Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CASP12 (mouse)

Overview
CASP12 Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.-; Protease
Cellular Component: intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; intracellular; cytosol; nucleus
Molecular Function: peptidase activity; protein binding; protease binding; hydrolase activity; cysteine-type endopeptidase activity; endopeptidase activity; cysteine-type peptidase activity
Biological Process: regulation of apoptosis; protein autoprocessing; apoptosis; positive regulation of apoptosis; unfolded protein response; positive regulation of caspase activity; proteolysis
Reference #:  O08736 (UniProtKB)
Alt. Names/Synonyms: CASP-12; Casp12; caspase 12; Caspase-12; CASPC
Gene Symbols: Casp12
Molecular weight: 47,854 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP12

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S104-p QKICTPSsPSESKRK
0 1 T220 VVLKENLTAQEMETE
0 1 S408-p MPTIERVsMTRyFyL
0 1 Y412-p ERVsMTRyFyLFPGN
0 1 Y414-p VsMTRyFyLFPGN__
  human

 
- gap
T142-p VVIKENLtAQEMETA
S330 LPTIERLSMTRYFYL
Y334 ERLSMTRYFYLFPGN
Y336 LSMTRYFYLFPGN__
  rat

 
S105 QKMFTPSSASESRGK
T221 VVIKENLTAQEMETE
S409 MPTIERVSMTRYFYL
Y413 ERVSMTRYFYLFPGN
Y415 VSMTRYFYLFPGN__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.