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NRP2 (human)

Overview NRP2 High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Heterodimer with NRP1. Binds PLXNB1. Belongs to the neuropilin family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis Cellular Component: membrane; axon; plasma membrane; integral to membrane Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; semaphorin receptor activity; growth factor binding; metal ion binding; cytokine binding; receptor activity Biological Process: axon guidance; heart development; negative chemotaxis; positive regulation of endothelial cell proliferation; angiogenesis; cell adhesion; vascular endothelial growth factor receptor signaling pathway; neural crest cell migration Reference #:  O60462 (UniProtKB) Alt. Names/Synonyms: MGC126574; neuropilin 2; Neuropilin-2; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); NP2; NPN2; NRP2; PRO2714; receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; vascular endothelial growth factor-165 receptor 2; VEGF165R2 Gene Symbols: NRP2 Molecular weight: 104,859 Da Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states

Select Structure to View Below NRP2 2QQJ - A=275-595 (human) 2QQK - A=23-595 (human) 2QQL - A=23-595 (human) 2QQO - A/B=145-595 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2QQJ 2QQK 2QQL 2QQO  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S454	DSQISASSTQEYLWS
0	1		-	gap

	NRP2 iso5
S454	DSQISASSTQEYLWS
Y882-p	ITYKTSHyTNGAPLA

	mouse ► Hide Isoforms
S454-p	DTQISASsTREYLWS
-	gap

	NRP2 iso5
S454	DTQISASSTREYLWS
Y877	ITYKTSHYTNGAPLA

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