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Protein Page:
DTX2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DTX2 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin ligase; Transcription, coactivator/corepressor; Ubiquitin conjugating system
Cellular Component: nuclear membrane; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; zinc ion binding; ligase activity
Biological Process: Notch signaling pathway; protein ubiquitination
Reference #:  Q86UW9 (UniProtKB)
Alt. Names/Synonyms: deltex homolog 2 (Drosophila); Deltex2; DTX2; hDTX2; KIAA1528; MGC71098; Protein deltex-2; RING finger protein 58; RNF58; zinc ion binding protein
Gene Symbols: DTX2
Molecular weight: 67,246 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DTX2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y75-p ADPSLAPyIIDLPSW
0 1 T153-p APLGYNYtVNyTTHT
0 3 Y156-p GYNYtVNyTTHTQTN
0 1 R213-m2 RTGPVSGrYrHSMTN
0 1 R215-m2 GPVSGrYrHSMTNLP
0 1 T219 GrYrHSMTNLPAYPV
0 1 R233-m2 VPQHPPHrTAsVFGT
0 3 S236-p HPPHrTAsVFGTHQA
0 4 Y247-p THQAFAPyNkPsLsG
0 2 K249-ac QAFAPyNkPsLsGAr
0 1 K249-ub QAFAPyNkPsLsGAr
0 1 S251-p FAPyNkPsLsGArsA
0 2 S253-p PyNkPsLsGArsAPR
0 2 R256-m1 kPsLsGArsAPRLNT
0 1 S257-p PsLsGArsAPRLNTT
0 5 Y280-p SLGSQPLyRSSLSHL
0 3 S360-p SRAPQPTsPPAsRLA
0 2 S364-p QPTsPPAsRLAsKSH
0 1 S368-p PPAsRLAsKSHGsVK
0 1 S373-p LAsKSHGsVKRLRkM
0 1 K379-ac GsVKRLRkMSVkGAT
0 1 K383-ac RLRkMSVkGATPKPE
0 1 Y425-p KLSTASGySDVTDSK
0 1 K553-ac RKVLELLkVAWkRRL
0 2 K553-ub RKVLELLkVAWkRRL
0 1 K557-ac ELLkVAWkRRLIFTV
  mouse

 
Y75 ADPSLAPYIIDLPSW
T153 APLGYNYTVNYATLT
Y156 GYNYTVNYATLTQTN
R213 GTGPVSGRYRHSMtN
R215 GPVSGRYRHSMtNLP
T219-p GRYRHSMtNLPAYPA
R232 PAPQAPHRTTTVSGA
T235 QAPHRTTTVSGAHQA
Y246 AHQAFAPYNKPSLSG
K248 QAFAPYNKPSLSGAR
K248 QAFAPYNKPSLSGAR
S250 FAPYNKPSLSGARSA
S252 PYNKPSLSGARSAPR
R255 KPSLSGARSAPRLNT
S256 PSLSGARSAPRLNTT
F279 VAGNQSLFHSSLSHL
G359 SRAPRPTGPPASRPA
S363 RPTGPPASRPASKSH
S367 PPASRPASKSHSSVK
S372 PASKSHSSVKRLRKM
K378 SSVKRLRKMSVKEGA
K382 RLRKMSVKEGAPKPE
Y422 KLAVASGYSDMTDSK
K550 RKVLELLKVAWKRRL
K550-ub RKVLELLkVAWKRRL
K554 ELLkVAWKRRLIFTV
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