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Protein Page:
S6 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
S6 May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Belongs to the ribosomal protein S6e family. Note: This description may include information from UniProtKB.
Protein type: Translation
Cellular Component: small ribosomal subunit; nucleolus; nucleus; cytosol; ribonucleoprotein complex
Molecular Function: protein binding; structural constituent of ribosome; protein kinase binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; TOR signaling pathway; viral reproduction; translation; positive regulation of apoptosis; viral infectious cycle; translational termination; glucose homeostasis; mRNA metabolic process; ribosomal small subunit biogenesis and assembly; cellular protein metabolic process; translational elongation; RNA metabolic process; insulin receptor signaling pathway; mRNA catabolic process, nonsense-mediated decay; translational initiation; gene expression; viral transcription; rRNA processing
Reference #:  P62753 (UniProtKB)
Alt. Names/Synonyms: 40S ribosomal protein S6; Phosphoprotein NP33; ribosomal protein S6; RPS6; RS6
Gene Symbols: RPS6
Molecular weight: 28,681 Da
Basal Isoelectric point: 10.85  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

S6

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: S235‑p, S236‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S6-p __MKLNIsFPATGCQ
0 5 K14-u FPATGCQkLIEVDDE
0 1 K30-a KLRTFYEkRMATEVA
0 6 K58-u RISGGNDkQGFPMkQ
0 1 K64-u DkQGFPMkQGVLtHG
0 1 T69-p PMkQGVLtHGRVRLL
0 2 S78-p GRVRLLLsKGHSCYR
0 2 K116-u LNLVIVKkGEKDIPG
0 1 T128-p IPGLTDTtVPRRLGP
0 3 K143-u KRASRIRkLFNLskE
0 4 S148-p IRkLFNLskEDDVRQ
0 6 K149-u RkLFNLskEDDVRQY
0 2 T181-p PKIQRLVtPRVLQHK
0 2 K203 KQRTKKNKEEAAEyA
0 4 K203-u KQRTKKNkEEAAEyA
0 15 Y209-p NkEEAAEyAkLLAKR
0 2 K211-a EEAAEyAkLLAKRMK
0 6 K211-u EEAAEyAkLLAKRMK
127 967 S235-p IAKRRRLssLRAsts
122 1123 S236-p AKRRRLssLRAstsK
51 863 S240-p RLssLRAstsKsEss
0 274 T241-p LssLRAstsKsEssQ
0 275 S242-p ssLRAstsKsEssQK
50 572 S244-p LRAstsKsEssQK__
0 126 S246-p AstsKsEssQK____
3 307 S247-p stsKsEssQK_____
2211 : Phospho-S6 Ribosomal Protein (Ser235/236) Antibody
3945 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Biotinylated)
3985 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
4803 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4851 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4854 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4856 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb
4857 : Phospho-S6 Ribosomal Protein (Ser235/236) (91B2) Rabbit mAb
4858 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb
5006 : Phospho-S6 Ribosomal Protein (Ser235/236) (M20B19) Mouse mAb
5316 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (PE Conjugate)
8520 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Pacific Blue(TM) Conjugate)
9865 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
2211 : Phospho-S6 Ribosomal Protein (Ser235/236) Antibody
3945 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Biotinylated)
3985 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
4803 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4851 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4854 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4856 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb
4857 : Phospho-S6 Ribosomal Protein (Ser235/236) (91B2) Rabbit mAb
4858 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb
5006 : Phospho-S6 Ribosomal Protein (Ser235/236) (M20B19) Mouse mAb
5316 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (PE Conjugate)
8520 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Pacific Blue(TM) Conjugate)
9865 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
2215 : Phospho-S6 Ribosomal Protein (Ser240/244) Antibody
4278 : Phospho-S6 Ribosomal Protein (Ser240/244) (61H9) Rabbit mAb (Biotinylated)
5018 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5044 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5364 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb
9468 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
13020 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Biotinylated)
2215 : Phospho-S6 Ribosomal Protein (Ser240/244) Antibody
4278 : Phospho-S6 Ribosomal Protein (Ser240/244) (61H9) Rabbit mAb (Biotinylated)
5018 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5044 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5364 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb
9468 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
13020 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Biotinylated)
  mouse

 
S6 __MKLNISFPATGCQ
K14-u FPATGCQkLIEVDDE
K30 KLRTFYEKRMATEVA
K58-u RISGGNDkQGFPMKQ
K64 DkQGFPMKQGVLTHG
T69 PMKQGVLTHGRVRLL
S78 GRVRLLLSKGHSCYR
K116-u LNLVIVKkGEKDIPG
T128 IPGLTDTTVPRRLGP
K143-u KRASRIRkLFNLskE
S148-p IRkLFNLskEDDVRQ
K149-u RkLFNLskEDDVRQY
T181 PKIQRLVTPRVLQHK
K203-a KQRTKKNkEEAAEYA
K203-u KQRTKKNkEEAAEYA
Y209 NkEEAAEYAkLLAKR
K211-a EEAAEYAkLLAKRMK
K211-u EEAAEYAkLLAKRMK
S235-p IAKRRRLssLRAsts
S236-p AKRRRLssLRAstsK
S240-p RLssLRAstsKsEss
T241-p LssLRAstsKsEssQ
S242-p ssLRAstsKsEssQK
S244-p LRAstsKsEssQK__
S246-p AstsKsEssQK____
S247-p stsKsEssQK_____
2211 : Phospho-S6 Ribosomal Protein (Ser235/236) Antibody
3945 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Biotinylated)
3985 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
4803 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4851 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4854 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4856 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb
4857 : Phospho-S6 Ribosomal Protein (Ser235/236) (91B2) Rabbit mAb
4858 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb
5006 : Phospho-S6 Ribosomal Protein (Ser235/236) (M20B19) Mouse mAb
5316 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (PE Conjugate)
8520 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Pacific Blue(TM) Conjugate)
9865 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
2211 : Phospho-S6 Ribosomal Protein (Ser235/236) Antibody
3945 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Biotinylated)
3985 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
4803 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4851 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4854 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4856 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb
4857 : Phospho-S6 Ribosomal Protein (Ser235/236) (91B2) Rabbit mAb
4858 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb
5006 : Phospho-S6 Ribosomal Protein (Ser235/236) (M20B19) Mouse mAb
5316 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (PE Conjugate)
8520 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Pacific Blue(TM) Conjugate)
9865 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
2215 : Phospho-S6 Ribosomal Protein (Ser240/244) Antibody
4278 : Phospho-S6 Ribosomal Protein (Ser240/244) (61H9) Rabbit mAb (Biotinylated)
5018 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5044 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5364 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb
9468 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
13020 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Biotinylated)
2215 : Phospho-S6 Ribosomal Protein (Ser240/244) Antibody
4278 : Phospho-S6 Ribosomal Protein (Ser240/244) (61H9) Rabbit mAb (Biotinylated)
5018 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5044 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5364 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb
9468 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
13020 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Biotinylated)
  rat

 
S6 __MKLNISFPATGCQ
K14 FPATGCQKLIEVDDE
K30 KLRTFYEKRMATEVA
K58 RISGGNDKQGFPMKQ
K64 DKQGFPMKQGVLTHG
T69 PMKQGVLTHGRVRLL
S78 GRVRLLLSKGHSCYR
K116 LNLVIVKKGEKDIPG
T128 IPGLTDTTVPRRLGP
K143 KRASRIRKLFNLSKE
S148 IRKLFNLSKEDDVRQ
K149 RKLFNLSKEDDVRQY
T181 PKIQRLVTPRVLQHK
K203 KQRTKKNKEEAAEYA
K203 KQRTKKNKEEAAEYA
Y209 NKEEAAEYAKLLAKR
K211 EEAAEYAKLLAKRMK
K211 EEAAEYAKLLAKRMK
S235-p IAKRRRLssLRAsts
S236-p AKRRRLssLRAstsK
S240-p RLssLRAstsKsESs
T241-p LssLRAstsKsESsQ
S242-p ssLRAstsKsESsQK
S244-p LRAstsKsESsQK__
S246 AstsKsESsQK____
S247-p stsKsESsQK_____
2211 : Phospho-S6 Ribosomal Protein (Ser235/236) Antibody
3945 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Biotinylated)
3985 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
4803 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4851 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4854 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4856 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb
4857 : Phospho-S6 Ribosomal Protein (Ser235/236) (91B2) Rabbit mAb
4858 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb
5006 : Phospho-S6 Ribosomal Protein (Ser235/236) (M20B19) Mouse mAb
5316 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (PE Conjugate)
8520 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Pacific Blue(TM) Conjugate)
9865 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
2211 : Phospho-S6 Ribosomal Protein (Ser235/236) Antibody
3945 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Biotinylated)
3985 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
4803 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4851 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
4854 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4856 : Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb
4857 : Phospho-S6 Ribosomal Protein (Ser235/236) (91B2) Rabbit mAb
4858 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb
5006 : Phospho-S6 Ribosomal Protein (Ser235/236) (M20B19) Mouse mAb
5316 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (PE Conjugate)
8520 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Pacific Blue(TM) Conjugate)
9865 : Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
2215 : Phospho-S6 Ribosomal Protein (Ser240/244) Antibody
4278 : Phospho-S6 Ribosomal Protein (Ser240/244) (61H9) Rabbit mAb (Biotinylated)
5018 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5044 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5364 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb
9468 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
13020 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Biotinylated)
2215 : Phospho-S6 Ribosomal Protein (Ser240/244) Antibody
4278 : Phospho-S6 Ribosomal Protein (Ser240/244) (61H9) Rabbit mAb (Biotinylated)
5018 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5044 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5364 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb
9468 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
13020 : Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP(R) Rabbit mAb (Biotinylated)
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