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Protein Page:
Rab11A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rab11A Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP- dependent manner. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rab; G protein, monomeric
Cellular Component: cytoplasmic vesicle membrane; protein complex; mitochondrion; recycling endosome membrane; trans-Golgi network; phagocytic vesicle; recycling endosome; phagocytic vesicle membrane; transport vesicle; perinuclear region of cytoplasm; axon; plasma membrane; cleavage furrow
Molecular Function: GTPase activity; protein binding; GTP binding; syntaxin binding
Biological Process: regulation of long-term neuronal synaptic plasticity; vesicle-mediated transport; regulation of protein transport; protein transport; GTP catabolic process; water transport; positive regulation of axon extension; small GTPase mediated signal transduction; cytokinesis; plasma membrane to endosome transport; melanosome transport; transmembrane transport; neurite development
Reference #:  P62491 (UniProtKB)
Alt. Names/Synonyms: MGC1490; RAB 11A, member oncogene family; Rab-11; RAB11; RAB11A; RAB11A, member RAS oncogene family; Ras-related protein Rab-11A; RB11A; YL8
Gene Symbols: RAB11A
Molecular weight: 24,394 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rab11A

Protein Structure Not Found.


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Sites Implicated In
endocytosis, inhibited: S177‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 69 Y8-p MGTRDDEyDYLFKVV
0 2 K24-ub IGDSGVGkSNLLSRF
0 8 S42-p EFNLESKstIGVEFA
0 3 T43-p FNLESKstIGVEFAT
0 115 Y73-p DTAGQERyRAITsAY
0 5 S78-p ERyRAITsAYYRGAV
0 1 S115-p ELRDHADsNIVIMLV
0 5 K145-ub EARAFAEkNGLSFIE
0 1 T167 NVEAAFQTILTEIYR
0 1 T170 AAFQTILTEIYRIVs
0 1 Y173 QTILTEIYRIVsQkQ
1 0 S177-p TEIYRIVsQkQMSDR
0 4 K179-ub IYRIVsQkQMSDRRE
0 2 S190-p DRRENDMsPSNNVVP
0 1 K207-ub VPPTTENkPKVQCCQ
  mouse

 
Y8-p MGTRDDEyDYLFKVV
K24-ub IGDSGVGkSNLLSRF
S42-p EFNLESKstIGVEFA
T43-p FNLESKstIGVEFAT
Y73 DTAGQERYRAITsAY
S78-p ERYRAITsAYYRGAV
S115-p ELRDHADsNIVIMLV
K145-ub EARAFAEkNGLSFIE
T167-p NVEAAFQtILtEIyR
T170-p AAFQtILtEIyRIVS
Y173-p QtILtEIyRIVSQkQ
S177 tEIyRIVSQkQMSDR
K179-ub IyRIVSQkQMSDRRE
S190-p DRRENDMsPSNNVVP
K207 VPPTTENKPKVQCCQ
  rat

 
Y8 MGTRDDEYDYLFKVV
K24 IGDSGVGKSNLLSRF
S42 EFNLESKSTIGVEFA
T43 FNLESKSTIGVEFAT
Y73 DTAGQERYRAITsAY
S78-p ERYRAITsAYYRGAV
S115 ELRDHADSNIVIMLV
K145 EARAFAEKNGLSFIE
T167 NVEAAFQTILTEIYR
T170 AAFQTILTEIYRIVS
Y173 QTILTEIYRIVSQKQ
S177 TEIYRIVSQKQMSDR
K179 IYRIVSQKQMSDRRE
S190 DRRENDMSPSNNVVP
K207 VPPTTENKPKVQCCQ
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