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Rab11A (human)

Overview Rab11A Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP- dependent manner. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB. Protein type: G protein, monomeric (Rab); G protein; Motility/polarity/chemotaxis Cellular Component: transport vesicle; protein complex; cytoplasmic vesicle membrane; mitochondrion; recycling endosome membrane; plasma membrane; trans-Golgi network; cleavage furrow Molecular Function: GTPase activity; protein binding; GTP binding; syntaxin binding Biological Process: regulation of long-term neuronal synaptic plasticity; regulation of protein transport; vesicle-mediated transport; protein transport; GTP catabolic process; water transport; small GTPase mediated signal transduction; cytokinesis; plasma membrane to endosome transport; cell cycle; transmembrane transport; neurite development Reference #:  P62491 (UniProtKB) Alt. Names/Synonyms: MGC1490; RAB 11A, member oncogene family; Rab-11; RAB11; RAB11A; RAB11A, member RAS oncogene family; Ras-related protein Rab-11A; RB11A; YL8 Gene Symbols: RAB11A Molecular weight: 24,394 Da Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rab11A 1OIV - A/B=1-173 (human) 1OIW - A=1-173 (human) 1OIX - A=1-173 (human) 1YZK - A=8-175 (human) 2D7C - A/B=7-173 (human) 2GZD - A/B=1-173 (human) 2GZH - A=1-173 (human) 2HV8 - A/B/C=6-175 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
endocytosis, inhibited: S177‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	67		Y8-p	MGTRDDEyDYLFKVV
0	2		K24-u	IGDSGVGkSNLLSRF
0	7		S42-p	EFNLESKstIGVEFA
0	3		T43-p	FNLESKstIGVEFAt
0	1		T50-p	tIGVEFAtRSIQVDG
0	128		Y73-p	DTAGQERyRAITsAY
0	3		S78-p	ERyRAITsAYYRGAV
0	1		S115-p	ELRDHADsNIVIMLV
0	5		K145-u	EARAFAEkNGLSFIE
0	1		T167	NVEAAFQTILTEIYR
0	1		T170	AAFQTILTEIYRIVs
0	1		Y173	QTILTEIYRIVsQkQ
1	0		S177-p	TEIYRIVsQkQMSDR
0	4		K179-u	IYRIVsQkQMSDRRE
0	1		S190	DRRENDMSPSNNVVP
0	1		K207-u	VPPTTENkPKVQCCQ

	mouse
Y8-p	MGTRDDEyDYLFKVV
K24-u	IGDSGVGkSNLLSRF
S42-p	EFNLESKstIGVEFA
T43-p	FNLESKstIGVEFAT
T50	tIGVEFATRSIQVDG
Y73	DTAGQERYRAITsAY
S78-p	ERYRAITsAYYRGAV
S115-p	ELRDHADsNIVIMLV
K145-u	EARAFAEkNGLSFIE
T167-p	NVEAAFQtILtEIyR
T170-p	AAFQtILtEIyRIVS
Y173-p	QtILtEIyRIVSQkQ
S177	tEIyRIVSQkQMSDR
K179-u	IyRIVSQkQMSDRRE
S190-p	DRRENDMsPSNNVVP
K207	VPPTTENKPKVQCCQ

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