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S6 (human)

Overview S6 May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Belongs to the ribosomal protein S6e family. Note: This description may include information from UniProtKB. Protein type: Translation Cellular Component: small ribosomal subunit; cytoplasm; nucleolus; nucleus; cytosol; ribonucleoprotein complex Molecular Function: protein binding; structural constituent of ribosome; protein kinase binding Biological Process: SRP-dependent cotranslational protein targeting to membrane; TOR signaling pathway; viral reproduction; translation; positive regulation of apoptosis; translational termination; viral infectious cycle; glucose homeostasis; mRNA metabolic process; ribosomal small subunit biogenesis and assembly; cellular protein metabolic process; translational elongation; RNA metabolic process; mRNA catabolic process, nonsense-mediated decay; translational initiation; insulin receptor signaling pathway; gene expression; viral transcription; rRNA processing Reference #:  P62753 (UniProtKB) Alt. Names/Synonyms: 40S ribosomal protein S6; Phosphoprotein NP33; ribosomal protein S6; RPS6; RS6 Gene Symbols: RPS6 Molecular weight: 28,681 Da Basal Isoelectric point: 10.85  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below S6 3J3A - I=1-208 (human)

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	Sites Implicated In
molecular association, regulation: S235‑p, S236‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		S6-p	__MKLNIsFPATGCQ
0	5		K14-u	FPATGCQkLIEVDDE
0	1		Y28-p	ERKLRTFyEkRMATE
0	1		K30-a	KLRTFyEkRMATEVA
0	1		K58	RISGGNDKQGFPMkQ
0	6		K58-u	RISGGNDkQGFPMkQ
0	1		K64-u	DkQGFPMkQGVLTHG
0	2		S78-p	GRVRLLLsKGHSCYR
0	2		K116-u	LNLVIVKkGEKDIPG
0	1		K119	VIVKkGEKDIPGLTD
0	3		K143-u	KRASRIRkLFNLskE
0	3		S148-p	IRkLFNLskEDDVRQ
0	6		K149-u	RkLFNLskEDDVRQY
0	2		T181-p	PKIQRLVtPRVLQHK
0	2		K203	KQRTKKNKEEAAEyA
0	4		K203-u	KQRTKKNkEEAAEyA
0	15		Y209-p	NkEEAAEyAkLLAKR
0	2		K211-a	EEAAEyAkLLAKRMk
0	6		K211-u	EEAAEyAkLLAKRMk
0	1		K218-a	kLLAKRMkEAKEKRQ
119	964		S235-p	IAKRRRLssLRAsts
113	1119		S236-p	AKRRRLssLRAstsK
48	859		S240-p	RLssLRAstsKsEss
0	274		T241-p	LssLRAstsKsEssQ
0	273		S242-p	ssLRAstsKsEssQK
47	569		S244-p	LRAstsKsEssQK__
0	125		S246-p	AstsKsEssQK____
3	305		S247-p	stsKsEssQK_____

	mouse
S6	__MKLNISFPATGCQ
K14-u	FPATGCQkLIEVDDE
Y28	ERKLRTFYEKRMATE
K30	KLRTFYEKRMATEVA
K58-a	RISGGNDkQGFPMKQ
K58-u	RISGGNDkQGFPMKQ
K64	DkQGFPMKQGVLTHG
S78	GRVRLLLSKGHSCYR
K116-u	LNLVIVKkGEkDIPG
K119-u	VIVKkGEkDIPGLTD
K143-u	KRASRIRkLFNLskE
S148-p	IRkLFNLskEDDVRQ
K149-u	RkLFNLskEDDVRQY
T181	PKIQRLVTPRVLQHK
K203-a	KQRTKKNkEEAAEYA
K203-u	KQRTKKNkEEAAEYA
Y209	NkEEAAEYAkLLAKR
K211-a	EEAAEYAkLLAKRMK
K211-u	EEAAEYAkLLAKRMK
K218	kLLAKRMKEAKEKRQ
S235-p	IAKRRRLssLRAsts
S236-p	AKRRRLssLRAstsK
S240-p	RLssLRAstsKsEss
T241-p	LssLRAstsKsEssQ
S242-p	ssLRAstsKsEssQK
S244-p	LRAstsKsEssQK__
S246-p	AstsKsEssQK____
S247-p	stsKsEssQK_____

	rat
S6	__MKLNISFPATGCQ
K14	FPATGCQKLIEVDDE
Y28	ERKLRTFYEKRMATE
K30	KLRTFYEKRMATEVA
K58	RISGGNDKQGFPMKQ
K58	RISGGNDKQGFPMKQ
K64	DKQGFPMKQGVLTHG
S78	GRVRLLLSKGHSCYR
K116	LNLVIVKKGEKDIPG
K119	VIVKKGEKDIPGLTD
K143	KRASRIRKLFNLSKE
S148	IRKLFNLSKEDDVRQ
K149	RKLFNLSKEDDVRQY
T181	PKIQRLVTPRVLQHK
K203	KQRTKKNKEEAAEYA
K203	KQRTKKNKEEAAEYA
Y209	NKEEAAEYAKLLAKR
K211	EEAAEYAKLLAKRMK
K211	EEAAEYAKLLAKRMK
K218	KLLAKRMKEAKEKRQ
S235-p	IAKRRRLssLRAsts
S236-p	AKRRRLssLRAstsK
S240-p	RLssLRAstsKsESs
T241-p	LssLRAstsKsESsQ
S242-p	ssLRAstsKsESsQK
S244-p	LRAstsKsESsQK__
S246	AstsKsESsQK____
S247-p	stsKsESsQK_____

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