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Protein Page:
SLC6A8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC6A8 Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: creatine transporter activity; neurotransmitter:sodium symporter activity; creatine:sodium symporter activity; choline transmembrane transporter activity
Biological Process: muscle contraction; transport; neurotransmitter transport; sodium ion transport; choline transport; creatine metabolic process; creatine transport
Reference #:  P48029 (UniProtKB)
Alt. Names/Synonyms: Creatine transporter 1; creatine transporter SLC6A8; CRT; CRTR; CT1; MGC87396; SC6A8; SLC6A8; Sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Solute carrier family 6 member 8
Gene Symbols: SLC6A8
Molecular weight: 70,523 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below

SLC6A8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-ub ____MAKksAENGIy
0 1 S5-p ___MAKksAENGIyS
0 47 Y11-p ksAENGIySVSGDEk
0 1 K18-ac ySVSGDEkkGPLIAP
0 2 K18-ub ySVSGDEkkGPLIAP
0 1 K19-ac SVSGDEkkGPLIAPG
0 1 K19-ub SVSGDEkkGPLIAPG
0 1 K33-ac GPDGAPAkGDGPVGL
0 2 K33-ub GPDGAPAkGDGPVGL
0 4 T42-p DGPVGLGtPGGRLAV
0 2 K217-ub VIEFWENkVLRLSGG
0 2 T617-p DADVRGLttLtPVsE
0 1 T618-p ADVRGLttLtPVsEs
0 8 T620-p VRGLttLtPVsEssk
0 5 S623-p LttLtPVsEsskVVV
0 2 S625-p tLtPVsEsskVVVVE
0 2 S626-p LtPVsEsskVVVVES
0 1 K627-ub tPVsEsskVVVVESV
  mouse

 
K4 ____MAKKSAENGIy
S5 ___MAKKSAENGIyS
Y11-p KSAENGIySVSGDEk
K18 ySVSGDEKKGPLIVS
K18-ub ySVSGDEkKGPLIVS
K19 SVSGDEkKGPLIVSG
K19 SVSGDEkKGPLIVSG
K33 GPDGAPAKGDGPAGL
K33-ub GPDGAPAkGDGPAGL
A42 DGPAGLGAPGGRLAV
K217-ub VIEFWENkVLRLSTG
T622 DADVRGLTTLtPVsE
T623 ADVRGLTTLtPVsES
T625-p VRGLTTLtPVsESSK
S628-p LTTLtPVsESSKVVV
S630 TLtPVsESSKVVVVE
S631 LtPVsESSKVVVVES
K632 tPVsESSKVVVVESV
  rat

 
K4 ____MAKKSAENGIY
S5 ___MAKKSAENGIYS
Y11 KSAENGIYSVSGDEK
K18 YSVSGDEKKGPLIVS
K18 YSVSGDEKKGPLIVS
K19 SVSGDEKKGPLIVSG
K19 SVSGDEKKGPLIVSG
K33 GPDGAPSKGDGPAGL
K33 GPDGAPSKGDGPAGL
A42 DGPAGLGAPSSRLAV
K217 VIEFWENKVLRLSTG
T617 DADVRGLTTLTPVSE
T618 ADVRGLTTLTPVSES
T620 VRGLTTLTPVSESSK
S623 LTTLTPVSESSKVVV
S625 TLTPVSESSKVVVVE
S626 LTPVSESSKVVVVES
K627 TPVSESSKVVVVESV
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