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Protein Page:
LLGL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LLGL1 Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Belongs to the WD repeat L(2)GL family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: Golgi membrane; cortical actin cytoskeleton; cytoskeleton; early endosome membrane; axon; cytoplasm; Golgi cis cisterna; trans-Golgi network membrane
Molecular Function: protein binding; Rab GTPase activator activity; structural molecule activity; protein kinase binding
Biological Process: Golgi to plasma membrane transport; exocytosis; axonogenesis; protein complex assembly; cortical actin cytoskeleton organization and biogenesis; positive regulation of Rab GTPase activity; maintenance of apical/basal cell polarity
Reference #:  Q15334 (UniProtKB)
Alt. Names/Synonyms: DLG4; HUGL; Hugl-1; HUGL1; Human homolog to the D-lgl gene protein; L2GL1; lethal giant larvae homolog 1 (Drosophila); Lethal(2) giant larvae protein homolog 1; LLGL; LLGL1
Gene Symbols: LLGL1
Molecular weight: 115,418 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LLGL1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S663‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K19-ub DPQREKLkQELFAFN
0 1 K27-ub QELFAFNkTVEHGFP
0 1 K293-ub FPCKAINkILWRNCE
0 1 K502-ub DDWPPFRkVGCFDPy
0 90 Y509-p kVGCFDPysDDPRLG
0 2 S510-p VGCFDPysDDPRLGV
0 1 T567-p LQDREGFtWKGHERL
1 0 S651 LAMEGPLSRVKsLKK
1 4 S655-p GPLSRVKsLKKsLRQ
1 11 S659-p RVKsLKKsLRQsFRR
2 13 S663-p LKKsLRQsFRRIRKs
0 1 S670-p sFRRIRKsRVsGKKR
1 0 S673-p RIRKsRVsGKKRAAN
0 2 T704-p CPHDVEMtPVQRRIE
0 1 K906 VHYSCIRKEDISGIA
0 14 S967-p ASYRIREsPKLSQAN
0 5 S971 IREsPKLSQANGTPS
0 8 S985 SILLAPQSLDGSPDP
0 8 S989 APQSLDGSPDPAHSM
0 1 D991 QSLDGSPDPAHSMGP
0 4 P992 SLDGSPDPAHSMGPD
0 3 S995 GSPDPAHSMGPDTPE
  mouse

 
K19 DPQREKLKQELFAFH
K27 QELFAFHKTVEHGFP
K292 FPCKAINKILWRSCE
K501 DDWPPFRKVGCFDPy
Y508-p KVGCFDPySDDPRLG
S509 VGCFDPySDDPRLGI
T566 LQDREGFTWKGHERL
S650-p LAMEGPLsRVKsLKK
S654-p GPLsRVKsLKKsLRQ
S658-p RVKsLKKsLRQsFRR
S662-p LKKsLRQsFRRIRKS
S669 sFRRIRKSRVsGKKR
S672-p RIRKSRVsGKKRTPA
T703 CPHDLEMTPVQRRIE
K905-ub VHYSCIRkEDISGIA
S964-p TQPRLQEsPKLsQAN
S968-p LQEsPKLsQANGTRD
S982-p DIILAPEsCEGsPss
S986-p APEsCEGsPssAHsK
S988-p EsCEGsPssAHsKRA
S989-p sCEGsPssAHsKRAD
S992-p GsPssAHsKRADTME
  rat

 
K19 DPQREKLKQELFTFH
K27 QELFTFHKTVEHGFP
K292 FPCKAINKILWRSCE
K501 DDWPPFRKVGCFDPy
Y508-p KVGCFDPySDDPRLG
S509 VGCFDPySDDPRLGI
T566 LQDREGFTWKGHERL
S650 LAMEGPLSRVKSLKK
S654 GPLSRVKSLKKSLRQ
S658 RVKSLKKSLRQSFRR
S662 LKKSLRQSFRRIRKS
S669 SFRRIRKSRVSGKKR
S672 RIRKSRVSGKKRATT
T703 CPHDVEMTPVQRRIE
K905 VHYSCIRKEDISGIA
S964-p TQPRLQEsPKLSQAN
S968 LQEsPKLSQANGTRD
S982 DIILAPESCEGsPSS
S986-p APESCEGsPSSAHSK
S988 ESCEGsPSSAHSKRA
S989 SCEGsPSSAHSKRAD
S992 GsPSSAHSKRADTME
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