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LLGL1 (human)

Overview LLGL1 Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Belongs to the WD repeat L(2)GL family. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: Golgi membrane; cortical actin cytoskeleton; cytoskeleton; axon; early endosome membrane; cytoplasm; Golgi cis cisterna; trans-Golgi network membrane Molecular Function: protein binding; Rab GTPase activator activity; structural molecule activity; protein kinase binding Biological Process: Golgi to plasma membrane transport; exocytosis; axonogenesis; protein complex assembly; positive regulation of Rab GTPase activity; cortical actin cytoskeleton organization and biogenesis; maintenance of apical/basal cell polarity Reference #:  Q15334 (UniProtKB) Alt. Names/Synonyms: DLG4; HUGL; Hugl-1; HUGL1; Human homolog to the D-lgl gene protein; L2GL1; lethal giant larvae homolog 1 (Drosophila); Lethal(2) giant larvae protein homolog 1; LLGL; LLGL1 Gene Symbols: LLGL1 Molecular weight: 115,418 Da Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LLGL1

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	Sites Implicated In
intracellular localization: S663‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K19-u	DPQREKLkQELFAFN
0	1		K27-u	QELFAFNkTVEHGFP
0	1		K293-u	FPCKAINkILWRNCE
0	1		K502-u	DDWPPFRkVGCFDPy
0	93		Y509-p	kVGCFDPysDDPRLG
0	2		S510-p	VGCFDPysDDPRLGV
0	1		T567-p	LQDREGFtWKGHERL
1	0		S651	LAMEGPLSRVKsLKK
1	4		S655-p	GPLSRVKsLKKsLRQ
1	9		S659-p	RVKsLKKsLRQsFRR
2	10		S663-p	LKKsLRQsFRRIRKs
0	1		S670-p	sFRRIRKsRVSGKKR
1	0		S673	RIRKsRVSGKKRAAN
0	1		T704-p	CPHDVEMtPVQRRIE
0	1		K906	VHYSCIRKEDISGIA
0	12		S967-p	ASYRIREsPKLsQAN
0	5		S971-p	IREsPKLsQANGTPS
0	8		S985	SILLAPQSLDGSPDP
0	6		S989	APQSLDGSPDPAHSM
0	1		D991	QSLDGSPDPAHSMGP
0	3		P992	SLDGSPDPAHSMGPD
0	2		S995	GSPDPAHSMGPDTPE

	mouse
K19	DPQREKLKQELFAFH
K27	QELFAFHKTVEHGFP
K292	FPCKAINKILWRSCE
K501	DDWPPFRKVGCFDPy
Y508-p	KVGCFDPySDDPRLG
S509	VGCFDPySDDPRLGI
T566	LQDREGFTWKGHERL
S650-p	LAMEGPLsRVKsLKK
S654-p	GPLsRVKsLKKsLRQ
S658-p	RVKsLKKsLRQsFRR
S662-p	LKKsLRQsFRRIRKS
S669	sFRRIRKSRVsGKKR
S672-p	RIRKSRVsGKKRTPA
T701	CPHDLEMTPVQRRIE
K903-u	VHYSCIRkEDISGIA
S962-p	TQPRLQEsPKLsQAN
S966-p	LQEsPKLsQANGTRD
S980-p	DIILAPEsCEGsPss
S984-p	APEsCEGsPssAHsK
S986-p	EsCEGsPssAHsKRA
S987-p	sCEGsPssAHsKRAD
S990-p	GsPssAHsKRADTME

	rat
K19	DPQREKLKQELFTFH
K27	QELFTFHKTVEHGFP
K292	FPCKAINKILWRSCE
K501	DDWPPFRKVGCFDPy
Y508-p	KVGCFDPySDDPRLG
S509	VGCFDPySDDPRLGI
T566	LQDREGFTWKGHERL
S650	LAMEGPLSRVKSLKK
S654	GPLSRVKSLKKSLRQ
S658	RVKSLKKSLRQSFRR
S662	LKKSLRQSFRRIRKS
S669	SFRRIRKSRVSGKKR
S672	RIRKSRVSGKKRATT
T703	CPHDVEMTPVQRRIE
K905	VHYSCIRKEDISGIA
S964	TQPRLQESPKLSQAN
S968	LQESPKLSQANGTRD
S982	DIILAPESCEGSPSS
S986	APESCEGSPSSAHSK
S988	ESCEGSPSSAHSKRA
S989	SCEGSPSSAHSKRAD
S992	GSPSSAHSKRADTME

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