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PTEN
a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Tumor suppressor; Nuclear receptor co-regulator; Phosphatase, lipid; EC 3.1.3.48; EC 3.1.3.16; EC 3.1.3.67; Carbohydrate Metabolism - inositol phosphate |
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Cellular Component: PML body; neuron projection; internal side of plasma membrane; cell projection; cytoplasm; plasma membrane; nucleus; cytosol
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Molecular Function: phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; magnesium ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity; protein kinase binding; PDZ domain binding; protein binding; enzyme binding; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; lipid binding
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Biological Process: central nervous system development; male mating behavior; prepulse inhibition; nerve growth factor receptor signaling pathway; heart development; regulation of cellular component size; anaphase-promoting complex activation during mitotic cell cycle; Wnt receptor signaling pathway through beta-catenin; T cell receptor signaling pathway; regulation of B cell apoptosis; myelin maintenance in the central nervous system; negative regulation of axonogenesis; rhythmic synaptic transmission; dentate gyrus development; fibroblast growth factor receptor signaling pathway; negative regulation of myelination; social behavior; forebrain morphogenesis; negative regulation of organ growth; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; endothelial cell migration; positive regulation of transcription factor activity; multicellular organismal response to stress; negative regulation of apoptosis; synapse maturation; apoptosis; regulation of protein stability; locomotory behavior; negative regulation of cell size; protein amino acid dephosphorylation; regulation of myeloid cell apoptosis; negative regulation of cell proliferation; locomotor rhythm; learning and/or memory; synaptogenesis; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; positive regulation of cell proliferation; brain morphogenesis; protein kinase B signaling cascade; nerve-nerve synaptic transmission; angiogenesis; negative regulation of cell migration; negative regulation of epithelial cell proliferation; cardiac muscle development; epidermal growth factor receptor signaling pathway; cell migration; phosphoinositide-mediated signaling; negative regulation of protein kinase B signaling cascade; protein stabilization; central nervous system neuron axonogenesis; maternal behavior; negative regulation of focal adhesion formation; cell proliferation; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; induction of apoptosis; phosphoinositide dephosphorylation; regulation of cyclin-dependent protein kinase activity; negative regulation of phosphoinositide 3-kinase cascade
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Reference #:
P60484 (UniProtKB)
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| Alt. Names/Synonyms: 10q23del; BZS; DEC; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTEN; PTEN1; TEP1 |
| Gene Symbols: PTEN |
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Molecular weight: 47,166 Da
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Basal Isoelectric point: 5.94
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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mTOR Signaling
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PI3K/Akt Signaling
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Regulation of Microtubule Dynamics
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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