a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric (Rho); Motility/polarity/chemotaxis
Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding; myosin binding
Biological Process: axon guidance; positive regulation of cell adhesion; positive regulation of translation; nerve growth factor receptor signaling pathway; cell-matrix adhesion; response to glucocorticoid stimulus; regulation of dendrite development; positive regulation of caspase activity; positive regulation of NF-kappaB import into nucleus; regulation of axonogenesis; regulation of cell migration; Rho protein signal transduction; regulation of osteoblast proliferation; positive regulation of neuron apoptosis; transforming growth factor beta receptor signaling pathway; small GTPase mediated signal transduction; positive regulation of stress fiber formation; response to glucose stimulus; stress-activated protein kinase signaling pathway; negative regulation of axonogenesis; negative regulation of neuron apoptosis; response to drug; positive regulation of cytokinesis; platelet activation; negative regulation of steroid hormone receptor signaling pathway; skeletal muscle development; positive regulation of I-kappaB kinase/NF-kappaB cascade; apical junction assembly; phosphoinositide-mediated signaling; regulation of calcium ion transport; negative regulation of I-kappaB kinase/NF-kappaB cascade; response to amino acid stimulus; positive regulation of cell growth; regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; regulation of small GTPase mediated signal transduction; response to ethanol; positive regulation of actin filament polymerization; response to mechanical stimulus; virus-host interaction; androgen receptor signaling pathway; positive regulation of vasoconstriction; response to hypoxia; stress fiber formation; positive regulation of axonogenesis; positive regulation of neuron differentiation; blood coagulation; actin cytoskeleton organization and biogenesis; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.