Home

radixin (human)

Overview radixin a cytoskeletal protein of the ERM family which includes ezrin and moiesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. May play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: ruffle; stereocilium; extrinsic to membrane; focal adhesion; cytoskeleton; apical part of cell; lamellipodium; cytoplasm; plasma membrane; cleavage furrow; filopodium Molecular Function: protein binding; actin binding Biological Process: microvillus biogenesis; apical protein localization; actin filament capping Reference #:  P35241 (UniProtKB) Alt. Names/Synonyms: DFNB24; RADI; Radixin; RDX Gene Symbols: RDX Molecular weight: 68,564 Da Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below radixin 1GC6 - A=1-297 (mouse) 1GC7 - A=1-297 (mouse) 1J19 - A=1-310 (mouse) 2D10 - A/B/C/D=1-310 (mouse) 2D11 - A/B/C/D=1-310 (mouse) 2D2Q - A/B=1-310 (mouse) 2EMS - A=1-310 (mouse) 2EMT - A/B=1-310 (mouse) 2YVC - A/B/C=1-310 (mouse) 2ZPY - A=1-310 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 179410 611022  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K3-u	_____MPkPINVRVT
0	2		K35-u	QLFDQVVkTVGLREV
0	7		Y55-p	QYVDSKGySTWLKLN
0	3		T66-p	LKLNKKVtQQDVKkE
0	2		K72-u	VtQQDVKkENPLQFk
0	4		K79-a	kENPLQFkFRAkFFP
0	39		K79-u	kENPLQFkFRAkFFP
0	3		K83-u	LQFkFRAkFFPEDVS
0	1		Y128-p	TAVLLASyAVQAKyG
0	5		Y134-p	SyAVQAKyGDyNkEI
0	1		Y137-p	VQAKyGDyNkEIHKP
0	2		K139-u	AKyGDyNkEIHKPGY
0	1		K143	DyNkEIHKPGYLAND
0	25		K162-u	QRVLEQHkLTKEQWE
0	1		K165	LEQHkLTKEQWEERI
0	5		K209-u	GVNYFEIkNkKGTEL
0	1		K211-u	NYFEIkNkKGTELWL
0	7		K237-u	HDDKLTPkIGFPWSE
0	27		K253-a	RNISFNDkKFVIKPI
0	3		K253-u	RNISFNDkKFVIKPI
0	1		K254	NISFNDkKFVIKPID
0	7		K263-u	VIKPIDKkAPDFVFy
0	207		Y270-p	kAPDFVFyAPRLRIN
0	14		Y291-p	CMGNHELyMRRRKPD
0	3		K306-u	TIEVQQMkAQAREEK
0	1		K335-u	KKREIAEkEKERIER
0	2		K352-u	EELMERLkQIEEQTI
0	2		K360-u	QIEEQTIkAQKELEE
0	1		K363	EQTIkAQKELEEQtR
0	1		T369-p	QKELEEQtRKALELD
0	1		K400	RRAAEEAKSAIAKQA
0	1		K405	EAKSAIAKQAADQMK
0	1		K427-u	ELAEFTAkIALLEEA
0	1		K435	IALLEEAKKKKEEEA
0	1		K448	EATEWQHKAFAAQED
0	1		K458	AAQEDLEKTKEELKT
0	1		K520	ERVTETQKNERVKkQ
0	7		K526-u	QKNERVKkQLQALSs
0	1		S533-p	kQLQALSsELAQARD
0	1		K543	AQARDETKKtQNDVL
0	1		K544	QARDETKKtQNDVLH
0	2		T545-p	ARDETKKtQNDVLHA
0	1		K556-a	VLHAENVkAGRDKyK
0	2		K556-u	VLHAENVkAGRDKyK
0	3		Y562-p	VkAGRDKyKtLRQIR
14	16		T564-p	AGRDKyKtLRQIRQG

	mouse
K3-u	_____MPkPINVRVT
K35-u	QLFDQVVkTVGLREV
Y55-p	QYVDSKGySTWLKLN
T66-p	LKLNKKVtQQDVKkE
K72-u	VtQQDVKkENPLQFk
K79	kENPLQFKFRAkFFP
K79-u	kENPLQFkFRAkFFP
K83-u	LQFkFRAkFFPEDVS
Y128	TAVLLASYAVQAKYG
Y134	SYAVQAKYGDYNkEI
Y137	VQAKYGDYNkEIHkP
K139-u	AKYGDYNkEIHkPGY
K143-u	DYNkEIHkPGYLAND
K162-u	QRVLEQHkLTkEQWE
K165-u	LEQHkLTkEQWEERI
K209-u	GVNYFEIkNkKGTEL
K211-u	NYFEIkNkKGTELWL
K237-u	HDDKLTPkIGFPWSE
K253-a	RNISFNDkkFVIKPI
K253-u	RNISFNDkkFVIKPI
K254-a	NISFNDkkFVIKPID
K263-u	VIKPIDKkAPDFVFy
Y270-p	kAPDFVFyAPRLRIN
Y291-p	CMGNHELyMRRRKPD
K306-u	TIEVQQMkAQAREEK
K335	KKREIAEKEKERIER
R352	EELMERLRQIEEQTV
K360-u	QIEEQTVkAQkELEE
K363-u	EQTVkAQkELEEQTR
T369	QkELEEQTRKALELE
K400-u	RRAAEEAkSAIAkQA
K405-u	EAkSAIAkQAADQMK
K427	ELAEFTAKIALLEEA
K435-u	IALLEEAkKKKEEEA
K448-u	EATEWQHkAFAAQED
K458-u	AAQEDLEkTKEELKT
K520-u	ERVTETQkNERVKkQ
K526-u	QkNERVKkQLQALSS
S533	kQLQALSSELAQARD
K543-u	AQARDETkkTQNDVL
K544-u	QARDETkkTQNDVLH
T545	ARDETkkTQNDVLHA
K556	VLHAENVKAGRDKyK
K556-u	VLHAENVkAGRDKyK
Y562-p	VkAGRDKyKtLRQIR
T564-p	AGRDKyKtLRQIRQG

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.