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Casp12 (mouse)

Overview Casp12 Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protease; EC 3.4.22.- Cellular Component: intracellular membrane-bound organelle; endoplasmic reticulum; intracellular; cytosol; nucleus Molecular Function: peptidase activity; protein binding; protease binding; hydrolase activity; cysteine-type endopeptidase activity; endopeptidase activity; cysteine-type peptidase activity Biological Process: regulation of apoptosis; virus-infected cell apoptosis; protein autoprocessing; positive regulation of apoptosis; apoptosis; unfolded protein response; induction of apoptosis; positive regulation of caspase activity; proteolysis Reference #:  O08736 (UniProtKB) Alt. Names/Synonyms: CASP-12; Casp12; caspase 12; Caspase-12; CASPC Gene Symbols: Casp12 Molecular weight: 47,854 Da Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  ErbB/HER Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Casp12

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		T220	VVLKENLTAQEMETE
0	1		S408-p	MPTIERVsMTRyFyL
0	1		Y412-p	ERVsMTRyFyLFPGN
0	1		Y414-p	VsMTRyFyLFPGN__

	human
T142-p	VVIKENLtAQEMETA
S330	LPTIERLSMTRYFYL
Y334	ERLSMTRYFYLFPGN
Y336	LSMTRYFYLFPGN__

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