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Protein Page:
NRP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NRP2 High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Heterodimer with NRP1. Binds PLXNB1. Belongs to the neuropilin family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Cellular Component: membrane; axon; integral to membrane; extracellular region; plasma membrane
Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; semaphorin receptor activity; growth factor binding; cytokine binding; metal ion binding; receptor activity
Biological Process: axon extension involved in axon guidance; axon guidance; heart development; negative chemotaxis; nerve development; positive regulation of endothelial cell proliferation; angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell adhesion; neural crest cell migration
Reference #:  O60462 (UniProtKB)
Alt. Names/Synonyms: MGC126574; neuropilin 2; Neuropilin-2; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); NP2; NPN2; NRP2; PRO2714; receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; vascular endothelial growth factor-165 receptor 2; VEGF165R2
Gene Symbols: NRP2
Molecular weight: 104,859 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Select Structure to View Below

NRP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T319-p HGDDNGWtPNLDSNK
0 1 S454 DSQISASSTQEYLWS
0 1 T595-ga EVLGCDWtDSKPtVE
0 1 T600-ga DWtDSKPtVEtLGPt
0 1 T603-ga DSKPtVEtLGPtVKS
0 1 T607-ga tVEtLGPtVKSEETT
0 1 S672-ga LRTTWASsSSPNDRT
0 1 - gap
  NRP2 iso5  
T319 HGDDNGWTPNLDSNK
S454 DSQISASSTQEYLWS
T595 EVLGCDWTDSKPTVE
T600 DWTDSKPTVETLGPT
T603 DSKPTVETLGPTVKS
T607 TVETLGPTVKSEETT
S672 LRTTWASSSSPNDRT
Y882-p ITYKTSHyTNGAPLA
  mouse

► Hide Isoforms
 
T319 HGDDNGWTPNLDSNK
S454-p DTQISASsTREYLWS
T595 EVLGCDWTDSKPTVE
T600 DWTDSKPTVETLGPT
T603 DSKPTVETLGPTVKS
T607 TVETLGPTVKSEETT
S672 LRSTWISSANPNDRT
- gap
  NRP2 iso5  
T319 HGDDNGWTPNLDSNK
S454 DTQISASSTREYLWS
T595 EVLGCDWTDSKPTVE
T600 DWTDSKPTVETLGPT
T603 DSKPTVETLGPTVKS
T607 TVETLGPTVKSEETT
S672 LRSTWISSANPNDRT
Y877 ITYKTSHYTNGAPLA
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