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RhoA (human)

Overview RhoA a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB. Protein type: G protein; G protein, monomeric (Rho); Motility/polarity/chemotaxis Cellular Component: apical junction complex; cytoskeleton; mitochondrion; lamellipodium; plasma membrane; cell cortex; midbody; cytosol; cell junction; nucleus; cleavage furrow Molecular Function: GTPase activity; protein binding; GTP binding; myosin binding Biological Process: axon guidance; nerve growth factor receptor signaling pathway; cell-matrix adhesion; positive regulation of NF-kappaB import into nucleus; regulation of axonogenesis; regulation of cell migration; Rho protein signal transduction; regulation of osteoblast proliferation; small GTPase mediated signal transduction; transforming growth factor beta receptor signaling pathway; positive regulation of stress fiber formation; negative regulation of axonogenesis; negative regulation of neuron apoptosis; platelet activation; skeletal muscle development; negative regulation of steroid hormone receptor signaling pathway; phosphoinositide-mediated signaling; apical junction assembly; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription from RNA polymerase II promoter; regulation of small GTPase mediated signal transduction; virus-host interaction; androgen receptor signaling pathway; stress fiber formation; positive regulation of axonogenesis; positive regulation of neuron differentiation; actin cytoskeleton organization and biogenesis; blood coagulation Reference #:  P61586 (UniProtKB) Alt. Names/Synonyms: Aplysia ras-related homolog 12; ARH12; ARHA; h12; oncogene RHO H12; ras homolog gene family, member A; Rho cDNA clone 12; RHO12; RHOA; RHOH12; small GTP binding protein RhoA; Transforming protein RhoA Gene Symbols: RHOA Molecular weight: 21,768 Da Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RhoA 1A2B - A=1-181 (human) 1CC0 - A/C=1-190 (human) 1CXZ - A=1-181 (human) 1DPF - A=1-180 (human) 1FTN - A=1-193 (human) 1KMQ - A=4-181 (human) 1LB1 - B/D/F/H=1-189 (human) 1OW3 - B=1-193 (human) 1S1C - A/B=1-181 (human) 1TX4 - B=3-179 (human) 1X86 - B/D/F/H=1-193 (human) 1XCG - B/F=3-180 (human) 2RGN - F/C=1-193 (human) 3KZ1 - F/E=1-181 (human) 3LW8 - A/D/C/B=2-181 (human) 3LWN - A/B=2-181 (human) 3LXR - A=2-181 (human) 3MSX - A=1-180 (human) 3T06 - F/B=3-180 (human) 3TVD - A/B=1-193 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell motility, induced: S188‑p cytoskeletal reorganization: S188‑p inhibition: S188‑p intracellular localization: S188‑p molecular association, regulation: S188‑p protein stabilization: S188‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	13		Y34-p	KDQFPEVyVPTVFEN
1	0		Y34-ad	KDQFPEVyVPTVFEN
0	8		Y66-p	DTAGQEDyDRLRPLS
0	3		K104-u	EKWTPEVkHFCPNVP
0	5		K118-u	PIILVGNkkDLRNDE
0	3		K119-u	IILVGNkkDLRNDEH
0	1		K133-u	HTRRELAkMkQEPVk
0	101		K135-u	RRELAkMkQEPVkPE
0	2		K140-u	kMkQEPVkPEEGRDM
0	26		Y156-p	NRIGAFGyMECSAKT
0	1		K162	GyMECSAKTkDGVRE
0	1		K164-u	MECSAKTkDGVREVF
0	1		-	gap
0	1		-	gap
9	0		S188-p	ARRGKKKsGCLVL__

	RhoA iso3
Y34	KDQFPEVYVPTVFEN
Y34	KDQFPEVYVPTVFEN
Y66	DTAGQEDYDRLRPLS
K104	EKWTPEVKHFCPNVP
K118	PIILVGNKKDLRNDE
K119	IILVGNKKDLRNDEH
K133	HTRRELAKMKQEPHC
K135	RRELAKMKQEPHCVA
-	gap
-	gap
-	under review
-	gap
S168-p	FKRFPCLsLLSsWGY
S172-p	PCLsLLSsWGYRRPL
-	gap

	mouse
Y34	KDQFPEVYVPTVFEN
Y34	KDQFPEVYVPTVFEN
Y66	DTAGQEDYDRLRPLS
K104-u	EKWTPEVkHFCPNVP
K118-u	PIILVGNkkDLRNDE
K119-u	IILVGNkkDLRNDEH
K133	HTRRELAKMkQEPVK
K135-u	RRELAKMkQEPVKPE
K140	KMkQEPVKPEEGRDM
Y156-p	NRIGAFGyMECSAkT
K162-u	GyMECSAkTKDGVRE
K164	MECSAkTKDGVREVF
-	gap
-	gap
S188-p	ARRGKKKsGCLIL__

	rat
Y34	KDQFPEVYVPTVFEN
Y34	KDQFPEVYVPTVFEN
Y66	DTAGQEDYDRLRPLS
K104	EKWTPEVKHFCPNVP
K118	PIILVGNKKDLRNDE
K119	IILVGNKKDLRNDEH
K133	HTRRELAKMkQEPVK
K135-u	RRELAKMkQEPVKPE
K140	KMkQEPVKPEEGRDM
Y156-p	NRIGAFGyMECSAKT
K162	GyMECSAKTKDGVRE
K164	MECSAKTKDGVREVF
-	gap
-	gap
S188	ARRGKKKSGCLIL__

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