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Protein Page:
PTEN (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PTEN a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.67; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Tumor suppressor; Phosphatase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.48; EC 3.1.3.16
Cellular Component: postsynaptic membrane; PML body; internal side of plasma membrane; neuron projection; cell projection; mitochondrion; cytoplasm; dendritic spine; plasma membrane; nucleolus; nucleus; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; platelet-derived growth factor receptor binding; magnesium ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity; protein kinase binding; PDZ domain binding; protein binding; enzyme binding; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; lipid binding
Biological Process: central nervous system development; male mating behavior; prepulse inhibition; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; regulation of cellular component size; heart development; response to arsenic; anaphase-promoting complex activation during mitotic cell cycle; Wnt receptor signaling pathway through beta-catenin; T cell receptor signaling pathway; regulation of B cell apoptosis; myelin maintenance in the central nervous system; response to glucose stimulus; negative regulation of axonogenesis; response to drug; rhythmic synaptic transmission; fibroblast growth factor receptor signaling pathway; dentate gyrus development; negative regulation of myelination; social behavior; negative regulation of organ growth; forebrain morphogenesis; response to ethanol; response to zinc ion; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; endothelial cell migration; positive regulation of transcription factor activity; multicellular organismal response to stress; negative regulation of apoptosis; negative regulation of phagocytosis; synapse maturation; inositol phosphate metabolic process; apoptosis; regulation of protein stability; platelet-derived growth factor receptor signaling pathway; locomotory behavior; negative regulation of cell size; protein amino acid dephosphorylation; regulation of myeloid cell apoptosis; response to estradiol stimulus; negative regulation of cell proliferation; locomotor rhythm; synaptogenesis; learning and/or memory; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; positive regulation of cell proliferation; brain morphogenesis; protein kinase B signaling cascade; nerve-nerve synaptic transmission; angiogenesis; negative regulation of cell migration; response to nutrient; negative regulation of epithelial cell proliferation; aging; epidermal growth factor receptor signaling pathway; cardiac muscle development; cell migration; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; central nervous system neuron axonogenesis; protein stabilization; maternal behavior; negative regulation of focal adhesion formation; response to ATP; memory; cell proliferation; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; innate immune response; phosphoinositide dephosphorylation; regulation of cyclin-dependent protein kinase activity; negative regulation of phosphoinositide 3-kinase cascade
Reference #:  P60484 (UniProtKB)
Alt. Names/Synonyms: 10q23del; BZS; DEC; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTEN; PTEN1; TEP1
Gene Symbols: PTEN
Molecular weight: 47,166 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTEN

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: S380‑p, T382‑p, T383‑p
cell growth, altered: Y240‑p, Y315‑p
cell motility, altered: S229‑p, T232‑p, S380‑p, T382‑p, T383‑p
transcription, altered: S380‑p, T382‑p, T383‑p
activity, inhibited: T366‑p
enzymatic activity, induced: Y240‑p, Y315‑p
enzymatic activity, inhibited: S370‑p, S380‑p, T382‑p, T383‑p, S385‑p
intracellular localization: K254‑s, T366‑p, S370‑p
molecular association, regulation: Y155‑p, Y336‑p, T366‑p, S370‑p, T382‑p, T383‑p, T401‑p
protein stabilization: Y155‑p, Y336‑p, S370‑p, S380‑p, T382‑p, T383‑p, S385‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K6-a __MTAIIkEIVSRNk
2 0 K13-u kEIVSRNkRRYQEDG
0 44 Y46-p AERLEGVyRNNIDDV
0 1 K66 SKHKNHYKIyNLCAE
1 1 Y68-p HKNHYKIyNLCAERH
0 1 K80 ERHYDTAKFNCRVAQ
1 0 K125-a HVAAIHCkAGkGRTG
1 0 K128-a AIHCkAGkGRTGVMI
2 0 Y138-p TGVMICAyLLHRGKF
1 0 Y155-p AQEALDFyGEVRTRD
0 13 Y174-p TIPSQRRyVyyysyL
0 12 Y176-p PSQRRyVyyysyLLK
0 12 Y177-p SQRRyVyyysyLLKN
0 12 Y178-p QRRyVyyysyLLKNH
0 3 S179-p RRyVyyysyLLKNHL
0 3 Y180-p RyVyyysyLLKNHLD
1 2 S229-p VKIYSSNsGPtRRED
1 2 T232-p YSSNsGPtRREDKFM
2 0 Y240-p RREDKFMyFEFPQPL
2 0 K254-s LPVCGDIkVEFFHKQ
2 0 K266-s HKQNKMLkKDKMFHF
1 0 K289-s GPEETSEkVENGsLC
3 0 K289-u GPEETSEkVENGsLC
0 2 S294-p SEkVENGsLCDQEID
2 0 Y315-p RADNDKEyLVLTLTK
1 0 Y336-p NKDKANRyFSPNFKV
1 0 S362-p SNPEASSsTSVtPDV
4 1 T366-p ASSsTSVtPDVsDNE
9 2 S370-p TSVtPDVsDNEPDHY
23 0 S380-p EPDHYRYsDttDsDP
12 1 T382-p DHYRYsDttDsDPEN
13 1 T383-p HYRYsDttDsDPENE
7 6 S385-p RYsDttDsDPENEPF
1 0 T398-p PFDEDQHtQItkV__
1 0 T401-p EDQHtQItkV_____
1 0 K402-a DQHtQItkV______
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9551 : Phospho-PTEN (Ser380) Antibody
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
  mouse

 
K6 __MTAIIKEIVSRNK
K13 KEIVSRNKRRYQEDG
Y46-p AERLEGVyRNNIDDV
K66-u SKHKNHYkIYNLCAE
Y68 HKNHYkIYNLCAERH
K80-u ERHYDTAkFNCRVAQ
K125 HVAAIHCKAGKGRTG
K128 AIHCKAGKGRTGVMI
Y138 TGVMICAYLLHRGKF
Y155 AQEALDFYGEVRTRD
Y174-p TIPSQRRyVyyySYL
Y176-p PSQRRyVyyySYLLK
Y177-p SQRRyVyyySYLLKN
Y178-p QRRyVyyySYLLKNH
S179 RRyVyyySYLLKNHL
Y180 RyVyyySYLLKNHLD
S229 VKIYSSNSGPTRRED
T232 YSSNSGPTRREDKFM
Y240 RREDKFMYFEFPQPL
K254 LPVCGDIKVEFFHKQ
K266 HKQNKMLKKDKMFHF
K289 GPEETSEKVENGsLC
K289 GPEETSEKVENGsLC
S294-p SEKVENGsLCDQEID
Y315 RADNDKEYLVLTLTK
Y336 NKDKANRYFSPNFKV
S362 SNPEASSSTSVtPDV
T366-p ASSSTSVtPDVsDNE
S370-p TSVtPDVsDNEPDHY
S380-p EPDHYRYsDttDsDP
T382-p DHYRYsDttDsDPEN
T383-p HYRYsDttDsDPENE
S385-p RYsDttDsDPENEPF
S398-p PFDEDQHsQItKV__
T401-p EDQHsQItKV_____
K402 DQHsQItKV______
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9551 : Phospho-PTEN (Ser380) Antibody
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
  rat

 
K6 __MTAIIKEIVSRNK
K13 KEIVSRNKRRYQEDG
Y46 AERLEGVYRNNIDDV
K66 SKHKNHYKIyNLCAE
Y68-p HKNHYKIyNLCAERH
K80 ERHYDTAKFNCRVAQ
K125 HVAAIHCKAGKGRTG
K128 AIHCKAGKGRTGVMI
Y138 TGVMICAYLLHRGKF
Y155 AQEALDFYGEVRTRD
Y174 TIPSQRRYVYYYSYL
Y176 PSQRRYVYYYSYLLK
Y177 SQRRYVYYYSYLLKN
Y178 QRRYVYYYSYLLKNH
S179 RRYVYYYSYLLKNHL
Y180 RYVYYYSYLLKNHLD
S229 VKIYSSNSGPTRRED
T232 YSSNSGPTRREDKLM
Y240 RREDKLMYFEFPQPL
K254 LPVCGDIKVEFFHKQ
K266 HKQNKMLKKDKMFHF
K289 GPEETSEKVENGSLC
K289 GPEETSEKVENGSLC
S294 SEKVENGSLCDQEID
Y315 RADNDKEYLVLTLTK
Y336 NKDKANRYFSPNFKV
S362 SNPEASSSTSVTPDV
T366 ASSSTSVTPDVSDNE
S370 TSVTPDVSDNEPDHY
S380-p EPDHYRYsDTTDSDP
T382 DHYRYsDTTDSDPEN
T383 HYRYsDTTDSDPENE
S385 RYsDTTDSDPENEPF
S398 PFDEDQHSQITKV__
T401 EDQHSQITKV_____
K402 DQHSQITKV______
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