtKB)
Alt. Names/Synonyms: c305C8.4; c380F5.1; DKFZp564L232; FLJ10306; FLJ30571; gs114; IF140; IFT140; intraflagellar transport 140 homolog (Chlamydomonas); Intraflagellar transport protein 140 homolog; KIAA0590; WD and tetratricopeptide repeats 2; WD and tetratricopeptide repeats protein 2; WDTC2
Gene Symbols: IFT140
Molecular weight: 165,193 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Select Structure to View Below

IFT140

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K171-ub EDLVQLAkAAVSGDE
0 1 S190 MFNWKKSSSGSLLKM
0 1 M197 SSGSLLKMGsHEGLL
0 2 S199-p GSLLKMGsHEGLLFF
0 1 L204 MGsHEGLLFFVsLMD
0 1 S208-p EGLLFFVsLMDGtVH
0 1 T213-p FVsLMDGtVHyVDEK
0 2 Y216-p LMDGtVHyVDEKGKT
0 1 K318-ub YILSPDEkFGFEKGE
0 4 S360-p KVPDFLGsPGAEGkD
0 1 K366-ub GsPGAEGkDRWALQT
0 1 S388-p ITQIQWGsRKNLLAV
0 1 S405-p VISVAILsERAMSSH
0 1 Y602-p PDSKICFyDVEMDTV
0 1 K644-ub LFVDEGLkNYVPVNH
0 1 K799-ub FKSIKLIkSEAVWEN
0 1 K877-ub KRHDLLNkFYQAAGR
0 1 S944 MLSEDLPSLELYVNk
0 1 K951-ac SLELYVNkMKDKTLW
0 1 K951-ub SLELYVNkMKDKTLW
0 1 Y1014-p TGNLAASyHLARQYE
0 1 K1077-ub AARYYEEkGVQMDRA
0 1 K1178-ub AEKMTVAkDSSDLPE
0 1 S1239-p EKITFFAsVSRQKEI
0 1 S1334-p TRLAQLQsRMALVKR
0 8 S1443-p PEQVRHNsMEDAREL
  mouse

 
K171 EDLVQLAKAAVSGDE
S190-p MFNWRKSsFGSFLKt
T197-p sFGSFLKtGsQEGLs
S199-p GSFLKtGsQEGLsFF
S204-p tGsQEGLsFFVSLMD
S208 EGLsFFVSLMDGTVH
T213 FVSLMDGTVHYVDEK
Y216 LMDGTVHYVDEKGKT
K318 YILSLQEKFGFEKGE
G360 KVPSFPNGRGAEGKD
K366 NGRGAEGKDMWALQT
S388 ITQIKWGSRKNLLAV
S405 TESVSILSEQAMSSH
Y602 PDSKIYIYDVEMDTV
A644 SFMDKSLAGYTPVNH
K800 FKSIKLIKSEAVWEN
K878 KRYDLLNKFYQASDQ
S945-p MLSEDLQsLELYINR
R952 sLELYINRMKDKTLW
R952 sLELYINRMKDKTLW
Y1015 TGDWAASYHLARQYE
K1078 AARYYEEKGEQMDRA
K1179 AEKMTVSKDSKDMSE
G1240 EKIVFFAGVSRQKEI
S1335 TKLAQLQSKMTLVKR
S1445-p PERVRHNsMEDHKEV
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.