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Protein Page:
PTEN (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTEN a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; EC 3.1.3.16; Motility/polarity/chemotaxis; Phosphatase, lipid; EC 3.1.3.48; Carbohydrate Metabolism - inositol phosphate; Tumor suppressor; EC 3.1.3.67
Cellular Component: postsynaptic membrane; PML body; internal side of plasma membrane; neuron projection; cell projection; mitochondrion; cytoplasm; plasma membrane; dendritic spine; nucleolus; nucleus; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; magnesium ion binding; platelet-derived growth factor receptor binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity; protein kinase binding; PDZ domain binding; protein binding; enzyme binding; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; lipid binding; phosphoprotein phosphatase activity
Biological Process: male mating behavior; central nervous system development; nerve growth factor receptor signaling pathway; prepulse inhibition; positive regulation of apoptosis; regulation of cellular component size; response to arsenic; heart development; anaphase-promoting complex activation during mitotic cell cycle; Wnt receptor signaling pathway through beta-catenin; T cell receptor signaling pathway; regulation of B cell apoptosis; myelin maintenance in the central nervous system; response to glucose stimulus; negative regulation of axonogenesis; response to drug; rhythmic synaptic transmission; fibroblast growth factor receptor signaling pathway; dentate gyrus development; negative regulation of myelination; social behavior; negative regulation of organ growth; forebrain morphogenesis; response to ethanol; response to zinc ion; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; endothelial cell migration; positive regulation of transcription factor activity; multicellular organismal response to stress; negative regulation of apoptosis; negative regulation of phagocytosis; synapse maturation; inositol phosphate metabolic process; apoptosis; regulation of protein stability; locomotory behavior; platelet-derived growth factor receptor signaling pathway; negative regulation of cell size; regulation of myeloid cell apoptosis; protein amino acid dephosphorylation; response to estradiol stimulus; negative regulation of cell proliferation; locomotor rhythm; learning and/or memory; synaptogenesis; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; positive regulation of cell proliferation; protein kinase B signaling cascade; brain morphogenesis; nerve-nerve synaptic transmission; angiogenesis; negative regulation of cell migration; response to nutrient; aging; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; cardiac muscle development; cell migration; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; central nervous system neuron axonogenesis; protein stabilization; maternal behavior; negative regulation of focal adhesion formation; response to ATP; memory; cell proliferation; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; phosphoinositide dephosphorylation; innate immune response; regulation of cyclin-dependent protein kinase activity; negative regulation of phosphoinositide 3-kinase cascade
Reference #:  P60484 (UniProtKB)
Alt. Names/Synonyms: 10q23del; BZS; DEC; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTEN; PTEN1; TEP1
Gene Symbols: PTEN
Molecular weight: 47,166 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PTEN

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: S380‑p, T382‑p, T383‑p
cell growth, altered: Y240‑p, Y315‑p
cell motility, altered: S229‑p, T232‑p, S380‑p, T382‑p, T383‑p
transcription, altered: S380‑p, T382‑p, T383‑p
activity, inhibited: T366‑p
enzymatic activity, induced: Y240‑p, Y315‑p
enzymatic activity, inhibited: S370‑p, S380‑p, T382‑p, T383‑p, S385‑p
intracellular localization: K254‑sm, T366‑p, S370‑p
molecular association, regulation: Y155‑p, Y336‑p, T366‑p, S370‑p, T382‑p, T383‑p, T401‑p
protein stabilization: Y68‑p, Y155‑p, Y336‑p, S370‑p, S380‑p, T382‑p, T383‑p, S385‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K6-ac __MTAIIkEIVSRNk
2 0 K13-ub kEIVSRNkRRYQEDG
1 45 Y46-p AERLEGVyRNNIDDV
0 1 K66 SKHKNHYKIyNLCAE
2 1 Y68-p HKNHYKIyNLCAERH
0 1 K80 ERHYDTAKFNCRVAQ
0 1 S113 EDLDQWLSEDDNHVA
1 0 K125-ac HVAAIHCkAGkGRTG
1 0 K128-ac AIHCkAGkGRTGVMI
2 0 Y138-p TGVMICAyLLHRGKF
2 1 Y155-p AQEALDFyGEVRTRD
0 1 K163-ac GEVRTRDkkGVTIPS
0 1 K164-ac EVRTRDkkGVTIPSQ
1 14 Y174-p TIPSQRRyVyyysyL
0 12 Y176-p PSQRRyVyyysyLLK
0 12 Y177-p SQRRyVyyysyLLKN
0 12 Y178-p QRRyVyyysyLLKNH
0 3 S179-p RRyVyyysyLLKNHL
0 3 Y180-p RyVyyysyLLKNHLD
0 1 S227-p LKVKIYSsNsGPtRR
1 2 S229-p VKIYSsNsGPtRRED
1 2 T232-p YSsNsGPtRREDKFM
3 1 Y240-p RREDKFMyFEFPQPL
2 0 K254-sm LPVCGDIkVEFFHKQ
2 0 K266-sm HKQNKMLkKDKMFHF
1 0 K289-sm GPEETSEkVENGsLC
3 0 K289-ub GPEETSEkVENGsLC
0 2 S294-p SEkVENGsLCDQEID
3 1 Y315-p RADNDKEyLVLTLTK
0 1 T319 DKEyLVLTLTKNDLD
0 1 K332-ac LDKANKDkANRyFSP
1 0 Y336-p NKDkANRyFSPNFKV
1 0 S362-p SNPEASSsTSVtPDV
5 2 T366-p ASSsTSVtPDVsDNE
10 3 S370-p TSVtPDVsDNEPDHy
1 1 Y377-p sDNEPDHyRYsDttD
25 0 S380-p EPDHyRYsDttDsDP
14 2 T382-p DHyRYsDttDsDPEN
15 1 T383-p HyRYsDttDsDPENE
9 6 S385-p RYsDttDsDPENEPF
1 0 T398-p PFDEDQHtQItkV__
1 0 T401-p EDQHtQItkV_____
1 0 K402-ac DQHtQItkV______
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9551 : Phospho-PTEN (Ser380) Antibody
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
  mouse

 
K6 __MTAIIKEIVSRNK
K13 KEIVSRNKRRYQEDG
Y46-p AERLEGVyRNNIDDV
K66-ub SKHKNHYkIYNLCAE
Y68 HKNHYkIYNLCAERH
K80-ub ERHYDTAkFNCRVAQ
S113 EDLDQWLSEDDNHVA
K125 HVAAIHCKAGKGRTG
K128 AIHCKAGKGRTGVMI
Y138 TGVMICAYLLHRGKF
Y155 AQEALDFYGEVRTRD
K163 GEVRTRDKKGVTIPS
K164 EVRTRDKKGVTIPSQ
Y174-p TIPSQRRyVyyySYL
Y176-p PSQRRyVyyySYLLK
Y177-p SQRRyVyyySYLLKN
Y178-p QRRyVyyySYLLKNH
S179 RRyVyyySYLLKNHL
Y180 RyVyyySYLLKNHLD
S227 LKVKIYSSNSGPTRR
S229 VKIYSSNSGPTRRED
T232 YSSNSGPTRREDKFM
Y240 RREDKFMYFEFPQPL
K254 LPVCGDIKVEFFHKQ
K266 HKQNKMLKKDKMFHF
K289 GPEETSEKVENGsLC
K289 GPEETSEKVENGsLC
S294-p SEKVENGsLCDQEID
Y315 RADNDKEYLVLTLTK
T319 DKEYLVLTLTKNDLD
K332 LDKANKDKANRYFSP
Y336 NKDKANRYFSPNFKV
S362 SNPEASSSTSVtPDV
T366-p ASSSTSVtPDVsDNE
S370-p TSVtPDVsDNEPDHy
Y377-p sDNEPDHyRYsDttD
S380-p EPDHyRYsDttDsDP
T382-p DHyRYsDttDsDPEN
T383-p HyRYsDttDsDPENE
S385-p RYsDttDsDPENEPF
S398-p PFDEDQHsQItKV__
T401-p EDQHsQItKV_____
K402 DQHsQItKV______
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9551 : Phospho-PTEN (Ser380) Antibody
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
  rat

 
K6 __MTAIIKEIVSRNK
K13 KEIVSRNKRRYQEDG
Y46 AERLEGVYRNNIDDV
K66 SKHKNHYKIYNLCAE
Y68 HKNHYKIYNLCAERH
K80 ERHYDTAKFNCRVAQ
S113-p EDLDQWLsEDDNHVA
K125 HVAAIHCKAGKGRTG
K128 AIHCKAGKGRTGVMI
Y138 TGVMICAYLLHRGKF
Y155 AQEALDFYGEVRTRD
K163 GEVRTRDKKGVTIPS
K164 EVRTRDKKGVTIPSQ
Y174 TIPSQRRYVYYYSYL
Y176 PSQRRYVYYYSYLLK
Y177 SQRRYVYYYSYLLKN
Y178 QRRYVYYYSYLLKNH
S179 RRYVYYYSYLLKNHL
Y180 RYVYYYSYLLKNHLD
S227 LKVKIYSSNSGPTRR
S229 VKIYSSNSGPTRRED
T232 YSSNSGPTRREDKLM
Y240 RREDKLMYFEFPQPL
K254 LPVCGDIKVEFFHKQ
K266 HKQNKMLKKDKMFHF
K289 GPEETSEKVENGSLC
K289 GPEETSEKVENGSLC
S294 SEKVENGSLCDQEID
Y315 RADNDKEYLVLtLTK
T319-p DKEYLVLtLTKNDLD
K332 LDKANKDKANRYFSP
Y336 NKDKANRYFSPNFKV
S362 SNPEASSSTSVTPDV
T366 ASSSTSVTPDVSDNE
S370 TSVTPDVSDNEPDHY
Y377 SDNEPDHYRYsDTTD
S380-p EPDHYRYsDTTDSDP
T382 DHYRYsDTTDSDPEN
T383 HYRYsDTTDSDPENE
S385 RYsDTTDSDPENEPF
S398 PFDEDQHSQITKV__
T401 EDQHSQITKV_____
K402 DQHSQITKV______
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