Home

POLR2A (human)

Overview POLR2A DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA- dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. The phosphorylated C-terminal domain interacts with FNBP3 and SYNCRIP. Interacts with SAFB/SAFB1. Interacts with CCNL1 and MYO1C. Interacts with CCNL2 and SFRS19. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with PAF1. Interacts (via C-terminus) with FTSJD2, CTDSP1 and SCAF8. Interacts via the phosphorylated C-terminal domain with WDR82 and with SETD1A and SETD1B only in the presence of WDR82. Interacts with ATF7IP. When phosphorylated at 'Ser-5', interacts with MEN1; the unphosphorylated form, or phosphorylated at 'Ser-2' does not interact. Interacts with DDX5. Belongs to the RNA polymerase beta' chain family. Note: This description may include information from UniProtKB. Protein type: EC 2.7.7.6; Nucleotide Metabolism - purine; Transferase; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; EC 2.7.7.48 Cellular Component: nucleoplasm; nucleolus; DNA-directed RNA polymerase II, core complex; nucleus Molecular Function: identical protein binding; protein binding; RNA-directed RNA polymerase activity; DNA binding; DNA-directed RNA polymerase activity; ubiquitin protein ligase binding; metal ion binding; protein kinase activity Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA splicing; DNA repair; protein amino acid phosphorylation; nuclear mRNA splicing, via spliceosome; mRNA capping; regulation of transcription, DNA-dependent; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; gene expression Reference #:  P24928 (UniProtKB) Alt. Names/Synonyms: DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; hRPB220; hsRPB1; MGC75453; POLR2; POLR2A; POLRA; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1; RPB1; RPBh1; RpIILS; RPO2; RPOL2 Gene Symbols: POLR2A Molecular weight: 217,176 Da Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below POLR2A 2GHQ - D=1725-1733 (human) 2LTO - B=1804-1816 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2GHQ 2LTO  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S1621‑p transcription, altered: S1616‑p, S1619‑p, S1621‑p transcription, induced: S1619‑p, R1810‑m2 enzymatic activity, induced: S1616‑p, S1619‑p intracellular localization: S1616‑p, S1619‑p molecular association, regulation: S1616‑p, S1619‑p, S1621‑p phosphorylation: S1621‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K32-u	VLSPDELkRMSVtEG
0	1		T37-p	ELkRMSVtEGGIkYP
0	2		K42-u	SVtEGGIkYPEttEG
0	1		T46-p	GGIkYPEttEGGRPK
0	1		T47-p	GIkYPEttEGGRPKL
0	1		S121	CSKLLVDSNNPKIKD
0	1		K127	DSNNPKIKDILAKSk
0	1		K134-a	KDILAKSkGQPKkRL
0	2		K139-a	KSkGQPKkRLTHVyD
0	42		Y145-p	KkRLTHVyDLCKGKN
0	6		K177-u	EGDEDLTkEkGHGGC
0	1		K179-u	DEDLTkEkGHGGCGR
0	1		K226	ERVHEIFKRISDEEC
0	1		S269-p	PAVVMQGsARNQDDL
0	1		K279-u	NQDDLTHkLADIVkI
0	2		K285-a	HkLADIVkINNQLRR
0	2		K285-u	HkLADIVkINNQLRR
0	1		K417-u	NSQYPGAkYIIRDNG
0	1		S530-p	RMIVTPQsNRPVMGI
0	1		T587-p	LKPRPLWtGKQIFSL
0	4		S607-p	INCIRTHstHPDDED
0	1		T608-p	NCIRTHstHPDDEDS
0	1		Y618-p	DDEDSGPykHISPGD
0	1		K619-u	DEDSGPykHISPGDT
0	1		K643-u	IMGILCKkSLGTSAG
0	1		T698-p	DSIADSKtyQDIQNT
0	1		Y699-p	SIADSKtyQDIQNTI
0	1		K707-u	QDIQNTIkkAkQDVI
0	1		K708-m1	DIQNTIkkAkQDVIE
0	3		K710-a	QNTIkkAkQDVIEVI
0	2		K710-u	QNTIkkAkQDVIEVI
0	1		K719-u	DVIEVIEkAHNNELE
0	2		T732-p	LEPTPGNtLRQTFEN
0	2		K751-u	ILNDARDkTGSSAQk
0	35		K758-u	kTGSSAQkSLSEyNN
0	5		Y763-p	AQkSLSEyNNFksMV
0	3		K767-u	LSEyNNFksMVVsGA
0	1		S768-p	SEyNNFksMVVsGAk
0	1		S772-p	NFksMVVsGAkGsKI
0	1		K775-u	sMVVsGAkGsKINIS
0	1		S777-p	VVsGAkGsKINISQV
0	14		K796-u	GQQNVEGkRIPFGFK
0	3		K812-u	RTLPHFIkDDYGPES
0	2		K853-u	GLIDTAVkTAETGYI
0	2		K866-u	YIQRRLIkSMESVMV
0	1		K874-u	SMESVMVkYDATVRN
0	1		T878	VMVkYDATVRNSINQ
0	2		K910-u	FQNLATLkPSNkAFE
0	8		K914-u	ATLkPSNkAFEkkFR
0	5		K918-u	PSNkAFEkkFRFDYT
0	3		K919-u	SNkAFEkkFRFDYTN
0	1		K940-u	TLQEDLVkDVLSNAH
0	3		K976-u	IFPTGDSkVVLPCNL
0	3		K1008-u	PSDLHPIkVVEGVkE
0	2		K1014-u	IkVVEGVkELSKkLV
0	1		K1019-u	GVkELSKkLVIVNGD
0	1		Y1109-p	MTLNTFHyAGVSAKN
0	2		K1125-u	TLGVPRLkELINISK
0	1		K1225-u	RKHMTDRkLTMEQIA
0	1		K1254-u	FNDDNAEkLVLRIRI
0	1		S1264	LRIRIMNSDENkMQE
0	2		K1268-u	IMNSDENkMQEEEEV
0	1		K1278-u	EEEEVVDkMDDDVFL
0	1		K1317-u	HLPQTDNkKkIIITE
0	1		K1319-u	PQTDNkKkIIITEDG
0	7		K1350-u	LMRVLSEkDVDPVRT
0	1		Y1383-p	KALERELyHVISFDG
0	1		T1406-p	ALLCDTMtCRGHLMA
0	2		T1415-p	RGHLMAItRHGVNRQ
0	3		T1424-p	HGVNRQDtGPLMKCS
54	0		S1616-p	TPQSPSYsPtsPsYS
1	0		T1618-p	QSPSYsPtsPsYSPT
2	0		T1618-g	QSPSYsPtsPsYSPT
58	0		S1619-p	SPSYsPtsPsYSPTS
6	0		S1621-p	SYsPtsPsYSPTSPS
1	0		R1810-m2	SYSPSSPrytPQsPT
0	2		Y1811-p	YSPSSPrytPQsPTY
0	2		T1812-p	SPSSPrytPQsPTYt
0	34		S1815-p	SPrytPQsPTYtPss
0	1		T1817	rytPQsPTYtPssPs
0	6		T1819-p	tPQsPTYtPssPsys
0	9		S1821-p	QsPTYtPssPsysPs
0	31		S1822-p	sPTYtPssPsysPss
0	2		S1824-p	TYtPssPsysPssPs
0	2		Y1825-p	YtPssPsysPssPsy
0	1		S1826-p	tPssPsysPssPsys
0	7		S1828-p	ssPsysPssPsysPA
0	6		S1829-p	sPsysPssPsysPAs
0	4		S1831-p	sysPssPsysPAsPK
0	3		Y1832-p	ysPssPsysPAsPKy
0	4		S1833-p	sPssPsysPAsPKyT
0	3		A1835	ssPsysPAsPKyTPt
0	6		S1836-p	sPsysPAsPKyTPts
0	2		Y1839-p	ysPAsPKyTPtsPsy
0	1		T1840	sPAsPKyTPtsPsys
0	2		T1842-p	AsPKyTPtsPsysPs
0	25		S1843-p	sPKyTPtsPsysPss
0	23		S1845-p	KyTPtsPsysPssPE
0	2		Y1846-p	yTPtsPsysPssPEy
0	4		S1847-p	TPtsPsysPssPEyt
0	16		S1849-p	tsPsysPssPEytPt
0	25		S1850-p	sPsysPssPEytPts
0	5		Y1853-p	ysPssPEytPtsPKy
0	4		T1854-p	sPssPEytPtsPKys
0	4		T1856-p	ssPEytPtsPKysPt
0	20		S1857-p	sPEytPtsPKysPts
1	0		K1859	EytPtsPKysPtsPK
0	6		Y1860-p	ytPtsPKysPtsPKY
0	7		S1861-p	tPtsPKysPtsPKYs
0	9		T1863-p	tsPKysPtsPKYsPt
0	3		S1864-p	sPKysPtsPKYsPts
1	0		K1866	KysPtsPKYsPtsPK
0	2		Y1867	ysPtsPKYsPtsPKy
0	6		S1868-p	sPtsPKYsPtsPKys
0	3		T1870-p	tsPKYsPtsPKysPt
0	10		S1871-p	sPKYsPtsPKysPts
1	0		K1873	KYsPtsPKysPtsPt
0	9		Y1874-p	YsPtsPKysPtsPty
0	3		S1875-p	sPtsPKysPtsPtys
0	6		T1877-p	tsPKysPtsPtysPt
0	19		S1878-p	sPKysPtsPtysPtt
0	8		T1880-p	KysPtsPtysPttPK
0	14		Y1881-p	ysPtsPtysPttPKY
1	8		S1882-p	sPtsPtysPttPKYs
1	4		T1884-p	tsPtysPttPKYsPt
1	8		T1885-p	sPtysPttPKYsPts
1	0		K1887	tysPttPKYsPtsPt
0	2		Y1888	ysPttPKYsPtsPty
0	2		S1889-p	sPttPKYsPtsPtys
0	7		T1891-p	ttPKYsPtsPtysPt
0	8		S1892-p	tPKYsPtsPtysPts
0	5		T1894-p	KYsPtsPtysPtsPV
0	1		Y1895-p	YsPtsPtysPtsPVy
0	3		S1896-p	sPtsPtysPtsPVyt
0	4		T1898-p	tsPtysPtsPVytPt
0	4		S1899-p	sPtysPtsPVytPts
0	3		Y1902-p	ysPtsPVytPtsPKy
0	4		T1903-p	sPtsPVytPtsPKys
0	7		T1905-p	tsPVytPtsPKysPt
0	7		S1906-p	sPVytPtsPKysPts
1	0		K1908	VytPtsPKysPtsPt
0	11		Y1909-p	ytPtsPKysPtsPty
0	5		S1910-p	tPtsPKysPtsPtys
0	13		T1912-p	tsPKysPtsPtysPt
0	24		S1913-p	sPKysPtsPtysPts
1	42		T1915-p	KysPtsPtysPtsPK
0	26		Y1916-p	ysPtsPtysPtsPKy
1	15		S1917-p	sPtsPtysPtsPKys
0	13		T1919-p	tsPtysPtsPKysPt
1	25		S1920-p	sPtysPtsPKysPts
1	0		K1922	tysPtsPKysPtsPt
0	10		Y1923-p	ysPtsPKysPtsPty
0	6		S1924-p	sPtsPKysPtsPtys
0	10		T1926-p	tsPKysPtsPtysPt
0	22		S1927-p	sPKysPtsPtysPts
0	43		T1929-p	KysPtsPtysPtsPK
0	25		Y1930-p	ysPtsPtysPtsPKG
0	14		S1931-p	sPtsPtysPtsPKGS
0	11		T1933-p	tsPtysPtsPKGSTY
1	22		S1934-p	sPtysPtsPKGSTYs
0	1		S1941-p	sPKGSTYsPTSPGYS
0	1		T1950	TSPGYSPTsPTYSLT
0	1		S1951-p	SPGYSPTsPTYSLTS
0	1		S1958	sPTYSLTSPAISPDD
0	2		S1966-p	PAISPDDsDEEN___

	POLR2A var1
K32	VLSPDELKRMSVTEG
T37	ELKRMSVTEGGIKYP
K42	SVTEGGIKYPETTEG
T46	GGIKYPETTEGGRPK
T47	GIKYPETTEGGRPKL
S121	CSKLLVDSNNPKIKD
K127	DSNNPKIKDILAKSK
K134	KDILAKSKGQPKKRL
K139	KSKGQPKKRLTHVYD
Y145	KKRLTHVYDLCKGKN
K177	EGDEDLTKEKGHGGC
K179	DEDLTKEKGHGGCGR
K226	ERVHEIFKRISDEEC
S269	PAVVMQGSARNQDDL
K279	NQDDLTHKLADIVKI
K285	HKLADIVKINNQLRR
K285	HKLADIVKINNQLRR
K417	NSQYPGAKYIIRDNG
S530	RMIVTPQSNRPVMGI
T587	LKPRPLWTGKQIFSL
S607	INCIRTHSTHPDDED
T608	NCIRTHSTHPDDEDS
Y618	DDEDSGPYKHISPGD
K619	DEDSGPYKHISPGDT
K643	IMGILCKKSLGTSAG
T698	DSIADSKTYQDIQNT
Y699	SIADSKTYQDIQNTI
K707	QDIQNTIKKAKQDVI
K708	DIQNTIKKAKQDVIE
K710	QNTIKKAKQDVIEVI
K710	QNTIKKAKQDVIEVI
K719	DVIEVIEKAHNNELE
T732	LEPTPGNTLRQTFEN
K751	ILNDARDKTGSSAQK
K758	KTGSSAQKSLSEYNN
Y763	AQKSLSEYNNFKSMV
K767	LSEYNNFKSMVVSGA
S768	SEYNNFKSMVVSGAK
S772	NFKSMVVSGAKGSKI
K775	SMVVSGAKGSKINIS
S777	VVSGAKGSKINISQV
K796	GQQNVEGKRIPFGFK
K812	RTLPHFIKDDYGPES
K853	GLIDTAVKTAETGYI
K866	YIQRRLIKSMESVMV
K874	SMESVMVKYDATVRN
T878	VMVKYDATVRNSINQ
K910	FQNLATLKPSNKAFE
K914	ATLKPSNKAFEKKFR
K918	PSNKAFEKKFRFDYT
K919	SNKAFEKKFRFDYTN
K940	TLQEDLVKDVLSNAH
K976	IFPTGDSKVVLPCNL
K1008	PSDLHPIKVVEGVKE
K1014	IKVVEGVKELSKKLV
K1019	GVKELSKKLVIVNGD
Y1109	MTLNTFHYAGVSAKN
K1125	TLGVPRLKELINISK
K1225	RKHMTDRKLTMEQIA
K1254	FNDDNAEKLVLRIRI
S1264	LRIRIMNSDENKMQE
K1268	IMNSDENKMQEEEEV
K1278	EEEEVVDKMDDDVFL
K1317	HLPQTDNKKKIIITE
K1319	PQTDNKKKIIITEDG
K1350	LMRVLSEKDVDPVRT
Y1383	KALERELYHVISFDG
T1406	ALLCDTMTCRGHLMA
T1415	RGHLMAITRHGVNRQ
T1424	HGVNRQDTGPLMKCS
S1616	TPQSPSYSPTSPSYS
T1618	QSPSYSPTSPSYSPT
T1618	QSPSYSPTSPSYSPT
S1619	SPSYSPTSPSYSPTS
S1621	SYSPTSPSYSPTSPS
R1810	SYSPSSPRYTPQSPT
Y1811	YSPSSPRYTPQSPTY
T1812	SPSSPRYTPQSPTYT
S1815	SPRYTPQSPTYTPSS
T1817	RYTPQSPTYTPSSPS
T1819	TPQSPTYTPSSPSYS
S1821	QSPTYTPSSPSYSPS
S1822	SPTYTPSSPSYSPSS
S1824	TYTPSSPSYSPSSPS
Y1825	YTPSSPSYSPSSPSY
S1826	TPSSPSYSPSSPSYS
S1828	SSPSYSPSSPSYSPt
S1829	SPSYSPSSPSYSPtS
S1831	SYSPSSPSYSPtSPK
Y1832	YSPSSPSYSPtSPKY
S1833	SPSSPSYSPtSPKYT
T1835-p	SSPSYSPtSPKYTPT
S1836	SPSYSPtSPKYTPTS
Y1839	YSPtSPKYTPTSPSY
T1840	SPtSPKYTPTSPSYS
T1842	tSPKYTPTSPSYSPS
S1843	SPKYTPTSPSYSPSS
S1845	KYTPTSPSYSPSSPE
Y1846	YTPTSPSYSPSSPEY
S1847	TPTSPSYSPSSPEYT
S1849	TSPSYSPSSPEYTPT
S1850	SPSYSPSSPEYTPTS
Y1853	YSPSSPEYTPTSPKY
T1854	SPSSPEYTPTSPKYS
T1856	SSPEYTPTSPKYSPT
S1857	SPEYTPTSPKYSPTS
K1859	EYTPTSPKYSPTSPK
Y1860	YTPTSPKYSPTSPKY
S1861	TPTSPKYSPTSPKYS
T1863	TSPKYSPTSPKYSPT
S1864	SPKYSPTSPKYSPTS
K1866	KYSPTSPKYSPTSPK
Y1867	YSPTSPKYSPTSPKY
S1868	SPTSPKYSPTSPKYS
T1870	TSPKYSPTSPKYSPT
S1871	SPKYSPTSPKYSPTS
K1873	KYSPTSPKYSPTSPT
Y1874	YSPTSPKYSPTSPTY
S1875	SPTSPKYSPTSPTYS
T1877	TSPKYSPTSPTYSPT
S1878	SPKYSPTSPTYSPTT
T1880	KYSPTSPTYSPTTPK
Y1881	YSPTSPTYSPTTPKY
S1882	SPTSPTYSPTTPKYS
T1884	TSPTYSPTTPKYSPT
T1885	SPTYSPTTPKYSPTS
K1887	TYSPTTPKYSPTSPT
Y1888	YSPTTPKYSPTSPTY
S1889	SPTTPKYSPTSPTYS
T1891	TTPKYSPTSPTYSPT
S1892	TPKYSPTSPTYSPTS
T1894	KYSPTSPTYSPTSPV
Y1895	YSPTSPTYSPTSPVY
S1896	SPTSPTYSPTSPVYT
T1898	TSPTYSPTSPVYTPT
S1899	SPTYSPTSPVYTPTS
Y1902	YSPTSPVYTPTSPKY
T1903	SPTSPVYTPTSPKYS
T1905	TSPVYTPTSPKYSPT
S1906	SPVYTPTSPKYSPTS
K1908	VYTPTSPKYSPTSPT
Y1909	YTPTSPKYSPTSPTY
S1910	TPTSPKYSPTSPTYS
T1912	TSPKYSPTSPTYSPT
S1913	SPKYSPTSPTYSPTS
T1915	KYSPTSPTYSPTSPK
Y1916	YSPTSPTYSPTSPKY
S1917	SPTSPTYSPTSPKYS
T1919	TSPTYSPTSPKYSPT
S1920	SPTYSPTSPKYSPTS
K1922	TYSPTSPKYSPTSPT
Y1923	YSPTSPKYSPTSPTY
S1924	SPTSPKYSPTSPTYS
T1926	TSPKYSPTSPTYSPT
S1927	SPKYSPTSPTYSPTS
T1929	KYSPTSPTYSPTSPK
Y1930	YSPTSPTYSPTSPKG
S1931	SPTSPTYSPTSPKGS
T1933	TSPTYSPTSPKGSTY
S1934	SPTYSPTSPKGSTYS
S1941	SPKGSTYSPTSPGYS
T1950	TSPGYSPTSPTYSLT
S1951	SPGYSPTSPTYSLTS
S1958	SPTYSLTSPAISPDD
S1966	PAISPDDSDEEN___

	mouse
K32	VLSPDELKRMSVTEG
T37	ELKRMSVTEGGIKYP
K42	SVTEGGIKYPETTEG
T46	GGIKYPETTEGGRPK
T47	GIKYPETTEGGRPKL
S121-p	CSKLLVDsNNPKIkD
K127-a	DsNNPKIkDILAKSK
K134	kDILAKSKGQPKkRL
K139-a	KSKGQPKkRLTHVyD
Y145-p	KkRLTHVyDLCKGKN
K177-u	EGDEDLTkEKGHGGC
K179	DEDLTkEKGHGGCGR
K226-a	ERVHEIFkRISDEEC
S269	PAVVMQGSARNQDDL
K279	NQDDLTHKLADIVkI
K285-a	HKLADIVkINNQLRR
K285	HKLADIVKINNQLRR
K417	NSQYPGAKYIIRDNG
S530	RMIVTPQSNRPVMGI
T587	LKPRPLWTGKQIFSL
S607	INCIRTHSTHPDDED
T608	NCIRTHSTHPDDEDS
Y618	DDEDSGPYKHISPGD
K619	DEDSGPYKHISPGDT
K643	IMGILCKKSLGTSAG
T698	DSIADSKTYQDIQNT
Y699	SIADSKTYQDIQNTI
K707	QDIQNTIKKAkQDVI
K708	DIQNTIKKAkQDVIE
K710-a	QNTIKKAkQDVIEVI
K710	QNTIKKAKQDVIEVI
K719	DVIEVIEKAHNNELE
T732	LEPTPGNTLRQTFEN
K751	ILNDARDKTGSSAQk
K758-u	KTGSSAQkSLSEYNN
Y763	AQkSLSEYNNFKSMV
K767	LSEYNNFKSMVVSGA
S768	SEYNNFKSMVVSGAK
S772	NFKSMVVSGAKGSKI
K775	SMVVSGAKGSKINIS
S777	VVSGAKGSKINISQV
K796-u	GQQNVEGkRIPFGFK
K812	RTLPHFIKDDYGPES
K853	GLIDTAVKTAETGYI
K866	YIQRRLIKSMESVMV
K874	SMESVMVKYDAtVRN
T878-p	VMVKYDAtVRNSINQ
K910	FQNLATLKPSNkAFE
K914-u	ATLKPSNkAFEkkFR
K918-u	PSNkAFEkkFRFDYT
K919-u	SNkAFEkkFRFDYTN
K940	TLQEDLVKDVLSNAH
K976	IFPTGDSKVVLPCNL
K1008	PSDLHPIKVVEGVkE
K1014-u	IKVVEGVkELSKKLV
K1019	GVkELSKKLVIVNGD
Y1109	MTLNTFHYAGVSAKN
K1125	TLGVPRLKELINISK
K1225	RKHMTDRKLTMEQIA
K1254	FNDDNAEKLVLRIRI
S1264-p	LRIRIMNsDENkMQE
K1268-u	IMNsDENkMQEEEEV
K1278	EEEEVVDKMDDDVFL
K1317	HLPQTDNKKKIIITE
K1319	PQTDNKKKIIITEDG
K1350-u	LMRVLSEkDVDPVRT
Y1383	KALERELYHVISFDG
T1406	ALLCDTMTCRGHLMA
T1415	RGHLMAITRHGVNRQ
T1424-p	HGVNRQDtGPLMKCS
S1616-p	TPQSPSYsPtsPSYS
T1618	QSPSYsPTsPSYSPT
T1618-g	QSPSYsPtsPSYSPT
S1619-p	SPSYsPtsPSYSPTS
S1621	SYsPtsPSYSPTSPS
R1810-m2	SYSPSSPrytPQsPt
Y1811-p	YSPSSPrytPQsPtY
T1812-p	SPSSPrytPQsPtYt
S1815-p	SPrytPQsPtYtPSs
T1817-p	rytPQsPtYtPSsPS
T1819-p	tPQsPtYtPSsPSYS
S1821	QsPtYtPSsPSYSPs
S1822-p	sPtYtPSsPSYSPss
S1824	tYtPSsPSYSPssPS
Y1825	YtPSsPSYSPssPSy
S1826	tPSsPSYSPssPSyS
S1828-p	SsPSYSPssPSySPt
S1829-p	sPSYSPssPSySPts
S1831	SYSPssPSySPtsPK
Y1832-p	YSPssPSySPtsPKy
S1833	SPssPSySPtsPKyt
T1835-p	ssPSySPtsPKytPt
S1836-p	sPSySPtsPKytPts
Y1839-p	ySPtsPKytPtsPsy
T1840-p	SPtsPKytPtsPsys
T1842-p	tsPKytPtsPsysPs
S1843-p	sPKytPtsPsysPss
S1845-p	KytPtsPsysPssPE
Y1846-p	ytPtsPsysPssPEy
S1847-p	tPtsPsysPssPEyt
S1849-p	tsPsysPssPEytPA
S1850-p	sPsysPssPEytPAs
Y1853-p	ysPssPEytPAsPky
T1854-p	sPssPEytPAsPkys
A1856	ssPEytPAsPkysPt
S1857-p	sPEytPAsPkysPts
K1859-u	EytPAsPkysPtsPk
Y1860-p	ytPAsPkysPtsPky
S1861-p	tPAsPkysPtsPkys
T1863-p	AsPkysPtsPkysPt
S1864-p	sPkysPtsPkysPts
K1866-u	kysPtsPkysPtsPk
Y1867-p	ysPtsPkysPtsPky
S1868-p	sPtsPkysPtsPkys
T1870-p	tsPkysPtsPkysPt
S1871-p	sPkysPtsPkysPts
K1873-u	kysPtsPkysPtsPt
Y1874-p	ysPtsPkysPtsPty
S1875-p	sPtsPkysPtsPtys
T1877-p	tsPkysPtsPtysPt
S1878-p	sPkysPtsPtysPtt
T1880-p	kysPtsPtysPttPk
Y1881-p	ysPtsPtysPttPky
S1882-p	sPtsPtysPttPkys
T1884-p	tsPtysPttPkysPt
T1885-p	sPtysPttPkysPts
K1887-u	tysPttPkysPtsPt
Y1888-p	ysPttPkysPtsPty
S1889-p	sPttPkysPtsPtys
T1891-p	ttPkysPtsPtysPt
S1892-p	tPkysPtsPtysPts
T1894-p	kysPtsPtysPtsPV
Y1895-p	ysPtsPtysPtsPVy
S1896-p	sPtsPtysPtsPVyt
T1898-p	tsPtysPtsPVytPt
S1899-p	sPtysPtsPVytPts
Y1902-p	ysPtsPVytPtsPky
T1903-p	sPtsPVytPtsPkys
T1905-p	tsPVytPtsPkysPt
S1906-p	sPVytPtsPkysPts
K1908-u	VytPtsPkysPtsPt
Y1909-p	ytPtsPkysPtsPty
S1910-p	tPtsPkysPtsPtys
T1912-p	tsPkysPtsPtysPt
S1913-p	sPkysPtsPtysPts
T1915-p	kysPtsPtysPtsPk
Y1916-p	ysPtsPtysPtsPky
S1917-p	sPtsPtysPtsPkys
T1919-p	tsPtysPtsPkysPt
S1920-p	sPtysPtsPkysPts
K1922-u	tysPtsPkysPtsPt
Y1923-p	ysPtsPkysPtsPty
S1924-p	sPtsPkysPtsPtys
T1926-p	tsPkysPtsPtysPt
S1927-p	sPkysPtsPtysPts
T1929-p	kysPtsPtysPtsPK
Y1930-p	ysPtsPtysPtsPKG
S1931-p	sPtsPtysPtsPKGS
T1933-p	tsPtysPtsPKGSTY
S1934-p	sPtysPtsPKGSTYS
S1941	sPKGSTYSPTSPGYS
T1950-p	TSPGYSPtsPTYSLT
S1951-p	SPGYSPtsPTYSLTs
S1958-p	sPTYSLTsPAISPDD
S1966-p	PAISPDDsDEEN___

	rat
K32	VLSPDELKRMSVTEG
T37	ELKRMSVTEGGIKYP
K42	SVTEGGIKYPETTEG
T46	GGIKYPETTEGGRPK
T47	GIKYPETTEGGRPKL
S121	CSKLLVDSNNPKIKD
K127	DSNNPKIKDILAKSK
K134	KDILAKSKGQPKKRL
K139	KSKGQPKKRLTHVYD
Y145	KKRLTHVYDLCKGKN
K177	EGDEDLTKEKGHGGC
K179	DEDLTKEKGHGGCGR
K226	ERVHEIFKRISDEEC
S269	PAVVMQGSARNQDDL
K279	NQDDLTHKLADIVKI
K285	HKLADIVKINNQLRR
K285	HKLADIVKINNQLRR
K417	NSQYPGAKYIIRDNG
S530	RMIVTPQSNRPVMGI
T587	LKPRPLWTGKQIFSL
S607	INCIRTHSTHPDDED
T608	NCIRTHSTHPDDEDS
Y618	DDEDSGPYKHISPGD
K619	DEDSGPYKHISPGDT
K643	IMGILCKKSLGTSAG
T698	DSIADSKTYQDIQNT
Y699	SIADSKTYQDIQNTI
K707	QDIQNTIKKAKQDVI
K708	DIQNTIKKAKQDVIE
K710	QNTIKKAKQDVIEVI
K710	QNTIKKAKQDVIEVI
K719	DVIEVIEKAHNNELE
T732	LEPTPGNTLRQTFEN
K751	ILNDARDKTGSSAQK
K758	KTGSSAQKSLSEYNN
Y763	AQKSLSEYNNFKSMV
K767	LSEYNNFKSMVVSGA
S768	SEYNNFKSMVVSGAK
S772	NFKSMVVSGAKGSKI
K775	SMVVSGAKGSKINIS
S777	VVSGAKGSKINISQV
K796	GQQNVEGKRIPFGFK
K812	RTLPHFIKDDYGPES
K853	GLIDTAVKTAETGYI
K866	YIQRRLIKSMESVMV
K874	SMESVMVKYDATVRN
T878	VMVKYDATVRNSINQ
K910	FQNLATLKPSNKAFE
K914	ATLKPSNKAFEKKFR
K918	PSNKAFEKKFRFDYT
K919	SNKAFEKKFRFDYTN
K940	TLQEDLVKDVLSNAH
K976	IFPTGDSKVVLPCNL
K1008	PSDLHPIKVVEGVKE
K1014	IKVVEGVKELSKKLV
K1019	GVKELSKKLVIVNGD
Y1109	MTLNTFHYAGVSAKN
K1125	TLGVPRLKELINISK
K1225	RKHMTDRKLTMEQIA
K1254	FNDDNAEKLVLRIRI
S1264	LRIRIMNSDENKMQE
K1268	IMNSDENKMQEEEEV
K1278	EEEEVVDKMDDDVFL
K1317	HLPQTDNKKKIIITE
K1319	PQTDNKKKIIITEDG
K1350	LMRVLSEKDVDPVRT
Y1383	KALERELYHVISFDG
T1406	ALLCDTMTCRGHLMA
T1415	RGHLMAITRHGVNRQ
T1424	HGVNRQDTGPLMKCS
S1616-p	TPQSPSYsPTsPSYS
T1618	QSPSYsPTsPSYSPT
T1618	QSPSYsPTsPSYSPT
S1619-p	SPSYsPTsPSYSPTS
S1621	SYsPTsPSYSPTSPS
R1810	SYSPSSPRYTPQSPT
Y1811	YSPSSPRYTPQSPTY
T1812	SPSSPRYTPQSPTYT
S1815	SPRYTPQSPTYTPSS
T1817	RYTPQSPTYTPSSPS
T1819	TPQSPTYTPSSPSYS
S1821	QSPTYTPSSPSYSPS
S1822	SPTYTPSSPSYSPSS
S1824	TYTPSSPSYSPSSPS
Y1825	YTPSSPSYSPSSPSY
S1826	TPSSPSYSPSSPSYS
S1828	SSPSYSPSSPSYSPT
S1829	SPSYSPSSPSYSPTS
S1831	SYSPSSPSYSPTSPK
Y1832	YSPSSPSYSPTSPKY
S1833	SPSSPSYSPTSPKYT
T1835	SSPSYSPTSPKYTPT
S1836	SPSYSPTSPKYTPTS
Y1839	YSPTSPKYTPTSPSY
T1840	SPTSPKYTPTSPSYS
T1842	TSPKYTPTSPSYSPS
S1843	SPKYTPTSPSYSPSS
S1845	KYTPTSPSYSPSSPE
Y1846	YTPTSPSYSPSSPEY
S1847	TPTSPSYSPSSPEYT
S1849	TSPSYSPSSPEYTPT
S1850	SPSYSPSSPEYTPTS
Y1853	YSPSSPEYTPTSPKY
T1854	SPSSPEYTPTSPKYS
T1856	SSPEYTPTSPKYSPT
S1857	SPEYTPTSPKYSPTS
K1859	EYTPTSPKYSPTSPK
Y1860	YTPTSPKYSPTSPKY
S1861	TPTSPKYSPTSPKYS
T1863	TSPKYSPTSPKYSPT
S1864	SPKYSPTSPKYSPTS
K1866	KYSPTSPKYSPTSPK
Y1867	YSPTSPKYSPTSPKY
S1868	SPTSPKYSPTSPKYS
T1870	TSPKYSPTSPKYSPT
S1871	SPKYSPTSPKYSPTs
K1873	KYSPTSPKYSPTsPT
Y1874	YSPTSPKYSPTsPTY
S1875	SPTSPKYSPTsPTYS
T1877	TSPKYSPTsPTYSPT
S1878-p	SPKYSPTsPTYSPTt
T1880	KYSPTsPTYSPTtPK
Y1881	YSPTsPTYSPTtPKY
S1882	SPTsPTYSPTtPKYS
T1884	TsPTYSPTtPKYSPT
T1885-p	sPTYSPTtPKYSPTS
K1887	TYSPTtPKYSPTSPT
Y1888	YSPTtPKYSPTSPTY
S1889	SPTtPKYSPTSPTYS
T1891	TtPKYSPTSPTYSPT
S1892	tPKYSPTSPTYSPTS
T1894	KYSPTSPTYSPTSPV
Y1895	YSPTSPTYSPTSPVY
S1896	SPTSPTYSPTSPVYT
T1898	TSPTYSPTSPVYTPT
S1899	SPTYSPTSPVYTPTS
Y1902	YSPTSPVYTPTSPKY
T1903	SPTSPVYTPTSPKYS
T1905	TSPVYTPTSPKYSPt
S1906	SPVYTPTSPKYSPts
K1908	VYTPTSPKYSPtsPT
Y1909	YTPTSPKYSPtsPTY
S1910	TPTSPKYSPtsPTYS
T1912-p	TSPKYSPtsPTYSPT
S1913-p	SPKYSPtsPTYSPTs
T1915	KYSPtsPTYSPTsPK
Y1916	YSPtsPTYSPTsPKY
S1917	SPtsPTYSPTsPKYS
T1919	tsPTYSPTsPKYSPT
S1920-p	sPTYSPTsPKYSPTS
K1922	TYSPTsPKYSPTSPT
Y1923	YSPTsPKYSPTSPTY
S1924	SPTsPKYSPTSPTYS
T1926	TsPKYSPTSPTYSPT
S1927	sPKYSPTSPTYSPTs
T1929	KYSPTSPTYSPTsPK
Y1930	YSPTSPTYSPTsPKG
S1931	SPTSPTYSPTsPKGS
T1933	TSPTYSPTsPKGSTY
S1934-p	SPTYSPTsPKGSTYS
S1941	sPKGSTYSPTSPGYS
T1950	TSPGYSPTSPTYSLT
S1951	SPGYSPTSPTYSLTS
S1958	SPTYSLTSPAISPED
S1966	PAISPEDSDEEN___

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.