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Protein Page:
SPTBN4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPTBN4 Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: spectrin; axon hillock; PML body; nuclear matrix; adherens junction; membrane; cell soma; paranode region of axon; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; spectrin binding; structural constituent of cytoskeleton; phospholipid binding; ankyrin binding; actin binding; phosphatase binding
Biological Process: axon guidance; clustering of voltage-gated sodium channels; negative regulation of heart rate; actin filament capping; cytoskeletal anchoring; regulation of peptidyl-serine phosphorylation; central nervous system projection neuron axonogenesis; transmission of nerve impulse; regulation of sodium ion transport; positive regulation of multicellular organism growth; adult walking behavior; vesicle-mediated transport; fertilization; sensory perception of sound; axonogenesis
Reference #:  Q9H254 (UniProtKB)
Alt. Names/Synonyms: Beta-IV spectrin; betaIV spectrin; KIAA1642; QV; Spectrin beta chain, brain 3; spectrin, beta, non-erythrocytic 4; Spectrin, non-erythroid beta chain 3; SPNB4; SPTBN3; SPTBN4; SPTN4
Gene Symbols: SPTBN4
Molecular weight: 288,985 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below

SPTBN4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S27 NPAARWESPDRGWER
0 1 T41-p REQPAAStAAASLFE
0 2 K69-ub VQKKTFTkWVNSHLA
0 1 S208-p NIQNFTTsWRDGLAF
0 1 K234 VDFSKLTKSNANYNL
0 1 S643 RRAELEASRSLWALL
0 1 K702-ac ARLLAQHkILQGELG
0 1 S1025 GALQWRLSGLEAALQ
0 2 Y1146 VDQREEDYARIVAAS
0 3 S1431-p KKLLHMEsQLQDVDP
0 3 S1454 SQLKKLQSMESQVEE
0 1 S1457 KKLQSMESQVEEWYR
0 1 T1541-p RLPLAMQtERGNGLQ
0 4 S1586 GALASLRSPEAEAVR
0 2 S1752 EKEVVAGSPELGQDF
0 1 T1861-p RRRLPRLtTPPEPRP
0 1 S1869 TPPEPRPSASSMQRT
0 1 S1939-p EDARLHVsSTADALR
0 1 S2007-p TCQELGRsLLLNKSA
0 1 S2079 QSRELGSSVDEVEQL
0 2 T2111-p FSSLRRLttIEKIKA
0 2 T2112-p SSLRRLttIEKIKAE
0 1 K2117 LttIEKIKAEQsKQP
0 2 S2121-p EKIKAEQsKQPPTPL
0 3 S2165 EPLARRASDTLSAEV
0 4 S2254 RRPERQESVDQSEEA
0 2 S2272-p RRPERQEsAEHEAAH
0 7 S2305 RRLERQESSEQEMPI
0 3 S2306 RLERQESSEQEMPIR
0 1 M2310 QESSEQEMPIRGDLV
0 1 S2344-p PGLPAGPsLPQPREL
0 1 S2395 EGGEGGGSRRSRSAP
0 2 S2400 GGSRRSRSAPAQGGS
0 2 S2441 NRKSSNRSWVSLYCV
0 1 T2542 WGQTLPTTSSTDEGN
0 1 S2543 GQTLPTTSSTDEGNP
  mouse

 
S28-p NPSARWEsPDRGWDR
N42 REPPAAANAAASLFE
K70-ub VQKKTFTkWVNSHLA
S209 NIQNFTTSWRDGLAF
K235-ub VDLSKLTkSNANYNL
S644-p RRAELEAsRSLWALL
K698 ARLLAQHKILQGELG
S1021-p GALQWRLsGLEAALQ
Y1142 VDQREEDYARIVAAS
S1427-p KRLLHMEsQLQDVDP
S1450-p SQLKKLQsMEsQVEE
S1453-p KKLQsMEsQVEEWCR
T1537 RLPLAMQTERGTGLQ
S1582-p GVLASLRsPEAEAVR
S1748-p EKEVVAGsPELGQDF
T1857 RRRLPRLTAPPEPRP
S1865-p APPEPRPsASSMQRT
S1935 EDARLHVSSTADALR
S2003 ACQELGRSLLLNKSA
S2075-p QSRELGSsVDEVEQL
T2107 FSSLRRLTTIEKLkA
T2108 SSLRRLTTIEKLkAE
K2113-ac LTTIEKLkAEQSKQP
S2117 EKLkAEQSKQPPTPL
S2161-p EPLARRAsDTLSAEV
S2250-p RRSERQEsVDQPEET
S2268-p RRPERQEsADHEGPH
S2301-p RRIERQEssEQEtPT
S2302-p RIERQEssEQEtPTR
T2306-p QEssEQEtPTRGELV
S2341 GIPAGVPSLPQPREL
S2392-p EGGEGGGsRRSRsAP
S2397-p GGsRRSRsAPAQGGS
S2438-p NRKSSNRsWVSLYCV
T2539-p WGQTLPTtsSTDEGN
S2540-p GQTLPTtsSTDEGNP
  rat

 
S28-p NPAARWEsPDRGWDR
N42 REPPAAANAAASLFE
K70 VQKKTFTKWVNSHLA
S209 NIQNFXTSWRDGLAF
K235 VDLSKLTKSNANYNL
S644 RRAELEASRSLWALL
K698 ARLLAQHKILQGELG
S1021 GALQWRLSGLEAALQ
Y1142-p VDQREEDyARIVAAS
S1427 KRLLHMESQLQDVDP
S1450 SQLKKLQSMESQVEE
S1453 KKLQSMESQVEEWCR
T1537 RLPLAMLTERGTGLQ
S1582 GVLASLRSPEAEAVR
S1748-p EKEVVAGsPELGQDF
T1857 RRRLPRLTAPPEPRP
S1865 APPEPRPSASSMQRT
S1931 TKRFPHVSSPADALR
S1999 ACQELGRSLLLNKSA
S2071 QSRELGSSVDEVEQL
T2103 FSSLRRLTTIEKLKA
T2104 SSLRRLTTIEKLKAE
K2109 LTTIEKLKAEQSKQP
S2113 EKLKAEQSKQPPTPL
S2157 EPLARRASDTLSAEV
S2246-p RRSERQEsTDQPEEA
S2264-p RRPERQEsADHEGPH
S2297-p RRIERQEssEQETPT
S2298-p RIERQEssEQETPTR
T2302 QEssEQETPTRGELV
S2337 GLPAAVPSLPQPREL
S2388 EGGEGGGSRRSRSAP
S2393 GGSRRSRSAPAQGGS
S2434 NRKSSNRSWVNLYCV
T2535 WGQTLPTTSSTDEGN
S2536 GQTLPTTSSTDEGNP
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