Home

IFITM3 (mouse)

Overview IFITM3 IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Interacts with SPP1; the interaction reduces OPN expression. By IFN-alpha and IFNG/IFN-gamma. Belongs to the CD225/Dispanin family. Note: This description may include information from UniProtKB. Protein type: Cell surface; Membrane protein, integral Cellular Component: membrane; endoplasmic reticulum; lysosome; cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane; endosome Biological Process: negative regulation of cell proliferation; negative regulation of virion penetration into host cell; response to biotic stimulus; response to virus; innate immune response; defense response to virus Reference #:  Q9CQW9 (UniProtKB) Alt. Names/Synonyms: 1110004C05Rik; Cd225; Cdw217; Fgls; Fragilis; Ifitm3; Interferon induced transmembrane protein 3; Interferon-inducible protein 15; IP15; MCG22590; mil-1; Putative uncharacterized protein Gene Symbols: Ifitm3 Molecular weight: 14,954 Da Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IFITM3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		T10	HTSQAFITAASGGQP
0	23		Y20-p	SGGQPPNyERIkEEy
0	13		K24-u	PPNyERIkEEyEVAE
0	143		Y27-p	yERIkEEyEVAEMGA
0	1		S38-p	EMGAPHGsASVRTTV
0	1		V52	VINMPREVSVPDHVV
0	5		K88-u	SVKSRDRkMVGDVTG
0	4		Y99-p	DVTGAQAyASTAKCL

	human
S10-p	HTVQTFFsPVNSGQP
Y20-p	NSGQPPNyEMLkEEH
K24-u	PPNyEMLkEEHEVAV
H27	yEMLkEEHEVAVLGA
P38	VLGAPHNPAPPTSTV
T52-p	VIHIRSEtSVPDHVV
K88-u	SVKSRDRkMVGDVTG
Y99-p	DVTGAQAyASTAKCL

	rat
N10	HTSQAFVNAATGGQP
Y20	TGGQPPNYERIKEEy
K24	PPNYERIKEEyEVSE
Y27-p	YERIKEEyEVSELGA
S38	ELGAPHGSASVRTTV
V52	VINMPREVSVPDHVV
K88	SVKSRDRKMVGDMTG
Y99	DMTGAQAYASTAKCL

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.