Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP- dependent manner. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric, Rab; Motility/polarity/chemotaxis; G protein, monomeric
Cellular Component: cytoplasmic vesicle membrane; protein complex; mitochondrion; recycling endosome membrane; phagocytic vesicle; trans-Golgi network; recycling endosome; phagocytic vesicle membrane; transport vesicle; perinuclear region of cytoplasm; axon; plasma membrane; cleavage furrow
Molecular Function: GTPase activity; protein binding; GTP binding; syntaxin binding
Biological Process: vesicle-mediated transport; regulation of long-term neuronal synaptic plasticity; regulation of protein transport; protein transport; water transport; small GTPase mediated signal transduction; positive regulation of axon extension; cytokinesis; plasma membrane to endosome transport; melanosome transport; transmembrane transport; neurite development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.